Effect of Acer tegmentosum Maxim. Extracts on Acute Hepatitis and Fatty Liver in Rats

Yoonhee Seo,Davaa Bazarsad,최수영 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

This study was performed to investigate the preventing effects to liver injury of Acer tegmentosum Maxim. extract (ATE). After oral administration ATE to SD rats, liver injuries were induced by CCl4, galactosamine or ethionine treatments. The aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride and cholesterols in blood were used as indicators of liver damage. When acute hepatitis was induced by CCl4 or galactosamine, ATE-fed rats showed low level of AST and ALT in plasma than the ATE-unfed rats. In case of ethionine-induced fatty liver, the triglyceride in plasma were shown to reduced level in ATE-fed rats than ATE-unfed rats. These results indicate that Acer tegmentosum Maxim. extract protected hepatic failure.

Effect of Angelica gigas Nakai ethanol extract on osteoporosis in OVX rats

Yoonhee SEO,Kyeong-Hee Kim,Soo-Young Choe 한국실험동물학회 2018 한국실험동물학회 학술발표대회 논문집 Vol.2018 No.7

Effect of Acer tegmentosum Maxim. Extracts on Acute Hepatitis and Fatty Liver in Rats

Soo Young Choe, Yoonhee Seo, Davaa Bazarsad 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.2

This study was conducted in order to investigate the effects of Acer tegmentosum Maxim. extract (ATE) in prevention of liver injury. After oral administration of ATE to SD rats, liver injuries were induced by treatment with CCl4, galactosamine, or ethionine. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride, and cholesterols in blood were used as indicators of liver damage. When acute hepatitis was induced by CCl4 or galactosamine, ATE-fed rats showed a lower level of AST and ALT in plasma than ATE-unfed rats. In the case of ethionine-induced fatty liver, triglyceride levels in plasma were reduced in ATE-fed rats, compared with ATE-unfed rats. These results indicate that Acer tegmentosum Maxim. extract protected against hepatic failure.

THE ELEMENTARY STUDENTS` CONCEPTIONS OF THE SIMPLE ELECTRIC CIRCUIT IN KOREA

Seo, Sangoh,Choi, Hyukjoon,Moon, Seongsook,Hong, Yoonhee,Kwon, Jaesool 한국교원대학교 과학교육연구소 2001 청람과학교육연구논총 Vol.11 No.1

The purpose of this study was to investigate students' conceptions of the simple electric circuit using a battery and a bulb. 19fourth grade students from a rural elementary school in Korea participated in this study. Data on the children's understandings of electric circuit were collected through three sources; prediction tests, drawing tests and individual interviews. The prediction tests were paper and pencil tests composed of 10 problems predicting whether bulbs in 10 simple circuit diagrams would light. For each prediction, the children were asked to provide a written explanation of their thinking. The drawing tests consisted of 6 problems. One was to draw the inside of the bulb base, and the others were to make the wire connections between a battery and a bulb in the diagrams to light the bulb. The interviews were conducted with seven children who showed differing degrees of understanding. No student was aware of the wire connections inside the bulb base. Many students stated whether the bulb would light or not, according to the tip of the bulb contacting the positive battery terminal and an end of wire contacting the negative battery terminal. Most of them thought that the tip of the bulb should contact the positive battery terminal so that the bulb would light. In short, students did not use a scientific conception of electric current to predict and explain the electric circuit.

Giant Intradiploic Epidermoid Cyst in the Occipital Bone: A Case Report

( Yoonhee Choo ),( Youngbeom Seo ),( Joonhyuk Choi ) 대한뇌종양학회 대한신경종양학회 2021 Brain Tumor Research and Treatment Vol.9 No.1

Epidermoid cysts are uncommon intracranial tumors. As one of the extradural types of epidermoid cysts, intradiploic epidermoid cysts are even rarer tumors and occur in any part of the skull. We herein report a rare case of a giant intradiploic epidermoid cyst of the occipital bone. A 57-year-old woman presented with a 1-year history of localized headache in the occipital area. CT and MRI showed an extradural mass measuring 50×70 mm in the occipital bone with bony destruction. The patient underwent surgical resection. The tumor was completely removed with its capsule. There was no extension to the intradural space. The pathological report confirmed that the tumor was an epidermoid cyst. Follow- up MRI 24 months after the operation showed no recurrence. The headache was well controlled without any medications. We report a rare case of intradiploic epidermoid cyst with clinical and radiologic features and surgical treatment. It is important to consider this diagnosis for a patient with persistent regional headache with or without a growing scalp mass.

