Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration in the Diagnosis of Lymphoma

Senturk, Aysegul,Babaoglu, Elif,Kilic, Hatice,Hezer, Habibe,Dogan, Hayriye Tatli,Hasanoglu, Hatice Canan,Bilaceroglu, Semra Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10

Background: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is highly accurate in diagnosing mediastinal lymphadenopathies of lung cancer and benign disorders. However, the utility of EBUS-TBNA in the diagnosis of mediastinal lymphomas is unclear. The aim of this study was to determine the diagnostic value of EBUS-TBNA in patients with suspected lymphoma. Materials and Methods: Sixty-eight patients with isolated mediastinal lymphadenopathy and suspected of lymphoma were included in the study. EBUS-TBNA was performed on outpatients under moderate sedation. The sensitivity, specificity, negative predictive value and diagnostic accuracy of EBUS-TBNA were calculated. Results: Sixty-four patients were diagnosed by EBUS-TBNA, but four patients with non-diagnostic EBUS-TBNA required surgical procedures. Thirty-five (51.5%) patients had sarcoidosis, six (8.8%) had reactive lymphadenopathy, nine (13.3%) had tuberculosis, one (1.5%) had squamous cell carcinoma, two (2.9%) had sarcoma and fifteen (22%) had lymphoma (follicular center cell, large B-cell primary, and Hodgkin lymphomas in three, two, and ten, respectively). Of the 15 lymphoma patients, thirteen were diagnosed by EBUS and two by thoracotomy and mediastinoscopy. The sensitivity, specificity, negative predictive value, and diagnostic accuracy of EBUS-TBNA for the diagnosis of lymphoma were calculated as 86.7%, 100%, 96.4%, and 97%, respectively. Conclusions: EBUS-TBNA can be employed in the diagnosis of mediastinal lymphoma, instead of more invasive surgical procedures.

Can Right-Handed Surgeons Insert Upper Thoracic Pedicle Screws in much Comfortable Position? Right-Handedness Problem on the Left Side

Akyoldas, Goktug,Senturk, Salim,Yaman, Onur,Ozdemir, Nail,Acaroglu, Emre The Korean Neurosurgical Society 2018 Journal of Korean neurosurgical society Vol.61 No.5

Objective : Thoracic pedicles have special and specific properties. In particular, upper thoracic pedicles are positioned in craniocaudal plane. Therefore, manipulation of thoracic pedicle screws on the left side is difficult for right-handed surgeons. We recommend a new position to insert thoracic pedicle screw that will be much comfortable for spine surgeons. Methods : We retrospectively reviewed 33 patients who underwent upper thoracic pedicle screw instrumentation. In 15 patients, a total of 110 thoracic pedicle screws were inserted to the upper thoracic spine (T1-6) with classical position (anesthesiologist and monitor were placed near to patient's head. Surgeons were standing classically near to patient's body while patients were lying in prone position). In 18 patients, a total of 88 thoracic pedicle screws were inserted to the upper thoracic spine with the new standing position-surgeons stand by the head of the patient and the anesthesia monitor laterally and under patient's belt level. All the operations performed by the same senior spine surgeons with the help of C-arm. Postoperative computed tomography scans were obtained to assess the screw placement. The screw malposition and pedicle wall violations were divided and evaluated separately. Cortical penetration were measured and graded at either : 1-2 mm penetration, 2-4 mm penetration and >4 mm penetration. Results : Total 198 screws were inserted with two different standing positions. Of 198 screws 110 were in the classical positioning group and 88 were in the new positioning group. Incorrect screw placement was found in 33 screws (16.6%). The difference between total screw malposition by both standing positions were found to be statistically significant (p=0.011). The difference between total pedicle wall violations by both standing positions were found to be statistically significant (p=0.003). Conclusion : Right-handedness is a problem during the upper thoracic pedicle screw placement on the left side. Changing the surgeon's position standing near to patient's head could provide a much comfortable position to orient the craniocaudal plane of the thoracic pedicles.

The effect of disease-modifying antirheumatic drugs on sleep and quality of life in older patients with rheumatoid arthritis

Azizli Ali,Sargın Gökhan,Senturk Taskin 대한류마티스학회 2023 대한류마티스학회지 Vol.30 No.2

Objective: The sleep quality is worse in rheumatoid arthritis (RA) patients than in healthy controls and it is more difficult to achieve a satisfactory quality of life after treatment with age. Our aim is to assess the quality of life and sleep in elderly onset RA patients and to analyze the effect of disease-modifying agents on sleep and quality of life. Methods: Thirty-four older patients with RA patients and 30 healthy controls are included in the study. Sleep quality was evaluated with the Pittsburg sleep quality index and quality of life with Short Form-36. Parametric/non-parametric tests and Spearman/ Pearson correlation analysis were applied for the data according to the distribution. Results: While the rate of poor sleep quality before treatment was 67.6%, the rate was 26.5% after treatment. There was a statistically significant difference before and after treatment in terms of subjective sleep quality, sleep latency, sleep duration, sleep efficiency, and scores for sleep disturbance. The mean steroid dose and Disease Activity Score-28 were higher in patients with poor sleep quality than in patients with good sleep quality. Patients with poor sleep quality had lower mean physical function, pain, general health, social function, emotional role difficulties, and energy/vitality values than patients with good sleep quality. Conclusion: Both sleep and quality of life improved after treatment in older patients with RA patients. In older patients, it should be regularly evaluated in terms of sleep and quality of life and appropriate treatment should be provided.

