Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

영도에서 조망하는 부산항 경관의 시각적 특성

박문순,강영조,조승래,강헌우,차명숙,Park, Moon-Sook,Kang, Young-Jo,Cho, Seung-Rae,Kang, Hyon-Woo,Cha, Myeong-Sook 한국조경학회 2010 韓國造景學會誌 Vol.38 No.4

본 연구는 영도에서 부산항을 체험할 수 있는 조망점을 대상으로 조망점의 공간적 분포, 부산항을 체험하는 시선의 유형, 항구경관의 구도적 특성 그리고 조망점의 시각특성을 밝히고자 하였다. 선정된 조망점 27개소를 대상으로 한 연구의 결과는 다음과 같다. 첫째, 조망점의 공간적 분포 유형은 공원형, 공공시설형, 도로변형으로 구분되었다. 조망점은 도로변형에서 가장 많이 분포하는 것으로 나타났다. 둘째, 부산항을 체험하는 시선의 유형은 수제선회유형, 항만대변형, 도시관통형으로 나타났다. 영도에서 바라보는 부산항 경관에 대한 시선의 유형은 도시관통형이 가장 많이 나타났다. 이유로는 영도라는 섬이 도시화로 인해 시가지와 도로가 점점 확장되면서 부산항을 바라보는 시선이 도시를 관통하여 바다를 조망하는 시선이 많아지게 된 것으로 보인다. 셋째, 항구경관의 구도적 특성은 파노라마형, 회랑형, 지붕너머형으로 파악되었다. 그 중 지붕너머형이 가장 많이 나타났다. 이를 통해 영도에서 체험하는 부산항의 모습은 대부분 경관의 연속성이 상실되고, 주거지의 지붕이 거리감을 차단하여 일종의 차경 역할을 하는 것을 알 수 있었다. 마지막으로 조망점의 시각특성을 분석하였다 조망정의 부각은 수평경에 가까운 $-3^{\circ}{\sim}-1^{\circ}$사이에 13개소, $-6^{\circ}{\sim}-4^{\circ}$의 범위에 12개소로 가장 많은 분포를 보였다. 부감의 시축에 해당되는 조망점은 2개소로 나타났다. 이는 시가지가 확장되면서 건물에 의해 내려다보는 시선이 차단된 결과로 판단되었다. 그리고 시거리의 지리적 범위는 0.2km~6.4km에 이르는 광범위한 조망역을 이루고 있었다. 최적의 부감경을 체험할 수 있는 조망점 2개소는 지속적으로 조망을 보전하기 위한 방법을 제안하였다. 본 연구의 성과는 부산의 경우와 같은 항만도시에 있어서 조망점의 관리 및 보전 등의 경관계획에 기초자료로 활용할 수 있을 것으로 기대한다. This study will define the features of the viewpoint that best enables the view of Busan Port from Young-Do. Special focus will be on spatial distribution, the type Busan Port sights that can be experienced from Young-Do, the compositional characteristic of a port landscape and visual characteristic. The results are based on 27 selected viewpoints and are as follows. Firstly, the patterns of the spatial distribution of viewpoints are classified as park, public facility and wayside types. It was found that most viewpoints are located along a wayside. Secondly, the types of Busan Port sights that can be experienced from Young-Do are divided into three kinds: surrounding stand-line type, facing the port and the type of penetrating city. The major type was of penetrating city among the three patterns. The reason for this is that the point of view for Busan Port was changed into a prospect over the sea since city and road sections have been expanding due to the urbanization of Young-Do. Thirdly, the compositional characteristics of the port landscape are divided into three styles: panoramic, corridor, and rooftop. The most frequent type is the rooftop style among the three characteristics. This fact indicates that the picture of Busan Port seen from Young-Do loses continuity of view and that housetops inhibit the sense of distance. Lastly, the visual characteristics of the viewpoint were analyzed. The angles of the declination of the viewpoints are concentrated on the horizontally closed parts. Thirteen points lie between $-3^{\circ}$ and $-1^{\circ}$, and twelve points between $-6^{\circ}$ and $-4^{\circ}$. The visual axes of the depression are two points because sight is interrupted by buildings which are built when the city expands. Two viewpoints for experiencing the optimum landscape of depression should be prepared to ensure continuous preservation of the viewpoints. The sight creates a wide prospect, reaching from 0.2km to 6.4km. It is expected that the results of this study can be used for the landscape plans of port cities including the management and preservation of viewpoints.

