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      • KCI등재

        응급실에서 기관내 삽관후 발생한 후두육아종 1례

        조남수,김용배,조수형,송민엽,송성용 大韓應急醫學會 1996 大韓應急醫學會誌 Vol.7 No.1

        Endotracheal intubation has been used widely for the maintenance of airway in the emergency patient and CPR in the acute airway obstruction patient and to treat respiratory insufficiency. Endotracheal intubation has many advantages but it may cause several complications which rate about 4% of endotracheal intubation patient. Among these complications, laryngeal granuloma is a relatively rare complication arising about 1 case per 10,000∼20,000 cases. Authors report a case of laryngeal granuloma which developed after endotracheal intubation required during emergency treatment. Case: A 55-year old female patient visited Chosun University Hospital Emergency Room complaining of dyspnea, cyanosis and sweating on Feb. 8th 1995. According to past history, she had a little obesity, dyspnea on exercise and mild hypertension. At arrival, blood pressure was 240/110mmHg, pulse rate 150 rates/min, respiratory rate 12/min, body temperature 36.5℃ and cyanosis with sweating on whole body was observed. And the mental state was semicoma. At 5 minutes after arrival, sudden respiratory arrest developed and immediate endotracheal intubation which emergency treatment was performed it was difficult to intubate endotracheally due to short neck and obesity. At 1 hour after arrival, general condition of the patient recovered well and extubation was done. The patient was transferred to internal medicine department and discharged after 12 days of medical treatment. At 2 months after discharge, the patient felt a progressive hoarseness and foreign body sensation of larynx. She was diagnosed as laryngeal granuloma at ENT department of Chosun University. She underwent the surgical operation and discharged in good health after 7 days of admission.

      • Changes in cAMP Response and Testosterone to 17β-Estradiol to FSH in Isolated Rat Sertoli Cells-Age and Dose Related Differences

        Cho, Sung Hoon,Lee, Byung Churl,Seong, Sang Min CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1

        The Seroli cell was identified as> the main primary target site for the action of follicle stimulating hormone (FSH) in the testis. FSH has been known to bind specifically to Sertoli cell and to evoke a series of biochemical responses such as increased accumulation of cyclic AMP, production of androgen binding protein, and steroid metabolism. Recently age related changes in FSH stimulation of cAMP and aromatization of testosterone of 17β-estradiol were demonstrated. The purpose of this study was to investigate the changes in cAMP and testosterone to 17β-estradiol aromatization responses of FSH with dose differences in isolated rat Sertoli cells of different age. Methods for preparation of rat Sertoli cells were adapted from those used to prepare rat Sertoli cells. Homogenous preparations of primary Sertoli cell cultures were obtained from the testis of the rat of different age: prepubertal (14 days old rat), pubertal (18 days old rat) and adult (60 days old rat). For cAMP determinations, cells were stimulated for 30 min at 37?C with different dose of FSH in media containing 0.1 mg/m]l l-methyl-3-isobutylxanthine. cAMP assays were performed in duplicate using radioimmunoassay kit. FSH stimulated aromatization of testosterone of 17j3-estradiol was determined in cells stimulated with different dose of FSH in media containing 0.5 μmol/ml testosterone. 170-estradiol assays were performed in duplicate by means of specific radioimmunoassay. The results were as follows: 1. Sertoli cells from adult rats responded to FSH stimulation with over 30-fold rise at 5 min. At 30 min, cAMP is significantly lower and down to baseline level by 60 min. 2. There were age-related differences in Sertoli cell cAMP response after 30 min of FSH stimulation. Sertoli cells from pubertal rats responded most sensitively to FSH with a dose response relationship. 3. The heighest aromatase enzyme activity in converting testosterone to 17(3-estradiol was found in pubertal rat Sertoli cells. Sertoli cells from pubertal rats demonstrated a dose-response of FSH stimulation of testosterone to estradiol conversion. In conclusion, these results demonstrate that the age and dose-related differences in rat Sertoli cell response to FSH, and also provide direct evidence that the Sertoli cells represent a primary target site for FSH activity in the testes.

