http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Zhongde Shan,Shaoyan Qin,Qian Liu,Feng Liu 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.
Based on analysis of the current situation in the mechanical equipment industry, this paper introduces manufacturing technologies and equipment for sustainable development in the mechanical equipment industry. This paper will consider 8aspects: digital technology, new material, near-net shape forming technology, clean production, short production process technology, waste-free manufacturing technology, automatic control technology, and remanufacturing and reusing technology. It is also important to consider, that as a powerful manufacturing country, we should develop technology and equipment in such a way that protects resources and promotes sustained environmental development. This way, we are able to provide technical support while building a resource-conserving and environment-friendly society.
Jianmin Gu,Baipeng Yin,Shaoyan Fu,Cuihong Jin,Xin Liu,Zhenpan Bian,Jianjun Li,Lu Wang,Xiaoyu Li 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.2
Due to the intense influence of the shape and size of the photon building blocks on the limitation and guidance of opticalwaves, an important strategy is the fabrication of different structures. Herein, organic semiconductor tris-(8-hydroxyquinoline)aluminium (Alq3) nanostructures with controllable morphology, ranging from one-dimensional nanowires to twodimensionalplates, have been prepared through altering intermolecular interactions with employing the anti-solvent diffusioncooperate with solvent-volatilization induced self-assembly method. The morphologies of the formed nanostructures, whichare closely related to the stacking modes of the molecules, can be exactly controlled by altering the polarity of anti-solventsthat can influence various intermolecular interactions. The synthesis strategy reported here can potentially be extended toother functional organic nanomaterials.
Do-Yeon Cho,Daniel Skinner,Shaoyan Zhang,Ahmed Lazrak,Dong Jin Lim,Christopher G. Weeks,Catherine G. Banks,Chang Kyun Han,Si-Kwan Kim,Guillermo J. Tearney,Sadis Matalon,Steven M. Rowe,Bradford A.Woodw 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.1
Background: Abnormal chloride (Cl⁻) transport has a detrimental impact on mucociliary clearance in both cystic fibrosis (CF) and non-CF chronic rhinosinusitis. Ginseng is a medicinal plant noted to have anti-inflammatory and antimicrobial properties. The present study aims to assess the capability of red ginseng aqueous extract (RGAE) to promote transepithelial Cl⁻ secretion in nasal epithelium. Methods: Primary murine nasal septal epithelial (MNSE) [wild-type (WT) and transgenic CFTR<SUP>-/-</SUP>], fisher-rat-thyroid (FRT) cells expressing human WT CFTR, and TMEM16A-expressing human embryonic kidney cultures were utilized for the present experiments. Ciliary beat frequency (CBF) and airway surface liquid (ASL) depth measurements were performed using microeoptical coherence tomography (mOCT). Mechanisms underlying transepithelial Cl⁻ transport were determined using pharmacologic manipulation in Ussing chambers and whole-cell patch clamp analysis. Results: RGAE (at 30㎍/mL of ginsenosides) significantly increased Cl⁻ transport [measured as change in short-circuit current (ΔISC = ㎂/㎠)] when compared with control in WT and CFTR<SUP>-/-</SUP> MNSE (WT vs control = 49.8±2.6 vs 0.1 +/- 0.2, CFTR<SUP>-/-</SUP> = 33.5±1.5 vs 0.2±0.3, p < 0.0001). In FRT cells, the CFTR-mediated ΔISC attributed to RGAE was small (6.8 ± 2.5 vs control, 0.03 ± 0.01, p < 0.05). In patch clamp, TMEM16A-mediated currents were markedly improved with co-administration of RGAE and uridine 5-triphosphate (8406.3 +/- 807.7 pA) over uridine 5-triphosphate (3524.1 +/- 292.4 pA) or RGAE alone (465.2 +/- 90.7 pA) (p < 0.0001). ASL and CBF were significantly greater with RGAE (6.2 +/- 0.3 ㎛ vs control, 3.9 +/- 0.09 ㎛; 10.4+/-0.3 ㎐ vs control, 7.3 ± 0.2 ㎐; p < 0.0001) in MNSE. Conclusion: RGAE augments ASL depth and CBF by stimulating Cl⁻ secretion through CaCC, which suggests therapeutic potential in both CF and non-CF chronic rhinosinusitis.
