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Shabnam Asfaram,Ahmad Daryani,Shahabeddin Sarvi,Abdol Sattar Pagheh,Seyed Abdollah Hosseini,Reza Saberi,Seyede Mahboobeh Hoseiny,Masoud Soosaraei,Mehdi Sharif 한국역학회 2019 Epidemiology and Health Vol.41 No.-
OBJECTIVES: Blastocystis hominis is a very common large intestinal protozoan with global prevalence in humans and non-human hosts. No precise statistics exist regarding the geographical distribution of Blastocystis that would enable the identification of high-risk communities. Therefore, the current research aimed to characterize the spatial patterns and demographic factors associated with B. hominis occurrence in northern Iran. METHODS: The current study was performed among 4,788 individuals referred to health centers in Mazandaran Province, from whom stool samples were obtained. Socio-demographic data were gathered using a questionnaire. Samples were examined by a direct wet mount, the formalin-ethyl acetate concentration technique, and trichrome staining. Moran local indicators of spatial association and a geographically weighted regression model were utilized to analyze the results. RESULTS: Generally, the infection rate of Blastocystis parasites was 5.2%, and was considerably higher in the age group of 10-14 years (10.6%) than in other age groups (p=0.005). Our data showed important associations between the occurrence of B. hominis and age, residence, job, contact with domestic animals, anti-parasitic drug consumption, and elevation above sea level (p<0.001). CONCLUSIONS: The current study characterized for the first time the infection rate and risk of B. hominis in the north of Iran, and produced a prediction map. It is expected that this map will help policymakers to plan and implement preventive measures in high-risk areas and to manage already-infected patients.
Shabnam Anjum Ara,Uzma Viquar,Mohammed Zakir,Gulam Mohammed Husain,Mohammed Abdul Rasheed Naikodi,Mohd Urooj,Munawwar Husain Kazmi 셀메드 세포교정의약학회 2021 셀메드 (CellMed) Vol.11 No.3
Background and Objective: Nux-vomica based traditional Unani formulation, Habb-e-Azaraqi (HAZ) is an important drug used by Unani physicians since several decades. It possesses Muqawwi-i-A’sab (nervine tonic), Muharrik-i-A’sab (nervine stimulant) properties and is an effective treatment option for diseases like Laqwa (facial palsy), Falij (paralysis), Niqris (gout) and Waja’al-Mafasil (arthritis) etc. The aim of the study is to access and provide information of HAZ for its TLC, HPTLC Fingerprinting defining its clear qualitative perspective and acute oral toxicity evaluation for its safety assessment which was not done earlier, thus contributing in the field of research. Materials and Methods: The chief ingredient, nux-vomica was detoxified as per method mentioned in Unani Pharmacopeia before its use in formulation. TLC and HPTLC was developed under four detection system i.e., UV 366nm, UV 254nm, exposure to iodine vapours and after derivatization with anisaldehyde sulphuric acid. Acute toxicity studies were performed as per OECD Guidelines 425 at a limit dose of 2000 mg/kg. Observations were done for signs of toxicity, body weight, and feed consumption at regular intervals followed by haematological and biochemistry evaluation. Results: The generated data proved the authenticity and established the TLC and HPTLC profile of the formulation. Acute toxicity revealed no significant differences in HAZ-treated animals with respect to body weight gain, feed consumption, haematology, clinical biochemistry evaluation. No significant gross pathological observation was noticed in necropsy. Conclusion: Data of the present study is substantial and scientific proof of HAZ in terms of standardization and toxicity study that can be utilize in future research activities.
A new lossless snubber for DC-DC converters with energy transfer capability
Shabnam Nasr Esfahani,Majid Delshad,Mohhamad Bagher Tavakoli 국제구조공학회 2020 Smart Structures and Systems, An International Jou Vol.25 No.3
In this paper, a new passive lossless snubber circuit with energy transfer capability is proposed. The proposed lossless snubber circuit provides Zero-Current Switching (ZCS) condition for turn-on instants and Zero-Voltage Switching (ZVS) condition for turn-off instants. In addition, its diodes operate under soft switching condition. Therefore, no significant switching losses occur in the converter. Since the energy of the snubber circuit is transferred to the output, there are no significant conduction losses. The proposed snubber circuit can be applied on isolated and non-isolated converters. To verify the operation of the snubber circuit, a boost converter using the proposed snubber is implemented at 70W. Also, the measured conducted Efficiency Electromagnetic Interference (EMI) of the proposed boost converter and conventional ones are presented which show the effects of proposed snubber on EMI reduction. The experimental results confirm the presented theoretical analysis.
Neutropenia with Multiple Antipsychotics Including Dose Dependent Neutropenia with Lurasidone
Shabnam Sood 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.4
Antipsychotic-induced agranulocytosis is a significant side effect that is known to occur with most of the antipsychotic medications. It usually resolves once the medications are stopped and patients are able to be switched over to another antipsychotic medication. Lurasidone has not been reported to cause leukopenia and neutropenia. This case report is of a patient with a past history of risperidone induced-aganulocytosis developing dose related leukopenia and neutropenia with lurasidone
Optimization of vitamin B12 nano-emulsification and encapsulation using spontaneous emulsification
Shabnam Karbalaei-Saleh,Shima Yousefi,Masoud Honarvar 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.2
In this study, the use of low-energy methods for nanoemulsification of vitamin B12 was investigated to protect this bioactive substance. The effects of sunflower oil concentrations (4–8%), Tween 80 (8–16%), and vitamin B12 (5–15%) on the physicochemical properties of B12 nanoemulsion were evaluated using response surface methodology (RSM). The results indicated that the quadratic model was the most fitting model for experimental data. Optimization revealed that the optimal formulation contained 6.5% sunflower oil, 9.6% Tween 80, and 13% vitamin B12, resulting in maximum efficiency, viscosity, and vitamin B12 content, as well as minimum pH, turbidity, p-Anisidine index, particle size, and polydispersity index (PDI). Under optimal conditions, pH, viscosity, turbidity, efficiency, vitamin B12, p-Anisidine index, PDI, and particle size were 7.24, 17.0024 cp, 2.19, 51.98%, 5.54 ppm, 0.01, 0.34, and 322 nm, respectively. This study highlights the effectiveness of spontaneous emulsification as a carrier for the encapsulation of bioactive compounds.