      • KCI등재

        Purification and Characterization of Helicobacter pylori γ-Glutamyltranspeptidase

        Jae-Young Song,Yeo-Jeong Choi,Jeong-Min Kim,Yoo-Ree Kim,Jin-Seong Jo,Jin-Sik Park,Hee-Jin Park,Yun-Gyu Song,Kon-Ho Lee,Hyung-Lyun Kang,Seung-Chul Baik,Hee-Shang Youn,Myung-Je Cho,Kwang-Ho Rhee,Woo-Kon 대한미생물학회 2011 Journal of Bacteriology and Virology Vol.41 No.4

        Gamma-glutamyltranspeptidase (GGT) was purified to electrophoretic homogeneity from the cell extract of H. pylori. The purified enzyme consisted of heavy and light subunits with molecular weights of 38 kDa and 21 kDa, respectively. N-terminal amino acid sequence of heavy and light subunits revealed that H. pylori GGT was processed into 3 parts for a signal peptide of 27 amino acid residues, a heavy subunit of 352 residues, and a light subunit of 188 residues during translation. The reaction rate for hydrolysis of γ-GpNA was 84.4 μmol/min per milligram of protein, and that for the γ-glutamyl transfer from γ-GpNA to gly-gly was 23.8 μmol/min per milligram of protein. The apparent Km values of H. pylori GGT for γ-glutamyl compounds were on the order of 10-3 to 10-4 M and those for acceptor peptides and amino acids were on the order of 10-11 to 10-2 M. The GGT protein kept approximately 80% of the initial enzymatic activity on incubation at 60℃ for 15 min. The optimum temperature and pH for reactions of both hydrolysis and transpeptidation were 40℃ and 9.0, respectively. The transpeptidation and hydrolysis reactions catalyzed by H. pylori GGT were strongly inhibited by L-Gln and moderately inhibited by L-Ala, L-Ser, β-chloro-L-Ala, and L-Glu. These results demonstrated that the biochemical properties of H. pylori GGT are different from those of other bacterial GGTs. Further, H. pylori GGT might degrade glutathione in the gastric mucous layer of humans if the enzyme could be secreted in the bacterial niches.

      • SCOPUSKCI등재

        Purification and Characterization of Helicobacter pylori ${\gamma}$-Glutamyltranspeptidase

        Song, Jae-Young,Choi, Yeo-Jeong,Kim, Jeong-Min,Kim, Yoo-Ree,Jo, Jin-Seong,Park, Jin-Sik,Park, Hee-Jin,Song, Yun-Gyu,Lee, Kon-Ho,Kang, Hyung-Lyun,Baik, Seung-Chul,Youn, Hee-Shang,Cho, Myung-Je,Rhee, Kw The Korean Society for Microbiology 2011 Journal of Bacteriology and Virology Vol.41 No.4

        Gamma-glutamyltranspeptidase (GGT) was purified to electrophoretic homogeneity from the cell extract of H. pylori. The purified enzyme consisted of heavy and light subunits with molecular weights of 38 kDa and 21 kDa, respectively. N-terminal amino acid sequence of heavy and light subunits revealed that H. pylori GGT was processed into 3 parts for a signal peptide of 27 amino acid residues, a heavy subunit of 352 residues, and a light subunit of 188 residues during translation. The reaction rate for hydrolysis of ${\gamma}$-GpNA was 84.4 ${\mu}mol/min$ per milligram of protein, and that for the ${\gamma}$-glutamyl transfer from ${\gamma}$-GpNA to gly-gly was 23.8 ${\mu}mol/min$ per milligram of protein. The apparent Km values of H. pylori GGT for ${\gamma}$-glutamyl compounds were on the order of $10^{-3}$ to $10^{-4}$ M and those for acceptor peptides and amino acids were on the order of $10^{-1}$ to $10^{-2}$ M. The GGT protein kept approximately 80% of the initial enzymatic activity on incubation at $60^{\circ}C$ for 15 min. The optimum temperature and pH for reactions of both hydrolysis and transpeptidation were $40^{\circ}C$ and 9.0, respectively. The transpeptidation and hydrolysis reactions catalyzed by H. pylori GGT were strongly inhibited by L-Gln and moderately inhibited by L-Ala, L-Ser, ${\beta}$-chloro-L-Ala, and L-Glu. These results demonstrated that the biochemical properties of H. pylori GGT are different from those of other bacterial GGTs. Further, H. pylori GGT might degrade glutathione in the gastric mucous layer of humans if the enzyme could be secreted in the bacterial niches.

