두 가족의 가족성 모야모야병 환자 4례

구자성,노재규,박성호,이한보,이용석,윤창호,송치성,송재우 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

2.5-헥산디온에 노출된 근로자에게서 발생한 말초 신경병증

조성용,장용석,최은경,김진석,유재영,우극현,최태성 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 영상음향장비 제조업체에서 2,5-헥산디온을 취급한 근로자에게서 발생한 다발성 말초 신경병증 환례를 보고하고, 동일 공정근로자들의 말초 신경기능을 조사하고 자 한다. 방법: 환례에 대해 방사선학적 검사, 소변 및 혈액 검사, 신경전달속도 검사, 작업환경 측정을 하였으며, 2,5-헥산디온의 노출을 중단시킨 후 5개월 후에 다시 신경전달속도 검사를 하였다. 동일공정 근로자들의 영향평가에서는 2,5-헥산디온에 노출된 13명의 남자 근로자를 노출 군으로, 해당 물질에 노출된 적이 없는 5명의 남자 근로자를 비노출군으로 선정하여 검사를 하였다. 결과: 환례의 신경전도 검사결과 양측 척골신경과 정중 신경에 이상소견을 보였으며, 호전여부를 관찰하기 위하여 5개월 후 추적검사를 실시한 결과 증상 및 신경전달속도 검사결과가 호전되었다. 동일공정 근로자들의 영향평가에서 노출군의 정중 신경과 척골신경이 비노출군에 비하여 유의하게 감소되어 있었다. 감각 신경의 진폭의 경우, 노출군의 정중 신경과 비복 신경이 감소되었으며, 운동 신경 전도속도에서는 노출군의 비골신경이 유의하게 감소되어 있었다. 말단 잠복기에서는 노출군의 정중신경, 척골신경, 비골신경, 경골신경이 비노출군에 비해서 유의하게 연장되어 있었다. 결론: 환례의 증상과 신경전달속도 검사의 이상소견은 2,5-헥산디온에 의한 말초신경병증에 부합되었다. 동일공정 근로자 건강영향평가에서 신경전달속도 검사결과 노출 군과 비노출군간의 유의한 차이가 있었는데, 이를 통해 2,5-헥산디온이 근로자들의 신경독성에 영향을 줄 수 있다는 것을 확인할 수가 있었다. Objectives: This study is a case report of 2,5-hexanedione induced occupational peripheral polyneuropathy. We also investigated the peripheral nerve function of all workers who had been exposed to 2,5-hexanedione in the same process. Methods: In June, 2006, a 2,5-hexanedione exposed worker complained of both hand numbness. He received neurologic, radiologic, laboratorial and electrophysiologic evaluation, including measurements of workplace environment. Five months after cessation of exposure to 2,5-hexanedione, a follow-up electrophysiologic examination was done. We evaluated the peripheral nerve function of 2,5-hexanedione exposed workers by comparing 13 male 2,5-hexanedione exposed workers who were in same company with the patient and 5 male workers who had not been exposed to 2,5-hexanedione. Results: Under electrophysiologic examination, there were abnormalities in sensory and motor nerve velocity, terminal latency, and F-latency of both median nerve and ulnar nerve. After 5 months, the patient symptoms and the results of follow-up electrophysiologic examinations were improved. Comparing the 2,5-hexanedione exposed group with the unexposed group, the sensory nerve velocity of the median and ulnar nerves in the exposed group was decreased. The motor nerve velocity of the peroneal nerve, and sensory nerve velocity of the median and sural nerves were decreased. Terminal latency of median, ulnar, peroneal, and tibial nerves in the exposed group were increased compared with the unexposed group(<0.05). Conclusions: 2.5-hexandione can induce peripheral polyneuropathy in male workers.

