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Expression and prognostic significance of human peroxiredoxin isoforms in endometrial cancer
HAN, SEULHEE,SHEN, HAIYING,JUNG, MINHYUNG,HAHN, BUM-SOO,JIN, BYUNG KWAN,KANG, INSUG,HA, JOOHUN,CHOE, WONCHAE Spandidos Publications 2012 Oncology letters Vol.3 No.6
<P>Endometrial cancer is a common type of malignant tumor of the human female genital tract, which typically occurs after menopause. Asian nations, including Korea, Japan and China, have a 4-5 times lower incidence than Western industrialized nations. However, in recent years, there has been a marked increase in the incidence of the disease. Peroxiredoxin (Prx) is an antioxidant enzyme that consists of six isoforms in mammals. These enzymes share a common reactive Cys residue in the N-terminal region, and are capable of breaking down H(2)O(2) as a peroxidase and involving thioredoxin or glutathione as the electron donor. In the present study, we evaluated the expression of Prx isoforms in normal endometrium, endometrial hyperplasia and endometrial cancer. A total of 240 patients, diagnosed with endometrial cancer by immunohistochemistry, were enrolled in this study. Results showed that Prx I, III, IV and V were negative or weakly expressed in normal endometrium, whereas levels of Prx II and VI were strongly expressed. Notably, the expression levels of Prx III and V were upregulated in endometrial cancer, compared with normal endometrium and endometrial hyperplasia. However, no differences in the staining intensities according to the grade of lesion were observed in the other Prx isoforms. The Kaplan-Meier survival analysis demonstrated that Prx V expression in endometrial cancer is significantly associated with survival rate. Therefore, we suggest that Prx V is a clinically significant prognostic marker for the development of endometrial cancer.</P>
PROGRESS REPORT: INVESTIGATION OF THE MORPHOLOGY OF CLUSTER GALAXIES
OH, SEULHEE,YI, SUKYOUNG K. The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
We investigated the galaxy morphology of 6 Abell clusters at z = 0.0784 - 0.145 based on deep images obtained using MegaCam on the CFHT. For hundreds of galaxies in our data, we classified their morphology based on criteria related to secular or merger related evolution. We found that the morphological mixture of galaxies varies considerably from cluster to cluster. This article contains a general description of our deep imaging campaign and preliminary results for galaxy morphologies in cluster environments.
Lee, Sangmin,Jung, Seulhee,Koo, Heebeom,Na, Jin Hee,Yoon, Hong Yeol,Shim, Man Kyu,Park, Jooho,Kim, Jong-Ho,Lee, Seulki,Pomper, Martin G.,Kwon, Ick Chan,Ahn, Cheol-Hee,Kim, Kwangmeyung IPC Science and Technology Press 2017 Biomaterials Vol.148 No.-
<P><B>Abstract</B></P> <P>Herein, we developed nano-sized metabolic precursors (Nano-MPs) for new tumor-targeting strategy to overcome the intrinsic limitations of biological ligands such as the limited number of biological receptors and the heterogeneity in tumor tissues. We conjugated the azide group-containing metabolic precursors, triacetylated <I>N</I>-azidoacetyl-<SMALL> <I>D</I> </SMALL>-mannosamine to generation 4 poly(amidoamine) dendrimer backbone. The nano-sized dendrimer of Nano-MPs could generate azide groups on the surface of tumor cells homogeneously regardless of cell types via metabolic glycoengineering. Importantly, these exogenously generated ‘artificial chemical receptors’ containing azide groups could be used for bioorthogonal click chemistry, regardless of phenotypes of different tumor cells. Furthermore, in tumor-bearing mice models, Nano-MPs could be mainly localized at the target tumor tissues by the enhanced permeation and retention (EPR) effect, and they successfully generated azide groups on tumor cells <I>in vivo</I> after an intravenous injection. Finally, we showed that these azide groups on tumor tissues could be used as ‘artificial chemical receptors’ that were conjugated to bioorthogonal chemical group-containing liposomes via <I>in vivo</I> click chemistry in heterogeneous tumor-bearing mice. Therefore, overall results demonstrated that our nano-sized metabolic precursors could be extensively applied to new alternative tumor-targeting technique for molecular imaging and drug delivery system, regardless of the phenotype of heterogeneous tumor cells.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
First satellite tracking of a free-ranging spotted seal (Phoca largha) from the Baengnyeongdo Island
Hyun Woo Kim,Namgyu Uh,Seulhee Lee 한국수산과학회 2023 Fisheries and Aquatic Sciences Vol.26 No.11
The spotted seal (Phoca largha) in the Yellow Sea has declined due to poaching and habitat destruction. To aid conservation efforts, Argos satellite tracking were used to monitor the movements of a free ranging spotted seal around Baengnyeongdo Island. The satellite-transmitting tag successfully attached to the seal provided 1,556 location data collected during 107 days. The seal mostly moved between two haul-out sites, Yeonbong Rock and Mulbeom Rock. From October 6th to December 12th, the seal stayed within a 7 km radius of Yeonbong Rock. However, as the signal was lost, it was not possible to identify when the seal started to migrate from Baengnyeongdo Island to winter breeding area. This study provide understanding into the habitat preferences and movement patterns of spotted seals around Baengnyeongdo Island, contributing to the conservation and management of this species. Further research with more individuals and different age groups is essential to understand their habitat preference and develop effective conservation measures for the spotted seal population in the Yellow Sea.