Health Beliefs Concerning Breast Self-examination of Nurses in Turkey

Sevinc Tastan,Emine Iyigün,Ayse Kılıc,Vesile Unver 한국간호과학회 2011 Asian Nursing Research Vol.5 No.3

Purpose: The purpose of the study was to evaluate the health beliefs regarding breast self-examination (BSE) and their relationship with age, educational status and history of breast cancer in the family among nurses working in a university hospital. Methods: A cross-sectional design was used, with a convenience sample of 381 nurses at a military university hospital in Ankara in Turkey. Data were collected by using a personal data form and the Champion’s Health Belief Model Scale. Descriptive statistics, logistic regression, Mann-Whitney U test and Kruskal Wallis Test were conducted. Results: The proportion of nurses reported doing BSE regularly is 47.2%. Controlling variables such as age,body mass index, the age at first birth, breast cancer in the family history and educational background,we found that the subscales of the health belief model, BSE benefit (OR ¼ 0.782), self-efficacy (OR ¼ 0.919), and risk perception (OR ¼ 0.114) have statistically significant effects on the risk of not making BSE. Conclusion: It is important to be aware of the health beliefs of nurses regarding BSE so that their own health can be protected and improved. Beneficial attitudes and behaviors of nurses regarding BSE will enable them to provide more effective services to women regarding breast cancer. Understanding the nurses’ health beliefs, attitude and behavior that are influential to make BSE will guide nursing practices towards early diagnosis of breast cancer at the societal level.

Microstructure characterization and mechanical properties of Cr-Ni/ZrO₂ nanocomposites

Sevinc, O zlem,Diler, Ege A. Techno-Press 2022 Advances in nano research Vol.13 No.4

The microstructure and mechanical properties of Cr-Ni steel and Cr-Ni steel-matrix nanocomposites reinforced with nano-ZrO₂ particles were investigated in this study. Cr-Ni steel and Cr-Ni/ZrO₂ nanocomposites were produced using a combination of high-energy ball milling, pressing, and sintering processes. The microstructures of the specimens were analyzed using EDX and XRD. Compression and hardness tests were performed to determine the mechanical properties of the specimens. Nano-ZrO₂ particles were effective in preventing chrome carbide precipitate at the grain boundaries. While t-ZrO₂ was detected in Cr-Ni/ZrO₂ nanocomposites, m-ZrO₂ could not be found. Few α'-martensite and deformation bands were formed in the microstructures of Cr-Ni/ZrO₂ nanocomposites. Although nano-ZrO₂ particles had a negligible impact on the strength improvement provided by deformation-induced plasticity mechanisms in Cr-Ni/ZrO₂ nanocomposites, the mechanical properties of Cr-Ni steel were significantly improved by using nano-ZrO₂ particles. The hardness and compressive strength of Cr-Ni/ZrO₂ nanocomposite were higher than those of Cr-Ni steel and enhanced as the weight fraction of nano-ZrO₂ particles increased. Cr-Ni/ZrO₂ nanocomposite with 5wt.% nano-ZrO₂ particles had almost twofold the hardness and compressive strength of Cr-Ni steel. The nano-ZrO₂ particles were considerably more effective on particle-strengthening mechanisms than deformation-induced strengthening mechanisms in Cr-Ni/ZrO₂ nanocomposites.

Association of miR-1266 with Recurrence/Metastasis Potential in Estrogen Receptor Positive Breast Cancer Patients

Sevinc, Elif Demirdogen,Egeli, Unal,Cecener, Gulsah,Tezcan, Gulcin,Tunca, Berrin,Gokgoz, Sehsuvar,Tasdelen, Ismet,Tolunay, Sahsine,Evrensel, Turkkan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

