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Shao Bo Li,Zhi Hong Zhang,Shao Qing Li,Yang Sheng Li,You Lin Zhu,Ying Guo Zhu 한국유전학회 2008 Genes & Genomics Vol.30 No.4
Grain yield is a result of dry matter accumulation and partitioning in rice (Oryza sativa L.). To characterize the genetic basis of dynamics of traits representing dry matter accumulation and partitioning as well as their relationships with each other, composite interval mapping of quantitative trait loci (QTL) was conducted based on time-related phenotypic data obtained from a population of 258 recombinant inbred lines (F12), which was derived from a cross between Lemont (japonica var.) and Teqing (indica var.). A total of twenty-three QTL were identified for leaf weight, stem weight and panicle weight at four measuring stages after heading. However, these three dynamic traits were observed to be controlled by different QTL (genes) at different growth stages. An extreme example was that at least three types of QTL (genes) might be involved in the development of panicle weight. Growth duration, which is closely related to dry matter accumulation and partitioning, was also identified to be significantly affected by four QTL. The close correlations among the studied four traits were explained to some extent by six co-located QTL. Nevertheless, it would be of great importance to distinguish the pleiotropic or linked effects of the co-located QTL. In addition, the chromosome regions or QTL identified in this study were compared with those previously reported for the same or related traits with the same RIL population.
Qing-Chun Shao,Cui-Juan Zhang,Jie Li 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.9
The protein kinase C (PKC) is a family of serine/threonine kinases with a broad range of cellular targets. Members of the PKC family participate at the diverse biologicalevents involved in cellular proliferation, differentiationand survival. The PKCisoformzeta (PKCf) is an atypicalmember that has recently been found to play an essential rolein promoting human uterine contractility and thus been raisedas a new target for treating preterm labour and other tocolyticdiseases. In this study, an integrative protocol was describedto graft hundreds of inhibitor ligands from their complexcrystal structures with cognate kinases into the active pocketof PKCf and, based on the modeled structures, to evaluate thebinding strength of these inhibitors to the non-cognate PKCfreceptor by using a consensus scoring strategy. A total of 32inhibitors with top score were compiled, and eight out of themwere tested for inhibitory potency against PKCf. Consequently,five compounds, i.e. CDK6 inhibitor fisetin, PIM1inhibitor myricetin, CDK9 inhibitor flavopiridol and PknBinhibitor mitoxantrone as well as the promiscuous kinaseinhibitor staurosporine showed high or moderate inhibitoryactivity on PKCf, with IC50 values of 58 ± 9, 1.7 ± 0.4,108 ± 17, 280 ± 47 and 0.019 ± 0.004 lM, respectively,while other three compounds, including two marketed drugsdasatinib and sunitinib as well as the Rho inhibitor fasudil,have not been detected to possess observable activity. Next,based on the modeled structure data we modified three flavonoidkinase inhibitors, i.e. fisetin, myricetin and flavopiridol,to generate a number of more potential molecularentities, two of which were found to have a moderatelyimproved activity as compared to their parent compounds.
Wang, Shao-Ming,Zhang, Shao-Kai,Pan, Xiong-Fei,Ren, Ze-Fang,Yang, Chun-Xia,Wang, Zeng-Zhen,Gao, Xiao-Hong,Li, Man,Zheng, Quan-Qing,Ma, Wei,Zhao, Fang-Hui,Qiao, You-Lin,Sivasubramaniam, Priya Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: College students are recommended as the target groups for catch-up human papillomavirus (HPV) vaccination. Systematical exploration of awareness, acceptability, and decision-making factors of HPV vaccination among Chinese college students has been limited. Materials and Methods: A multi-center survey was conducted in mainland China between November 2011 and May 2012. College students aged 18-22 years were stratified by their grade, gender, and major for sampling. Socio-demographic and HPV-related information such as knowledge, perceptions, acceptability, and attitudes were collected through a questionnaire. Results: A total of 3,497 undergraduates completed the questionnaire, among which 1,686 were males. The acceptability of the HPV vaccine was high (70.8%). Undergraduates from high-level universities, at lower grade, or with greater prior knowledge of HPV vaccines showed higher acceptability of HPV vaccination ($p_{trend}$ <0.001). Additionally, undergraduates with vaccination experience outside the National Expanded Program on Immunization (OR=1.29; 95%CI: 1.10-1.51) or fear of HPV-related diseases (OR=2.79; 95%CI: 2.28-3.41) were more willing to accept HPV vaccination. General knowledge of HPV vaccine was low among undergraduates, and safety was a major concern (71.05%). The majority of students wished to pay less than 300RMB for HPV vaccine and chose the Chinese Center for Disease Control and Prevention as the most appropriate venue for vaccination. Conclusions: Although most undergraduates demonstrate positive attitudes towards HPV vaccination, challenges pertaining to introduction exist in China. Corresponding proactive education and governmental subsidy to do so are urgently needed by this age-group population. Suggestions and potential strategies indicated may help shape the future HPV vaccination program in China.
