Effectiveness and Safety of Apatinib Plus Programmed Cell Death Protein 1 Blockades for Patients with Treatment-refractory Metastatic Colorectal Cancer: A Retrospective Exploratory Study

Li Shenglong,Zheng Hao,Ge Qinghong,Xia Shuli,Zhang Ke,Wang Chunjing,Wang Fujing 대한암예방학회 2023 Journal of cancer prevention Vol.28 No.3

This study aimed to investigate the efficacy and safety of apatinib plus programmed cell death protein 1 (PD-1) blockades for patients with metastatic colorectal cancer (CRC) who were refractory to the standard regimens. In this retrospective study, patients with metastatic CRC who received apatinib plus PD-1 blockades in clinical practice were included. The initial dosage of apatinib was 250 mg or 500 mg, and PD-1 blockades were comprised of camrelizumab, sintilimab and pembrolizumab. Efficacy and safety data were collected through the hospital’s electronic medical record system. From October 2018 to March 2022, a total of 43 patients with metastatic CRC were evaluated for efficacy and safety. The results showed an objective response rate of 25.6% (95% CI, 13.5%-41.2%) and a disease control rate of 72.1% (95% CI, 56.3%-84.7%). The median progression-free survival (PFS) of the cohort was 5.8 months (95% CI, 3.81-7.79), and the median overall survival (OS) was 10.3 months (95% CI, 5.75-14.85). The most common adverse reactions were fatigue (76.7%), hypertension (72.1%), diarrhea (62.8%), and hand-foot syndrome (51.2%). Multivariate Cox regression analysis revealed that Eastern Cooperative Oncology Group (ECOG) performance status and location of CRC (left or right-side) were independent factors to predict PFS of patients with metastatic CRC treated with the combination regimen. Consequently, the combination of apatinib and PD-1 blockades demonstrated potential efficacy and acceptable safety for patients with treatment-refractory metastatic CRC. This conclusion should be confirmed in prospective clinical trials subsequently

성과주의 보상제도와 조직유효성 간의 관계에서 동기부여의 매개효과

이생룡(Shenglong Li),이승계(Seunggye Lee),이의연(Yiran Li) 한국인적자원개발학회 2017 인적자원개발연구 Vol.20 No.3

근대전환기 신문 연재 국한문체 소설과 국문체 소설의 비교적 고찰 -『一捻紅』과 『혈의 누』를 중심으로

윤성룡 ( Yin Shenglong ) 중국한국(조선)어교육연구학회 2021 한국(조선)어교육연구 Vol.18 No.0

This paper is a comparative study of Hangul-Hanja Mixed Script novels and Hangul-only Script novels published in the news during the transition period of modern era. In order to figure out the formation process of modern Korean novel, we need to examine Hangul-Hanja Mixed Script novels and Hangul-only Script novels together. By analyzing several news serial novels published in 1906, such as Ilnyum Hong (A Beautiful Red Flower) and Hyeorui nu (Tears of Blood), this paper draws the following conclusions. First, both the Hangul-Hanja Mixed Script novels and Hangul-only Script novels of the modern transition period made the novels to proceed in the present by actively reflecting the modern time. This was in response to the urgent practical needs of the time, promoting ideas such as the improvement of customs and the enlightenment of civilization. However, when confronted with the problem of the novel's open ending, the Hangul-Hanja Mixed Script novels choose to keep the structure intact, while Hangulonly Script novels leave the ending for the next volume. Second, the Hangul-Hanja Mixed Script novels and Hangul-only Script novels try to construct a modern spacetime, actively setting up secondary characters in the novel to bring the protagonist into this time and space. In this process, the author is woven into the modern order as well, which creates a tension between the author and the novel. Third, the author is aware of the protagonist's perspective and tries to present it in the novel. However, since the ubiquity of the author's involvement in the novel, the author's authority is thus dismantled. In general, the above phenomenon reflects the limitations of authors and readers, but itself is also a process in the formation of modern Korean novel.