Protective effects of Gymnaster koraiensis extract on high fat diet-induced fatty liver in mice

최수영,Seo Yoonhee,Bang Chae Young,Woo Seok Hoon,Kang Moonkyu 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.2

Obesity produces non-alcoholic liver disease, with relationship of the beginning of abnormal lipid metabolism. Recent studies show that abnormal cholesterol metabolism has a specific role in the pathological cause of non-alcoholic fatty liver disease (NAFLD). Gymnaster koraiensis (GK), a worthy perennial Korean wild plant has specific polyacetylene compounds. Many researches have presented that GK has many pharmacological properties, such as oxidation prevention, liver protection, and inflammation prevention. However, the conservative effect of GK on non-alcoholic fatty liver has not been researched so far. Male C57/BL6J mice were randomly separated to normal feeding (ND) (fed a ND for 12 weeks) and high fat feeding (HF) groups. Mice in the HF group were administered a high fat feeding (60% kcal high fat diet) and administered GK extract (125, 250, or 500 mg/kg/day), silymarin (200 mg/kg/day), or no treatment for 12 weeks. Each treatment group contained eight mice. The administration with GK decreased serum levels of triglycerides, total cholesterol, LDL-cholesterol, alanine aminotransferase and aspartate aminotransferase, while decreased body weight, body fat and liver weight. Alterations in liver histology, as assessed by H&E and Oil-red O staining, showed that the GK treatment decreased amass of lipids and NAFLD activity scores in liver. These results present that GK extract may be potential therapeutic agent for NAFLD by preventing increases of serum lipids and increases of body weight and fat, while decreasing lipid accumulation and increase of liver weight in high fat diet-triggered fatty liver.

A Study on Education and Training Collaboration between Large and Small & Medium-sized Enterprises: Focusing on the Time of Promoting Policy for Win-Win Cooperation between Large and Small Enterprises in 2012

박윤희(Yoonhee Park),서유정(Yoojeong Nadine Seo) 중앙대학교 한국인적자원개발전략연구소 2021 역량개발학습연구 Vol.16 No.4

한국 정부는 기업 경쟁력 제고를 위한 주요 경제정책으로 대기업과 중소기업의 상생협력을 강조하고, 동반성장 추진 대책을 발표하여 실행해왔다. 본 연구는 동반성장 추진 대책 발표 이후의 시점에서 대기업과 협력 중소기업 간 교육훈련 협력 추진 현황과 대기업과 중소기업 담당자들의 인식 조사 결과를 제시하고 정책적 함의점을 제시하는데 목적을 두고 수행되었다. 설문조사를 통해 151개의 대기업과 더불어 그들과 협력관계에 있는 401개의 중소기업을 조사하였다. 총 80.1%의 대기업과 68.3%의 중소기업이 교육훈련 협력에 참여하고 있으며, 기업 규모가 클수록 참여가능성이 커지는 것으로 나타났다. 대기업이 중소기업에 비해 교육훈련에 대해 더욱 긍정적인 관점과 인식을 갖고 있었다. 주요 협력 내용은 생산성 증대와 직접적으로 관련 깊은 품질관리와 기술 지원이었으며, 대중소기업의 상호 이익을 위해서도 가장 중요한 것으로 고려되었다. 교육훈련 참여의 주요 장애 요인은 훈련 참여 시간의 부족인 것으로 나타났다. 교육훈련 협력은 상생협력을 지원하기 위한 합의를 달성하고, 건강한 대중소 기업간의 소통 채널을 마련하며, 기업에서 가치를 인정받는 교육훈련 영역의 증대를 위해서도 활용될 수 있다 The Korean government has announced win-win growth policy and been promoting collaboration between large enterprises (LEs) and small & medium-sized enterprises (SMEs). This study examined the status and perception in education and training (E&T) collaboration between LEs and SMEs in supply chains following the promotion of the win-win growth policy. Particular focus was placed on E&T which is applicable to most of the collaboration domains. A survey method was employed and LEs and SMEs that are partners in their supply chain participated (151 LEs and 401 SMEs). Overall, 80.1% of the LEs and 68.3% of the SMEs were engaged in E&T collaboration. The larger their sizes, the more likely they were to be engaged. The LEs tended to have a more positive perspective and recognition for E&T collaboration than the SMEs. Main contents of collaboration were directly related to enhancing productivity (i.e., quality control and technology support) and they were also considered the most important for LEs and SMEs’ mutual benefits. The major hindrance was ‘a lack of time for training’. E&T collaboration could act as a means to achieve consensus to support win-win collaboration, healthy inter-organizational communication, and expand the domains of E&Ts valued at enterprises.

Protective effects of Gymnaster koraiensis extract on ethanol-induced fatty liver in rats

최수영,Yoonhee Seo,Chae Young Bang,Seok Hoon Woo,강문규 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3