Zhang, Qing-Mei,Shen, Ning,Xie, Sha,Bi, Shui-Qing,Luo, Bin,Lin, Yong-Da,Fu, Jun,Zhou, Su-Fang,Luo, Guo-Rong,Xie, Xiao-Xun,Xiao, Shao-Wen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Melanoma-associated antigen (MAGE) family genes have been considered as potentially promising targets for anticancer immunotherapy. MAGED4 was originally identified as a glioma-specific antigen. Current knowledge about MAGED4 expression in glioma is only based on mRNA analysis and MAGED4 protein expression has not been elucidated. In the present study, we investigated this point and found that MAGED4 mRNA and protein were absent or very lowly expressed in various normal tissues and glioma cell line SHG44, but overexpressed in glioma cell lines A172,U251,U87-MG as well as glioma tissues, with significant heterogeneity. Furthermore, MAGED4 protein expression was positively correlated with the glioma type and grade. We also found that the expression of MAGED4 inversely correlated with the overall methylation status of the MAGED4 promoter CpG island. Furthermore, when SHG44 and A172 with higher methylation were treated with the DNA demethylating agent 5-aza-2'-deoxycytidine (5-AZA-CdR) reactivation of MAGED4 mRNA was mediated by significant demethylation in SHG44 instead of A172. However, 5-AZA-CdR treatment had no effect on MAGED4 protein in both SHG44 and A172 cells. In conclusion, MAGED4 is frequently and highly expressed in glioma and is partly regulated by DNA methylation. The results suggest that MAGED4 might be a promising target for glioma immunotherapy combined with 5-AZA-CdR to enhance its expression and eliminate intratumor heterogeneity.
Compressive performances of concrete filled Square CFRP-Steel Tubes (S-CFRP-CFST)
Qingli Wang,Yong-Bo Shao 국제구조공학회 2014 Steel and Composite Structures, An International J Vol.16 No.5
Sixteen concrete filled square CFRP-steel tubular (S-CFRP-CFST) stub columns under axial compression were experimentally investigated. The experimental results showed that the failure mode of the specimens is strength loss of the materials, and the confined concrete has good plasticity due to confinement of the CFRP-steel composite tube. The steel tube and CFRP can work concurrently. The load versus longitudinal strain curves of the specimens can be divided into 3 stages, i.e., elastic stage, elasto-plastic stage and softening stage. Analysis based on finite element method showed that the longitudinal stress of the steel tube keeps almost constant along axial direction, and the transverse stress at the corner of the concrete is the maximum. The confinement effect of the outer tube to the concrete is mainly focused on the corner. The confinements along the side of the cross-section and the height of the specimen are both non-uniform. The adhesive strength has little effect both on the load versus longitudinal strain curves and on the confinement force versus longitudinal strain curves. With the increasing of the initial stress in the steel tube, the load carrying capacity, the stiffness and the peak value of the average confinement force are all reduced. Equation for calculating the load carrying capacity of the composite stub columns is presented, and the estimated results agree well with the experimental results.
Shao-shuai Yu,Hai-yan Che,Sheng-jie Wang,Cai-li Lin,Ming-xing Lin,Wei-wei Song,Qing-hua Tang,Wei Yan,Wei-quan Qin 한국식물병리학회 2020 Plant Pathology Journal Vol.36 No.5
Areca palm yellow leaf (AYL) disease caused by the 16SrI group phytoplasma is a serious threat to the development of the Areca palm industry in China. The 16S rRNA gene sequence was utilized to establish a rapid and efficient detection system efficient for the 16SrI-B subgroup AYL phytoplasma in China by loopmediated isothermal amplification (LAMP). The results showed that two sets of LAMP detection primers, 16SrDNA-2 and 16SrDNA-3, were efficient for 16SrIB subgroup AYL phytoplasma in China, with positive results appearing under reaction conditions of 64oC for 40 min. The lowest detection limit for the two LAMP detection assays was the same at 200 ag/μl, namely approximately 53 copies/μl of the target fragments. Phytoplasma was detected in all AYL disease samples from Baoting, Tunchang, and Wanning counties in Hainan province using the two sets of LAMP primers 16SrDNA-2 and 16SrDNA-3, whereas no phytoplasma was detected in the negative control. The LAMP method established in this study with comparatively high sensitivity and stability, provides reliable results that could be visually detected, making it suitable for application and research in rapid diagnosis of AYL disease, detection of seedlings with the pathogen and breeding of diseaseresistant Areca palm varieties.