Effect of DREAMMO<SUP>®</SUP> Scalp Lotion on Hair Growth Promotion in an Alopecia Model of C57BL/6 Mice

Seung Ho Lee,Hwa Jeung Lee,In Jeoung Baek,Jung Min Yon,Sang Yoon Nam,Beom Jun Lee,Young Won Yun,Yun-Bae Kim,Seock Yeon Hwang,Jin Tae Hong 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.1

Scalp hair loss has increased recently in young-aged people as well as middle-aged people, and although there are no serious in health problems, scalp hair loss may significantly affect a variety of psychological and social experiences and the individual's quality of life. DREAMMO scalp lotion is composed of several plant extracts which are known to be used as oriental medicine to prevent hair loss or promote hair growth in alopecia. This study was carried out to investigate the effect of DREAMMO scalp lotion on hair growth in an alopecia model of C57BL/6 mice. Mice were divided into three experimental groups including control, DREAMMO scalp lotion and 3% Minoxidil (MXD). The test compounds were topically treated with 0.2 ㎖ per mouse per day for 4 weeks. The hair growth was determined photographically and histologically in an alopecia model of C57BL/6 mice. After 3-4 weeks, DREAMMO scalp lotion significantly increased hair growth compared to the controls in the dorsal skin of C57BL/6 mice. DREAMMO scalp lotion also promoted the elongation of hair follicles than the controls. These results suggest that DREAMMO scalp lotion has a hair growth activity and can be useful for the treatment of alopecia.

고삼 추출물을 이용한 해독물질의 개발

양희태,정승일,이영철,윤경아,백승화 한국식품영양학회 2002 韓國食品營養學會誌 Vol.15 No.1

고삼 메탄올 추출물로부터 분리한 flavonoids를 IR, NMR등의 분광학적인 방법으로 Leachianone A(LA)과 Sophoraflavanone G(SFG)로 동정하였고, 카드뮴의 세포독성효과를 고삼 및 고삼추출물이 방어할 수 있는 지를 검색하기 위하여 NIG 3T3 세포에 고삼 및 LA와 SFG, LA+SFG를 처리하고 MTT assay 및 광학현미경으로 세포의 생존률을 검색하여 다음과 같은 결론은 얻었다. MIT의 흡광도는 카드뮴의 농도에 의존하여 감소하였으며, IC_50인 MTT50은 12.5??이었으며 카드뮴을 IC_50농도로 처리하고 고삼 및 LA, SFG, LA+SFG를 각 화합물의 자체 세포독성을 갖지 않는 농도로 처리한 후 MTT assay로 세포 생존율을 측정한 결과 LA, SFG, LA+SFG 처리군들은 카드뮴 처리군(MTT_50)에 비해 세포생존률이 증가되었으며 이들은 고삼 및 고삼추출물의 농도에 의존적으로 증가되었고 각각의 단일 화합물보다 두 화합물 LA+SFG 병용처리군에서 수복 효과가 더 좋은 것으로 나타났으며 광학현미경적 소견에서도 세포재생이 뚜렷하게 보였다. 이상과 같이 고삼에서 분리한 flavonoids가 카드뮴 독성에 의하여 손상된 NIH 3T3 섬유아세포의 재생효과에 영향이 있는 것으로 판단된다. The aim of this study was to assess the antitoxic compounds, flavanones (Leachinanone A=LA and Sophora flavanone G=SFG), from Sophora flavescents (S. Flavescens). We investigated the possibility of antitoxicity of LA and SFG against NIH 3T3 fibroblasts cell lines using colorimetric MTT[3-(4-5-dimethylthiazol-2-yl)-2-5diphenyl-2H-tetra-azolium bromide] assay. The results were as follows : After cadmium was treated against NIH 3T3 cell lines, we determined IC_50. Accordingly we have examined the detoxification effects of S. flavescens, LA and SFG under cadmium IC_50=12.5?? and was carried out to observe morphological changes by the light microscopic study. In NIH 3T3 cells, Sophora flavescens, LA, SFG and LA+ SFG showed inhibitory effects on the cytotoxicity of cadmium and these detoxication effects increased in proportion to the concentration of these drugs. These results suggest that LA and SFG from S. flavescens retain a potential antitoxic activity.

