자궁경부암에서 혈관 내피 성장인자 ( VEGF ) 및 VEGF Mrna 의 발현에 대한 연구

이선경(Seon Kyung Lee),김승보(Seung Bo Kim),지성길(Sung Gil Chi),염윤석(Yoon Seok Yum),이주희(Ju Hee Lee) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.1

N/A Objective : Angiogenesis, the formation of blood vessels by sprouting from pre-existing ones, is essential for the growth of solid tumors beyond 2~3mm in diameter and for tumor metastasis. Vascular endothelial growth factor (VEGF), is known as vascular permeability factor(VPF) and mediates vascularization and tumor-induced angiogenesis. This study examined the potential of growth, invasion, and metastasis of uterine cervical carcinomas associated with neovascularization. Methods : From January 1996 to December 1999, at the Department of Obstetrics and Gynecology, Kyung-Hee University Hospital, 37 uterine cervical carcinomas and 7 normal cervical tissues were obtained and the samples were immediately frozen and stored at -70℃. Immunohistochemical staining for VEGF was carried out to study VEGF localization, and the levels of VEGF subtype mRNAs were determined by quantitative RT-PCR in specimens. The relation between VEGF subtypes expression of cervical cancers was analysed. Results : The positive staining for VEGF is seen dominantly in the cytoplasm of the cancer cells, and faintly in interstitial cells. The intensity of staining was stronger in squamous carcinomas than in adenocrcinomas, but there was no significant difference (p>0.05). Quantitative RT-PCR analysis demonstrated significantly increased VEGF121/VEGF165 mRNA expression levels (>0.56/>0.72) in 21 (56.8%) and 15 (40.5%) of 37 cervical carcinomas comparing to control groups (mean: 0.28/0.36). There was no obvious relationship between VEGF121/VEGF165 mRNA expression levels and the clinical parameters examined including age, pathology, differentiation, tumor size, lymphovascular space invasion, LN involvement and invasion depth except clinical stage (p<0.05). Conclusions : The overexpression of VEGF mRNA may be an important contributing factor in cervical carcinomas. There is no significant differenece of VEGF mRNAs levels according to clinical parameters, so it seems that the expression of VEGF is involved in the promotion of angiogenesis on cervical cancer and plays an important role in early invasion.

The diagnosis of coronoid impingement using computed tomography

Baik, Jee-Seon,Huh, Kyung-Hoe,Park, Kwan-Soo,Park, Moo-Soon,Heo, Min-Suk,Lee, Sam-Sun,,Choi, Soon-Chul 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.4

Coronoid impingement can cause limitation of mouth opening. In many cases, it appears to be related to the coronoid hyperplasia. We present a case of mouth opening limitation caused by coronoid impingement on the posterior surface of the zygomatic bone without coronoid hyperplasia. The bony changes in coronoid and zygoma including surface irregularity and discontinuity of the cortex and sclerotic change of inner medullary space were noted on computed tomography (CT) scans in different level of axial planes. Through another CT scans in open mouth position could demonstrate that those bony changes were caused by the contact of both surfaces against each other. In case coronoid impingement is suspected of the many possible causes, the open mouth CT scans will be needed to reveal the direct impingement of coronoid on zygoma even without coronoid hyperplasia.

실리카흄을 흔입한 고강도 콘크리트 개발

홍창우,김태경,김경진,김성환,김남윤,심도식,이정호,윤청호,백민경,원치문,박제선,이주형,정경일 강원대학교 석재복합신소재제품연구센터 1996 석재연 논문집 Vol.1 No.-

