Cepharanthine Enhances TRAIL-Mediated Apoptosis Through STAMBPL1-Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells

Shahriyar, Sk Abrar,Woo, Seon Min,Seo, Seung Un,Min, Kyoung-jin,Kwon, Taeg Kyu MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.10

<P>Cepharanthine (CEP) is a natural plant alkaloid, and has anti-inflammatory, antineoplastic, antioxidative and anticancer properties. In this study, we investigated whether CEP could sensitize renal carcinoma Caki cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. CEP alone and TRAIL alone had no effect on apoptosis. However, combined CEP and TRAIL treatment markedly enhanced apoptotic cell death in cancer cells, but not in normal cells. CEP induced downregulation of survivin and cellular-FLICE inhibitory protein (c-FLIP) expression at post-translational levels. Ectopic expression of survivin blocked apoptosis by combined treatment with CEP plus TRAIL, but not in c-FLIP overexpression. Interestingly, CEP induced survivin downregulation through downregulation of deubiquitin protein of STAM-binding protein-like 1 (STAMBPL1). Overexpression of STAMBPL1 markedly recovered CEP-mediated survivin downregulation. Taken together, our study suggests that CEP sensitizes TRAIL-mediated apoptosis through downregulation of survivin expression at the post-translational levels in renal carcinoma cells.</P>

Remote Controlling of Home Appliances using Mobile Telephony

Rifat Shahriyar,Enamul Hoque,S.M. Sohan,Iftekhar Naim,Md. Mostafa Akbar,Masud Karim Khan 보안공학연구지원센터 2008 International Journal of Smart Home Vol.2 No.3

In modern days, we must use various high-tech machineries and equipments to get our jobs done and make the life easier. These machineries should be controlled by the homeowner from any location as the homeowner might be away from home at workplace or traveling in a different place in the weekend. Thus a system of remote monitoring and controlling are very much necessary. Smart home is one of these types of system equipped with home appliances which we wish to control smartly from anywhere. Some products are commercially available which allow remote home appliance controlling through internet which is undoubtedly emerging. But it lacks the true sense of real mobility and security, making the remote home appliance controlling a limited term than it is supposed to be. In search of a true remote and adequately secure solution to be really effective and practicable, mobile telephony is better than any other solutions. Mobile phones have become almost an inseparable part of civil lives today. In this paper we introduce a new mechanism so that the ordinary services of the mobile phones can be leveraged to communicate with and control the home appliances and make our homes a really smart one.

Intelligent Mobile Health Monitoring System (IMHMS)

Rifat Shahriyar,Md. Faizul Bari,Gourab Kundu,Sheikh Iqbal Ahamed,Md. Mostofa Akbar 보안공학연구지원센터 2009 International Journal of Control and Automation Vol.2 No.3

Comparison of Efficiency for Different Switching Tables in Six-Phase Induction Motor DTC Drive

Asghar Taheri,Abdolreza Rahmati,Shahriyar Kaboli 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.1

In this paper, different switching tables proposed for the Direct Torque Controlled (DTC) of a six-phase induction machine are simulated and implemented. A six-phase induction motor has 64 space voltage vectors which result in increased complexity in the selecting of inverters switching. The unsuitable selection of a switching table leads to large harmonics especially at low speed and it also reduces drive efficiency. A six-phase induction machine has large zero sequence harmonic currents of the order 6k1. These harmonic currents are varied in various techniques. Decreasing this loss is essential in a six-phase induction machine. The main purpose of this paper is to improve the ST-DTC of six-phase induction machines to reduce the voltage and current harmonics and the torque pulsation. Selecting a suitable method for minimizing these harmonics is very important.

Comparison of Efficiency for Different Switching Tables in Six-Phase Induction Motor DTC Drive

Taheri, Asghar,Rahmati, Abdolreza,Kaboli, Shahriyar The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.1

In this paper, different switching tables proposed for the Direct Torque Controlled (DTC) of a six-phase induction machine are simulated and implemented. A six-phase induction motor has 64 space voltage vectors which result in increased complexity in the selecting of inverters switching. The unsuitable selection of a switching table leads to large harmonics especially at low speed and it also reduces drive efficiency. A six-phase induction machine has large zero sequence harmonic currents of the order $6{\kappa}{\pm}1$. These harmonic currents are varied in various techniques. Decreasing this loss is essential in a six-phase induction machine. The main purpose of this paper is to improve the ST-DTC of six-phase induction machines to reduce the voltage and current harmonics and the torque pulsation. Selecting a suitable method for minimizing these harmonics is very important.