Use of chronic alcohol produces alcoholic liver disease, with relationship of the beginning of abnormal lipid metabolism. Recent studies show that abnormal cholesterol metabolism has a specific role in the pathological cause of alcoholic fatty liver disease. Gymnaster koraiensis (GK), a worthy perennial Korean wild plant has specific polyacetylene compounds. Many researches have presented that GK has many pharmacological properties, such as oxidation prevention, liver protection, and inflammation prevention. However, the conservative effect of GK on alcoholic fatty liver has not been researched so far. Male Sprague-Dawley rats were randomly separated to normal feeding (fed a normal feeding for 4 weeks) and ethanol feeding (ED) groups. Rats in the ED group were administered a Lieber-DeCarli liquid feeding (containing 6.7% ethanol) and administered GK extract (125, 250, or 500 mg/kg/day), silymarin (200 mg/kg/day), or no treatment for 4 weeks. Each treatment group contained six rats. The administration with GK decreased serum levels of triglycerides, alcohol, alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase, while increased serum level of adiponectin and activity of alcohol dehydrogenase. In alcohol-triggered fatty liver, GK decreased total cholesterol and fatty acid synthase, while increased catalase and superoxide dismutase. Alterations in liver histology, as assessed by H&E staining, showed that the GK treatment decreased amass of lipids in liver. These results present that GK extract may be potential therapeutic agent for alcoholic fatty liver disease by preventing fatty acid synthesis and activating anti-oxidation enzymes, while in activating alcohol degradation in ethanol-triggered fatty liver.

파열된 위장관 기질종양의 간 전이에 대한 동맥 색전술 치료

장서진 ( Seo Jin Jang ),권재현 ( Jae Hyun Kwon ),한윤희 ( Yoonhee Han ) 대한소화기학회 2018 대한소화기학회지 Vol.72 No.4

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract and occur most frequently in the stomach. The liver is the most common metastatic site of a GIST, and spontaneous rupture of the hepatic metastasis of a malignant gastric GIST is rare. We report the case of a 70-year-old man who presented with sudden right lower quadrant abdominal pain and was diagnosed with a spontaneously ruptured hepatic metastasis of a malignant gastric GIST. The patient was successfully managed with transcatheter arterial embolization of the hepatic artery. (Korean J Gastroenterol 2018;72:205-208)

자원순환형 첨단농업파크모델 국내외 사례연구

서동욱 ( Donguk Seo ),손옥용 ( Ockyong Son ),이준구 ( Joongu Lee ),지달님 ( Dallim Ji ),정남수 ( Namsu Jung ),이윤희 ( Yoonhee Lee ) 한국농공학회 2014 한국농공학회 학술대회초록집 Vol.2014 No.-

자원순환형 농업은 농축산 폐기물이나 부산물, 물, 가스 등을 다시 활용하거나 재사용하여 생산비용을 절감하는 방식인데, 연중 신선한 고품질 식료품을 공급하고 농촌 경관 및 농촌 체험을 위한 공간들을 위해 자원순환형의 첨단농업파크의 형태를 시도하고 있다. 자원순환농업의 개념은 전통적으로 농촌공간에 화석연료 및 화학비료와 농약을 사용하는 집약형태의 농업이 토양오염, 수질 및 대기오염 등과 같은 환경문제를 일으키게 되고, 농축산물의 품질과 식품 안정성의 문제들을 발생하면서 이를 해결하기 위한 방안으로 나타나게 되었다. 이는 식품 생산, 가공, 유통 및 연구개발, 관광, 경관 등과 결합하여 하나의 집적된 농업파크 형태로 개발되고 있는데, 본 연구에서 자원이 순환될 수 있는 개념을 담고 농업파크를 구성한 국내외 사례를 분석하여 국내 적용할 수 있는 방안들을 검토하였다. 해외사례로는 아그리포트(Agriport) A7 등 5개소, 국내사례는 김제 중촌 자원순환형 녹색마을 등 4개소 사례를 분석하였다. 분석 결과, 해외에서는 화석에너지 고갈과 국제 유가 상승에 따른 에너지 비용 상승에 대비하고 친환경적이며 지속가능한 농업을 위해 다양한 에너지 절감 기술들을 개발하고 실용화하면서 자원순환 농업을 실현하고 있다. 이러한 자원순환 농업은 에너지 순환을 통한 생산 및 운영비 절감이라는 경제적 이익뿐만 아니라 탄소저감 및 환경보전, 관련 시설을 운영하는 기업들의 동반 이익 등 공익 및 사회적 이익을 동시에 추구하고 있다. 국내의 경우 현재 기술의 처리가능한 바이오매스의 범위를 앞으로 일반 농작물까지 확대하여 경축순환 뿐만 아니라, 기능성 식물, 바이오 공업원료, 바이오 연료 등으로 확대시킬 수 있는 방안이 더 필요로 하였다. 또한 정부주도형보다 소비자주도형이 바람직하고, 식품클러스터 뿐만 아니라 국가 및 지역 클러스터들이 성공하기 위해서는 중국시장 등 안전한 판로가 동시에 개척되어야 하며, 태양열과 지열을 활용한 친환경 에너지를 활용하고 지역주민을 위한 복지문화시설 등을 통해 지역주민, 직원과 조합이 소비자와 연결되는 선순환 구조를 형성이 필요하다는 것을 알 수 있었다. 본 연구결과는 향후 우리 농업이 앞으로 생태환경 보전과 에너지 및 자원 재생 등을 통한 지속가능한 자원순환형 농업으로 실현되기 위해 필요로 하는 요소들과 조성 및 운영방안들을 도출하는데 활용할 수 있을 것이다.