Yunfei Chen,Qian Shen,Yueyue Wang,Tao Wang,Shaoyan Wu,Ling Zhang,Xu Lu,Fangyuan Zhang,Weimin Jiang,Bo Qiu,Erdi Gao,Xiaofen Sun,Kexuan Tang 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.3
Artemisinin is an endoperoxide sesquiterpenelactone isolated from the aerial parts of Artemisia annua L.,and is presently the most potent anti-malarial drug. Owingto the low yield of artemisinin from A. annua as well as thewidespread application of artemisinin-based combinationtherapy recommended by the World Health Organization,the global demand for artemisinin is substantially increasingand is therefore rendering artemisinin in short supply. An economical way to increase artemisinin production is toincrease the content of artemisinin in A. annua. In thisstudy, three key genes in the artemisinin biosynthesispathway, encoding farnesyl diphosphate synthase, amorpha-4, 11-diene C-12 oxidase and its redox partner cytochromeP450 reductase, were over-expressed in A. annuathrough Agrobacterium-mediated transformation. Thetransgenic lines were confirmed by Southern blotting andthe over-expressions of the genes were demonstrated byreal-time PCR assays. The HPLC analysis showed that theartemisinin contents in transgenic lines were increasedsignificantly, with the highest one found to be 3.6-foldhigher (2.9 mg/g FW) than that of the control. Theseresults demonstrate that multigene engineering is aneffective way to enhance artemisinin content in A. annua.
He, Shan,Ning, Yan,Ma, Fei,Liu, Dayan,Jiang, Shaoyan,Deng, Shaojie The Korean Society for Microbiology and Biotechnol 2022 Journal of microbiology and biotechnology Vol.32 No.6
As a vital problem in reproductive health, recurrent spontaneous abortion (RSA) affects about 1% of women. We performed this study with an aim to explore the molecular mechanism of interleukin-23 (IL-23) and find optimal or effective methods to improve RSA. First, ELISA was applied to evaluate the expressions of IL-23 and its receptor in HTR-8/SVneo cells after IL-23 treatment. CCK-8, TUNEL, wound healing and transwell assays were employed to assess the proliferation, apoptosis, migration and invasion of HTR-8/SVneo cells, respectively. Additionally, the expressions of apoptosis-, migration-, epithelial-mesenchymal transition- (EMT-) and p38 MAPK signaling pathway-related proteins were measured by western blotting. To further investigate the relationship between IL-23 and p38 MAPK signaling pathway, HTR-8/SVneo cells were treated for 1 h with p38 MAPK inhibitor SB239063, followed by a series of cellular experiments on proliferation, apoptosis, migration and invasion, as aforementioned. The results showed that IL-23 and its receptors were greatly elevated in IL-23-treated HTR-8/SVneo cells. Additionally, IL-23 demonstrated suppressive effects on the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells. More importantly, the molecular mechanism of IL-23 was revealed in this study; that is to say, IL-23 inhibited the proliferation, apoptosis, migration, invasion and EMT of IL-23-treated HTR-8/SVneo cells via activating p38 MAPK signaling pathway. In conclusion, IL-23 inhibits trophoblast proliferation, migration, and EMT via activating p38 MAPK signaling pathway, suggesting that IL-23 might be a novel target for the improvement of RSA.
Li Wenlong,Wang Lianshan,Chai Ruohao,Wen Ling,Lu Haixia,Wang Huanhua,Yang Shaoyan,Sun Wenhong 한국물리학회 2022 Current Applied Physics Vol.39 No.-
Semipolar (1122) GaN epitaxial films were grown on m-plane sapphire substrates by metal-organic chemical vapor deposition and additional high-temperature nitridation was introduced during the growth. The growth mechanism, surface microtopography, and the full width at half maximum (FWHM) of X-ray rocking curves (XRCs) of on-axis and off-axis (1122) GaN planes were investigated. The results demonstrate that additional high-temperature nitridation process could reduce surface roughness and anisotropy, and suppress the other orientations, and partially improve the crystalline quality of (1122) GaN epitaxial films. The XRCs FWHM of the off-axis (1122) GaN planes decrease and show a different varying tendency after additional high-temperature nitridation process associated with the partial dislocations and basal plane stacking faults (BSFs). The results of the modified Williamson-Hall (W–H) analysis and photoluminescence spectrum show the BSFs increased while the partial dislocations decreased after an additional high-temperature nitridation process. The improvement of crystalline quality was mainly correlated to the reduction of partial dislocations.