콘크리트 구조물이 대형화됨에 따라 설계단면이 증대되어 상대적으로 많은 경제적 손실을 부담하게 된다. 따라서 단면을 감소시키면서도 소요의 하중에 안전한 구조물을 건설하기 위해서는 우선적으로 구조물 건설에 기초가 되는 고품질, 고내구성의 고강도 콘크리트 개발이 절실히 요구된다 본 연구에서는 일정 시멘트비 및 혼화재 비율하에서 소요의 워커빌리티가 확보되는 고강도 콘크리트를 시간과 온도의 변화에 따라 증기 양생하여, 압축, 인장, 휨강도 뿐만 아니라 파괴특성을 실험적으로 연구하였다. 시료 제작시 시멘트 입자 사이의 공극 및 불연속 영역을 충전하여 고밀도화하기 위한 콘크리트용 혼화재로 시멘트 비표면적이 상당히 작은 초미립 분말인 실리카흄을 이용하였다. 또한 AE감수제 및 고성능 유동화제를 사용하여 혼화재의 첨가에 의하여 발생될 수 있는 워커빌리티의 감소를 방지하였다. 실험결과에 의하면 일정 양생 지속 시간하에서 온도의 증가에 따라 콘크리트의 압축, 인장 및 휨강도가 전반적으로 증가하였다. 동일하게 일정 온도하에서 양생 지속시간이 커짐에 따라 강도들이 증가됨을 알 수 있었다. 따라서 상대적으로 높은 온도와 긴 지속 양생 조건하에서 파괴에 대한 저항력이 크게 나타났다. The compressible, tensible, and flexibleresistance of the high strength concrete is analyzed by the experimentation in the present study. For the test, we cure several samples with the silica fume as a mixture being become dense the spaces between the particle of cement under the variation of both the temperature and the curing-interval. Then, the superplasticizer and the ezcon are also used to satisfy the required workability for construction. The compressible, tensible, and flexible resistances to a stress are increased as increasing the temperature and the time interval for the curing. Therefore it is concluded that the overal fractural and mechanical properties is improved by mixing the silica fume into the cement.

얼굴 연조직 강화를 위한 자가지방 이식 후 발생한 급성 경계부위 뇌경색

민경현, 이혜림, 여민주, 김지선, 이성현, 이상수, 신동익 충북대학교 의과대학 충북대학교 의학연구소 2016 忠北醫大學術誌 Vol.26 No.1

본문참고

SHS법으로 TiAl 금속간 화합물의 제조시 첨가원소에 따른 기계적 성질에 관한 연구

宣炅杓,李龍鎬 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.2

TiAl intermetallic compounds are very attractive for high temperature structural applications because of their high specific strength, high temperature oxidation resistance, and superior creep characteristics. In this study, processing of TiAl using self-propagating high temperature synthesis was investigated. The effects of processing varibles including holding temperature and pressure, and alloying element on the microstructure, mechanical properties of TiAl were studied. It was demonstrated that the SHS process could yield TiAls with properties comparable with those of TiAl produced via the ingot metallurgy route.

객체지향 설계 방법론을 토대로 한 객체-관계 데이터베이스 시스템 설계 및 구현에 관한 연구

임종선,주경수 순천향대학교 부설 산업기술연구소 1998 순천향 산업기술연구소논문집 Vol.4 No.1

After 1990s there have been a lot of researches on Object-Relational Database System and Object-Oriented Analysis and Design methods for multimedia application systems. In this paper, we developed a unified analysis and design methodology for multimedia application systems based on Object-Relational Database System. For the unified methodology, Rumbaugh's OMT and Object-Relational Data Modeling method are combined.

기저세포모반 증후군 환아의 증례보고

허수경,최남기,김선미,양규호 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

기저세포모반증후군은 상염색체 우성으로 유전하며 외배엽성과 중배엽성 기관과 장기에 이환된다. 기저세포모반 증후군은 특징적으로 피부 이상,치아와 골격 이상,안과적 장애,신경 장애,생식계 이상 등이 나타난다. 악골의 병소는 보통 여러 부위를 포함하는 치성각화 낭종이며 상,하악에 모두 나타난다. 다발성 악골 낭종은 워낙 높은 재발율을 가진 각화성 낭종이기 때문에 완전 적출을 위해 적극적인 치료를 해야 한다. 제거 후는 재발 여부를 확인하기 위해 신중한 주기적 재검진이 필요하다. 본 증례는 다별성 치성낭종의 치료를 위해 내원한 환자가 기저세포모반증후군으로 진단되어 양호한 결과를 얻었기에 이를 보고하는 바이다. 이 환자는 전두골 돌출,양안격리증,정신지체 및 상,하악에 2개의 치성 각화낭종을 가지고 있었다. 낭종은 조대술로 치료되었고 현재 obturator와 공간유지장치로 유지하고 있으며 치아 맹출 여부를 관찰하고 있다. Nevoid basal cell carcinoma syndrome is an ecto-mesodermal polydysplasia with numerous manifestations that affect multiple organs. The syndrome is an autosomal dominant inherited, with a high penetration and visible expression. The syndrome is characterized by a series of associated anomalies such as cutaneous, dentofacial, skeletal, ophthalmologic. neurological, and genital anomalies. Generally. the jaw cysts are multiple odontogenic keratocysts. affecting any area of maxilla and mandible. Multiple odontogenic keratocysts of this syndrome are more recurrent than the keratocysts of non-syndrome. thus they are treated aggressively for complete removal, We report a case of multiple jaw cysts associated with nevoid basal cell carcinoma syndrome. In clinical and radiological examinations. frontal bossing. hypertelorism. mild mental retardation and two odontogenic keratocysts in both the maxilla and mandible were observed. Two cysts were treated by marsupialization. For the management of eruption of unerupted teeth. periodic recall check and orthodontic treatment are required.

