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      • KCI등재후보SCOPUS

        Effect of Substitutional Doping on Temperature Dependent Electrical Parameters of Amorphous Se-Te Semiconductors

        Neha,Sharma,Sunanda,Sharda,Dheeraj,Sharma,Vineet,Sharma,P.,B.,Barman,S.C.,Katyal,Pankaj,Sharma,S.,K.,Hazra 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.5

        Steady state current-voltage characteristics of the amorphous (Se80Te20)98Y2 (Y = Ag, Bi, Ge, Cd) semiconductors at different temperatures are reported. The measurements were performed using direct-current voltage bias to understand the basic conductivity mechanism and to evaluate the impact of each substituent on electrical response. The space charge limited conduction mechanism, and the density of states near Fermi level have been calculated. The difference in electrical response due to different substitutions in the glassy matrix is analyzed.

      • SCIESCOPUSKCI등재

        Experimental investigation of effective atomic numbers for some binary alloys

        Sharma,,Renu,Sharma,,J.K.,Kaur,,Taranjot,Singh,,Tejbir,Sharma,,Jeewan,Singh,,Parjit,S. Korean Nuclear Society 2017 Nuclear Engineering and Technology Vol.49 No.7

        In the present work, the gamma ray backscattering technique was used to determine the effective atomic numbers for certain binary alloys. With the help of a muffle furnace, the binary alloys were synthesized using the melt quenching technique with different compositions of $_{82}Pb$, $_{50}Sn$, and $_{30}Zn$. The intensity distribution of backscattered photons from radioactive isotope $^{22}Na$ (511 keV) was recorded with the help of GAMMARAD5 [$76mm{\times}76mm$ NaI(Tl) scintillator detector] and analyzed as a function of both atomic number and thickness of the target material. The effective atomic numbers for the same binary alloys were also computed theoretically using the atomic to electronic cross-section method with the help of the mass attenuation coefficient database of WinXCom (2001). Good agreement was observed between theoretical and experimental results for the effective atomic numbers of all the selected alloys.

      • Triple Negative Breast Cancer in People of North East India: Critical Insights Gained at a Regional Cancer Centre

        Sharma,,Mousumi,Sharma,,Jagannath,Dev,Sarma,,Anupam,Ahmed,,Shiraj,Kataki,,Amal,Chandra,Saxena,,Rahul,Sharma,,Dilutpal Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

        Background: Breast cancer is a heterogeneous disease comprising of distinct biological subtypes with many targeted prognostic biomarkers having therapeutic implications. However, no specific targeted therapy for triple negative breast cancer has been discovered to date and hence further research is needed. Aim: The aim and objectives of the present study were to examine the prevalence of triple negative breast cancer (TNBC) in North-East India and to compare the clinicopathological parameters in two study groups defined by immunohistochemistry (IHC) - "TNBC" and "Others". Materials and Methods: We carried out a retrospective study in a cohort of 972 patients diagnosed with invasive breast carcinoma in the Department of Pathology, Dr. B. Borooah Cancer Institute, a Regional Cancer Centre for treatment and research, Guwahati, for a period of 3 years and 10 months from January 2010 to October 2013. Based on IHC findings, patients were divided into two groups - "TNBC" and "Others". All relevant clinicopathological parameters were compared in both. TNBC were defined as those that were estrogen receptor (ER), progesterone receptor (PR), and HER2/neu negative while those positive for any of these markers were defined as "Others". Results: In this study, out of total 972 cases 31.9% (310 cases) were defined as TNBC and 662 cases (68.1%) as "Others" based on IHC markers. Compared to the "Others" category, TNBC presented at an early age (mean 40 years), were associated with high grade large tumours and high rate of node positivity, IDC NOS being the most common histological subtype in TNBC. Conclusions: TNBC accounts for a significant portion of breast cancers in this part of India and commonly present at younger age and tend to be large high grade tumours.

