Quantitative Computed Tomography of Pulmonary Emphysema and Ventricular Function in Chronic Obstructive Pulmonary Disease Patients with Pulmonary Hypertension

Yu-Sen Huang,Hsao-Hsun Hsu,Jo-Yu Chen,Mei-Hwa Tai,Fu-Shan Jaw,Yeun-Chung Chang 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.6

Objective: This study strived to evaluate the relationship between degree of pulmonary emphysema and cardiac ventricular function in chronic obstructive pulmonary disease (COPD) patients with pulmonary hypertension (PH) using electrocardiographic-gated multidetector computed tomography (CT). Materials and Methods: Lung transplantation candidates with the diagnosis of COPD and PH were chosen for the study population, and a total of 15 patients were included. The extent of emphysema is defined as the percentage of voxels below -910 Hounsfield units in the lung windows in whole lung CT without intravenous contrast. Heart function parameters were measured by electrocardiographic-gated CT angiography. Linear regression analysis was conducted to examine the associations between percent emphysema and heart function indicators. Results: Significant correlations were found between percent emphysema and right ventricular (RV) measurements, including RV end-diastolic volume (R2 = 0.340, p = 0.023), RV stroke volume (R2 = 0.406, p = 0.011), and RV cardiac output (R2 = 0.382, p = 0.014); the correlations between percent emphysema and left ventricular function indicators were not observed. Conclusion: The study revealed that percent emphysema is correlated with RV dysfunction among COPD patients with PH. Based on our findings, percent emphysema can be considered for use as an indicator to predict the severity of right ventricular dysfunction among COPD patients.

지진대피공간으로써의 공원녹지 적절성 평가지표 연구

차오린썬,강태호,Cao, Lin-Sen,Kang, Tai-Ho 한국조경학회 2017 韓國造景學會誌 Vol.45 No.4

2016년 9월 12일 경상북도 경주시역에서 발생한 규모 5.8의 지진은 한국이 더 이상 지진으로부터 안전한 지역이 아님을 전 국민에게 확실하게 인지하게 하였다. 도시 녹지는 특성상 양호한 지진 대피 기능을 지니고 있는 도시 내 중요한 지진 대피 장소이다. 그러나 공원녹지는 지진 대피 적절성에 대한 연구의 부족으로 지진 발생 후 피난 장소로 활용되지 못하고 있는 경우가 많다. 본 연구는 도시 공원이 지진 대피 장소로써의 적절성을 평가하기 위한 지표를 개발하기 위해 델파이 기법을 활용하여 3차에 걸쳐 조사를 실시하였다. 조사 결과에 대한 평균(M), 표준편차(SD), 합의도, 수렴도, 내용타당도 지수(CVR) 등을 분석하여 총 37개 지표 중 10개의 지표들을 기준에 부합하지 않기 때문에 제거하였고, 최종 27개의 지표가 선정되었다. 최종 연구 결과, 공원녹지의 지진 대피 적절성 평가에 대한 안전성과 접근성, 서비스 효과성은 각각 8개, 6개, 13개의 평가지표가 선정되었다. Following the September $12^{th}$, 2016 earthquake in Gyeongju-city, the observation can be made that South Korea is not a non-earthquake country. Because of its particular characteristics, urban green spaces are good sites for protection during an earthquake but studies regarding the suitability of park green spaces as a form of earthquake shelter are few, making it difficult to highlight the function of park green spaces as emergency shelters. The purpose of this study is to identify indicators for suitability impact factors of comprehensive parks as emergency earthquake shelter zones. Using the Delphi method, three rounds of survey were implemented. According to the analysis results of Average value, CVR, Consultation and Convergence, ten candidate indicators were removed in the candidate group. Twenty-seven suitability impact factors of comprehensive parks were retained, including 8 indicators in the field of safety, 6 indicators in the field of accessibility, and 13 indicators in the field of service effectiveness.

High Mobility Group Box 1 Protein Is Methylated and Transported to Cytoplasm in Clear Cell Renal Cell Carcinoma

Wu, Fei,Zhao, Zuo-Hui,Ding, Sen-Tai,Wu, Hai-Hu,Lu, Jia-Ju Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: The high mobility group box 1 (HMGB1) protein is a widespread nuclear protein present in most cell types. It typically locates in the nucleus and functions as a nuclear cofactor in transcription regulation. However, HMGB1 can also localize in the cytoplasm and be released into extracellular matrix, where it plays critical roles in carcinogenesis and inflammation. However, it remains elusive whether HMGB1 is relocated to cytoplasm in clear cell renal cell carcinoma (ccRCC). Methods: Nuclear and cytoplasmic proteins were extracted by different protocols from 20 ccRCC samples and corresponding adjacent renal tissues. Western blotting and immunohistochemistry were used to identify the expression of HMGB1 in ccRCC. To elucidate the potential mechanism of HMGB1 cytoplasmic translocation, HMGB1 proteins were enriched by immunoprecipitation and analyzed by mass spectrometry (MS). Results: The HMGB1 protein was overexpressed and partially localized in cytoplasm in ccRCC samples (12/20, 60%, p<0.05). Immunohistochemistry results indicated that ccRCC of high nuclear grade possess more HMGB1 relocation than those with low grade (p<0.05). Methylation of HMGB1 at lysine 112 in ccRCC was detected by MS. Bioinformatics analysis showed that post-translational modification might affect the binding ability to DNA and mediate its translocation. Conclusion: Relocation of HMGB1 to cytoplasm was confirmed in ccRCC. Methylation of HMGB1 at lysine 112 might the redistribution of this cofactor protein.