인천지역 강하분진의 발생특성에 관한 연구

박경환,서광석,민달기,장재선,김종규 京畿專門大學 1994 京畿專門大學 論文集 Vol.- No.22

장애 영유아 가족지원 방안 연구

이미선,김경진 국립특수교육원 2000 연구보고서 Vol.- No.1

본 연구에서는 유아특수교육에 있어 가족참여 및 이를 위한 지원의 중요성을 인식하고, 장애아동 가족의 효율적 참여를 위한 가족지원 방안을 제시함으로써 궁극적으로 장애아동 가족이 장애아등의 발달을 촉진하고, 그들 자신의 요구를 스스로 충족시킬 수 있는 능력을 갖추도록 하는데 목적을 두었다. 이와 같은 목적을 달성하기 위해 본 연구에서는 우리 나라와 외국의 장애 영유아 가족지원 정책과 실천에 관한 문헌을 분석하고, 우리 나라 장애아동 가족을 대상으로 심층 면담을 실시하였으며, 문헌 및 심층 면담 분석 결과를 토대로 우리 나라 장애아동 가족지원의 방안을 다음과 같이 제시하였다. 첫째, 장애아동 친육에 있어 가족의 효율적인 참여를 확대하며, 이를 위해 장애아동과 개인별 가족의 특성 및 자원 등을 고려하여 가족의 참여 수준과 방법을 다양화한다. 둘째, 장애 영유아 가족이 원하는 경우, 가족진단을 실시하고, 이 결과에 따라 장애영유아의 현재 수준, 가족의 자원 ·우선 순위 관심사, 장애 영유아 및 가족의 주요 성취 목표, 담당교사 이름 등의 내용을 포함한 개별화가족지원계획(IFSP)을 개발·실시하는 것을 적극 권장한다. 셋째, 유아특수교육기관 뿐 아니라 국 ·공립기관 및 민간단체는 장애아동, 부모, 형제의 특성, 성별, 연령, 지역사회 실정 등에 따라 다양한 과정의 가족교육 프로그램을 실시한다. 가족교육은 인터넷 방송이나 원격교육 등 다양한 방법을 도입하여 실시하며, 유아특수교육기관을 다니지 않은 장애 영유아의 가족들에게도 개방하여 실시한다. 넷째, 유아특수교육교사 및 관련 전문가들이 가족 중심의 유아특수교육 실시할 수 있도록 가족참여와 이를 위한 지끈의 중요성, 개별화된 가족참여와 지원을 제공하는데 필요한 지식과 기술을 습득할 수 있도록 하며, 이를 위해 기존의 직전교육 및 현직연수프로그램을 수정·강화한다. 다섯째, 유아특수교육기관, 특히 다양한 인적·물적 자원을 갖추고 있는 특수학교는지역사회 내 관련 공공·민간기관이나 단체들에서 제공하는 장애아동 및 그 가족에 대한 지윈을 가족에게 연계하고, 범주별로 제공되는 다양한 자원을 조정하며, 지역사회내의 다양한 지원을 가능한 한 유아특수핀육기관이라는 단일한 장소에서 통합하여 제공하도록 한다. 여섯째, 장애영아에 대한 조기중재의 중요성 및 교육의 기회균등 보장, 장애아동 가족이 갖는 경제적 불이익 등을 고려하여 현재 보육의 대상인 O~2세 장애영아에게는무상교육을, 현재 무상교육 대상이나 무상교육의 혜택을 많이 받지 못하고 있는 3~5세장애유아의 교육은 의무교육으로 한다. 일곱째, 장애아동을 부양하는 가족에게 장애아동 부양 수당, 세금 감면 등의 경제적지원, 의료비 및 보조장구 지원, 장애아동 보육지원 및 기타 상담, 가사 보조 등과 같은다양하고도 실제적인 지원을 확대한다. 여덟째, 정부, 지방자치단체, 지역사회 내의 유아특수교육기관이나 관련 기관에서는장애아동의 부모집단, 형제지원 집단, 아버지 집단과 같은 자조집단을 육성하고 장려하여 이들 집단의 구성원들이 스스로 정보를 교환하고, 상호 지원을 하며, 스스로의 권익을 옹호하는 활동 등을 할 수 있도록 한다. 아홉째, 정부, 지방자치단체 및 지역사회 내 유아특수교육기관이나 관련 기관에서는장애아동 및 그 가족이 정상화된 사회에 진정으로 통합되고 잘 적응할 수 있도록 장애아동 및 그 가족에 대한 다양한 인식 개선 활동을 전개하며, 이들에 대한 종합적인 지원과 서비스의 필요성 및 가치를 인식시켜 이들에 대한 지원적인 환경을 창출하고 조성 한다. 마지막으로, 유아특수교육에 있어 우리 나라 현실에 맞는 장애아동 가족의 효율적인참여 및 이를 위한 지원 전략과 IFSP의 개발 및 실시 모형 등을 도출하고, 이를 널리보급하기 위해 시범 프로그램을 운영하며, 장애아동 출현률 조사에 장애아동 뿐 아니라 그 가족의 실태에 관한 조사를 포함시켜 이 조사결과를 근거로 장애아동 및 그 가족에대한 중재 혹은 지원정책 방안을 수립하도록 한다. 또한 이제까지 언급한 장애아동 가족에 대한 다양한 지원을 실현하기 위해 관련 법규 및 제도를 제정하거나 개정하며, 이러한 법규정의 실천을 보장하기 위해 필요한 예산을 확보한다. 장기적으로는 가족지원을 통합적으로 시행하기 위해 기존의 장애아동가족지원 관련 법규들을 보완, 정리하거나 장애아동가족지원법을 새로이 제정한다. Based on the acknowledsernent that family participation in the education of their young children with disabilities has positive influences on their development and therefore. supports for increasing effective family participationare very important, the purpose of the current study is to provide strategies for supporting the families of young children with disabllities in order to empowerfamilies to effectively participate in educating their children with disabilities, and ultimattly. enable them to facilitate the development of young children with disabilities and meet their needs. In order to accomplish the purpose of this study. the study analyzed and reviewfd literature on policies and practices in family support of Korea and 3foreign advanced countries. and implemented in-depth interview to the familiesof young children with disabilities which are enrolled in institutions for earlychildhood special education, including special schools for children with mentalretardation, physical disabilities, visual impairments, hearing impairments. and autistir'disorders. respectively. special classes in kindergartens. and earlychildhood special education programs in welfare facilities and private institutions both of which are not formally approved by the government. Based on theresults of analyzine !iterature and in-depth interview materials. the currentstudy provided strategies for supporting families of young children with disabilities as follows: First, family participation in early childhood special education has to beexpanded, but the levels and methods of the participation must to diversifiedaccording to the characteristics and resources of each family. Second. if families want family assessment. it has to be carried out and basedon the assessment results, it is recommended that Individualized Family Support Plans(IFSPs) should be developed and implemented, and include the followingcontents: the current level of young children