http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sheng-Huei Yang,Ching-Ming Chien,Mei-Chin Lu,Yi-Hsiung Lin,Xiu-Wei Hu,Shinne-Ren Lin 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.4
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis was confirmed by DNA fragmentation (DNA ladder, sub-G1 for-mation) and phosphatidylserine (PS) externalization with an IC50 value of 1.7 g/ml at 48 h. A mechanistic analysis demonstrated that CTX III-induced apop-totic cell death was accompanied by up-regulation of both Bax and endonuclease G (Endo G), and downregulation of Bcl-XL. CTX III had no effect on the levels of Bcl-2, Bid, XIAP survivin, and AIF proteins. CTX III treatment caused loss of the mitochondrial membrane potential (Ψm), release of mitochon-drial cytochrome c to the cytosol, and activation of both caspase-9 and -3. CTX III-induced apoptosis was significantly blocked by the broad-spectrum cas-pase inhibitor Z-VAD-FMK. However, CTX III did not generate reactive oxygen species (ROS) and talase, did not block CTX III-induced apoptosis in K562 cells. Modulation of Bax, Bcl-XL, and the Endo G proteins, release of mitochondrial cytochome c, and activation of caspase-3 and -9 all are involved in the CTX III-triggered apoptotic process in human leukemia K562 cells.
SMA OBSERVATIONS OF THE HOT CORES OF DR21(OH)
Minh, Young Chol,Chen, Huei-Ru,Su, Yu-Nung,Liu, Sheng-Yuan The Korean Astronomical Society 2012 Journal of The Korean Astronomical Society Vol.45 No.6
Using the Submillimeter Array (SMA), we identified two bright hot subcores, MM1a and MM1b (size ~ 1" and mass ~ 0.5 $M_{\odot}$) separated by about 1.600, in the 230 GHz continuum emission toward the massive star-forming region DR21(OH). Both display typical hot core characteristics but have slightly different chemical properties. For example, highly saturated species show stronger emission toward MM1a and seem to be evaporating directly from the grain mantles. In contrast, simple sulfur-bearing species have brighter emission at MM1b. These features indicate that MM1a is at an earlier stage than MM1b, and the small-scale chemical differences between these two cores may result from the age difference of the order of $10^4$ years.
Yung-Chung Chen,Yu-Yang Su,Sheng-Huei Hsiao 한국섬유공학회 2019 Fibers and polymers Vol.20 No.9
A series of fluorinated poly(ether imide)s (PEIs) were prepared from asymmetry, bulky featured of 1,2-bis(3,4-dicarboxyphenoxy)-4-tert-butylbenzene dianhydride and various trifluoromethyl-based bis(ether amine)s via conventionalthermal (H) or chemical (C) imidization. All fluorinated PEIs exhibited flexible, good mechanical properties and excellentsolubility in a variety of organic solvents. In addition, the chemical imidization based PEI thin films showed cut-offwavelengths of UV-vis absorptions below 380 nm with very low yellowness index (b* < 5.5). They also exhibited highthermal stability with the 10 % weight loss temperature from 486 to 550 oC of in nitrogen or air atmosphere. Compared withthe corresponding PEIs based on non-fluorinated bis(ether amine)s, fluorinated PEIs not only showed higher opticaltransparency, lower dielectric constants and water absorptions but also maintained thermal and mechanical properties.
( Cheng-en Hsieh ),( Yuh-ming Hwu ),( Sheng-hsiang Li ),( Chung-hao Lu ),( Ming-huei Lin ),( Robert Kuo-kuang Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
Objective: To investigate the effect of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) on revascularization, survival, and oocyte quality of cryopreserved, subcutaneously transplanted mouse ovarian tissue. Methods: Outbred ICR mice (n = 112) were used as the animal model. Vitrified mouse ovarian tissues were treated without (control group) or with VEGF and FGF2 before autologous subcutaneous transplantation. After transplantation for 2 or 3 weeks, grafts’ survival, angiogenesis, and oocyte quality were examined. Results: VEGF and FGF2 promoted revascularization and significantly increased the survival rate of subcutaneously transplanted cryopreserved ovarian tissues compared with the untreated grafted control. The two growth factors did not show long-term effects on the ovarian grafts. In contrast to the untreated ovarian grafts, active folliculogenesis was revealed as the number of various follicles was significantly higher or had an increased trend in the VEGF and FGF2-treated ones. Though the fertilization rate had no differences between VEGF/FGF2 and control group; however, the oocyte quality was much better in the VEGF/FGF2-treated grafts as demonstrated by the higher ratio of blastocyst development. Conclusions: Introducing of angiogenic factors such as VEGF and FGF2 may be a promising strategy to improve revascularization, survival, and oocyte quality of cryopreserved, subcutaneously transplanted mouse ovarian tissue.
Liang, Chi-Te,Lin, Li-Hung,Kuang Yoa, Chen,Lo, Shun-Tsung,Wang, Yi-Ting,Lou, Dong-Sheng,Kim, Gil-Ho,Yuan-Huei, Chang,Ochiai, Yuichi,Aoki, Nobuyuki,Chen, Jeng-Chung,Lin, Yiping,Chun-Feng, Huang,Lin, Sh Springer 2011 Nanoscale research letters Vol.6 No.1
<P>A direct insulator-quantum Hall (I-QH) transition corresponds to a crossover/transition from the insulating regime to a high Landau level filling factor ν > 2 QH state. Such a transition has been attracting a great deal of both experimental and theoretical interests. In this study, we present three different two-dimensional electron systems (2DESs) which are in the vicinity of nanoscaled scatterers. All these three devices exhibit a direct I-QH transition, and the transport properties under different nanaoscaled scatterers are discussed.</P>
Po-Han Lin,Yun-Wen Tien,Wen-Fang Cheng,Ying-Cheng Chiang,Chien-Huei Wu,Karen Yang,Chiun-Sheng Huang 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.5
Objective: Genetic high-risk assessment combines hereditary breast, ovarian and pancreatic cancer into one syndrome. However, there is a lack of data for comparing the germline mutational spectrum of the cancer predisposing genes between these three cancers. Methods: Patients who met the criteria of the hereditary breast, ovarian and pancreatic cancer were enrolled and received multi-gene sequencing. Results: We enrolled 730 probands: 418 developed breast cancer, 185 had ovarian cancer, and 145 had pancreatic cancer. Out of the 18 patients who had two types of cancer, 16 had breast and ovarian cancer and 2 had breast and pancreatic cancer. A total of 167 (22.9%) patients had 170 mutations. Mutation frequency in breast, ovarian and pancreatic cancer was 22.3%, 33.5% and 17.2%, respectively. The mutation rate was significantly higher in patients with double cancers than those with a single cancer (p<0.001). BRCA1 and BRCA2 were the most dominant genes associated with hereditary breast and ovarian cancer, whereas ATM was the most prevalent gene related to hereditary pancreatic cancer. Genes of hereditary colon cancer such as lynch syndrome were presented in a part of patients with pancreatic or ovarian cancer but seldom in those with breast cancer. Families with a history of both ovarian and breast cancer were associated with a higher mutation rate than those with other histories. Conclusion: The mutation spectrum varies across the three cancer types and family histories. Our analysis provides guidance for physicians, counsellors, and counselees on the offer and uptake of genetic counseling.