      • Data Protection in Clouds using Two Stage Encryption

        Pallav,Sharma,Varsha,Sharma,Sanjeev,Sharma,Jitendra,Agrawal 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.4

        Cloud Computing has been an emergent technology that has opened the space for virtualization, as it provides many computational services and storage services over the Internet with the help of a browser. Cloud computing's core comprises of services like platform, infrastructure and software as a service. The unpredicted boom in cloud computing is driven by its simple economic benefit. It helps in reducing capital expenses and minimizes operating expenses. This move however, has increased a major concern about the protection of data, as against the traditional system the data is now stored online and is far easily exposed than we realize. This raises a major security issue for data protection. Many techniques for protection of data have been proposed so far. However, the best available option till date is to encrypt user data before storing it over the cloud environment and decrypting it again before handing the data back to the cloud user. In this paper, we introduce a more efficient and stronger encryption process that allows a cloud service provider to protect user data more efficiently.

      • KCI등재SCOPUS

        Effect of Te on Linear and Non-linear Optical Properties of New Quaternary Ge-Se-Sb-Te Chalcogenide Glasses

        Neha,Sharma,Sunanda,Sharda,S.C.,Katyal,Vineet,Sharma,Pankaj,Sharma 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.1

        We report linear and non-linear optical properties of a new quaternary chalcogenide glass series Ge19-ySe63.8Sb17.2Tey (y = 0, 2, 4, 6, 8, 10). In linear optical properties; refractive index, extinction coefficient and the Tauc gap are reported and their variation with Te content has been discussed. In non-linear properties; third order nonlinear susceptibility and non-linear refractive index has been discussed. The variation of non-linear refractive index has also been reported with normalized photon energy. A correlation between the Tauc gap and nonlinear refractive index has been discussed. Results indicate that these materials may find applications in modern optical devices.

      • Effect of Fading on Performance of VANET in Realistic Scenarios Using NCTUns6.0

        Richa,Sharma,Jyoteesh,Malhotra,Komal,Sharma 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.1

        Road safety and increasing transport efficiency are the important goals for intelligent transport system (ITS). Vehicular Ad hoc Network is such a network which can help to achieve these goals. VANET routing is a crucial task for reliable communication among vehicles. The impact of fading on network throughput and packet drop is explored in this paper. Interesting results show the performance evaluation of without fading environment and Rayleigh fading in different scenarios. NCTUns 6.0 (National Chiao Tung University Network Simulator) is used to justify our results that is a GUI based open source platform for vehicular Ad-Hoc network. Various performance issues are also surveyed with the help of this simulator.

      • KCI등재후보SCOPUS

        Non-destructive evaluation of steel and GFRP reinforced beams using AE and DIC techniques

        Gaurav,Sharma,Shruti,Sharma,Sandeep,K.,Sharma 국제구조공학회 2021 Structural Engineering and Mechanics, An Int'l Jou Vol.77 No.5

        The paper presents an investigation of the widely varying mechanical performance and behaviour of steel and Glass Fibre Reinforced Polymer (GFRP) reinforced concrete beams using non-destructive techniques of Acoustic Emission (AE) and Digital Image Correlation (DIC) under four-point bending. Laboratory experiments are performed on both differently reinforced concrete beams with 0.33%, 0.52% and 1.11% of tension reinforcement against balanced section. The results show that the ultimate load-carrying capacity increases with an increase in tensile reinforcement in both cases. In addition to that, AE waveform parameters of amplitude and number of AE hits successfully correlates and picks up the divergent mechanism of cracking initiation and progression of failure in steel reinforced and GFRP reinforced concrete beams. AE activity is about 20- 30% more in GFRP-RC beams as compared to steel-RC beams. It was primarily due to the lower modulus of elasticity of GFRP bars leading to much larger ductility and deflections as compared to steel-RC beams. Furthermore, AE XY event plots and longitudinal strain profiles using DIC gives an online and real-time visual display of progressive AE activity and strains respectively to efficaciously depict the crack evolution and their advancement in steel-RC and GFRP-RC beams which show a close matching with the micro-and macro-cracks visually observed in the actual beams at various stages of loading.