with disabilities: resources, priorities, and concerns of their families: objectives of children and theirfamilies; and names of teachers in charge of the development and implementation of IFSPs. Third, national, public and private organizations as well as institutions for early childhood special education should provide a range of family education programs. considering the characteristics, age. and sex of children with disabilities and their family members, and current conditions of communities. When family education programs are implemented. various methods have to be used. including internet and teleconference communication systems. In audition, the programs should be also available to family members whose children or siblings are not yet enrolled in institutions for early childhood sfecial education. Fourth. teachers and other professionals involved in early childhood special education have to be provided with programs for teaching the importance of family participation and supports for facilitatine family participation, and knowledges and shills necessary to implement IFSPs. Therefore, existingpre-service and in-service training programs should be improved and strengthened. Fiftlh. institutions for early childhood special education. especially special schools with a range of staff members and facilities have to link supports fromrelated-organizations in communities to families of young children with disabilities, coordinate various resources which are provided catesorlcally. And make efforts to provide them in one place(j.e. special school). Sixth, considering the importance of early intervention for infants and toddlers with disabilities. guarantee of the equal opportunity to be educated, and economic disadvantages of the families of children with disabilities. 0 to 2 years of young children who are regarded as child care target populations under the currert regulations have to be provided with free education. and 3 through 5 years of young children who are regulated as free education tareet populations must be provided with compulsory education. Seventh, various and practical supports have to be offered to the families of young children with disabilities, including financial support such as child-rearing allowallces and reduction of and exemption from taxes, assistive equipments, child care, counseling, and household assistance. Eighth, central government and local governments. communities, institutions for early childhood special education. and related agencies have to promote and encourage a range of self-groups such as the groups of parents and siblings so that they exchange information, support each other, and advocate their rights. Ninth, central government and local governments, communities, institutions for early childhood special education, and related agencies should develop strategies for improving people's attitudes towards children with disabilities and their families, and create and facilitate the supportive environments by giving infornlation and materials regarding the necessity and value of comprehensive suppcrts and services for the purpose of their more integration into and adaptation to normalized society than before. Finally, models for family participation appropriate to the current status in Korea and strategies for supporting the participation. and IFSP development and implementation must be devetoped. Model, programs have to be operated to evaluate and distribute them. In addition, future incidence survey of children with disabilities moat include items regarding the current status of families of children with disabilities. and based on the survey results. policies in supports and interventions for children with disabilities and their families must be designed. Moreover, for the purpose of providing a range of supports for families of young children with disabilities. related-regulations and systems have to enactedor revised. and financial arrangements for carrying out such regulations have to be made. In the long run, existing regulations on family support should be supplemented or a new family support act be enacted in order to provide comprehensive and coordinated family support programs.