Superconducting MgB2 Wire Drawing Considering Anisotropic Hardening Behavior and Hydrostatic Effect

Young‑Seok Oh,Ho Won Lee,Kook‑Chae Chung,Duck‑Young Hwang,Seong‑Hoon Kang,Jeong Whan Yoon 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

Numerical modeling was conducted to investigate the deformation behavior of powder mixture during multi-pass drawingprocesses for multi-filamentary MgB2wire. A modified Drucker-Prager Cap (DPC) model with an elliptical cap surface usingthe new material characterization method was developed to capture the anisotropic hardening behavior and hydrostatic effectof the powder mixture. A number of uniaxial die compaction, cold isostatic pressing, diametrical compression, and uniaxialcompression tests were conducted using different powder densities to characterize the modified DPC model. A commercialfinite element software ABAQUS with a user subroutine was used to simulate the drawing of the MgB2wire. The densityand area fraction of the powder mixture during the wire-drawing process were verified with experimental results. The differencein packing density at the inner and outer filaments of the MgB2wire was successfully captured by simulation. Inaddition, the effect of the initial packing density on the superconducting properties of MgB2wire was numerically studied. It is shown that the increase in the superconducting area, which results from a high initial packing density, should be moreeffective compared to the increase in the grain connectivity in enhancing the critical current properties for the MgB2wirewhen the final packing density is saturated after a number of drawing processes.

벼 무논골뿌림栽培時 播種期 및 立毛數가 生育 및 收量에 미치는 影響

洪性澤,朴栽成,朴成圭,李尙榮,池在浚,孫錫龍 충북대학교 농업과학기술연구소 1999 農業科學硏究 Vol.16 No.-

This study was conducted to establish the cultural techniques of the puddled-soil drill seeding of race (Oryza sativa L.), which is one of the efficient labor saving cultural methods, in the central part of Korea. Seoanbyeo was seeded at three times from April 10 to May 20 with the 20 day interval in 1994. The number of seedling stands per m2 at each seeding date were 50, 90, 130 and 170. The tillering characteristics, lodging characters, dry matter production, yield components and yield were investigated. The number of days to the maximum tillering stage was reduced at the later seeding date. It was 70, 55 and 25 days in seedings on April 10, April 30 and May 20, respectively. The critical effective tillering stage was also shortened at the delayed seeding. The higher the number of seedling stands was, the higher number of tillers, the shorter duration to the maximum tillering stage and the earlier critical effective tillering stage were resulted. The number of tillers was higher at the earlier seeding date. The number of tillers was increased in the order of 50, 90, 130 and 170 seedling stands per m2. The ratios of effective tillers were 53, 61 and 63% at seeding on April 10, April 30 and May 20, respectively. The ratios were not significantly different at April 10. But the ratios in seeding on April 30 and May 20 were reduced as the number of seedling stands was increased. The weight of stem base related to lodging was the highest with 2.01g/10 plants in the optimum seeding on April 30, while it was 1.59g/10 plants in the late seeding on May 20. It was also decreased as the number of seedling stands was increased. The dry weights at 30 days before the heading stage were increased at the later seeding, while the dry weight at the heading stage was the highest at seeding on April 30 which is considered as the adequate seeding time. The dry weights at 30 days before the heading stage were increased as the number of seedling stands was increased and they were increased up to 130 seedling stands per m2 at the heading stage. The length of panicle exsertion was shortened at the later seeding. The length of panicle exsertion was increased up to 130 seedling stands. but it was shorter at 170 seedling stands. The heading dates were later at seeding on April 30 and May 20 than at seeding on April 10. They were not remarkedly different among seeding dates at 50 seedling stands, it was earlier at the higher number of seedling stands over 90. The number of spikelets per panicle was decreased at the higher number of seedling stands. The ratio of ripened grains was higher at earlier seeding than at later seeding. It was not significantly different among the number of seedling stands at the same seeding time. Yields at seeding on April 30, April 10 and May 20 were 644, 624 and 551kg/10a, respectively. The seeding on April 30, the optimum seeding time, resulted the highest yield. Rice quality was decreased due to the increase of the green kerneled rice as the seeding date was delayed.

