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The Synthesis and Preliminary Activity Assay In Vitro of Peptide-like Derivatives as APN Inhibitors
Shao-hua Li,Hui-ming Huang,Fang Xiong,Guo-gang Tu,Gang Li 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10
Both the aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis. A series of novel peptide-like derivatives were designed and synthesized as antitumor agents. Their structures were confirmed by IR, MS, and 1H-NMR. These compounds exhibited potent inhibitory activities against APN and low activity against MMP in vitro. The derivatives with methoxy group show better activities than those with other substituted group and could be used as lead compounds for exploring new APN inhibitors in the future.
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Shao-Hua Lee,Chia-Ying Lin,Ya-Chun Hsu,Yi-Sheng Liu,Ming-Tsung Chuang,Ming-Ching Ou 대한암학회 2020 Cancer Research and Treatment Vol.52 No.1
Purpose Transarterial chemoembolization (TACE) delivers cytotoxic drugs intra-arterially and induces ischemic necrosis by arterial embolization. Embolization is achieved using a variety of agents that differ widely in particle size and range, deformation, and in vivo arterial distribution. The clinical significance of these differences has not been thoroughly characterized. The present study is to compare the efficacy of Embosphere and Embozene microspheres in TACE therapy for hepatocellular carcinoma. Materials and Methods This retrospective study includes 108 hepatocellular carcinoma (HCC) patients who received TACE/doxorubicin with Embozene (70 patients) or Embosphere (38 patients) at a single medical center. Patient outcomes, including liver function, tumor size, tumor response, and complications after treatment, were analyzed. The change in total target lesion size and tumor response was evaluated according to embolization agent and clinical characteristics. Results The postoperative glutamate oxaloacetate transaminase (mean, 194.5 vs. 147.5; p=0.032) and bilirubin (mean, 1.11 mg/dL vs. 0.73 mg/dL; p=0.016) were higher among patients treated with Embozene, the decrease in the number (55.86±25.55% vs. 41.81±38.51%, p=0.027) and size (56.37±25.91 mm vs. 43.44±37.89 mm, p=0.001) of liver tumors relative to baseline was greater in these patients than in those treated with Embosphere. These greater antitumor effects were achieved using lower doses of doxorubicin than for treatment with Embozene. Minor complications were more common among patients treated with Embosphere than with Embozene. Conclusion These results suggest that Embozene is more efficacious than Embosphere for HCC treatment using TACE/doxorubicin.
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Shao Hua Wei 퇴계학부산연구원 2008 退溪學論叢 Vol.14 No.-
It seems that there's no connection to the Tui-xi academic conference to talk about Lu Xun, as for this, I'd like to make a little bit defence. As the most profound and bardian modern enlightenment thinker, Lu Xun's thought has a close connection to the cultural transformation of China from tradition to modern. However, this kind of transformational so happened in Korea and Japan, It can be even claimed that today's Eastern Asia is the right outcome of this transformation. Thus, Lu Xun, who thought about the problems of China, has a great significance for the EasternAsia. While his early thought of individual condensed thought of western advancement, which is also the thought of cultural deficiency of Chinese traditional culture. It seems that he has found the secrets of Western richness and strong and China's backwardness. Lu Xun thought that the advancement of the West due to its respect on individuals, what was just lacked in China, therefore, hetreated "respect individuals" as the effective prescription to save the nation. Fu Zeyujiin Japanal so holds that "what the East lacks are two points, one is materially math and science, and the other is invisibly independent mind". In my opinion, this point of view is also applicable in Korea. From the beginning of 15th century to the middle of 16th century, "Tui-xism", having integrated al lthe excellence of Zhu Xi's philosophy, came into for that the time when Zhu Xi's philosophy reach edits high est splend or in the "Period of Li Dynasty" in Korea. This had been deeply affected Korean people's soul. Professor Jin Rikunin, Pusan University, claims that "Confucian is mis the most predominant traditional culture in Japanand Korea, and is still being develop das order sand principles." But there appeared introspection current in modern Korea . After the late 19th century, the enlightenment thoughts in modern west influenced Korea greatly, Shen Caihao(1880-1936), the contemporary with Lu Xun, accepted the Evolution Theory of Darwinand put forward "thoughts of Personality Equality". From then on, besides traditional thoughts, modern thoughts appeared as the introspection or even doubt of traditional thoughts. Lu Xun is one of such modern thinkers. Lu Xun is one of the