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Innovation Intensity and Asset Prices
( Seunghyup Lee ) 한국금융연구원 2021 금융연구 working paper Vol.2021 No.14
This paper explores the implications for asset prices of shocks that raise the intensity of innovation for new consumption products. New innovation increases productivity by expanding product variety but requires time and resources to be implemented and become available for production. Therefore, higher intensity of innovation is associated with larger investment and higher marginal value of consumption, and firms whose values are more sensitive to the intensity of innovation, the growth firms, command lower risk premia. Based on this observation, I build a calibrated general equilibrium model with time-varying intensity of innovation that can potentially explain the market and the cross-sectional distribution of risk premia simultaneously. The model is consistent with the findings that value premium is mostly an intra-industry phenomenon, given that innovation intensity changes mostly at an industry level. Using a novel measure of radical innovation, I also provide empirical evidence that the time variation of the innovation intensity is a price risk factor in the financial market and explains value spread better than other variables that have been already proposed in the literature.
Seunghyup OH,Hiroshi MIZUNO,Toshinori KOZAKI,Soonsung HONG,Kyunghun PARK,Rokyeon Hwang,Yoshiaki KONO 한국응용곤충학회 2012 한국응용곤충학회 학술대회논문집 Vol.2012 No.05
Substrate affinity and insecticide sensitivity of acetylcholinesterase (AChE) from Daphnia magna S., Bombyx mori L., Musca domestica L., Myzus persicae S., Anguilla anguilla L., Cyprinus carpio L., Oryzias latipes T.&S., Homo sapiens L., Bos taurus L. were tested. The Km values of M. domestica AChE to acetylthiocholine (ATCh), propionylthiocholine (PTCh), butyrylthiocholine (BTCh) were 57.3 μM, 13.4 μM and 85.9 μM respectively, which were lower than those of A. anguilla, C. carpio, O. latipes, H. sapiens and B. taurus. In nontarget organisms, the I50 values of AChE to fenitroxon and DDVP were 1.5×10-6 M~7.8×10-5 M and 2.4×10-6 M~1.1×10-4 M respectively, thus they have lower sensitivity compared with M. domestica. The I50 value of M. persicae AChE to pirimicarb was 1.3×10-8 M, which was higher sensitivity compared with other test animals except D. magna. The I50 values of D. magna AChE to fenitroxon, DDVP, carbaryl, eserine, pirimicarb were 5.2×10-10 M~2.1×10-8 M, which were higher sensitivity compared with the other test animals used for this study. cDNA of Daphnia magna AChE precursor was sequenced and compared with those of Musca domestica, Drosophila melanogaster and Torpedo californica.
Seunghyup Jeong,Serenus Hua,Do-Young Choi,Pyong-Gon Moon,Rudolf Grimm,Kwang Pyo Kim,Moon Chang Baek,Hyun Joo An 한국당과학회 2013 한국당과학회 학술대회 Vol.2013 No.1
Exosomes (microvesicles, or micropaticles) are small membrane-enclosed vesicles and these are secreted by various cell types, including tumor cells. These vesicles play an important role as mediators in extracellular communication. They are composed of membrane, cellular proteins, DNA, and RNA derived from their origin cells. It is also known that exosomes are involved in tumor metastasis, angiogenesis, and antitumor immunity. These biological functions are probably due to the glycosylation on their membrane proteins. Thus, the study of glycosylation of exosomes will be another potential source of new biomarker. However, there is a little study about the glycosylation of exosomes. Here, we targeted and analyzed N-glycans of exosomes derived from five cancer cell lines (A549, PC9, PC9/ZD, MCF-7, and MDA-MB231) using nano-LC/MS. We also have compared glycans of exosomes with glycans on their origin cell membrane to examine glycosylation correlation between origin cells and exosomes on three lung cancer cell lines. Additionally, we have compared anticancer drug resistant cell line PC9/ZD (Gefitinib resistant) and untreated PC9 in terms of origin cells and exosomes glycan profiling via isomer separation. Exosomes and cell membranes were prepared from three lung cancer cell lines: A549, PC9, and PC9/ZD. And two breast cancer exosomes were prepared: MCF-7 and MDA-MB231. Glycans were released by PNGase F, then enriched by graphitized carbon solid phase extraction. Nano-LC/chip Q-TOF MS was used for overall glycan profiling and quantitation. We successfully release and profile N-glycans from exosomes. Origin cells and exosomes of lung cancer contain high-mannose glycans in abundance. Although, exosomes have less high-mannose glycans compared with origin cells. Both origin cells and exosomes, isomer separation of sialylated glycans are different between PC9 and PC9/ZD. On breast cancer exosomes, two different matastatic samples represent quite different profiling. This is the first study of comprehensive glycan profiling of exosomes using mass spectrometry.