20년전과 비교한 한국청년의 미소 변화에 관한 연구

범승균,정지혜,김태영,이경은,동진근 大韓齒科補綴學會 2012 대한치과보철학회지 Vol.50 No.3

Purpose: Teeth are generally exposed when people smiling. Moreover, the exposed teeth and soft tissue when smiling becomes an important guideline for esthetically prosthetic restoration. This research is to compare and find out differences of Korean young men's smile living in presence and twenty years ago. Materials and methods: Subjects, 100 young men (50 male and 50 female), were required about several aspects; normally developed physical condition, no psychological or genetic disorders, a fine face with no loss of teeth, no experience in orthodontic or prosthetic treatment, relatively normal occlusion, aged between 20 - 29. The photos of the subject at rest position and front face when fully smiled were taken three times. 100 photos (50 male and 50 female) were chosen at random from the 240 university students' smile photos taken by Yoon and his colleagues in 1991. By Hulsey's method of measuring smile, several factors; the change of upper lip curvature, the change of the relation between the upper lip and teeth, parallelism between Mx. incisor and lower lip, contact relation between Mx. incisor and lower lip and teeth displayed in a smile, were measured and analyzed. Meanwhile, ten dentists assessed aesthetic evaluation about men and women's smile for twice and recorded and compared smile score. The -test (P<.05) was used to compare the measured value. The difference of smile score was analyzed by t-test (P<.05). Results: The smile score calculated in 2011 (60.22) was higher than that of 1991 (52.80). Among five measurement categories, the noticeable difference was distinguished from two factors; the change of upper lip curvature and contact relation between Mx. incisor and lower lip. Conclusion: The Korean young men's smile has been considerably improved for twenty years. And it is found that the change of upper lip curvature plays an important role, that is, the smile formed with an ascended labial commissure has been increased significantly. 연구 목적: 일반적으로 치아는 미소 지을 때 가장 많이 노출되며, 미소 시에 나타나는 치아와 연조직과의 관계 등은 심미적인 보철 수복에 있어서 중요한 지침이 된다. 본 연구는 20년 전 한국 청년들의 미소와 현재 한국 청년들의 미소를 비교하여 그 차이를 알아보고자 하였다. 연구 재료 및 방법: 신체적인 발육 상태가 정상적이고 전신적 또는 유전적 질환이 없으며, 안모가 양호하고 치아의 결손이 없으며 교정 및 보철치료를 받은 경험이 없고, 교합상태가 비교적 정상적인 20 - 29세 사이의 청년 100명(남자 50명, 여자 50명)을 대상으로, Cephalometer에 사용되는 두부 고정 장치를 사용하여 피검자의 F-H plane이 지면에 평행하도록 한 후, 35 mm 카메라(400D. Cannon, Japan), 120 mm 렌즈 그리고 삼각대를 사용하여 피검자의 midsagittal plane에 카메라 렌즈의 중심을 맞추고 상악 중절치 절단과 렌즈와의 거리를 930 mm로 하여 안정위 및 full smile 시의 안모 정면 사진을 3회씩 촬영하였다. 1991년 윤 등이 촬영한 대학생 240명 중 무작위로 선택한 100명(남자 50명, 여 자 50명)의 미소사진과 함께 개인용 컴퓨터 및 V-ceph 6.0 프로그램을 이용하고 Hulsey의 미소 계측 방법을 참고로 하여, 상순의 형태, 상순과 치아와의 관계, 하순과 상악 전치 절단연과의 평행 관계, 하순과 상악 전치 절단연과의 접촉 관계, 미소시 나타나는 치아 등을 계측하고 분석하였다. 한편 치과의사 10인이 남,녀 각 2회씩 미소에 대한 미적 평가를 시행하여 미소평점을 기록하고 비교하였다. 결과: 지난 20년간 한국 청년의 미소가 크게 향상되었으며 이러한 변화는 주로 상순의 형태가 영향을 준 것을 알 수 있었다. 즉 입꼬리가 위로 올라가는 형태의 미소가 괄목할 만한 증가를 보인 반면 입 꼬리가 아래로 처지는 형태의 미소는 현저한 감소를 보였다. 결론: 지난 20년간 한국 청년의 미소가 크게 향상되었는데 이러한 변화는 주로 상순의 형태가 영향을 준 것으로 나타났다.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

Polypropylene Nanocomposites with Graphene Oxide Containing Flame Retardant Moieties

Seung Won Lee(이승원),Huiseob Shin(신휘섭),Yong Hun Lee(이용훈),Jong-Chan Lee(이종찬),Jae Young Jho(조재영) 한국고분자학회 2020 폴리머 Vol.44 No.5