      • KCI등재

        노인정신장애 평가척도(Psychogeriatric Assessment Scale)의 한국판 표준화 연구

        조맹제,박임순,신영민,김무진,정희연,정은기,최용성,조성진,서국희,함봉진 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

        연구목적 : 본 연구는 치매와 우울증을 다차원적으로 평가할 수 있는 도구인 Psychogeriatric Assessment Scale(PAS)의 한국판(PAS-K)을 개발하기 위한 것이다. 방 법 : 번역, 역번역, 그리고 세차례의 예비조사를 통하여 PAS-K를 제작하였다. 60세 이상의 노인 291명(임상환자군 : 58명, 지역사회노인군 : 168명, 수용시설 거주자 : 67명)과 그들의 정보제공자들을 대상으로 PAS-K, Geriatric Depression Scale(GDS), Korean version of Mini-Mental State Examination(MMSE-K), Hamilton Rating Scale for Depression(HRSD), 그리고 Hachinski Ischemic Score 를 적용하고, Diagnostic Interview chedule(DIS-Ⅲ-R)을 사용하여 치매와 우울증을 진단하였다. PAS-K의 신뢰도와 타당도를 평가하고, 예민도와 특이도, Kappa값, 그리고 ROC커브 분석법을 이용하여 PAS-K의 6개의 소척도들(피검자면접 : 인지기능 장애척도, 우울척도, 뇌졸중척도, 정보제공자면접 : 인지기능 저하척도, 행동변화척도, 뇌졸중척도)의 최적 절단점을 구하였다. 결 과 : PAS-K는 높은 내적 일관성을 보였고, 검사자간 신뢰도도 만족할 만한 수준이었다. PAS-K의 소척도들을 다른 표준화된 검사도구들과 비교하였을 때 인지기능 장애척도와 인지기능 저하척도는 MMSE-K와, 우울척도는 GDS 및 HRSD와 유의한 상관관계를 보였으며, 뇌졸중척도는 Hachinski Ischemic Score와 통계적으로 의미있는 상관관계를 보였다. 최적절단점은 인지기능 장애척도 10점, 인지기능 저하척도 3점, 우울척도 5점, 피검자면접과 정보제공자 뇌졸중척도 모두 1점, 그리고 행동변화척도 2점으로 추정하였다. 결 론 : 본 연구를 통해 PAS-K의 신뢰도와 타당도가 검증되었고, 노인정신의학 역학연구나 보건분야에서 치매와 우울증의 임상경과관찰 및 일차 선별도구로서 유용하게 사용될 수 있게 되었다. Objectives : This study was designed to develop the Korean version of the Psychogeriatric Assessment Scale(PAS-K), a multidimensional screening tool for the dementia and depression. Methods : Through three times preliminary trials, the authors translated PAS into Korean. The PAS-K, Geriatric Depression Scale, Hamilton Depression Rating Scale, Hachinski Ischemic Scale and Mini-Mental State Examination-Korean version were administered to 291 subjects over the age of 60 and the same number of their informants(67 subjects were institutionalized, 168 subjects were in community, 58 subjects were psychiatric hospital patients). And the Diagnostic Interview Schedule(DSM-Ⅲ-R) was independently administered to exactly diagnose dementia and depression. The reliability and validity test, optimal cut-off point estimation for six each scale and ROC curve analyses were done to investigate the diagnostic validity of PAS-K. Results : Internal consistency and interrater reliability of the PAS-K were high. Concurrent validity of each scales of PAS-K was good in being measured with other standardized scales. The optimal cut-off points of each scale of the PAS-K were estimated as follows : 1) Stroke Scale of subject interview : 1, 2) Cognitive Impairment Scale of subject interview: 10, 3) Depression Scale of subject interview : 5, 4) Stroke Scale of informant interview : 1, 5) Cognitive Decline Scale of informant interview : 3, and 6) Behavioral Change Scale of informant : 2. conclusions : The PAS-K was valid and reliable screening tools for detecting dementia and depression. Therefore the PAS-K could be widely and extensively used in psychogeriatric epidemiological research or clinical setting of primary screening for dementia and depression.

