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Relation of ATPase6 Mutations and Telomere Length in Schizophrenia Patients
Sevgi Karabulut Uzuncakmak(Sevgi Karabulut Uzuncakmak ),Ebubekir Dirican(Ebubekir Dirican ),Halil Ozcan(Halil Ozcan ),Ugur Takim(Ugur Takim ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Schizophrenia is a serious mental disorder. Mutations in mitochondrial genes can change energy metabolism. Telomere is a tandem sequence at the end of chromosomes. Shorter telomere length has been shown in schizophrenia. The aim of this study was to determine the relationship between ATPase6 gene mutations and telomere length in schizophrenia patients. Methods: Blood samples of 34 patients and 34 healthy controls were used. In this study conventional PCR, Sanger sequencing technic and real-time PCR were utilized. Results: Five different mutations (A8860G, A8836, G8697A, C8676T, and A8701G) in the ATPase6 gene were identified in schizophrenia patients. The most seen mutation was A8860G (94%). Telomere length analysis indicated the relation of ATPase6 gene mutations and telomere length variations (p = 0.001). Patients carrying the A8860G mutation had shorter telomere lengths than patients carrying other mutations. Comparing telomere length between schizophrenia patients and healthy controls revealed that the mean telomere length of schizophrenia patients was shorter than healthy controls (p = 0.006). The demographic analysis demonstrated a significant relationship between marital status and telomere length (p = 0.011). Besides that, the duration of the illness is another factor that impacts telomere length (p = 0.044). There is no significant relation between telomere length and other clinical and demographic characteristics including education status, age, gender, etc. Conclusion: In conclusion, telomere length and ATPase6 gene mutations have a significant relation. Studies with larger patient populations and investigation of other mitochondrial gene mutations will make the clearer link between telomere length and mitochondrial mutations.
( Sevgi Akarsu ),( Turna Ilknur ),( Ceylan Avc ),( Emel Fetil ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.5
We present 9-year-old fraternal twins from a family with piebaldism, having congenital depigmented macules and meeting the diagnostic criteria for neurofibromatosis type 1 (NF1) due to the multiple cafe-au-lait macules (CALMs) and intertriginous freckling at the same time. It’s still a debatable issue that CALMs and intertriginous freckling may be seen in the clinical spectrum of piebaldism or these patients should be regarded as coexistence of piebaldism and NF1. However, based on recent literature and our patients’ findings, we suggest that this rare phenotypic variant of piebaldism may not need the careful clinical follow-up and molecular testing for NF1. Besides, it may be suitable that these individuals with piebaldism showing NF1-like clinical phenotypes should be further tested for KIT and SPRED1 gene mutations. (Ann Dermatol 31(5) 567∼570, 2019)
On singular integral operators involving power nonlinearity
Sevgi Esen Almali,Gumrah Uysal,Vishnu Narayan Mishra,Ozge Ozalp Guller 강원경기수학회 2017 한국수학논문집 Vol.25 No.4
In the current manuscript, we investigate the pointwise convergence of the singular integral operators involving power nonlinearity given in the following form: \begin{equation*} T_{\lambda }(f;x)=\int \limits_{a}^{b}\sum \limits_{m=1}^{n}f^{m}(t)K_{\lambda ,m}(x,t)dt,\text{ }\lambda \in \Lambda ,\text{ }x\in \left( a,b\right) , \end{equation*} where $\Lambda $ is an index set consisting of the non-negative real numbers, and $n\geq 1$ is a finite natural number, at $\mu -$generalized Lebesgue points of integrable function $f$ $\in L_{1}\left( a,b\right) .$ Here, $f^{m}$ denotes $m-th$ power of the function $f$ and $\left( a,b\right)$ stands for arbitrary bounded interval in $ \mathbb{R} $ or $\mathbb{R}$ itself. We also handled the indicated problem under the assumption $f$ $\in L_{1}\left( \mathbb{R}\right) .$
Ozen, Sevgi,Uzal, Burak Techno-Press 2021 Advances in concrete construction Vol.12 No.1
In this study, pozzolanic reactivity and strength activity of zeolitic tuffs containing similar amount of zeolitic phase (clinoptilolite) and different types and amounts of impurities were examined in order to understand the role of mineralogical composition in the efficiency of zeolitic natural pozzolans. Mineralogical and chemical compositions as well as the physical properties of the zeolitic tuffs were determined. Their pozzolanic reactivity were measured as depletion of calcium hydroxide in the pastes containing lime and zeolitic tuff, which is determined by thermogravimetric analysis. Furthermore, compressive strength of blended cement mortars prepared with 20% replacement of Portland cement by finely ground tuffs were determined at 7, 28 and 56 days of age. It was demonstrated that the type and amount of impurities in mineralogical composition of zeolitic tuffs are significantly effective on their early pozzolanic reactivity. Zeolite mineral content, however, is more determinative on long term reactivity. For a strength activity, mineralogical composition was clearly effective on the preparation of mortar samples, which depends on water requirement of zeolitic tuffs.
SOME RESULTS ON THE LOCALLY EQUIVALENCE ON A NON-REGULAR SEMIGROUP
Atlihan, Sevgi Korean Mathematical Society 2013 대한수학회논문집 Vol.28 No.1
On any semigroup S, there is an equivalence relation ${\phi}^S$, called the locally equivalence relation, given by a ${\phi}^Sb{\Leftrightarrow}aSa=bSb$ for all $a$, $b{\in}S$. In Theorem 4 [4], Tiefenbach has shown that if ${\phi}^S$ is a band congruence, then $G_a$ := $[a]_{{\phi}^S}{\cap}(aSa)$ is a group. We show in this study that $G_a$ := $[a]_{{\phi}^S}{\cap}(aSa)$ is also a group whenever a is any idempotent element of S. Another main result of this study is to investigate the relationships between $[a]_{{\phi}^S}$ and $aSa$ in terms of semigroup theory, where ${\phi}^S$ may not be a band congruence.