Ubiquitous Secretary: A Ubiquitous Computing Application Based on Web Services Architecture

Salmin Sultana,Rezwana Karim,Rifat Shahriyar,Md. Mostofa Akbar,Sheikh Iqbal Ahamed 보안공학연구지원센터 2009 International Journal of Multimedia and Ubiquitous Vol.4 No.4

Due to the extensive availability of wireless internet connectivity and low cost light weight mobile devices, an omnipresent customizable service is not a vision anymore. With enhanced wireless connectivity, the handheld mobile devices (PDA, smart phone, cell phone, etc.) can act as a digital personal secretary, being employed in all aspects of life for the purposes ranging from accessing wide range of information to performing various types of activities with greater ease and comfort. If this type of service can be made a reality, it can be used by different types of users in different fields such as education, tourism, shopping or business, at any time and at any place. Here we present Ubiquitous Secretary, which is designed and developed to accomplish the above objectives. Ubiquitous computing applications developed so far are all independent and rich in their own domains but they suffer from the problem of non-inter operability and non scalability. Ubiquitous Secretary is developed upon the web services architecture that easily solves the interoperability and adaptability problem between different ubiquitous computing applications. We developed a prototype and presented how the implementation of the prototype satisfies the characteristics and features of Web Service based architecture.

Accuracy of linear measurement using cone-beam computed tomography at different reconstruction angles

Sima Nikneshan,Shadi Hamidi Aval,Neema Bakhshalian,Shahriyar Shahab,Mahdis Mohammadpour,Soodeh Sarikhani 대한영상치의학회 2014 Imaging Science in Dentistry Vol.44 No.4

Purpose: This study was performed to evaluate the effect of changing the orientation of a reconstructed image on the accuracy of linear measurements using cone-beam computed tomography (CBCT). Materials and Methods: Forty-two titanium pins were inserted in seven dry sheep mandibles. The length of these pins was measured using a digital caliper with readability of 0.01 mm. Mandibles were radiographed using a CBCT device. When the CBCT images were reconstructed, the orientation of slices was adjusted to parallel (i.e., 0˚), +10˚, +12˚, -12˚, and -10˚with respect to the occlusal plane. The length of the pins was measured by three radiologists, and the accuracy of these measurements was reported using descriptive statistics and one-way analysis of variance (ANOVA); p⁄0.05 was considered statistically significant. Results: The differences in radiographic measurements ranged from -0.64 to +0.06 at the orientation of -12˚, -0.66 to -0.11 at -10˚, -0.51 to +0.19 at 0˚, -0.64 to +0.08 at +10˚, and -0.64 to +0.1 at +12˚. The mean absolute values of the errors were greater at negative orientations than at the parallel position or at positive orientations. The observers underestimated most of the variables by 0.5-0.1 mm (83.6%). In the second set of observations, the reproducibility at all orientations was greater than 0.9. Conclusion: Changing the slice orientation in the range of -12˚to +12˚reduced the accuracy of linear measurements obtained using CBCT. However, the error value was smaller than 0.5 mm and was, therefore, clinically acceptable.

Arylquin 1, a potent Par‑4 secretagogue, induces lysosomal membrane permeabilization‑mediated non‑apoptotic cell death in cancer cells

Kyoung‑jin Min,Sk Abrar Shahriyar,권택규 한국독성학회 2020 Toxicological Research Vol.36 No.2