관광객 만족도 분석을 위한 IPA 기법 적용 연구 -경주 양동마을 방문 중국인을 대상으로-

차오린썬,시아티엔티엔,강태호,Cao, Lin-Sen,Xia, Tian-Tian,Kang, Tai-Ho 한국조경학회 2017 韓國造景學會誌 Vol.45 No.3

As a simple and practicable method, an Importance-Performance Analysis(IPA) is often used as a tool to study the satisfaction of tourists in Tourism. The IPA has two dimensions to attribute importance and performance(or satisfaction as in satisfaction research), and generally uses an interviewee self-reported approach to acquire performance and importance data. Many scholars have pointed out that the traditional IPA cannot meet the premise of its establishment. Therefore, several revised IPA have been proposed. Among them, Deng's IPA is the most representative. There are not many contrastive analyses between the traditional IPA and revised IPA in academia. The lack of comparative study will make it difficult to judge the difference and effectiveness of different IPA techniques. Taking Gyeongju Yangdong Village as an example, this study investigated and researched the degree of satisfaction of Chinese tourists using the traditional IPA method and Deng's modified IPA method respectively, and then analysed the differences between the two methods and their causes. Based on the analysis results, the study put forward suggestions for the improvement of tourism management in Gyeongju Yangdong Village. IPA 기법은 간단하고 효과적인 분석방법으로써 관광객 만족도 연구에 중요한 연구 방법이다. IPA 분석 기법은 피조사자를 중요도와 성취도로 구분하여 조사 대상의 지표를 평가한다. 일부 연구자들은 전통 IPA 기법이 이들 조건을 충족시킬 수 없음을 발견하고, 여러 가지 수정 IPA 기법을 제시하였다. 그 중에 Deng의 수정 IPA 방법이 가장 대표적이다. 국 내외 연구를 조사한 결과, 전통 IPA 기법과 수정 IPA 기법에 대한 비교 연구는 없는 실정으로, 서로 다른 IPA 기법의 차별성과 효율성에 대한 판단이 쉽지 않다. 본 연구는 사례연구와 비교연구를 위해 경주시 양동마을을 방문하는 중국 관광객을 대상으로 만족도 분석 중에 전통 IPA 기법과 수정 IPA의 적용성에 대하여 연구하였다. 아울러 전통 IPA와 수정 IPA 분석 결과에 대한 차이점과 원인을 분석하였다. 이를 바탕으로 양동마을의 바람직한 관리를 위한 개선 방안을 제시하였다.

New Method to Improve the Secondary Path Modeling Accuracy for Active Noise Control Systems

Shan-zhen Yi,Ren-yuan Fei,Da-sen Zhou,Tai-wen Liu,Jian-ping Yu,Jin-feng Yang,Kui-cheng Gong 한국소음진동공학회 2003 한국소음진동공학회 국제학술대회논문집 Vol.2003 No.8

Gallbladder Cancer: a Subtype of Biliary Tract Cancer Which is a Current Challenge in China

Qu, Kai,Liu, Si-Nan,Chang, Hu-Lin,Liu, Chang,Xu, Xin-Sen,Wang, Rui-Tao,Zhou, Lei,Tian, Feng,Wei, Ji-Chao,Tai, Ming-Hui,Meng, Fan-Di Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Biliary tract cancers, broadly described as malignancies that arise from the biliary tract epithelia, are usually divided into two major clinical phenotypes: cholangiocarcinoma and gallbladder cancer, differing in etiopathogenesis, risk factors, and perhaps molecular and genetic signatures. Atypical symptoms and lack of tumor biomarkers make it difficult to diagnose in early stages. At the time of presentation, few patients are candidates for potentially curative surgical resection. We here assessed and compared features of a total of 150 cases divided into extra- and intrahepatic cholangiocarcinomas and gallbladder cancers (GBC). Althought there were no significant differences in serum tumour marker levels, GBC patients had the poorest prognosis. Furthermore, gallbladder cancer respond poorly to chemotherapy or radiation therapy and approximately half of untreated patients died within 10 months. Therefore, treatment for patients with gallbladder cancer is still in challenge. Outcomes and survival of these patients had improved little over the past three decades - a period in which new successful treatments have greatly contributed to the prolonged patient survival for many other cancers.