Evaluation Expression of the Caspase-3 and Caspase-9 Apoptotic Genes in Schizophrenia Patients
Ebubekir Dirican(Ebubekir Dirican ),Halil Özcan(Halil Özcan ),Sevgi Karabulut Uzunçakmak(Sevgi Karabulut Uzunçakmak ),Uğur Takım(Uğur Takım ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Apoptosis is programmed cell death that occurs by several pathways. Caspase-3 is induced by active caspase-9 via the intrinsic pathway. The aim of this research was to explore the expression of caspase-3 and caspase-9 in schizophrenia patients and healthy samples. Methods: RNA was isolated from the peripheral blood of 39 schizophrenia patients’ and healthy samples. After cDNA synthesis, real time PCR (RT-PCR) was used to analyse caspase-3 and caspase-9 gene expression. The severity of psychopathological symptoms of schizophrenia was evaluated using the Positive and Negative Symptoms Scale for schizophrenia (PANSS) and Clinical Global Impressions (CGI). Results: The expression of caspase-3 and caspase-9 genes was higher in schizophrenia patients than in healthy samples (p = 0.012, p = 0.002, respectively). The increase in caspase-3 gene expression was significant with being male, smoking and with a duration of less than 6 years (p = 0.047, p = 0.049, p = 0.034, respectively). On the other hand, the increase in caspase-9 gene expression was significant in patients who is smoke, have children, and are under 33 years old (p = 0.040, p = 0.043, p = 0.045, respectively). A significant positive correlation was detected between the caspase-3 and caspase-9 gene expression (r = 0.3218, p = 0.049). Conclusion: Our findings indicate that caspase-3 and caspase-9 gene expression may activate cell death mechanisms by intrinsic apoptotic genes. Furthermore, caspase-3 and caspase-9 may play essential roles in different ways in schizophrenia. Hence there is a need to further study the apoptotic mechanism with expanded patient populations.
Ganoderma Lucidum Protects Rat Brain Tissue Against Trauma-Induced Oxidative Stress
Özevren Hüseyin,İrtegün Sevgi,Deveci Engin,Aşır Fırat,Pektanç Gülsüm,Deveci Şenay 대한신경손상학회 2017 Korean Journal of Neurotrauma Vol.13 No.2
Objective: Traumatic brain injury causes tissue damage, breakdown of cerebral blood flow and metabolic regulation. Thisstudy aims to investigate the protective influence of antioxidant Ganoderma lucidum (G. lucidum) polysaccharides (GLPs)on brain injury in brain-traumatized rats. Methods: Sprague-Dawley conducted a head-traumatized method on rats by dropping off 300 g weight from 1 m height. Groups were categorized as control, G. lucidum, trauma, trauma+ G. lucidum (20 mL/kg per day via gastric gavage). Braintissues were dissected from anesthetized rats 7 days after injury. For biochemical analysis, malondialdehyde, glutathioneand myeloperoxidase values were measured. Results: In histopathological examination, neuronal damage in brain cortex and changes in blood brain barrier were observed. In the analysis of immunohistochemical and western blot, p38 mitogen-activated protein kinase, vascular endothelial growth factor and cluster of differentiation 68 expression levels were shown. These analyzes demonstrated the benefcial effects of GLPs on brain injury. Conclusion: We propose that GLPs treatment after brain injury could be an alternative treatment to decraseing inflammationand edema, preventing neuronal and glial cells degeneration if given in appropriate dosage and in particular time intervals.
Effects of a fentanyl-propofol mixture on propofol injection pain: a randomized clinical trial
Nurcan Kizilcik,Ferdi Menda,Sevgi Bilgen,Ozgül Keskin,Ozge Koner 대한마취통증의학회 2015 Korean Journal of Anesthesiology Vol.68 No.6
Background: Propofol injection pain is a common problem that can be very distressing for patients. We compared the effects of injection with saline followed by injection with a fentanyl-propofol mixture, injection with fentanyl followed by a propofol injection, and injection with saline followed by propofol alone on propofol injection pain. Methods: The patients were assigned randomly to one of three groups. A rubber tourniquet was placed on the forearm to produce venous occlusion for 1 min. Before anesthesia induction, group C (control, n = 50) and group M (fentanylpropofol mixture, n = 50) received 5 ml of isotonic saline, while group F (fentanyl, n = 50) received 2 μg/kg of fentanyl. After the tourniquet was released, groups C and F received 5 ml of propofol and group M received 5 ml of a mixture containing 20 ml of propofol and 4 ml of fentanyl. At 10 s after the study drugs were given, a standard question about the comfort of the injection was asked of the patient. We used a verbal rating scale to evaluate propofol injection pain. Statistical analyses were performed with Student’s t-tests and Fisher’s exact tests; P < 0.05 was considered to indicate statistical significance. Results: The demographic data were similar among the groups. In group M, the number of patients reporting propofol injection pain was significantly lower than in groups F and C (both P < 0.001). No patient in group F or M experienced severe pain, whereas 24 patients (48%) had severe pain in group C (both P < 0.001). Conclusions: This study shows that a fentanyl-propofol mixture was more effective than fentanyl pretreatment or a placebo in preventing propofol injection pain.