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Md. Shahidul Islam,Md. Monjurul Islam,Md. Habibur Rahman,Sakina Khanam,Md. Shahidul Haque Bir,Le Thi Hien,Kee Woong Park 한국잡초학회·한국잔디학회 2020 Weed & Turfgrass Science Vol.9 No.3
This study was carried out at the agronomy farm of Bangladesh Institute of Nuclear Agriculture (BINA), Mymensingh, Bangladesh, between November 2015 and May 2016, to investigate the weed control on rice growth and yield performance of transplant Binadhan-14 (boro rice). Six selected herbicides (H₁: bensulfuron methyl 4% + acetachlor 14% 18 wettable powder [WP] 500 g·ha<SUP>-1</SUP>, H₂: pyrazosulfuron-ethyl 10 WP 125 g·ha<SUP>-1</SUP>, H₃: metsulfuron-methyl 20 water dispersible granule [WDG] 50 g·ha<SUP>-1</SUP>, H₄: pretilachlor 500 emulsifiable concentrate [EC] 1 L·ha<SUP>-1</SUP>, H5: 2, 4 D amine 480 soluble liquid [SL] 1.8 L·ha<SUP>-1</SUP>, H6: butachlor 5 granule [G] 25 kg·ha<SUP>-1</SUP>) were tested along with two hand weedings. Weed density, fresh and dry weight of weeds were taken from eight weed species (Echinochloa colonum, Paspalums crobiculatum, Monochoria vaginalis, Leersia hexandra, Scirpus mucronatus, Digitaria sanguinalis, Cyperus rotundus and Eclipta alba Hassk) belonging to five families were found to grow in the experimental plots. Among the weed control treatments highest grain yield (5.00 T·ha<SUP>-1</SUP>) was obtained with the treatment pretilachlor 500 EC 1 L·ha<SUP>-1</SUP> followed by two hand weedings (4.97 T·ha<SUP>-1</SUP>). It was observed that yield was increased due to application of herbicide contributed mainly from increasing the yield contributing characteristics of rice like, number of total tillers and effective tillers per plant, filled grains per panicle and 1000-seed weight (g). Maximum benefit- cost ratio with pretilachlor 500 EC 1 L·ha<SUP>-1</SUP> suggested that this herbicidal treatment can be used for effective in controlling weeds as an alternative when labor was crisis in producing for better yield of transplant Binadhan-14 (Oryza sativa) rice cultivar.
Mir Shahidul Islam,Qazi Manaan Masood,Arshad Bashir,Faisal Y Shah,Manzoor A Halwai 대한정형외과학회 2020 Clinics in Orthopedic Surgery Vol.12 No.1
Background: The aim of this study was to compare the results of the standard once-weekly Ponseti casting technique to an accelerated twice-weekly regimen in our population cohort. Methods: A prospective randomized controlled study was conducted with a total of 100 consecutive patients (158 feet) being enrolled for the study. Fifty patients were randomized to each group and followed up for at least one year. Results: Initial mean Pirani score was 4.67 ± 0.73 in the standard group and 4.35 ± 0.76 in the accelerated group, and the score decreased to 0.34 ± 0.38 and 0.35 ± 0.31, respectively. Initial mean Dimeglio score was 11.75 ± 2.75 in the standard group and 10.51 ± 2.57 in the accelerated group, and the score decreased to 0.79 ± 0.77 and 0.79 ± 0.71, respectively, immediately after casting. The average number of casts required to correct all the deformities was 6.3 ± 1.2 in the standard group and 6.1 ± 1.4 in the accelerated group (p = 0.45). Average time spent in cast was 58.2 ± 8.3 days in the standard group and 39.5 ± 5.2 days in the accelerated group (p < 0.001). Percutaneous Achilles tendon tenotomy was done in 86.42% in the standard group and in 84.41% in the accelerated group (p = 0.72). Final results were assessed by using a modified functional rating scoring system: 55.55% clubfeet had excellent results and 44.45% had good results in the standard group, whereas 66.23% clubfeet had excellent results and 33.77% had good results in the accelerated group. None amongst the two groups had fair or poor results. Conclusions: These results suggest that the accelerated Ponseti technique significantly reduces the correction time without affecting the final results and that it is as safe and effective as the traditional Ponseti technique.
Md. Shahidul Islam,Haymie Choi 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.2
The present study was conducted to examine the antidiabetic effects of two dietary dosages (0.5% and 2.0%) of freeze-dried Korean traditional Baechu (Chinese cabbage) kimchi in a high-fat (HF) diet-fed, streptozotocin (STZ)-induced type 2 diabetes (T2D) rat model. Five-week-old male Sprague-Dawley rats were fed HF diet for 2 weeks and then randomly divided into four groups of eight animals: normal control (NC), diabetic control (DBC), kimchi low (KML) (0.5%), and kimchi high (KMH) (2.0%) groups. Diabetes was induced by an intraperitoneal injection of STZ (40 mg/kg of body weight) in all groups except the NC group. After 4 weeks of feeding of experimental diets, serum insulin concentrations and Homeostatic Model Assessment pancreatic beta-cell function were increased and blood glycated hemoglobin was decreased in the kimchi-fed groups compared to the DBC group, while a significant (P < .05) difference was observed only in the KMH group for serum insulin concentration. Lower fasting blood glucose and better glucose tolerance were observed in the KMH group compared to the DBC and KML groups; however, differences were not significant. Food intake, body weight gain, Homeostatic Model Assessment insulin resistance index, and serum lipid profiles were not significantly influenced by kimchi-containing diets. Data of this study suggest that dietary Baechu kimchi has some antidiabetic effects even when fed with a HF-containing diet. Better results are possible if it is consumed with normal or low-fat rather than HF-containing diet.
miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes
Mohammad Shahidul Makki,Tariq M Haqqi 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3′ untranslated region (UTR) of MCPIP1 mRNA harbors a miR-139 ‘seed sequence’, therefore we examined the post-transcriptional regulation of MCPIP1 by miR-139 and its impact on IL-6 expression in OA chondrocytes. Expression of miR-139 was found to be high in the damaged portion of the OA cartilage compared with unaffected cartilage from the same patient and was also induced by IL-1β in OA chondrocytes. Inhibition of miR-139 decreased the expression of IL-6 mRNA by 38% and of secreted IL-6 protein by 40%. However, overexpression of miR-139 increased the expression of IL-6 mRNA by 36% and of secreted IL-6 protein by 56%. These data correlated with altered expression profile of MCPIP1 in transfected chondrocytes. Studies with a luciferase reporter construct confirmed the interactions of miR-139 with the ‘seed sequence’ located in the 3′ UTR of MCPIP mRNA. Furthermore, miR-139 overexpression increased the catabolic gene expression but expression of anabolic markers remained unchanged. Overexpression of miR-139 also induced apoptosis in OA chondrocytes. Importantly, we also discovered that IL-6 is a potent inducer of miR-139 expression in OA chondrocytes. These findings indicate that miR-139 functions as a post-transcriptional regulator of MCPIP1 expression and enhances IL-6 expression, which further upregulates miR-139 expression in OA chondrocytes. These results support our hypothesis that miR-139-mediated downregulation of MCPIP1 promotes IL-6 expression in OA. Therefore, targeting miR-139 could be therapeutically beneficial in the management of OA.