폴리프로필렌(polypropylene, PP)/산화그래핀(graphene oxide, GO) 복합재료의 난연성과 기계적 성질을 향상시키기 위해 GO를 인계 난연제로 개질시켰다. 복합재료는 무수말레인산이 수식된 PP(maleic anhydride-grafted PP, MAPP)를 상용화제로 사용하여 용융 혼합 방식으로 제작되었다. 푸리에 적외선 분광학(Fourier transform infrared, FTIR), 광전자분광법(X-ray photoelectron spectroscopy, XPS)을 통해 난연제와 GO 사이에 공유 결합이 형성된 것을 확인할 수 있었다. GO의 기능화와 상용화제 사용이 PP/GO 복합재료의 형태학, 난연성, 기계적 성질에 미치는 영향을 평가하였다. 주사전자현미경(SEM)을 이용한 형태학 분석 결과, MAPP를 첨가함으로써 충전제와 기지재 사이의 계면 상호작용이 증가되어 GO의 박리 및 분산성이 향상되었다. PP/기능화된 GO 복합재료의 한계산소지수, 영 탄성률, 인장 강도가 PP/GO 복합재료에 비해 증가된 결과를 나타냈다. Graphene oxide (GO) was functionalized with phosphorus-containing groups to give the flame retardancy to the polypropylene (PP)/GO nanocomposites. The composites were prepared via melt mixing with maleic anhydride-grafted PP (MAPP) as a compatibilizer. Through the Fourier transform infrared (FTIR) spectroscopy, and X-ray photoelectron spectroscopy (XPS), covalently-bonded flame retardant moieties on GO were characterized. The effect of the functionalization of GO and the use of compatibilizer on the morphology, flame retardancy, and mechanical properties of the PP/GO composites were investigated. SEM observation of the composites showed that the addition of MAPP improved the exfoliation and dispersion state of the GO sheets by improving the interfacial interaction between the filler and the matrix. For PP/functionalized GO composites, the limiting oxygen index (LOI), Young’s modulus, and tensile strength were increased compared with PP/GO composites.

급성 골수성 백혈병 환자에서 발생한 침습성 아스페르길루스중에 대한 수술적치료 1 예

배영환;어원식;어상민;김승만 김태영;박수영;서영경;정은주;안효정 인제대학교 2011 仁濟醫學 Vol.32 No.-

Invasive pulmonary aspergillosis is known to have a poor prognosis and major cause of morbidity and motality in patients with hematologic disease. Without adequate therapy, invasive pulmonary aspergillosis will almost always progress to fatal pneumonia. Early administration of antifungal agents in patient with invasive pulmonary aspergillosis is most important. And surgical resection of aspergillous-infected tissue may be useful in patients with lesions that are contiguous with great vessel and lesions causing hemoptysis. We reported a rare case of surgical resection as curative treatment for invasive pulmonary aspergillosis patient in 58-year-old man who had the history of acute myeloid leukemia.

배관결함 검출을 위한 자왜형 초음파 센서의 특성

안봉영,김영주,김영길,이승석 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.1

석유화학 설비 등과 같은 노출 배관의 결함을 검출하는데 효율적으로 이용될 수 있는 자왜형 초음파 센서를 제작하였다. 최대의 초음파 발생 효율을 얻기 위한 최적 조건을 설정하였으며, 실험에 사용된 배관의 경우 250~350Oe의 정자기장이 최적이었으며, 180kHz의 주파수를 갖는 초음파를 발생시키기 위해서는 15mm 폭의 코일을 사용하는 것이 가장 좋았다. 최적의 조건에서 발생된 초음파는 50m 이상을 충분히 진행할 수 있으며, 결함의 단면적이 증가함에 따라 수신된 결함 신호는 직선적으로 증가함을 확인하였다. Magnetostrictive sensors which can be used effectively to detect flaws in pipe were fabricated. The optimal conditions to obtain the maximum generation efficiency of the ultrasonic wave were established. In case of the used steel pipe the optimal magnetic field was 250~350Oe and the coil width of 15mm showed the best efficiency for generating a wave with the frequency of 180 kHz. In the best condition, the wave can propagate further than 50m without serious attenuation. The amplitude of the ultrasonic wave reflected from artificial flaw had a good linear relationship to the cross-sectional area of the flaw.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.