The Homeobox B13 (HOXB13):Interleukin 17 Receptor B (IL17BR) index of estrogen receptor (ER)-positive breast cancer (ER (+) BC) patients may be a potential biomarker of recurrence/ metastasis. However, effects of microRNA (miRNA) binding to the 3' untranslated region (3' UTR) of HOXB13 and IL17BR and its function on recurrence/metastasis in ER (+) BC remains elusive. The aims of this study were to determine the expression of miRNAs that bind to 3' UTR of HOXB13 and IL17BR in ER (+) BC patients and asess the effects of these miRNAs on recurrence/metastasis. The expression profiles of HOXB13 and IL17BR were evaluated using RT-PCR in tumors and normal tissue samples from 40 ER (+) BC patients. The expression level of 4 miRNAs, which were predicted to bind the 3' UTR of HOXB13 and IL17BR using TargetScan, microRNA.org and miRDB online databases, were further evaluated with RT-PCR. Our findings demonstrated that high miR-1266 levels might be significant prognostic factor for recurrence/metastasis occurrence (3.05 fold p=0.004) and tamoxifen response (3.90 fold; p=0.2514) in ER (+) BC cases. Although we suggest that modulation of miR-1266 expression may be an important mechanism underlying the chemoresistance of ER (+) BC, advanced studies and validation are required.

Anticancer Effects of Thymoquinone, Caffeic Acid Phenethyl Ester and Resveratrol on A549 Non-small Cell Lung Cancer Cells Exposed to Benzo(a)pyrene

Ulasli, Sevinc Sarinc,Celik, Sefa,Gunay, Ersin,Ozdemir, Mehmet,Hazman, Omer,Ozyurek, Arzu,Koyuncu, Tulay,Unlu, Mehmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Phytochemical compounds are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. The purpose of this study was to investigate the potential effcts of thymoquinone, caffeic acid phenylester (CAPE) and resveratrol on inflammatory markers, oxidative stress parameters, mRNA expression levels of proteins and survival of lung cancer cells in Vitro. Materials and Methods: The A549 cell line was treated with benzo(a)pyrene, benzo(a)pyrene plus caffeic acid phenylester (CAPE), benzo(a)pyrene plus resveratrol (RES), and benzo(a)pyrene plus thymoquinone (TQ). Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and anti-apoptotic proteins and cell viability were assessed and results were compared among study groups. Results: TQ treatment up-regulated Bax and down-regulated Bcl2 proteins and increased the Bax/Bcl2 ratio. CAPE and TQ also up-regulated Bax expression. RES and TQ down-regulated the expression of Bcl-2. All three agents decreased the expression of cyclin D and increased the expression of p21. However, the most significant up-regulation of p21 expression was observed in TQ treated cells. CAPE, RES and TQ up-regulated TRAIL receptor 1 and 2 expression. RES and TQ down-regulated the expression of NF-kappa B and IKK1. Viability of CAPE, RES and TQ treated cells was found to be significantly decreased when compared with the control group (p=0.004). Conclusions: Our results revealed up-regulation of the key upstream signaling factors, which ultimately cause increase in their regulatory p53 levels affecting the induction of G2/M cell cycle arrest and apoptosis. Overall these results provide mechanistic insights for understanding the molecular basis and utility of the anti-tumor activity of TQ, RES and CAPE.

Evaluation of the Knowledge, Behavior and Health Beliefs of Individuals over 50 Regarding Colorectal Cancer Screening

Tastan, Sevinc,Andsoy, Isil Isik,Iyigun, Emine Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

The aim of the study was to evaluate of the knowledge, behavior and health beliefs of individuals over 50 regarding colorectal cancer screening, with a descriptive and cross-sectional design at Karabuk Life and Health Center in Turkey. A total of 160 people meeting set criteria were included in the study. The questionnaire consisted of two parts. The first part was composed of questions on characteristics of participants and the second part of questions derived from the Champion's Health Belief Model Scale. Only 15.0% of participants (n=24) had undergone a fecal occult blood test (FOBT), 11.3% (n=18) had had colonoscopy and 4.4% (n=7) had had sigmoidoscopy. Some 90.6% of the participants had low levels of risk awareness about the colorectal cancer. It was found that the average point of severity subscale of participants over 65 is higher than that of participants under 65 (p<0.05). In conclusion, because of the many barriers and health beliefs for the colorectal cancer screening program, the rate of participation in screening programs is not sufficient. Healthcare providers have important responsibilities for increasing rate of attendance in colorectal cancer screening programs.