earliest who has sensitively touched the root of western thoughts among Chinese intellectuals in the 20th century. respect individuals became the core prescription for him to health illness of China. Liang Qichao, who is older than Lu Xun, is also one of the earliest Chinese, who has dabbled modern thoughts of the West. But the differences between them are that Liang strongly preaches thoughts of nation and debases thoughts of individual, and he also views that the origin of China's backwardness is "deficiency of public morality" of the people, China desperately needs "nationalism" to find a foot hold in the world. He emphasizes "group freedom" and disregards "individual independence". While in 1908, in <On Cultural Bigotry>, Lu Xun pointed that "Hereby, the initial thing for survival and competition with other countries and participating world affairs is to respect and support individuals, then other business can be started after that; as for its way, that must be respecting and developing individuality and personality." What's Lu Xun different from Liang Qichao is that he definitely put forward "supporting individuals and elbowing crowds." When he studied aboard in Japan, he had been affected by Nietzsche and Stirner's "thought of individual". Individual was not considered as a part of a group, but self-sensed as "existence of individual". According to thoughts of YiTenghuwan, "there lation between individual and group is not as the relation of part and whole". That is to say, one's value can only be displayed as long as he achieves true individual independence. He also holds that the proposition of "individual" represents the "root and base" of western modern culture. According to him, Lu Xun' sunder standing and acceptance of we stern modern thoughts are the right grasp of this kind of "root and base." There is no doubt that Lu Xun's such value orientation was influenced by Japanese cultural current at that time. In the middle of the 19th century, British and French philosophy, emphasizing politics, sociology and economics, were popular in Japan. This current had great effecton Lu Xun, he had transferred his interest tosurvival of individuals. He put forward abrand-newnation-saving proposal that is completely different with Westernization is ts, Reform is ts and Revolutionary group. Lu Xun's early "thought of individual" was advocated earlier than that of new culture movement. Chen Duxiu, Zhou Zuoren, Hu Shi ect all emphasize the importance of individuals. Chen thinks that "western nations focus on, while eastern nations support family departmentalism", "western countries are completely nations of individualism in all ages. "While the variety phenomena of beggary, illegitimacy and declination all due to lack of individualism", "to change this situation, individualism should be supported, and families as the standard should be changed." Zhou mentions that "individualism should be the central standard of the world". Hu advocates "perfect and wholesome individualism", "individuals should fully developed their own talents and personalities", "the most devil of the society is to devastate individual's personality". No matter what divergence exists among illuminati of May Fourth generation, the advocation of "individualism" are consistent. However, the "thought of individual" advocated by Lu Xun and other modern intellectuals are shadowed several times in the following nearly a century's history, which led to the misunderstanding of individualism for a long time, even be treated as"misleading and harmful egoism". Individualism is not only the concern about the thought itself, but also the developing drive of society, economy and culture of modern society. China has achieved great acc
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Shao-Hua Zheng,Xiao-Peng Mei 대한치과마취과학회 2021 Journal of Dental Anesthesia and Pain Medicine Vol.21 No.3
Background: This study aimed to observe the effect of internship in a pre-anesthetic clinic on the teaching quality of pre-anesthesia evaluation for undergraduates. Methods: A total of 120 undergraduates from July 2017 to July 2018 in the anesthesia department of our hospital were randomly divided into two groups: pre-anesthetic clinic internship teaching group (n = 60) and traditional teaching group (n = 60). The knowledge in the pre-anesthesia evaluation teaching chapters was evaluated between the two groups of undergraduates. Results: There were no significant differences in the demographic information between the two groups. The scores in the case analysis and theoretical knowledge test in the pre-anesthetic clinic internship teaching group were significantly higher than those in the traditional teaching group. In addition, the students’ satisfaction with the curriculum design was significantly higher in the pre-anesthetic clinic internship teaching group than in the traditional teaching group. Conclusion: Pre-anesthetic clinic internships can improve the quality of pre-anesthesia assessment teaching for undergraduates.