상아질의 경도, 위치 및 잔존 상아질 후경이 상아질에 대한 부위별 미세 전단결합강도에 미치는 영향 : EFFECTS OF DENTINAL HARDNESS, POSITION, AND REMAINING DENTIN THICKNESS

황선성,임미경,이용근 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1

The aim of this study was to measure the regional mictr-shear bond strength of dentin bonding sgents to dentin, and to investigate the relationship between the micro-shear bond strength and two dentinal characteristics ; Vickers hardness and remaining dentin thickness. Twenty-four freshly extracted, noncarious human molars were selected for this study. The materials tested in this study consisted of two commercially available dentin bonding agents(MAC-BOND, ONE-STEP) and two restorative light-cured composite resins (AELITEFIL, Z100). The occlusal of side surface of tooth crown was sectioned to expose dentin, and the exposed surface was finally polished with # 600 sandpaper, Four groups of application methods were used combining the filling materials and the dentin bonding agents. The composite resin-attached tooth specimens were embeded in a cold cure acrylic resin. and were obtained from each tooth. The cut spectimens were divided into three groups depending on the position of the dentin bonding wurface. The micro-shear bond strength. remaining dentin thickness, and dentinal hardness were measured. Experimental results were then statestically analyzed with ANOVA, t-test, Scheffe test. and regression analysis. From this experiment, the following results were obtained : 1. In the case of occlusal surface bonding, the pooled micro-shear bond strength of ONSTAELIT group (16.62 MPa) was singificantly higher than that of MACB-AELIT group (9.91 MPa) (p<0.05). However, there was no significant difference in the mictr-shear bond strength depending on the centin positon (p>0.05). 2. In the case of side surface bonding of crown, the pooled micro-shear bond strength of four different bonding groups was not significantly different among each other (p>0.05). However, in three of the test groups (ONST-AELIT, MACB-Z100, ONST-Z100), the micro-sheer bond strength to the lower 1/3(Ⅲ) position was sugnuficantly lower than that to middle 1/3(Ⅱ) position of surface (p<0.05). 3. In the ONST-AELIT bonding group, the pooled micro-shear bond strength to the occlusal surface was significantly lower than that to the side surface of crown (p<0.05). 4. There was no significant correlation between the micro-shear bond strength and dentin hardness / remaining dentin thickness (p>0.05).