Analysis and Prevention of the Realistic Threats of Bioterrorism

Li Heng(Heng Li),Zhou Shenglong(Shenglong Zhou),Hu Shuangqing(Shuangqing Hu) 아시아사회과학학회 2022 International Science Research Vol.2 No.3

At present, the abuse of biotechnology achievements is gradually escalating, and it has become the most urgent emerging biological threat source. The biosafety risks in laboratories are constantly escalating, and the procurement, transportation, transfer and research of virus samples often violate operational norms, posing a serious threat to public safety. From the perspective of the environment faced by China, the situation of anti-bioterrorism threat is not optimistic. There are still obvious shortcomings in internal risk control such as pathogenic microorganism laboratory safety. External risks such as biological virus transmission, biological weapon development, bioterrorism attack and biotechnology abuse continue to intensify, and new risk factors such as loss of biological genetic resources are making waves. All countries in the world should join hands to deal with the threat of bioterrorism.

Diversity-Guided Dynamic Step Firefly Algorithm

Shuhao Yu,Shenglong Zhu,Renjin Liu,Xiancun Zhou 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.8

Firefly Algorithm is a nature-inspired optimization method, which has been shown to implement well on numerous optimization problems. But it can easily fall into the local optima and low precision. Therefore, it is very important to overcome these defects. In this paper, we use a dynamic strategy for step setting, which takes into account the population diversity of fireflies. The experiments show that the proposed algorithm improves the performance of original firefly algorithm.

An Improved Firefly Algorithm Based on Nonlinear Time-varying Step-size

Shuhao Yu,Shenglong Zhu,Xiancun Zhou 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.7

Firefly algorithm (FA) is a novel population-based stochastic optimization algorithm and has been shown to yield good performance for solving varieties of optimization problems. Meanwhile, it sustains premature convergence because it is easily to fall into the local optima which may generate a low accuracy of solution or even fail. To overcome this defect, a nonlinear time-varying step strategy for firefly algorithm (NTSFA) is presented. It uses a nonlinear decreasing and time-varying step-size for fireflies to better balance the algorithm’s ability of exploration and exploitation. Numerical simulation on 20 test benchmark functions display that the proposed algorithm can increase the accuracy of the original FA. Finally, we apply NTSFA to integrate into k-means clustering for mouse dataset. The results show that NTSFA is an effective optimization algorithm.

The Effect of HPMC and CNC on the Structure and Properties of Alginate Fibers

Meiyu Ci,Jie Liu,Shenglong Shang,Zhiming Jiang,Ping Zhu,Shuying Sui 한국섬유공학회 2020 Fibers and polymers Vol.21 No.10

Bio-composite alginate fibers with binary and ternary blends were prepared by using cellulose nanocrystal (CNC)and hydroxypropyl methylcellulose (HPMC) as composite fillers through wet-spinning method. Structural, thermal,mechanical properties and surface morphology of fibers were characterized by Fourier transform infrared spectroscopy (FTIR),X-ray diffraction (XRD), Thermogravimetric Analysis (TGA), Mechanical strength testing, Scanning ElectronMicroscopy (SEM). The thermal stability and mechanical performance of SA/HPMC and SA/HPMC/CNC composite fibersimproved as the increasing of crystallinity and intermolecular H-bonding interaction of the fibers. HPMC is helpful toimprove the extensibility and stiffness of alginate fibers, and CNC can further enhance the stiffness of SA/HPMC compositefibers. The tensile strength, elongation at break, the initial modulus and work at break of SA/HPMC/CNC composite fiberswere superior to those of alginate fibers. Roughness of surface and tensile section of SA/HPMC and SA/HPMC/CNCcomposite fibers got increased. Water absorbency and salt resistance were significantly improved.

Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner

Ziyu Song,Meng Jin,Shenglong Wang,Yanzuo Wu,Qi Huang,Wangda Xu,Yongsheng Fan,Fengyuan Tian The Korean Society of Ginseng 2024 Journal of Ginseng Research Vol.48 No.2

Background: Deposition of immune complexes drives podocyte injury acting in the initial phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly, targeting B cell subsets represents a potential therapeutic approach for LN. Ginsenoside compound K (CK), a bioavailable component of ginseng, possesses nephritis benefits in lupus-prone mice; however, the underlying mechanisms involving B cell subpopulations remain elusive. Methods: Female MRL/lpr mice were administered CK (40 mg/kg) intragastrically for 10 weeks, followed by measurements of anti-dsDNA antibodies, inflammatory chemokines, and metabolite profiles on renal samples. Podocyte function and ultrastructure were detected. Publicly available single-cell RNA sequencing data and flow cytometry analysis were employed to investigate B cell subpopulations. Metabolomics analysis was adopted. SIRT1 and AMPK expression were analyzed by immunoblotting and immunofluorescence assays. Results: CK reduced proteinuria and protected podocyte ultrastructure in MRL/lpr mice by suppressing circulating anti-dsDNA antibodies and mitigating systemic inflammation. It activated B cell-specific SIRT1 and AMPK with Rhamnose accumulation, hindering the conversion of renal B cells into plasma cells. This cascade facilitated the resolution of local renal inflammation. CK facilitated the clearance of deposited immune complexes, thus reinstating podocyte morphology and mobility by normalizing the expression of nephrin and SYNPO. Conclusions: Our study reveals the synergistic interplay between SIRT1 and AMPK, orchestrating the restoration of renal B cell subsets. This process effectively mitigates immune complex deposition and preserves podocyte function. Accordingly, CK emerges as a promising therapeutic agent, potentially alleviating the hyperactivity of renal B cell subsets during LN.

Low Temperature Cure Film Adhesive

Liang, Bin,Zhao, Shenglong The Society of Adhesion and Interface 2004 접착 및 계면 Vol.5 No.2

A novel carboxyl terminated butadiene-acrylonitrile (CTBN) modified, low temperature cure epoxy film adhesive was developed in this paper. It can be cured at as low as $75^{\circ}C$ for 4 hours with a pressure of 0.1MPa. After post cure at $120^{\circ}C$ for 2 hours, the bonding strengths of Phosphoric Acid Anodizing(PAA) surface treated aluminum adherend were similar to those of structural film adhesives curing at $120^{\circ}C$. It is suitable to bond both metal/composite laminate-to-laminate and laminate to honeycomb structure.

Verification of neutronics and thermal-hydraulic coupled system with pin-by-pin calculation for PWR core

Li Zhigang,Pan Junjie,Xia Bangyang,Qiang Shenglong,Lu Wei,Li Qing 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9

As an important part of the digital reactor, the pin-by-pin wise fine coupling calculation is a research hotspot in the field of nuclear engineering in recent years. It provides more precise and realistic simulation results for reactor design, operation and safety evaluation. CORCA-K a nodal code is redeveloped as a robust pin-by-pin wise neutronics and thermal-hydraulic coupled calculation code for pressurized water reactor (PWR) core. The nodal green's function method (NGFM) is used to solve the threedimensional space-time neutron dynamics equation, and the single-phase single channel model and one-dimensional heat conduction model are used to solve the fluid field and fuel temperature field. The mesh scale of reactor core simulation is raised from the nodal-wise to the pin-wise. It is verified by two benchmarks: NEACRP 3D PWR and PWR MOX/UO2. The results show that: 1) the pin-by-pin wise coupling calculation system has good accuracy and can accurately simulate the key parameters in steadystate and transient coupling conditions, which is in good agreement with the reference results; 2) Compared with the nodal-wise coupling calculation, the pin-by-pin wise coupling calculation improves the fuel peak temperature, the range of power distribution is expanded, and the lower limit is reduced more