Seunghyup Jeong,Unyong Kim,Hyun Joo An 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01
Gastric cancer is one of the most common malignancy and leading cause of cancer death. Classically, CEA and CA19-9 have been used for gastric cancer detection. However, CEA and CA19-9 insufficient for cancer detection due to low specificity and sensitivity. Glycosylation is the most common post-translational modification and plays an important role in various biological processes. Whole serum based glycan profiling has been already developed and widely used in cancer biomarker study. While, targeted glycoproteomic approach is needed in clinic for better sensitivity and specificity. In previous study, we targeted serum haptoglobin for gastric cancer. We found glycosylation changes of haptoglobin on released N-glycan between gastric cancer patient and healthy control. Released glycan analysis provide compositional and isomer information while cannot give actual site of glycosylation. On the other hand, intact glycopeptide analysis provide site-specific information. Based on this actual glycosylation site and glycan heterogeneity, we monitored more detailed glycan changes and aberrant glycosylation of each site for more sensitive and specific diagnosis. In this study, we have developed the method for intact glycopeptide analysis for biomarker discovery using UHPLC MS. We successfully separated 3 glycopeptides and profiled the glycoform of 2 glycopeptides. The other one was difficult to profile glycoform according to two glycosylation sites. Therefore, this glycopeptide was fractionated and analyzed by nano LC chip Q-TOF MS. Further, cancer patient (n=40, stage IV) and healthy control (n=47) samples were applied for training set of biomarker study. A T-test based analysis was performed to identify potential biomarker (p<0.001). In the future, we will apply this platform to large clinical sample to validate potential biomarker.
벤치 시뮬레이션을 통한 차량 모의 성능 시험법에 대한 연구
백승협(Seunghyup Baik),강승화(Seunghwa Kang) 한국자동차공학회 2012 한국자동차공학회 부문종합 학술대회 Vol.2012 No.5
Unlike the past, at modern society, automobile is not only transport for human being, but also kind of asset as convenience and enjoyment. According to technological advancement, humans focus more on R&D regarding automobile and manufacture them using complex mechanical combination of all engineering. Nowadays, automobile has more complicated mechanical & electrical structure and its complex engineering system. Auto manufacturers develop devices for convenience, various functions for safety and protection in case of an emergency. In order to develop these functions, essential procedure is required. That is “Validation”. Basically, A vehicle is an transportation and power-driven machinery. Hence, the car must be developed in considering safety and the more this structure is getting complicated, the more appropriate “Validation” procedure is required in different situation. In conclusion, An automobile has to be developed with validation process, by verifying and checking the right operation for each functions and figuring out potential safety risk during actual driving. However, it’s hard to simulate real driving situation. When some car faces dangerous condition in high speed, although damageability can be measured by CAE, it is not able to be checked whether millions of signals are communicated each other correctly. Furthermore, even if there is logic that another signal is substituted for cutting a signal off, it’s not easy to make sure that this function is working properly under applying reliability for safety. The solution for the problem is Vehicle Bench Simulation test as a more effective validation method. Bench simulation is virtual simulation system that consolidates module system controlled in the vehicle, which shows various signals in real driving. GM developed GMLAN communication system and has been using it as a common serial data link communication applied to all GM vehicles since 2003. This GMLAN communication system is applied to bench simulation by High speed/Mid speed/ Low speed line and can be controlled through Vehicle Spy Simulation Program. Actually by this bench simulation, various virtual tests are being performed like shutting the fuel pump during vehicle collision, cooling fan control and fuel gauge display for fuel quantity.