벼 乾沓直播栽培時 播種期가 乾物生産에 미치는 影響

朴栽成,朴成圭,李尙榮,洪性澤,池在浚,趙東三,孫錫龍 충북대학교 농업과학기술연구소 1999 農業科學硏究 Vol.16 No.-

This experiment was carried out to obtain indispensable information to establish comprehensive cultural method of rice in direct seeding on dry paddy at Chungbuk Agricultural Research and Extension Services. Effect of seeding date on dry matter production, yield components and yield were studied. Seeding on May 5 ensured the highest maximum number of tillers, while transplanting on May 20 gave the highest rate of effective tillers. Number of effective tillers was greater in the order of Hwajinbyeo, Hwaseongbyeo, Daekwanbyeo. Lengths of upper three leaves were increased at later seeding, but leaf width was not affected by seeding date. Ratio of leaf blade weight was higher in earlier seeding during 30 days before heading but was higher in later seeding during 30 days after seeding, and was higher in the order of Hwajinbyeo, Hwaseongbyeo, Daekwanbyeo. CGR, RGR and NAR were not significantly different among seeding dates during 30 days before heading, but were lower in later seeding during 30 days after seeding. LAR was not affected by seeding date during 30 days before heading, but was higher at seeding on May 5 in heading date and during 30 days after heading. Dry weight of leaf blade, leaf sheath and culm, ear and total biomass during 30 days before heading and heading were highest in May 5 seeding. Daekwanbyeo and Hwaseongbyeo in May 5 seeding and Hwajinbyeo in April 20 seeding brought the highest yield with greater number of spikelets, higher ripening ratio and greater 1,000 grain weight, and harvest index and grain/straw ratio were Increased at earlier seeding. There were significantly positive correlations between number of panicles per m2 and LAI at 30 days before heading and heading, dry matter weight of leaf blade and total mass at heading. On the other hand, there were significantly negative correlations between seeding date and ripened grain ratio. 1,000 grain weight and yield, and between 1,000 grain weight and leaf length of 2nd, respectively.

소아에서 발생한 골수이형성 증후군 2례

홍성진,윤석중,김성우,조형구,오명호,김기혁,이인성 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

Myelodysplastic syndrome(MDS) is a group of acquired conditions characterized by progressive bone marrow failure associated with normocellular or hypercellular bone marrow that cannot be attributed to nutritional deficiency, chronic infection, or other chronic systemic illness, and cannot be reversed by the successful treatment of those conditions. Whereas the cases of secondary MDS occur at all ages, primary MDS is essentially a disease of elderly, though no age group is exempt and predomonant in men. The MDS is fundamentally clonal disorders at the level of the haemopoietic totipotent stem cell. Clinically, they are characterized by varing degrees of peripheral cytopenia(s) with morphological and functional abnormalities of blood elements. We have experienced two unrelated pediatric cases, who showed pancytopenia on admission and the characteristic marrow findings of MDS. The first case, a 12 months-old girl, showed increased reticulin with abnormal localization of immature precursor cells(ALIP) in her bone marrow, in addition to dysplastic features such as bi-and multi-nucleation of late normoblasts and internuclear bridging. She also showed 22% of blasts in her bone marrow cells thus classified in the category of RAEB-t after FAB classification. Also found were a chromosomal abnormality namely 46 XX t(14q21q), which was an unusual one. Her family brought her home and, 4 month later, she deceased. The second case, a 12 year-old boy, showed pancytopenia with Pseudo-Pelger-Huet anomaly in neutrophils but no blasts in the peripheral blood. Bone marrow of this case also showed the picture of dyserythropoiesis with binuclearity, internuclear bridging, nuclear fragments, multinuclearity of late normoblasts, in addition to megaloblastoid change in the normoblasts and increased mitosis in granulocytic series. No chromosomal abnormality was found. Classified as RA after FAB classification of MDS. Showed good response to conservative management for anemia for more than one year.