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명대(明代) 황실 관례(冠禮)의 행례(行禮) 특성 및 신분별 관례복(冠禮服) 연구 -조선(朝鮮)의 ‘익선관강사포(翼善冠絳紗袍)’에 대한 논의를 겸하여-
溫少華 ( Shao Hua Wen ),최연우 ( Yeon Woo Choi ) 한국의류학회 2021 한국의류학회지 Vol.45 No.2
The Gwan ceremony (冠禮) is a coming-of-age ceremony that takes place through traditional Gwan (冠: the hat) and clothes in the traditional era. The rite is performed by wearing hats and clothes three consecutive times (三加禮). It was an important rite which meant that underage children were formally recognized as members of society. This study examined costumes of people who participated in various coming-of-age ceremony rites in the Ming dynasty imperial court of China. For the research data, this study mainly used authentic chronicles (正史), codes of law and books on Ming dynasty rituals. This study examined the costumes used in the coming-of-age ceremony for the emperor, Prince Imperial, Emperor's eldest grandson, and emperor's sons. The results of this study were divided into an analysis of the document structure, institutional changes by time, characteristics of costumes, and characteristics of the rite. Of particular note in their ceremony, the emperor is presupposed to be a ‘human already full-equipped with virtue’, which means that the costume is worn only once. It is a case in which the emperor's absolute identity is revealed through the rite and costume.
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The Synthesis and Preliminary Activity Assay In Vitro of Peptide-like Derivatives as APN Inhibitors
Li, Shao-Hua,Li, Gang,Huang, Hui-Ming,Xiong, Fang,Liu, Cheng-Mei,Tu, Guo-Gang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10
Both the aminopeptidase N (APN) and matrix metalloproteinase (MMP) are essential metallopeptidases in the development of tumor invasion and angiogenesis. A series of novel peptide-like derivatives were designed and synthesized as antitumor agents. Their structures were confirmed by IR, MS, and $^1H$-NMR. These compounds exhibited potent inhibitory activities against APN and low activity against MMP in vitro. The derivatives with methoxy group show better activities than those with other substituted group and could be used as lead compounds for exploring new APN inhibitors in the future.
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명대(明代) 곤룡포(袞龍袍)와 곤룡문(袞龍紋)의 색(色) 연구
溫少華(Wen Shao-Hua),최연우(Choi Yeon-Woo) 한복문화학회 2021 韓服文化 Vol.24 No.3
A Gunlong-pao means a long dress expressed with a Gunlong pattern, and the Gunlong pattern expresses a "Gunlong," a dragon in a winding form as a pattern. Since the Gunlong-pao was worn daily by the emperor, the crown prince, and the prince of the Ming Dynasty, it was most often worn among various types of court fashions. Therefore, even for researchers and the general public, the Gunlong-pao is a very familiar dress. However, it was so familiar that a royal fashion history field did not conduct in-depth research on this dress. Therefore, this study investigated the color of the Gunlong-pao and the Gunlong pattern. As the research data, literature, relics, and paintings were comprehensively utilized. The research results are as follows. First, the shape and type of the Gunlong-pao and Gunlong pattern in the Ming Dynasty diversified from the former to the latter period, and this phenomenon also appeared in their colors. Second, in the early Ming Dynasty, the color of the Gunlong-pao was determined as five colors based on the season, and in a “Yongle 3rd year’s Ding(永樂3年定)” system, the color of the Gunlong-pao was determined as yellow (emperor) and red (crown prince and below classes) based on the status. However, in the actual use in the mid to late period of the Ming Dynasty, it was confirmed that the emperor"s Gunlong-pao had various colors, such as red and reddish-black, in addition to yellow. It was confirmed that the fashion colors of the crown prince or below classes were only the red according to the system. Third, the emperor"s "Gunfu", which appeared in the mid to late period, used the five colors, applying the coexistence of five elements to four Gunlong patterns on its upper body. Fourth, the Gunlong-pao gave to the status of the crown prince or lower by the emperor, was classified into three classes based on the color in the late period of the Ming Dynasty.
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