Expression Analysis of Two Cancer-testis Genes, FBXO39 and TDRD4, in Breast Cancer Tissues and Cell Lines

Seifi-Alan, Mahnaz,Shamsi, Roshanak,Ghafouri-Fard, Soudeh,Mirfakhraie, Reza,Zare-Abdollahi, Davood,Movafagh, Abolfazl,Modarressi, Mohammad Hossein,Kazemi, Golnesa,Geranpayeh, Lobat,Najafi-Ashtiani, Mi Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Breast cancer accounts for one third of new cancer cases among women. The need for biomarkers for early detection is the stimulus to researchers to evaluate altered expression of genes in tumours. Cancer-testis (CT) genes are a group with limited expression in normal tissues except testis but up-regulation in a wide variety of cancers. We here evaluated expression of two CT genes named FBXO39 and TDRD4 in 32 invasive ductal carcinoma samples, 10 fibroadenomas and 6 normal breast tissue samples, in addition to two breast cancer cell lines, MCF-7 and MDA-MB-231, by the means of quantitative real time RT-PCR. FBXO39 showed significant up-regulation in invasive ductal carcinoma samples in comparison with normal samples. It also was expressed in both cell lines and after RHOXF1 gene knock down it was down-regulated in MCF-7 but up-regulated in the MDA-MB-231 cell line. TDRD4 was not expressed in the MCF-7 cell line and any of the tissue samples except testis. However, it was expressed in MDA-MB-231 and was up-regulated after RHOXF1 gene knock down. Our results show that FBXO39 but not TDRD4 can be used for cancer detection and if proved to be immunogenic, might be a putative candidate for breast cancer immunotherapy.

Essential Oil Composition of Rosa damascena Mill. Produced With Different Storage Temperatures and Durations

Zeinolabedi Seify,Mehrab Yadegari,Abdollah Ghasemi Pirbalouti 한국원예학회 2018 원예과학기술지 Vol.36 No.4

The present study was conducted to investigate the effects of storage and temperature on the quality of Damask rose (Rosa damascena Mill.) flowers in southwestern Iran in 2016 and 2017. Flowers were harvested and distilled immediately or stored at 25°C, 4°C and -20°C for 6, 12, 24, 48 or 96 hours before distillation. Results obtained from GC/MS showed 39 essential oil components, most of which were beta citronellol, nonadecane, geraniol, trans geraniol, heneicosane, heptadecene and pentadecane. The highest (0.054% to 0.055%) and lowest (0.011% to 0.019%) levels of essential oil content were obtained at -20°C × 6 hours and 25°C × 96 hours post-harvesting, respectively. The highest percentage of beta citronellol (36.3 ± 1.2% to 35.1 ± 5.5%) was obtained at -20°C × 6 hours post-harvesting. Nonadecane levels increased with increasing storage time, particularly at -20°C × 96 hours post-harvesting (21.1 ± 0.08% to 16.2 ± 0.9%). Generally, the levels of most of the essential oil components decreased with increasing storage time, but this loss was avoided with freezing temperatures (-20°C).

Design and Implementation of a Low Cost Grid-Connected 5 kVA Photovoltaic System with Load Compensation Capability

Reza Seifi Mejdar,Mahdi Salimi,Adel Zakipour 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.6

Design and implementation of a low cost grid-connected 5kVA solar photovoltaic (PV) system is proposed in this paper. Since the inverter is a major component of the PV system, the B4 inverter used in this paper reduces the total cost of the PV system. In order to eliminate the massive transformer, the PV system is connected to the grid through IGBT switches. In addition to injection of active power into the grid, the B4 inverter can compensate reactive power and reduce harmonics of the nonlinear loads. A TMS320F28335 DSP processor is used for effective control of the B4 inverter. Various features of this processor enable the implementation of the necessary control algorithms. As a first step, the PV system is simulated and evaluated in Matlab/Simulink. In the second step, hardware circuits are designed and implemented based on the simulation results. The operation of the PV system has been evaluated under balanced, unbalanced, linear and nonlinear loads which proves its accuracy and efficiency.