Novel Foraminal Expansion Technique

Ali Fahir Ozer,Salim Senturk,Mert Ciplak,Tunc Oktenoglu,Mehdi Sasani,Emrah Egemen,Onur Yaman,Tuncer Suzer 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.4

The technique we describe was developed for cervical foraminal stenosis for cases in which a keyhole foraminotomy would not be effective. Many cervical stenosis cases are so severe that keyhole foraminotomy is not successful. However, the technique outlined in this study provides adequate enlargement of an entire cervical foraminal diameter. This study reports on a novel foraminal expansion technique. Linear drilling was performed in the middle of the facet joint. A small bone graft was placed between the divided lateral masses after distraction. A lateral mass stabilization was performed with screws and rods following the expansion procedure. A cervical foramen was linearly drilled medially to laterally, then expanded with small bone grafts, and a lateral mass instrumentation was added with surgery. The patient was well after the surgery. The novel foraminal expansion is an effective surgical method for severe foraminal stenosis.

A Case of Biliary Fascioliasis by Fasciola gigantica in Turkey

Vedat Goral,Senem Senturk,Omer Mete,Mutallib Cicek,Berat Ebik,Be?ir Kaya 대한기생충학열대의학회 2011 The Korean Journal of Parasitology Vol.49 No.1

COMPARISON OF REPAIR INTEGRITY AND FUNCTIONAL OUTCOMES BETWEEN KNOT-TYING AND KNOTLESS SUTURE-BRIDGE ARTHROSCOPIC ROTATOR CUFF REPAIR: A PROSPECTIVE RANDOMIZED CLINICAL TRIAL

Koray Sahin,Fatih Senturk,Mehmet Ersin,Mechmet Chodza,Ufuk Arzu,Ali Ersen 대한견주관절의학회 2021 대한견주관절학회 학술대회논문집 Vol.2021 No.3

Introduction and Background Suture-bridge (SB) rotator cuff repair (RCR) is widely used due to its superior biomechanical and clinical outcomes. However, knot-tying SB technique has been suspected to compromise the tendinous biology and to cause strangulation and medial repair failures. Therefore, knotless SB technique has been proposed to decrease retear rates. The purpose of this study is to compare clinical, structural outcomes and retear patterns between two techniques Material and Method 104 patients with full-thickness rotator cuff tear were randomly and prospectively allocated to knot-tying (group I) or knotless (group II) SB surgeries. Clinical outcome measures included range of motion values, subjective pain scores (VAS) and functional scores (Constant score). Repair integrity was evaluated with magnetic resonance imagings using Sugaya classification. Retears were also classified according to their patterns as type 1 (lateral) and type 2 (medial). 88 patients completed the follow-up period and were included to final analysis. Results Mean age of patients was 54.3 years in group I and 55.8 years in group II. Mean follow-up period was 25.4 and 23.3 months respectively. Mean pain score of group I decreased from 7.4 to 1.0 (p<0.0001). The corresponding values for group II decreased from 7.1 to 1.3 (p<0.0001). In group I, mean Constant score increased from 51.7 to 86.0 (p<0.0001) and in group II, mean Constant score increased from 49.4 to 87.2 (p<0.0001). There was not statistically significant difference between two groups regarding post-operative pain and functional scores (p>0.05). Post-operative MR imaging revealed that the retear rate was 19.0% (8/42) in group I and 28.3% (13/46) in group II (p>0.05). Type 2 failure rate was 75.0% (6/8) in group I and 23.1% (3/13) in group II (p=0.03). Conclusions Both techniques showed excellent improvement and comparable clinical outcomes. However, there was no significant difference in retear rates between techniques. Type 2 failure rate was higher in knot-tying technique.