Preparation, Characterization of Chitosan-Coated/Uncoated Boron Nanoparticles and In-Vitro Evaluation of Their Antimicrobial Effects

Rukiye Sevinc Ozakar,Mehmet Semih Bingol,Mehmet Cemal Adıguzel,Emrah Ozakar 한국고분자학회 2022 폴리머 Vol.46 No.6

Many studies have reported that the widespread use and abuse of antibiotics have led to the emergence of multidrug-resistant bacteria, a significant weakness of current antibiotic therapy. Therefore, the present scenario motivates scientists to develop biocompatible nanoparticles (Nps) that apply better antibacterial effects and biocompatible properties, including cost-effectiveness. The aim of this study was to evaluate the antibacterial effect of boron nitride (BN) and chitosan coated BN-Nps using different surfactants. In this regard, the potential antibacterial activity of prepared chitosan-coated and non-coated BN-Nps have been investigated against nine reference bacteria strains. BN-Nps and chitosan-coated BN-Nps were successfully developed and characterized. Nps determined that showed high zeta potential values (between -20.1 mV and +59.2 mV). Antimicrobial resistance results indicated that formulations of BN-Nps with negative zeta potential were found to be effective compared to chitosan-coated BN-Nps with high positive zeta potential. These findings emphasize the future availability of BN-Nps formulation providing antibacterial activity.

Effects of dentin moisture on the push-out bond strength of a fiber post luted with different self-adhesive resin cements

Turker, Sevinc Aktemur,Uzunoglu, Emel,Yilmaz, Zeliha The Korean Academy of Conservative Dentistry 2013 Restorative Dentistry & Endodontics Vol.38 No.4

Objectives: This study evaluated the effects of intraradicular moisture on the pushout bond strength of a fibre post luted with several self-adhesive resin cements. Materials and Methods: Endodontically treated root canals were treated with one of three luting cements: (1) RelyX U100, (2) Clearfil SA, and (3) G-Cem. Roots were then divided into four subgroups according to the moisture condition tested: (I) dry: excess water removed with paper points followed by dehydration with 95% ethanol, (II) normal moisture: canals blot-dried with paper points until appearing dry, (III) moist: canals dried by low vacuum using a Luer adapter, and (IV) wet: canals remained totally flooded. Two 1-mm-thick slices were obtained from each root sample and bond strength was measured using a push-out test setup. The data were analysed using a two-way analysis of variance and the Bonferroni post hoc test with p = 0.05. Results: Statistical analysis demonstrated that moisture levels had a significant effect on the bond strength of luting cements (p < 0.05), with the exception of G-Cem. RelyX U100 displayed the highest bond strength under moist conditions (III). Clearfil SA had the highest bond strength under normal moisture conditions (II). Statistical ranking of bond strength values was as follows: RelyX U100 > Clearfil SA > G-Cem. Conclusions: The degree of residual moisture significantly affected the adhesion of luting cements to radicular dentine.

Influence of a glide path on the dentinal crack formation of ProTaper Next system

Turker, Sevinc Aktemur,Uzunoglu, Emel The Korean Academy of Conservative Dentistry 2015 Restorative Dentistry & Endodontics Vol.40 No.4

Objectives: The aim was to evaluate dentinal crack formation after root canal preparation with ProTaper Next system (PTN) with and without a glide path. Materials and Methods: Forty-five mesial roots of mandibular first molars were selected. Fifteen teeth were left unprepared and served as controls. The experimental groups consist of mesiobuccal and mesiolingual root canals of remaining 30 teeth, which were divided into 2 groups (n = 15): Group PG/PTN, glide path was created with ProGlider (PG) and then canals were shaped with PTN system; Group PTN, glide path was not prepared and canals were shaped with PTN system only. All roots were sectioned perpendicular to the long axis at 1, 2, 3, 4, 6, and 8 mm from the apex, and the sections were observed under a stereomicroscope. The presence/absence of cracks was recorded. Data were analyzed with chi-square tests with Yates correction. Results: There were no significant differences in crack formation between the PTN with and without glide path preparation. The incidence of cracks observed in PG/PTN and PTN groups was 17.8% and 28.9%, respectively. Conclusions: The creation of a glide path with ProGlider before ProTaper Next rotary system did not influence dentinal crack formation in root canals.