Disaster Health Literacy of Middle-aged Women

Bahar Seifi,Ghader Ghanizadeh,Hesam Seyedin 대한폐경학회 2018 대한폐경학회지 Vol.24 No.3

As disasters have been increasing in recent years, disaster health literacy is gaining more important for a population such as middle-age women. This is because they face developmental crises (menopause) and situational crisis (disaster). Due to the growing elderly population, it is imperative to seriously consider the issue of aging women’s healthcare, and their educational needs relative to emergencies and disasters. The purpose of study was to clarify the importance of disaster health literacy for middle-age women. This study is a review of the literature using PubMed, ScienceDirect, Web of Science, Google Scholar, SCOPUS, OVID, ProQuest, Springer, and Wiley. Data was collected with keywords related to the research topic (“Women’s health” OR “Geriatric health”) AND (“Health literacy” OR “Disaster health literacy” OR “Disaster prevention literacy” OR “Risk knowledge” OR “Knowledge management”) AND (“Disasters” OR “Risk” OR “Crises”) in combination with the Boolean-operators OR and AND. We reviewed full text English-language articles published November 2011 November 2017. Additional references were identified from reference lists in targeted publications, review articles and books. This review demonstrated that disaster health literacy is critical for elderly women, because they may suffer from physical and psychological problems triggered by developmental crises such as menopause and situational crises such as disasters. Disaster literacy could enable them to improve resiliency and reduce disaster risk. Education has vital role in health promotion of middle-age women. Policymakers and health managers should be aware of the challenges of elderly women as a vulnerable group in disasters and develop plans to incorporate disaster health literacy for preparedness and prevention in educating this group.

Design and Implementation of a Low Cost Grid-Connected 5 kVA Photovoltaic System with Load Compensation Capability

Mejdar, Reza Seifi,Salimi, Mahdi,Zakipour, Adel The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.6

Design and implementation of a low cost grid-connected 5kVA solar photovoltaic (PV) system is proposed in this paper. Since the inverter is a major component of the PV system, the B4 inverter used in this paper reduces the total cost of the PV system. In order to eliminate the massive transformer, the PV system is connected to the grid through IGBT switches. In addition to injection of active power into the grid, the B4 inverter can compensate reactive power and reduce harmonics of the nonlinear loads. A TMS320F28335 DSP processor is used for effective control of the B4 inverter. Various features of this processor enable the implementation of the necessary control algorithms. As a first step, the PV system is simulated and evaluated in Matlab/Simulink. In the second step, hardware circuits are designed and implemented based on the simulation results. The operation of the PV system has been evaluated under balanced, unbalanced, linear and nonlinear loads which proves its accuracy and efficiency.

Effects of Monensin on Metabolism and Production in Dairy Saanen Goats in Periparturient Period

Sadjadian, Rasool,Seifi, Hesam A.,Mohri, Mehrdad,Naserian, Abbas Ali,Farzaneh, Nima Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.1

This trial evaluated the effects of dietary supplementation with monensin sodium on dry matter intake, metabolic parameters and milk yield and milk composition of dairy Saanen goats in the periparturient period. Twelve Saanen pregnant dairy goats were assigned to a treatment and a control group. Saanen goats were fed monensin as its 10% sodium salt in the amount of 33 mg/kg of total dry matter intake during 30 d before parturition till d 42 in milk. Blood samples were collected from each goat at d 30, 15 and 7 before expected kidding time and also in d 1, 7, 13, 19, 21, 28, 35 and 42 postpartum. The serum concentrations of ${\beta}$-Hydroxybutyrate (BHBA), non-esterifed fatty acid (NEFA), calcium, magnesium, inorganic phosphorus, cholesterol, triglyceride, urea, total protein, albumin and glucose and aspartate aminotransferase (AST) activity were determined. The BHBA concentration significantly decreased in goats, which received monensin in comparison to controls in the postpartum period (p = 0.049). The concentration of sodium (Na) was significantly influenced by monensin treatment in the postpartum period (p = 0.048). In addition, the difference in dry matter intake was highly significant between the two groups during the pre-partum period. Controls had more dry matter intake (DMI) than treatment goats (p = 0.0001). Mean 3.5% fat corrected milk production was not influenced by monensin treatment. However, milk fat percentage was significantly decreased in monensin treated goats (p = 0.0017).

