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Seigo Nakatani,Kosuke Okuwaki,Masafumi Watanabe,Hiroshi Imaizumi,Tomohisa Iwai,Takaaki Matsumoto,Rikiya Hasegawa,Hironori Masutani,Takahiro Kurosu,Akihiro Tamaki,Junro Ishizaki,Ayana Ishizaki,Mitsuhir 대한소화기내시경학회 2024 Clinical Endoscopy Vol.57 No.1
Background/Aims: In stereomicroscopic sample isolation processing, the cutoff value (≥4 mm) of stereomicroscopically visible white cores indicates high diagnostic sensitivity. We aimed to evaluate endoscopic ultrasound-guided tissue acquisition (EUS-TA) using a simplified stereomicroscopic on-site evaluation of upper gastrointestinal subepithelial lesions (SELs). Methods: In this multicenter prospective trial, we performed EUS-TA using a 22-gauge Franseen needle in 34 participants with SELs derived from the upper gastrointestinal muscularis propria, requiring pathological diagnosis. The presence of stereomicroscopically visible white core (SVWC) in each specimen was assessed using stereomicroscopic on-site evaluation. The primary outcome was EUS-TA’s diagnostic sensitivity with stereomicroscopic on-site evaluation based on the SVWC cutoff value (≥4 mm) for malignant upper gastrointestinal SELs. Results: The total number of punctures was 68; 61 specimens (89.7%) contained stereomicroscopically visible white cores ≥4 mm in size. The final diagnoses were gastrointestinal stromal tumor, leiomyoma, and schwannoma in 76.5%, 14.7%, and 8.8% of the cases, respectively. The sensitivity of EUS-TA with stereomicroscopic on-site evaluation based on the SVWC cutoff value for malignant SELs was 100%. The per-lesion accuracy of histological diagnosis reached the highest level (100%) at the second puncture. Conclusions: Stereomicroscopic on-site evaluation showed high diagnostic sensitivity and could be a new method for diagnosing upper gastrointestinal SELs using EUS-TA.
Activities for the Development of Targeted Radionuclide Therapy in Japan
Seigo Kinuya 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.1
Targeted radionuclide therapy (TRT) is unique because of its efficacy and its theranostic feature in the era of precision medicine. So far, introduction of new TRT has not been going well in Japan due to several reasons including strict regulations, shortage of facilities for TRT, and insufficient reimbursement for TRT in clinic. Japanese community had several strategies to develop TRT in these 10 years, including the establishment of the National Conference for Nuclear Medicine Theranostics in which physicians, scientists, patients, people supporting patients, and industrial people gather. To promote TRTwith supports from the government, the preparatory committee for the establishment of Japan Foundation of Medical Isotope Development (JAFMID) was launched. I would like to call TRT BPrecision Nuclear Medicine.^ When we can add genomic information here, we can put it to new stage of cancer therapy. It is time for us.
SEIGO ITO,TAKUROU N. MURAKAMI,SHAIK M. ZAKEERUDDIN,SUSUMU KAYAMA,MICHAEL GR€ ATZEL,Tetsuo Yazawa,MASAO MIZUNO 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.5
Di®erent-sized nanocrystalline-TiO 2 particles have been used for the optimization of photovoltaice®ects of dye-sensitized solar cells (DSCs) using an ionic-liquid (IL) electrolyte. Ru dye (Z907)was used for the IL-DSC optimization. The TiO 2 nanoparticle sizes and the thickness of nano-crystalline-TiO 2 electrodes ranged from 13 nm to 81 nm and 2 ? m to 23 ? m, respectively. Theparticle size of the nanocrystalline TiO 2 ¯lm greatly a®ected the photovoltaic characteristics,particularly for the IL electrolyte due to limitation of the photocurrent by I?/I?3-di®usion. Theoptimized electrode for IL-DSC had a 15 ? m thickness using a 27 nm diameter of nanocrystalline-TiO 2 particles. In order to characterize the e®ect of the TiO 2 particle size on the photovoltaice®ects of IL-DSCs, a scanning electron micrograph (surface and cross section of nanoparticles),BET speci¯c surface area analysis, pore-size distribution analysis, photocurrent transient measurements, haze spectroscopy, photovoltaic measurements, incident-photon-to-currentconversion e±ciency spectroscopy and impedance measurement have been used.
Erythema Nodosum Masking Kawasaki Disease with an Initial Manifestation of Skin Lesions
Seigo Okada,Yuichi Ishikawa,Maiko Shimomura,Shinpei Sunagawa,Reiji Hirano,Shinnosuke Fukunaga,Akiko Miyake,Yusuke Okada,Takashi Maki 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.3
We report the first case demonstrating an association between Kawasaki disease (KD) and erythema nodosum (EN). A 3-year-oldgirl presented with EN as an initial manifestation of KD. At the initial visit, she showed high fever of 40°C, injection of the oropharynx,cervical lymphadenopathy, and red-purple cutaneous nodules, particularly on the lower limbs. She complained of severepain in the neck and cutaneous lesions. Initially, the development of EN was attributed to Salmonella spp infection, which wasdetected in stool culture. However, the patient did not respond to high-dose ampicillin/sulbactam to which the Salmonella spp issensitive. Echocardiography performed as screening for fever of unknown origin revealed medium-sized aneurysms of the leftanterior descending artery. EN masked the diagnosis of KD, and the patient developed a coronary artery lesion. KD should beconsidered in the differential diagnosis of refractory EN in pediatric patients.