Can the Thiol/Disulfide Imbalance Be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?

Ahmet Omma,Sevinc Can Sandikci,Orhan Kücüksahin,Murat Alisik,Ozcan Erel 대한의학회 2017 Journal of Korean medical science Vol.32 No.10

Familial Mediterranean fever (FMF) is a chronic autoinflammatory condition characterized by fever attacks and recurrent polyserositis. Subclinical inflammation that persists during attack-free periods can result in oxidative stress (OS) damage. Thiol groups bind to reactive oxygen radicals and protect cells and tissues from OS damage. The aim of this study was to investigate the relationship between thiol-disulfide balance and colchicine resistance in FMF patients during an attack or attack-free period. A newly developed spectrophotometric method was used to measure native thiol (NT) and disulfide (DS) levels in FMF patients and an age-sex matched group of healthy controls. NT and DS levels were compared in FMF patients 1) with vs. without colchicine resistance; and 2) during an attack (FMF-AP) vs. attack-free period (FMF-AFP). A total of 118 FMF patients and 60 healthy controls were studied. NT (P < 0.001) and total thiol (TT) (P < 0.001) levels in FMF patients were significantly lower compared to healthy controls. NT (P = 0.030) and TT (P = 0.010) levels of FMF-AP patients were significantly lower than that of FMF-AFP patients. FMF-AP patients had significantly higher DS levels than FMF-AFP patients (P = 0.039). Compared to FMF patients without colchicine resistance, elevated levels of DS (P = 0.019) but not NT (P = 0.620) and TT (P = 0.718) were found in those with colchicine resistance. Thiol-disulfide homeostasis is altered in FMF patients during an attack period and this imbalance may be associated with colchicine resistance.

Validation of Three Breast Cancer Nomograms and a New Formula for Predicting Non-sentinel Lymph Node Status

Derici, Serhan,Sevinc, Ali,Harmancioglu, Omer,Saydam, Serdar,Kocdor, Mehmet,Aksoy, Suleyman,Egeli, Tufan,Canda, Tulay,Ellidokuz, Hulya,Derici, Solen Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

Background: The aim of the study was to evaluate the available breast nomograms (MSKCC, Stanford, Tenon) to predict non-sentinel lymph node metastasis (NSLNM) and to determine variables for NSLNM in SLN positive breast cancer patients in our population. Materials and Methods: We retrospectively reviewed 170 patients who underwent completion axillary lymph node dissection between Jul 2008 and Aug 2010 in our hospital. We validated three nomograms (MSKCC, Stanford, Tenon). The likelihood of having positive NSLNM based on various factors was evaluated by use of univariate analysis. Stepwise multivariate analysis was applied to estimate a predictive model for NSLNM. Four factors were found to contribute significantly to the logistic regression model, allowing design of a new formula to predict non-sentinel lymph node metastasis. The AUCs of the ROCs were used to describe the performance of the diagnostic value of MSKCC, Stanford, Tenon nomograms and our new nomogram. Results: After stepwise multiple logistic regression analysis, multifocality, proportion of positive SLN to total SLN, LVI, SLN extracapsular extention were found to be statistically significant. AUC results were MSKCC: 0.713/Tenon: 0.671/Stanford: 0.534/DEU: 0.814. Conclusions: The MSKCC nomogram proved to be a good discriminator of NSLN metastasis in SLN positive BC patients for our population. Stanford and Tenon nomograms were not as predictive of NSLN metastasis. Our newly created formula was the best prediction tool for discriminate of NSLN metastasis in SLN positive BC patients for our population. We recommend that nomograms be validated before use in specific populations, and more than one validated nomogram may be used together while consulting patients.