      • KCI등재SCOPUS

        Experimental investigation of effective atomic numbers for some binary alloys

        Renu,Sharma,J.K.,Sharma,Taranjot,Kaur,Tejbir,Singh,Jeewan,Sharma,Parjit,S.,Singh 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.7

        In the present work, the gamma ray backscattering technique was used to determine the effective atomic numbers for certain binary alloys. With the help of a muffle furnace, the binary alloys were synthesized using the melt quenching technique with different compositions of 82Pb, 50Sn, and 30Zn. The intensity distribution of backscattered photons from radioactive isotope 22Na (511 keV) was recorded with the help of GAMMARAD5 [76 mm × 76 mm NaI(Tl) scintillator detector] and analyzed as a function of both atomic number and thickness of the target material. The effective atomic numbers for the same binary alloys were also computed theoretically using the atomic to electronic cross-section method with the help of the mass attenuation coefficient database of WinXCom (2001). Good agreement was observed between theoretical and experimental results for the effective atomic numbers of all the selected alloys.

      • SCOPUSKCI등재

        Importance of Imidazolidinone Motif in 4-Phenyl-N-arylsulfonylimidazolidinone for their Anticancer Activity

        Sharma,,Vinay,K.,Lee,,Ki-Cheul,Joo,,Cheon-Ik,Sharma,,Niti,Jung,,Sang-Hun Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.suppl8

        To investigate the possible isosteric replacement of imidazolidinone moiety in 4-phenyl-N-arylsulfonylimidazolidinone for broad and potent anticancer agents, a series of 4-phenyl-l(N)-arylsulfonylimidazolidinones 6a-k, imidazolidinethione analogs 7a-i, and imidazolidine oxime analogs 8a-c were prepared and evaluated for their in vitro anticancer activity against four human cancer cell lines (human lung A549, human colon COLO205, human leukemia K562, human ovary SK-OV-3). Among all the derivatives of N-arylsulfonylimidazolidinone 6a-k, compounds 6f and 6g showed the best inhibition comparable to doxorubicin against all cancer cell lines. Increasing the carbon chain on alkyl moieties of carbamates as shown in 6c-g did not alter the activity. The imidazolidinethione analogs 7a-i and imidazolidin-2-one oxime derivatives 8a-c did not possess any good activity. Therefore, imidazolidinone moiety is the best pharmacophore among the 4-phenyl-Narylsulfonylimidazolidinone derivatives.

      • Glutathione S-transferase M1 and T1 Polymorphisms, Cigarette Smoking and HPV Infection in Precancerous and Cancerous Lesions of the Uterine Cervix

        Sharma,,Anita,Gupta,,Sanjay,Sodhani,,Pushpa,Singh,,Veena,Sehgal,,Ashok,Sardana,,Sarita,Mehrotra,,Ravi,Sharma,,Joginder,Kumar Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

        Glutathione S-transferases (GSTs) play an important role in detoxification of carcinogenic electrophiles. The null genotypes in GSTM1 and GSTT1 have been implicated in carcinogenesis. Present study was planned to evaluate the influence of genetic polymorphisms of GSTM1 and GSTT1 gene loci in cervical carcinogenesis. The study was conducted in Lok Nayak hospital, New Delhi. DNA from clinical scrapes of 482 women with minor gynaecologic complaints attending Gynaecology OPD and tumor biopsies of 135 cervical cancer cases attending the cancer clinic was extracted. HPV DNA was detected by standard polymerase chain reaction (PCR) using L1 consensus primer pair. Polymorphisms of GSTM1 and GSTT1 were analysed by multiplex PCR procedures. Differences in proportions were tested using Pearson's Chi-square test with Odds ratio (OR) and 95% confidence interval (CI). The risk of cervical cancer was almost three times in women with GSTM1 homozygous null genotype (OR-2.62, 95%CI, 1.77-3.88; p<0.0001). No association of GSTM1 or GSTT1 homozygous null genotypes was observed in women with normal, precancerous and cervical cancerous lesions among ${\leq}35$ or >35 years of age groups. Smokers with null GSTT1 genotype had a higher risk of cervical cancer as compared to non-smokers (OR-3.01, 95% CI, 1.10-8.23; p=0.03). The results further showed that a significant increased risk of cervical cancer was observed in HPV positive smoker women with GSTT1 (OR-4.36, 95% CI, 1.27-15.03; p=0.02) and GSTM1T1 (OR-3.87, 95% CI, 1.05-14.23; p=0.04) homozygous null genotypes as compared to HPV positive non smokers. The results demonstrate that the GST null genotypes were alone not associated with the development of cervical cancer, but interacted with smoking and HPV to exert effects in our Delhi population.

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