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

벼 무논골뿌림裁培時 播種期가 生育 및 收量에 미치는 影響

池在浚,朴裁成,朴成圭,李尙榮,洪性澤,孫錫龍 충북대학교 농업과학기술연구소 1999 農業科學硏究 Vol.16 No.-

This study was carried out to determine the optimum seeding date for the rice(Oryza sativa L.) cultivation of the puddled-soil drill seeding, which is one of the efficient labor saving cultural methods, at the central part of Korea. Namweonbyeo, Anjungbyeo and Ilpumbyeo were seeded on four dates from April 10 to May 25, 1994 with the 15 day interval in the paddy field. In order to examine the adequate seeding date, the growth characters, yield components and yields were investigated. The coleoptile emerged 1 or 2 days earlier in Namweonbyeo than in Anjungbyeo and Ilpumbyeo, and later seeding resulted earlier coleoptile emergence. The number of seedling stands were higher in the order of Namweonbyeo, Anjungbyeo and Ilpumbyeo, was increased at the later seeding and was 81 to 88 seedlings on April 10 seeding. The plant height, number of leaves, number of tillers and dry weight at 50 days after seeding of all three cultivars were higher at later seeding. Leaf area index(LAI) were higher in the order of Ilpumbyeo, Anjungbyeo and Namweonbyeo. LAIs at the heading stage, at 30 days after heading and at 30 days before heading were higher in that order. The dry matter weight at the 30 days before heading was higher in sheath and stem than that in leaf blade, while, at heading stage, it was higher in the order of sheath and stem, leaf blade and panicle. On the other hand, at 30 days after heading, it was higher in the order of panicle, sheath and stem and leaf blade. The number of panicles per m2 was greater in the order of Ilpumbyeo, Anjungbyeo and Namweonbyeo. The ratio of ripened grain was reduced as the later seeding date. Its ratio was higher in Namweonbyeo than in Anjungbyeo and Ilpumbyeo. Yield of Namweonbyeo was lower than those of Anjungbyeo and Ilpumbyeo. Yield was decreased as the seeding date was delayed. Namweonbyeo showed the highest yield at seeding on May 10, while Anjungbyeo and Ilpumbyeo showed at seeding on April 25. The seeding date was negatively correlated with the ratio of ripened grain. while the number of seedling stands was positively correlated with the number of panicle per m2.

Gilbert 증후군에서 열량 제한 시험과 Phenobarbital 자극 시험의 의의(14예)

