인체의 장기조직중 Dieldrin의 잔류량에 관한 조사

양승림,정갑열 부산대학교 환경문제 연구소 1986 環境硏究報 Vol.4 No.-

Dieldrin is belongs to the organochlorine pesticide compounds, but it's pharmacodynamic action and metabolic mechanism are different to the other organochlorine compounds. So this study was conducted to investigate the amounts of dieldrin residues in human organ tissues of 52 autopsy cases which were caried out in Pusan and Kyung-nam area. The obtained results were as follows; 1. The residues of dieldrin in each tissue were 20.19±14.97ppb in liver, 10.37±6.84ppb in kidney, 14.79±8.67ppb in heart, 3.27±1.98ppb in lung and 12.21±7.25ppb in pancreas. 2. Although there was no statistical significance, the values of dieldrin residues in male were generally higher than in female. 3. The residues of dieldrin in all tissues were showed increasing tendency with the age. 4. The frequency distribution type of dieldrin residues in liver and kidney showed as like "L" type, right-skewed distributed type in heart and pancreas and irregular pattern in lung tissue.

한국산 육서사류(陸棲蛇類)의 조충류 감염상태

조승열,송기원,이순형 중앙대학교 의과대학 의과학연구소 1982 中央醫大誌 Vol.7 No.4

One hundred Korean terrestial snakes,i.e.,7 Elaphe rufodorsata,17 E. dione, 10 Dinodon rufozonatum rufozatum,37 Natrix tigrina lateralis,21 Agkistrodon blomhoffii brevicaudus,6A.calibinosus and 2A. saxatiilis were examined from June 17, 1981 to Jun 1, 1982, to observe the fauna of Korean cestode parasities. They were collected from 13 localities of southern Korea: i.e., Chunseong Gun, Hong-cheon Gun, Hoengseong Gun, Weonseong Gun, Samcheog Gun, Gangweon Do; Namyangju Gun, PAju Gun, Ganghwa Gun, Gyeonggi Do; Youngdong Gun, Jeweon Gun, Chungcheongbug Do; Jangheung Gun, Jeonlanam Do; Sancheong Gun, Gyeongsangam Do and Bugjeju Gun, Jeju Do respectively. The results could be summarized as follows: 1. A total of 61 snakes was found to be infected withsparganum larvae of Spirometra mansoni out of 100 examined. Snakes from 11 localities were infected. By species of snake, N.t. lateralis and A.b. brevicaudus showed the higher infection rates. The mean density was 11.0 per examined snake and 18.1 per infected snake respectively. A. caliginosus and A. saxatilis were new hosts of spatganum in Korea. 2. Trtrathyridium of Mesocestoides sp. was found in one snake, Elaphe rufodorsala collected from ChunSeong Gun, Gangweon Do. A total of 16 tetrathyridia was found at serosa and mesemtery of the snake. The morphology of the larvae was described. This was thr first record of recovery of thtrathyridia in any vertebrate intermediate host in Korea. Elaphe rufodorsata was a new host. 3. proteocephalus japonensis(Yamaguti, 1935) n.comb.(syn.: Ophiotaenia Japonensis Yamaguti, 1935) were found in 10 snakes which were collected from Hongcheon Gun, Weonseong Gun, Namyangju Gun, Paju Gun, Jeweon Gun, and Sancheong Gun repectively. The infected snakes were Agkistrodon blomhoffii brevicaudus, A. caliginosus, A. saxatilis and Natrix tigrina lateralis. The habit was small instetine. The measurement data and morpholigy were described. The preaently observed worms were longer than those of original description and was a difference in mumber of uteerine branches. A. blomhoffii brevicaudus, A. caliginosus, A. saxatilis were new hosts for this protecephalid cestode. Korea was added to list of the locality.

포도종실 추출물이 Methylcellulose 필름 성질에 미치는 영향

유승모,박준서,정하열,심재용,김병호,박장우 한국산업식품공학회 2003 산업 식품공학 Vol.7 No.4

The film with methylcellulose(MC) and grape seed extract(GSE) were prepared by casting their aqueous solution at 80℃ and drying at 23℃ for 48 hrs. Effect of grape seed extract(GSE) on the barrier permeabilities and the thermomechanical property of methylcellulose(MC) film was studied. The barrier permeabilities and the thermomechanical property of MC film containing various contents of GSE were evaluated in terms of water vapor, oxygen permeabilities, and dynamic mechanical analysis(DMA). The rate of water vapor permeability of MC film decreased with GSE contnets in the MC films. Also, the rate of oxygen permeability also decreased with GSE contents indicating higher oxygen barrier property of MC film. The results showed that GSE had a good miscibility with MC and acted as a plasticizer for MC film resuling in lowering the glass transition temperature of the film.

