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Shao, Shuai,Cai, Jun,Du, Xin,Wang, ChangGao,Lin, JianGuo,Dai, Jun 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.6
Aflatoxin contamination of food and grain poses a serious economic and health problem globally. Aflatoxin $B_1$ ($AFB_1$) is extremely mutagenic and toxic as well as a potent carcinogen to both humans and livestock. In this study, the degradation of $AFB_1$ by extracellular extract of Cladosporium uredinicola was examined using high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC), and liquid chromatography mass spectrometry. Within 24 h of incubation, $AFB_1$ was efficiently eliminated by the culture supernatant of C. uredinicola ($84.5{\pm}5.7%$) at $37^{\circ}C$; the elimination was proven to be enzymatic, and the enzyme was thermostable. The biotransformation products of $AFB_1$ detected by HPLC and TLC were proven to be the same compound. Analysis with LCMS showed that $AFB_1$ was bio-transformed to a structurally different compound ($m/z=365[M+Na]^+$), which is first reported. The cytotoxicity study to HeLa cells indicated that culture supernatant-treated $AFB_1$ is less toxic as compared with $AFB_1$.
A Real-Time Surveillance System for Vaccine Cold Chain Based o n Internet of Things Technology
Shao-jun Jiang,Zhi-lai Zhang,Wen-yan Song 한국정보처리학회 2023 Journal of information processing systems Vol.19 No.3
In this study, a real-time surveillance system using Internet of Things technology is proposed for vaccine coldchains. This system fully visualizes vaccine transport and storage. It comprises a 4G gateway module, lowpowerand low-cost wireless temperature and humidity collection module (WTHCM), cloud service softwareplatform, and phone app. The WTHCM is installed in freezers or truck-mounted cold chain cabinets to collectthe temperature and humidity information of the vaccine storage environment. It then transmits the collecteddata to a gateway module in the radiofrequency_physical layer (RF_PHY). The RF_PHY is an interface forcalling the bottom 2.4-GHz transceiver, which can realize a more flexible communication mode. The gatewaymodule can simultaneously receive data from multiple acquisition terminals, process the received datadepending on the protocol, and transmit the collated data to the cloud server platform via 4G or Wi-Fi. Thecloud server platform primarily provides data storage, chart views, short-message warnings, and otherfunctions. The phone app is designed to help users view and print temperature and humidity data concerningthe transportation and storage of vaccines anytime and anywhere. Thus, this system provides a new vaccinemanagement model for ensuring the safety and reliability of vaccines to a greater extent.
소군 ( Jun Shao ),대국립 ( Guoli Dai ) 영산대학교 법률연구소 2015 영산법률논총 Vol.12 No.1
法科硏究生敎育是我國法學敎育的最高層次,最初只有法學碩士和法學博士兩種學術型學位,註重對學術型、硏究型人才的培養,培養規模不大,畢業生的職業選擇基本與培養目標相契合。隨著我國經濟社會的發展,各領域對法律應用型人才需求增加,國家增設法律碩士專業學位硏究生敎育,法科硏究生的招生規模也隨之擴張。在規模擴大,培養類型增多的情況下,我國的法科硏究生敎育出現了目標定位與就業現實不符、培養模式混同、培養質量下降等問題。控制總體規模,減少學術學位,擴大專業學位硏究生招生,通過與社會需求對接,實行精細化培養,提高硏究生培養質量是我國法科硏究生敎育發展的路徑選擇。 The research program in legal studies is the highest level of legal education in China. Initially, there are only two academic awards, i.e., Masters and PHD in law. These specific awards focus on research. Although the scale of candidates for those programs is limited, the educational objectives are consistent with career development of graduates. With a rapid economic growth, the demand for application-oriented law graduates is increasing. As a result, professional legal education has since been established and expended. Unfortunately, the expansion has caused the law school research graduates`` education objectives and career pursuits becoming unclear and mismatched. In addition, the education model seems premature and the quality of education deteriorated. This paper investigates the current education system in law school research programs in China and argues that the number of legal research students should be capped, research programs should be controlled. Instead, more specific and professional law degrees should be increased. In doing so, the legal education can be better connected with market needs so as to develop a quality legal educational system in the country.
Identification of a Potential Anticancer Target of Danshensu by Inverse Docking
Chen, Shao-Jun,Ren, Ji-Long Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Objective: To study potential targets of Danshensu via dual inverse docking. Method: PharmMapper and idTarget servers were used as tools, and the results were checked with the molecular docking program autodock vina in PyRx 0.8. Result: The disease-related target HRas was rated top, with a pharmacophore model matching well the molecular features of Danshensu. In addition, docking results indicated that the complex was also matched in terms of structure, H-bonds, and hydrophobicity. Conclusion: Dual inverse docking indicates that HRas may be a potential anticancer target of Danshensu. This approach can provide useful information for studying pharmacological effects of agents of interest.
Ya-Jun Gong,Jin-Cui Chen,Shao-Kun Guo,Pan Shi,Li-Jun Cao,Ming-Liang Li,Ary A. Hoffmann,Shu-Jun Wei 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.4
The fall webworm (FWW) Hyphantria cunea, native to North America, is a globally invasive pest of a wide range of forest and fruit trees. Spraying of pesticides is the primary method for the control of FWW. In this study, toxicity and feeding cessation of two potential pesticides against the FWW, chlorantraniliprole, and chromafenozide, were evaluated. Both pesticides were slow to affect FWW. For chlorantraniliprole, the highest mortality of third instar larvae occurred at 72 h with an LC 50 of 10.34 mg/L, while for chromafenozide, the highest mortality occurred at 72 h with an LC 50 value 74.0950 mg/L. Low concentrations of both pesticides led to larvae ceasing to feed after six hours (chlorantraniliprole) and 24 h (chromafenozide). Both pesticides had persistent effects; thirty days after being applied at concentrations of 16, 26.67, and 35.56 mg/L to leaves, 93.33% of newly contacted larvae died after seven days. Our study showed that chlorantraniliprole and chromafenozide could be alternatively used against FWW and form a component of integrated control programs. The results provide information to guide the usage of chlorantraniliprole and chromafenozide in FWW control.
Wang, Jun,Yu, Jin-Ming,Jing, Shao-Wu,Guo, Yin,Wu, Ya-Jing,Li, Na,Jiao, Wen-Peng,Wang, Li,Zhang, Yan-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Over-expression of epidermal growth factor receptor (EGFR) has been identified as a common feature associated with clinical outcome in many types of cancer, including squamous cell carcinoma of the oesophagus (SCCO). However, the clinical importance of EGFR over-expression in SCCO remains unsettled as conflicting results exist. Therefore we carried out the present meta-analysis of published studies for clarification. A total of 13 studies including 1, 150 patients were enrolled. EGFR over-expression was positive in 722 of these cases. With EGFR over-expression, patients had higher depth of invasion, vascular invasion, and poor prognosis. However, expression had no relation with degree of differentiation, histological grade, lymph node metastasis, clinical stage or lymphatic invasion. EGFR over-expression is probably a valuable predictor for the T stage, vascular invasion and OS, and it could be used as a poor prognosis indicator for the esophageal SCC patients. Targeting therapy to EFGR should be considered to the combined treatment in SCCO.