Disc Rehydration after Dynamic Stabilization: A Report of 59 Cases

Atilla Yilmaz,Salim Senturk,Mehdi Sasani,Tunc Oktenoglu,Onur Yaman,Hakan Yildirim,Tuncer Suzer,Ali Fahir Ozer 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.3

Study Design: A retrospective study investigating decrease in the nucleus pulposus signal intensity or disc height on magnetic resonance imaging (MRI) and disc degeneration. Purpose: Although a degenerated disc cannot self-regenerate, distraction or stabilization may provide suitable conditions for rehydration and possible regeneration. This study aimed to evaluate clinical outcomes and disc regeneration via MRI in a series of patients with degenerative disc disease (DDD) who underwent lumbar stabilization with a dynamic stabilization system (DSS). Overview of Literature: A dynamic system provides rehydration during early DDD. Methods: Fifty-nine patients (mean age, 46.5 years) who undedwent stabilization with DSS for segmental instability (painful black disc) between 2004 and 2014 were retrospectively evaluated. All patients underwent MRI preoperatively and 12 months postoperatively. Intervertebral disc (IVD) degeneration grades at the implanted segment were categorized using the Pfirrmann classification system. Patients were followed for a mean of 6.4 years, and clinical outcomes were based on visual analog scale (VAS) and Oswestry disability index (ODI) scores. Results: Significant improvements in back pain VAS and ODI scores from before surgery (7 and 68%, respectively) were reported at 6 (2.85 and 27.4%, respectively) and 12 months postoperatively (1.8 and 16.3%, respectively). Postoperative IVD changes were observed in 28 patients. Improvement was observed in 20 patients (34%), whereas progressive degeneration was observed in eight patients (13.5%). Thirty-one patients (52.5%) exhibited neither improvement nor progression. Single Pfirrmann grade improvements were observed in 29% of the patients and two-grade improvements were observed in 5%. Conclusions: Our observations support the theory that physiological movement and a balanced load distribution are necessary for disc regeneration. We conclude that DSS may decelerate the degeneration process and appears to facilitate regeneration.

Left Atrial Myxoma Mimicking Polyarteritis Nodosa

Gokhan Sargin,Taskin Senturk 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.4

Antimicrobial Resistance of Enterococcus Species Isolated from Chicken in Turkey

Pınar Sanlibaba,Basar Uymaz Tezel,Esra Senturk 한국축산식품학회 2018 한국축산식품학회지 Vol.38 No.2

The aim of the present work was to provide information about Enterococcus strains isolated from pre-packaged chicken samples in Ankara (Turkey), focusing on their prevalence, phenotypic and genotypic characteristics, and antibiotic resistance. We report the first study on the occurrence of antibiotic resistant enterococci in pre-packaged chicken samples in Ankara. A total of 97suspiciousenterococcal isolates were identified from 122 chicken samples. All isolates were identified to species level by phenotypic and molecular methods. In the 16S rDNA sequence analysis, Enterococcus faecium (61.85%) and Enterococcus faecalis(38.15%) were found to be the most frequently detected Enterococcus spp. Of the 97 isolates tested for hemolytic activity, 12.37% enterococcal strains were β-hemolytic. β-Hemolysin was most prevalent among E. faecium(58.33%) compared to E. faecalis(41.66%). Disk diffusion method was used for determining ofantibiotic resistance. The analysis of the antimicrobial resistance of the 97 Enterococcus isolates revealed that the resistance to kanamycin (98.96%), rifampicin (80.41%) and ampicillin (60.82%) was most frequent. Furthermore, resistance to erythromycin (38.14%) and ciprofloxacin (34.02%) was also observed. The frequencies of resistance to tetracycline (9.27%), penicillin G (8.24%), and chloramphenicol (3.09%), gentamicin (2.06%) and streptomycin (1.03%) were low. None of the isolates was resistant to vancomycin. Multi-drug resistance was found in 97.93% of Enterococcus strains. E. faecium strains showed a more resistant phenotype than E. faecalis strains according to the antibiotic resistance levels. The results of this study indicated that chicken meat is a potential reservoir for the transmission of antibiotic resistance from animals to humans.

Lycopene Partially Reverses Symptoms of Diabetes in Rats with Streptozotocin-Induced Diabetes

Aysegul Bayramoglu,Gokhan Bayramoglu,Hakan Senturk 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.2

In the present study, we describe the effects of lycopene on the symptoms of streptozotocin (STZ)–induced diabetes in rats. Lycopene at the dose of 2.5 mg/kg body weight (bw) per day was orally administered to STZ-induced diabetic rats for a period of 7 days after onset of diabetes. At the same time, food–water intake and body weight change were recorded daily. Upon sacrifice, biochemical parameters, such as the serum glucose, insulin, total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were measured in all experimental groups. Administration of lycopene at the dose of 2.5 mg/kg bw per day significantly reduced serum glucose, TC, TG, ALT, and AST levels, and increased serum insulin levels, but there were no improvements in food–water intake and body weight change parameters in lycopene-treated diabetic rats. The results suggest that orally administrated lycopene exhibits a potent hypoglycemic effect in STZ-induced diabetic rats and that lycopene may be useful for the management of diabetes mellitus.