Prognosis and Management for Gallbladder Cancer with Hepatic Invasion: Long-term Results of 139 Patients from a Single Center in China

Qu, Kai,Chang, Hu-Lin,Liu, Si-Nan,Liu, Chang,Xu, Xin-Sen,Wang, Rui-Tao,Zhou, Lei,Tian, Feng,Wei, Ji-Chao,Tai, Ming-Hui,Meng, Fan-Di Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Objective: To improve the diagnosis of primary gallbladder carcinoma (GBC) with/without hepatic metastases by analyzing our experience of different GBC treatment in our patients. Methods: A retrospective study was carried out to analyze the clinical data of the 139 patients with GBC who underwent hepatic resection in our unit from January 2003 to December 2007. Patients were divided into two groups according to whether they demonstrated hepatic invasion. Tumor presentation, surgical modes, and prognosis of each patient were retrospectively reviewed. Kaplan-Meier curves and log-rank tests were employed to compare the survival rates of those patients undergoing different surgical procedures. Results: Of the 139 patients, 46 were men and 93 were women with the male to female ratio of 1:2.0. Their ages were ranged from 35 to 86 years with a mean age of $62.8{\pm}10.4$ years. There were 73 patients complicated with hepatic invasion (group A), and no hepatic invasion occurred in the other 66 patients (group B). Compared with the group B, the patients with hepatic invasion suffered lower differentiation of tumor (p=0.000), more advanced Nevin staging (p=0.008) and poorer prognosis (p=0.013). Radical resection were more frequently performed in group B (75.76%) than in group A (45.20%) with better outcomes (p=0.000). Conclusion: GBC patients complicated with hepatic invasion had poorer prognosis than those without invasion in long-term follow-ups. Radical resection might result in a satisfied prognosis in patients without hepatic invasion, but appears less favorable than palliative resection in those who were complicated with hepatic invasion.

Effects of silkworm pupa protein hydrolysates on mitochondrial substructure and metabolism in gastric cancer cells

Weixin Li,Li-Xia Mu,Leiyan Wu,Yu-Xiao Zou,Hai-Feng Zhao,Sen-Tai Liao 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.2

The effects of silkworm pupa protein hydrolysates (SPPHs) on the apoptosis of MGC-803 gastric cancer cells were investigated in this study. The role of mitochondrial-dependent apoptosis in SPPHs-dependent inhibition of MGC-803 cell viability was also explored. SPPHs were found to induce apoptosis in MGC-803 cells with an IC 50 of 0.30 mg/ml. A series of changes in cellular organelle structural were observed during MGC-803 cell apoptosis that included mitochondrial swelling, vacuolation and rupture. These changes may ultimately impact on metabolic energy supply in MGC-803 cells. The expression of the pro- and anti-apoptotic proteins Bcl-2 and Bax, and the activation of cytochrome c (Cyt C), Caspase-3 and Caspase-9 were altered following induction of apoptosis by SPPHs in MGC-803 cells. Moreover, the increase in the ratio of Bax to Bcl-2 expression is known to play an important role in the activation of the mitochondrial-dependent apoptotic pathway.

Establishment of a model to evaluate the nutritional quality of Bombyx mori Linnaeus (Lepidoptera, Bombycidae) pupae lipid based on principal components

Yu-Xiao Zou,Teng-Gen Hu,Ying Shi,Jun Liu,Li-Xia Mu,Yang Xiao,Sen-Tai Liao 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.4

Silkworm pupae are a source of edible lipid with a high content of unsaturated fatty acids (UFAs) (70% of total lipid content) and are becoming a focus of pharmaceutical and dietary research in the functional oil field. To study the nutritional value of different silkworm strains, principal component analysis (PCA) was used to establish a mathematical model and cluster analysis on silkworm pupae lipid (SPL) in 90 strains based on Z-score. Single-factor correlation analysis indicated that the PUFAs content was significantly positively correlated with the α-linolenic acid (ALA) (ρ=0.98) and negatively correlated with the oleic acid (OA) (ρ=−0.73) contents, and comprehensive of principal components mathematical model (PC =0.148ZX1 +0.00 2ZX2 −0.197ZX3 −0.338ZX4 +0.220ZX5 +0.304ZX6 +0.314ZX7, ZXi is the standard score (Z-score) of X1, which was calculated as follow: ZXi = (Xi −−X )/S, where X1: palmitic acid, X2: palmitoleic acid, X3: stearic acid, X4: OA, X5: linoleic acid, X6: ALA, X7: PUFAs.−X is the arithmetic mean content of variable i, and S is the standard deviation of variable i for all samples included in the analysis.) showed the amount of ALA and PUFAs were the key factors determining the nutritional value of the pupae lipid. Cluster analysis on the composite scores calculated by the model of the principal component divided the 90 strains into three groups. A cluster of 6 strains (XHR, XIFF, ZX, YT, YO and BTN) with the best nutritional value was characterized by high contents of ALA and PUFAs and a low content of oleic acid.