      • SOL-GEL법을 이용한 강유전체 BaTiO₃박막 및 Ceramics 제조

        조채룡,이수재,장민수,김호종,정세영,노동택,김성철 동의대학교 기초과학연구소 1993 基礎科學硏究論文集 Vol.3 No.1

        Concentrated solution was prepared for a sol-gel process of BaTiO₃. Barium hydroxide and Ti-isopropoxide were used as the raw materials with methanol and isopropanol as solvents. Dense ferroelectric polycrystalline BaTiO₃thin films with the perovskite structure were fabricated by spin coating of the prepared concentrated solution on a few substrates. From XRD investigation, it was confirmed that tetragonal phase of polycrystalline BaTiO₃powders are formed after heat treatment above 550℃ in air and grain-oriented BaTiO₃thin films are obtained by coating of 0.06M concentrated solution on the substrates. It was observed that surfaces of thin films deposited on the substrates by our methods were formed crack-free and uniformly. The thickness of thin film which depends the concentration of the solution was 400∼900Å for 1 time coating, which was confirmed by SEM analysis. Ceramics and thin films show dielectric constant of 4600 (at 1㎑) and capacitance 300∼800㎊ (at 1㎑) at room temperature, respectively.

      • 200番체 通過率이 다짐效果에 미치는 影響

        趙誠正,閔興基 충북대학교 농업과학기술연구소 1991 農業科學硏究 Vol.9 No.2

        This study was conducted to investigate on the influence of the passing percent of No. 200 sieve on the compaction effect of adjusted soil sample, compared with the effect of natural soil sample, decreasing the passing percent of No. 200 sieve of natural soil sample. The results obtained were as follows ; 1.In the case of the passing percent of No. 200 sieve was much too small (A soil sample : 23%) or too large (B soil sample), though the passing percent of No. 200 sieve was decreased, the influence affecting the change of maximum dry density did not appear, but the optimum moisture content was decreased. 2.There Was a tendeney that the optimum moisture content was increased conversely, whereas the maximum dry density of adjusted soil sample was decreased.

      • 생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

        민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

        A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

      • KCI등재

        수학 교수-학습에서의 구성주의적 관점

        조성민,노선숙 이화여자대학교 교육과학연구소 1999 교육과학연구 Vol.30 No.-

        If constructivism is to be accepted as a fundamental framework for today's information oriented open education, it must offer something more concrete than just "student construct his/her knowledge". In order to clarify the role of constructivism in teaching and learning of mathematics, detailed review of research trend on constructivism widely spread in mathematics education was carried out. The study was conducted focusing on describing the role of the teacher. The study showed that constructivism in mathematics education can be described as a policy of non-interference by the teacher. The teacher needs to have the proper insight into mathematics education to know and recognize the process of student's construction to help the process of learning.

      • 생체분해성 안과제형의 안구내흡수정도와 안독성

        민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

        An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.

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