요꼬가와흡충에 감염된 고양이 소장의 배세표 변화

김병욱,이정빈,조승열 중앙대학교 의과대학 의과학연구소 1983 中央醫大誌 Vol.8 No.3

To observe the chronologic change of goblet cells in the course of experimental metagonimiasis in cat, a total of 6 parasite-free cats were infected with 10,000 metacercariae respectively. The cats were killed on 5, 10, 15 days and 4, 8, 10 weeks after infection. Two normal control cats were also killed to observe the normal histology. Three cm longitudinal samples of small intestine were taken at the initial portion of jujunum and jujuno-ileal junction. The samples were processed by routine histologic technique, and stained with hematoxylin-eosin, alcian blue(pH 1.0)/PAS, alcian blue(pH 2.5)/PAS methods. The obtained results could be summarized as follows: 1. The most prominent pathological change was found at mucosa, especially at villi. The length of villi were shortened, whereas the length of Lieberku¨hn's crypt remained normal or slightly hypertrophied. The reduction of villi length were the most remarkable during the period of 5~15 days after infection. 2. During the course of infection, the goblet cells in villi and crypt decreased in their number. The mucopolysaccharide stainability with alcian blue(pH 1.0 or pH 2.5) or PAS was identical with normal control. The mucopolysaccharide stained positively with alcian blue at pH 2.5 but not at pH 1.0. 3. The number of goblet cells reduced during 5~15 days after infection most significantly. Later than this period, the number returned to normal. The number of globlet cells reduced more significantly at villi than at Lieberku¨hn's crypt. From the above results, the reduction in number of goblet cells at small intestine during the course of experimental metagonimiasis were thought as one of manifestations of mechanical destruction by young and adult worms either at crypt or at intervillous space.

Pyrantel Pamoate(Combantrin)에 依한 蛔蟲症의 減量療法

徐丙卨,李純炯,趙昇烈,姜信榮,梁龍石,黃邱一,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

The mass treatment trial with low dosage of pyrantel pamoate against Ascaris lumbricoides infection was conducted to school children in rural areas of Korea. A comparative trial in the use of piperazine salt, santonin-kainic acid complex in the treatment of ascariasis was also attempted to evaluate the efficacy of' pyrantel pamoate. A total of 804 Ascaris infected school children selected out of 822-positives, who were screened from the total 1, 699 collected specimens, were classified into 7 groups. One of the three kinds of anthelmintics, i.e., pyrantel pamoate, piperazine adipate and santonin-kainic acid complex was administered to each group according to the planned regimen. For the evaluation, the egg negative conversion rate(cure rate) and egg reduction rate were calculated 4 weeks after treatment on 623 follow-up cases with the obtained results from the stool examinations (Cellophane Thick Smear Method and Stoll's Egg Counting Technique). The results obtained were; 1. The egg negative conversion rate was the highest in pyrantel treated groups (Group 1, 2, 3), santonin-kainic acid complex treated group (Group 7) coming next, and the lowest in piperazine treated groups (Group 4, 5, 6). 2. The reduction rates were also obtained just as the same order of the above results. 3. Among the pyrantel pamoate treated groups, the low dosage groups (Group 2 8: 3) showed 90.6% and 85.7% of negative conversion rate, and 99. 2% and 98. 2% of reduction rate respectively, while 94.1% of negative conversion rate and 97.9% of reduction rate were obtained in the conventional dosage group (Group 1). 4. On the analysis of efficacy in the groups treated with piperazine adipate, the best results were. shown in 2 or 3 consecutively treated groups (Group 4 &.- 6) under the supervision of qualified doctors, and the worst was in the group treated with 2 consecutive administration by teachers without supervision (Group 5). 5. The side reactions were so negligible in all the trial groups that none of the treated cases complained about the known side effect of those anthelmintics. From the present study, it can be suggested that the pyrantel pamoate is the most effective among three drugs, and also be recommended to apply the low dosage schedule of pyrantel pamoate in the masstreatment of ascariasis to reduce the expense of masstreatment.

Pyrantel Pamoate (Combantrin)에 依한 蛔蟲 및 鉤蟲感染의 集團治療

徐丙卨,朴定圭,趙昇烈,姜信榮,魚光本,康世喆,李源宰,李正雨,黃邱一 中央醫學社 1972 中央醫學 Vol.23 No.6

The mass treatment trial of pyrantel pamoate on Ascaris lumbricoides and Ancylostoma duodenale infections was carried out to school-children and inhabitants in rural areas in the central part of Korea. Pyrantel pamoate ("Combantrin") tablet (123 mg base) was administered as a single dose of 10. 0 mg per kg. body weight to a total of 4,198 Ascaris infected cases selected out of 4,436 (41. 6%) positives, who were screened from the total 10,660 collected stool specimens. Of these, only 3,169. cases were followed up after treatment to provide an analysis in this study. Incidentally 161 cases with concomittently infected hookworm were also subjected to assess the efficacy of pyrantel pamoate against A. duodenale. The egg negative conversion rate on A. lumbricoides was 95.3%, and on A. duodenale, 97.5% four weeks following treatment. In failed cases, the egg reduction rates on both of the infections were 97.6% and 97.3% respectively. No side effects and no problem in drug administration were demonstrated. It is concluded that this study confirms the high efficacy of pyrantel pamoate in the treatment of Ascaris lumbricoides and Ancylostoma duodenale infections and also proves the acceptability and safety of this drug in the mass treatment of ascariasis in a population with relatively high worm burden.