이헌영,채경훈,정재훈,강윤세,김연수,문희석,박기오,이엄석,김선문,김석현,성재규,이병석,이강욱 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Gilbert 증후군은 인구의 7%에서까지 나타날 수 있는 매우 흔한 증후군으로서 비진행성인 양성의 만성적 경과를 치하며, 간질환의 증상과 징후가 없는 경한 비포합형 고빌리루빈혈증이 특징인 일종의 체질적인 증상으로서 혈장 빌리루빈 농도에 대한 사춘기의 영향 때문에 10대와 20대에 자주 진단이 된다. 따라서 임상적인 중요성은 미약하지만 높은 빈도가 예상되는 점에 그 중요성이 부여되어야 할 것이다. 따라서 적정한 임상적 진단법으로 기왕에 소개된 열량제한 시험과 phenobarbital 유도 시험을 시행하고 이들의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 1990년 7월부터 1999년 4월까지 충남대학교병원에 내원하여 HBsAg, IgG anti-HBc 및 anti-HCV가 음성이고, 간 초음파 스캔에서 이상이 없으며, 혈청 AST, ALT 및 AP가 정상인 비음주자에서 경한 비포합형 고빌리루빈혈증이 있는 14예의 환자들을 대상으로 ^(99m)Tc-DISID 스캔을 시행하였으며, 기저 치 총빌리루빈 및 포합형 빌리루빈 치를 측정한 다음에 하루에 400Kcal로 48시간동안 제한한 열량 제한 시험을 시행하였고, phenobarbital을 하루 60mg씩 5일간 투여한 후에도 각각 총빌리루빈과 포합형 빌리루빈 치를 검사하여 비포합형을 구하였다. 대상 환자들은 모두 14예로서 남자가 11예(78.6%)였고 여자가 3예(21.4%)여서 3.7:1로 남자에서 많았으며, 20대가 6예(42.9%), 30대가 역시 6예(42.9%) 및 40대가 2예(14.2%)로서 2,30대가 대부분(85.8%)이었다. 열량 제한 시험 후의 총빌리루빈 치, 비포합형 및 포합형 빌리루빈 치들은 평균 각각 5.5±2.7, 4.2±2.3 및 1.3±10mg/dL 로서, 시험 전 치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg/dL 보다 유의하게(p=0.001, p=0.001, p=0.023) 상승하였다. 포합형 빌리루빈 치도 유의하게 상승하였으나 비포합형의 상승보다는 훨씬 낮아서 주로 비포합형이 증가하였다. phenobarbital 투여 중 설사가 발생하여 중단한 1예를 제외한 13예에서 열량 제한 시험 후에 상승하였던 총, 비포합형 및 포합형 빌리루빈 치가 phenobarbital 유도 시험후에는 2.0±1.1, 1.5±0.8 및 0.5±0.4mg/dL로서 열량 제한 시험 결과보다 유의하게 낮아졌고(p=0.00, p=0.000, p=0.001), 열량 제한 시험 전의 기초치들인 3.0±0.8, 2.2±0.8 및 0.7±0.4mg.dL 보다도 더욱 낮아졌으며 유의한 차이(p=0.001, p=0.02, p=0.005)를 나타내었다. 14예에서 시행한 ^(99m)-Tc DISIDA 스캔에서 9예(64.3%)가 정상이었고, 5예(35.7%)에서는 심장 및 신장으로의 간외 섭취가 3예였고, 60분까지 소장 배출이 없는 배설 지연 예와 담낭 수축 불량 예가 각각 1예 씩 발견되었다. Phenobarbital 투여시험에서 민감도가 열량제한시험에 비해 더 높았다(92.3%와 50.0%). Gilbert 증후군에서 1일 400 Kcal로 48시간의 열량제한 시험과 1일 60mg의 phenobarbital을 5일간 투여하는 유도 시험은 편리하고 유용한 임상적인 진단법으로 이용할 수 있다고 생각된다. 그러나 열량 제한 시험에서는 증가 기준의 통일이 필요하다고 유추되며 phenobarbital 유도 시험이 민감도가 더 높은 것으로 생각된다. Gilbert's syndrome is very frequent and benign chronic process characterized by mild, intermittent, unconjugated hyperbilirubinemia without any symptom and sign of liver disease. Previously intoduced caloric restriction test and phenobarbital stimulation test as two appropriate clinical tests had been examined and their diagnostic values were reevaluated. Fourteen patients with mild, persistent, unconjugated hyperbilirubinemia were included. Subsequently caloric restriction has been applicated by 400 Kcal/day for 48 hours and phenobarbital has been prescribed by 60 mg/day for 5 days. Therafter serum levels of total and direct bilirubin were measured. Most of the patients were third and fourth decade(85.8%) and male predominant. Each basal serum levels of total, indirect and direct bilirubin were 3.0±0.8, 2.2±0.8 and 0.7±0.4 mg/dL. After caloric restriction test, each levels were increased significantly to 5.5±2.7, 4.2±2.3 and 1.3±1.0 mg/dL(p=0.001, p=0.001, p=0.023). After phenobarbital stimulation test for 13 patients had been practiced, increased levels of each bilirubin after caloric restriction test were decreased significantly to 2.0±1.0, 1.5±0.8 and 0.5±0.4 mg/dL(p=0.000, p=0.000, p=0.001) and these levels were significantly lower than basal levels(p=0.001, p=0.02, p=0.005). The sensitivities of caloric restriction test were 85.7%, 50.0%, and 71.4%, 35.7%(1.0, 1.5 mg increase of total bilirubin and 1.0, 1.5 mg/dL increase of indirect bilirubin). The sensitivities of phenobarbital stimulation test were 93.2% and 92.3% at criteria of 1.5 mg/dL increase of total bilirubin and indirect bilirubin. On the diagnosis of Gilbert syndrome, caloric restriction test and phenobarbital stimulation test are convenient and useful diagnostic tools in clinical face. And also phenobarbital stimulation test has higher sensitivity than caloric restriction test. Furthermore, standardization of bilirubin increment would be necessary in caloric restriction test.

설계변경의 경향 및 원인 분석을 통한 설계 품질향상 방안

석성재,김재근,이철우,홍순구,유춘번 한국품질경영학회 2000 품질혁신 Vol.1 No.1

This study is prepared to introduce design quality improvement measures by the trend and cause analysis of design changes which have been made during operations of construction project for power plant. In this study, two types of analysis tool have mainly taken for the use of the improvement measures. One tool is the trend analysis to identify which action should be taken to cut down design changes. This is also useful to monitor whether project participant's endeavour for the action taken is effective or not, to the project performance and design quality improvement. The other is the cause analysis, by using cause and effect diagram, which is useful to identify main causes of the design changes and to establish the measures to reduce recurrence of the design changes.