Arylquin 1, a small-molecule prostate-apoptosis-response-4 (Par-4) secretagogue, targets vimentin to induce Par-4 secretion. Secreted Par-4 binds to its receptor, 78-kDa glucose-regulated protein (GRP78), on the cancer cell surface and induces apoptosis. In the present study, we investigated the molecular mechanisms of arylquin 1 in cancer cell death. Arylquin 1 induces morphological changes (cell body shrinkage and cell detachment) and decreases cell viability in various cancer cells. Arylquin 1-induced cell death is not inhibited by apoptosis inhibitors (z-VAD-fmk, a pan-caspase inhibitor), necroptosis inhibitors (necrostatin-1), and paraptosis inhibitors. Furthermore, arylquin 1 significantly induces reactive oxygen species levels, but antioxidants [N-acetyl-l-cysteine and glutathione ethyl ester] do not inhibit arylquin 1-induced cell death. Furthermore, Par-4 knock-down by small interfering RNA confers no effect on cytotoxicity in arylquin 1-treated cells. Interestingly, arylquin 1 induces lysosomal membrane permeabilization (LMP), and cathepsin inhibitors and overexpression of 70-kDa heat shock protein (HSP70) markedly prevent arylquin 1-induced cell death. Therefore, our results suggest that arylquin 1 induces non-apoptotic cell death in cancer cells through the induction of LMP.

Elucidation for modulation of death receptor (DR) 5 to strengthen apoptotic signals in cancer cells

Kyoung-jin Min,Seon Min Woo,Sk Abrar Shahriyar,Taeg Kyu Kwon 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.1

The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis via death receptor (DR) 4 or DR5 preferentially in cancer cells, and not in normal cells with relatively high decoy receptor expression. However, multiple mechanisms in cancer cells induce resistance to DRs-mediated apoptosis. Therefore, understanding of molecular mechanisms for resistance to DRs-mediated apoptosis can find the strategy to increase sensitivity. Although multiple proteins are involved in resistance to DRs-mediated apoptosis, we focus on modulation of DR5 to overcome resistance. Here, we discuss regulation of DR5 expression or activation by epigenetic modification, transcription factor at the transcriptional levels, micro RNA and RNA-binding proteins at the posttranscriptional levels, and ubiquitination and glycosylation at the post-translational levels. In addition, we also mention about relationship between localization of DR5 and death signaling activation. The purpose of this review is to help understand relationship between regulatory mechanisms of DR5 and resistance to TRAIL or DRs-targeted agonist monoclonal antibodies, and to develop innovative anticancer therapies through regulation of DR5 signaling.

Accuracy of linear measurement using cone-beam computed tomography at different reconstruction angles

Nikneshan, Sima,Aval, Shadi Hamidi,Bakhshalian, Neema,Shahab, Shahriyar,Mohammadpour, Mahdis,Sarikhani, Soodeh Korean Academy of Oral and Maxillofacial Radiology 2014 Imaging Science in Dentistry Vol.44 No.4

Purpose: This study was performed to evaluate the effect of changing the orientation of a reconstructed image on the accuracy of linear measurements using cone-beam computed tomography (CBCT). Materials and Methods: Forty-two titanium pins were inserted in seven dry sheep mandibles. The length of these pins was measured using a digital caliper with readability of 0.01 mm. Mandibles were radiographed using a CBCT device. When the CBCT images were reconstructed, the orientation of slices was adjusted to parallel (i.e., $0^{\circ}$), $+10^{\circ}$, $+12^{\circ}$, $-12^{\circ}$, and $-10^{\circ}$ with respect to the occlusal plane. The length of the pins was measured by three radiologists, and the accuracy of these measurements was reported using descriptive statistics and one-way analysis of variance (ANOVA); p<0.05 was considered statistically significant. Results: The differences in radiographic measurements ranged from -0.64 to +0.06 at the orientation of $-12^{\circ}$, -0.66 to -0.11 at $-10^{\circ}$, -0.51 to +0.19 at $0^{\circ}$, -0.64 to +0.08 at $+10^{\circ}$, and -0.64 to +0.1 at $+12^{\circ}$. The mean absolute values of the errors were greater at negative orientations than at the parallel position or at positive orientations. The observers underestimated most of the variables by 0.5-0.1 mm (83.6%). In the second set of observations, the reproducibility at all orientations was greater than 0.9. Conclusion: Changing the slice orientation in the range of $-12^{\circ}$ to $+12^{\circ}$ reduced the accuracy of linear measurements obtained using CBCT. However, the error value was smaller than 0.5 mm and was, therefore, clinically acceptable.