한국산 사류의 적혈구내 원충의 자연 감염상태에 대하여

김창욱,강신영,조승열 중앙대학교 의과대학 의과학연구소 1982 中央醫大誌 Vol.7 No.3

The natural infection of blood protozoa was surveyed in 53 Korean terrestrial snakes from June 1981 to April 1982. They were collected in 12 counties of 5 Provinces, and consisted of 10 Elaphe dione, 3 E. rufodorsata, 19 Natrix ligrina lateralis, 6 Dinodon rufozonatum rufozonatum and 15 Agkistrodon bromhoffi drevicaudus. Blood amear of each snake was made for one time, and Giemsa staining was undertaken. The liver was histologically processed to evaluate the tissue phase of any possible blood protozoa. The following results were obtained. 1. Out of 53 examined snakes, six(11.3%) revealed intraerythrocytic protozoa infections. they were found in Kangwha Gun, Kyunggi Do; Jecheon Gun and Youngdong Gun, Chungcheong Buk Do; Jangheung Gun, Jeonla Nam Do; and Hoengseong Gun, Kangwon Do repectively. 2. Out of detected intraerythrocytic protozoa, that from Natrix ligrina lateralis of Hoengseong Gun,Kangwon Do could not be identified. that protozoon was red- stained by Giemsa, 2-3㎛ in diameter and round or rhomboidal in shape. 3. Erythrocytic infections of haemogregarines were found in Dinodon rufozonatum rufozonatum, Elaphe dione, Natrix ligrina lateralis and Agkistrodon bromhoffi drevicaudus. Two different types of haemogregarines were detected in the blood of the examined Dinodon, whereas only one type, long and slender with pointed end, were found in the remaining infected snakes 4. In liver, tissue schizonts were not found either un unfected or in non-infected snakes.

10MgO-10Fe_2O_3-30Na_2O-5OSiO_2 유리의 Mo¨ssbauer 효과 연구

홍치유,박관호,백승도,문찬호,조수열 동국대학교 1987 論文集 Vol.26 No.-

The Mo¨ssbauer effect studies of the quenched glass and heat-treated glasses were performed. The Debye and Einstien temperatures of the quenched glass, determined using the center shift and kinetic temperature, are 540K and 430K respectively. The X-ray diffraction pattern showed that the heat-treated glasses were crystallized. Form the isomer shift of the heat-treated glasses, it was concluded that the Fe^(3+) ion is predominantly octahedrally coordinated.

요꼬가와흡충 감염에 의한 초기 장병변의 발생기전 관찰

노일현,김석일,강신영,조승열 중앙대학교 의과대학 의과학연구소 1984 中央醫大誌 Vol.9 No.1

In the early phase of experimental metagonimiasis in cats or dogs, non-specific villous changes were observed as shortening, widening, tip flattening, and fusion of villi, and as stromal edema. These changes reach their peak in 5-15 days after infection. Later than this period, these villous changes gradually returned to normal. The pathogenetic factor causing such villous pathology was investigated in the present study, mechanical destruction of enterocytes by worms as a main factor involved. A total of 8 domestic cats was experimentally infected with 5,000 metacercariae of Metagonimus yokogawai; then each cat was killed every day to 8th day after infection. Other 2 cats were killed as control. Three ㎝ long small intestinal tissue were taken from every 30 ㎝ from pylorus, and processed histologically. The observation results were as follows: 1. The intestinal lesions were limited to jejunum of the infected cats. At early phase of infection, the mucosal lesion were tortuous tissue defects or fibrinous exudates infiltrated by inflammatory cells at the upper portion of crypt of Lieberku¨hn. The reduction of villous length varied by individual cats. The sectioned worms were only very rarely observed in the crypt of Lieberku¨hn, unlike the cases of dogs. 2. By serial sections of jejunal tissues, that adult worms of Metagonimus yokogawai were found to make ulcer up to stromal tissue at villo-crypt junction. Enterocytes and goblet cells at the junction were degenerated and denuded by the retracting movements of anterior body of worms armed with tegumental spines. 3. The shallow ulcers which were formed by the worms were healed by syncytosis of enterocytes of nearby villus. By this healing process, adhesion of a villus to nearby one resulted in shortened, widened, or multilobed villi. And also intravillous epithelial tissue were resulted. From the above observations, the lesions of villi at the early stages of experimental metagonimiasis were considered as a result of uncompensated enterocytes deficit which was elicited by the mechanical destruction at upper parts of crypt of Lieberku¨hn or at villo-crypt junction.

Studies on the Parasitic Helminths of Korea Ⅳ. Intestinal Trematodes from Freshwater mud-turtle (Amyda sinensis Wiegmann) with description of new species, Cotylaspis coreensis

Seung-Yull Cho(趙昇烈),Byong-Seol Seo(徐丙卨) 대한기생충학열대의학회 1977 The Korean Journal of Parasitology Vol.15 No.1