Prooxidant-antioxidant balance and malondialdehyde over time in adult rats after tubal sterilization and vasectomy

Faramarzi, Azita,Seifi, Behjat,Sadeghipour, Hamid Reza,Shabanzadeh, Alireza,Ebrahimpoor, Mitra The Korean Society for Reproductive Medicine 2012 Clinical and Experimental Reproductive Medicine Vol.39 No.2

Objective: Sterilization (tubal sterilization and vasectomy) is a widely applied contraceptive method worldwide. Although most studies have described sterilization as a safe method, there are reports of tubal ligation (TL) and vasectomy complications. The aim of this study was to evaluate the effects of TL and vasectomy on the serum oxidative stress, specifically prooxidant-antioxidant balance (PAB) and malondialdehyde (MDA) levels, over time. Methods: Male and female rats were classified into vasectomy, sham-vasectomy, TL, and sham-TL groups, respectively. The PAB and MDA levels were measured on days 15 and 45 and months 3 and 6 after the intervention. For female rats, blood sampling was performed during the diestrous phase and estradiol and progesterone were also measured. Results: Serum PAB and MDA increased after TL (p<0.05). Vasectomy increased serum MDA remarkably after 45 days, 3 months, and 6 months (p<0.05). After vasectomy, serum PAB also increased although not significantly. Serum estradiol and progesterone decreased remarkably in the TL group compared to the sham group (p<0.05). Conclusion: Bilateral TL and vasectomy both increase the serum oxidative stress; however the imbalance after TL was very noticeable. As for the TL, the reduction of serum estrogen levels can be involved in this imbalance. Complications followed by TL or vasectomy could be due to increased levels of oxidants. Thus, prescribing antioxidants during and or after surgery may be a solution.

Association between polycystic ovary syndrome and risk of attention-deficit/hyperactivity disorder in offspring: a meta-analysis

Rastad Hadith,Seifi Alan Mahnaz 대한소아청소년과학회 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.3

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Sensitivity-Based Method for the Effective Location of SSSC

Eghtedarpour, Navid,Seifi, Ali Reza The Korean Institute of Power Electronics 2011 JOURNAL OF POWER ELECTRONICS Vol.11 No.1

Congestion management is one of the most challenging aspects in the recently deregulated electricity markets. FACTS devices have been shown to be an efficient alternative to control the flow of power in lines, resulting in increased loadability, lower system loss and a reduced cost of production. In this paper, the application of a static series synchronous compensator (SSSC) for the purpose of congestion management of power systems has been studied. A sensitivity-based analysis method is utilized for effective determination of the SSSC location in an electricity market. The method is topology based and it is independent of the system operation point. A power injection p-model is developed for the SSSC in this study. Numerical results based on the modified IEEE 14 bus system with/without the SSSC demonstrate the feasibility as well as the effectiveness of the SSSC for congestion management in a network. The results obtained when using the SSSC to improve system transfer capability and congestion management is encouraging.

Double Gate MOSFET Modeling Based on Adaptive Neuro-Fuzzy Inference System for Nanoscale Circuit Simulation

Mohsen Hayati,Majid Seifi,Abbas Rezaei 한국전자통신연구원 2010 ETRI Journal Vol.32 No.4

As the conventional silicon metal-oxide-semiconductor field-effect transistor (MOSFET) approaches its scaling limits, quantum mechanical effects are expected to become more and more important. Accurate quantum transport simulators are required to explore the essential device physics as a design aid. However, because of the complexity of the analysis, it has been necessary to simulate the quantum mechanical model with high speed and accuracy. In this paper, the modeling of double gate MOSFET based on an adaptive neuro-fuzzy inference system (ANFIS) is presented. The ANFIS model reduces the computational time while keeping the accuracy of physics-based models, like non-equilibrium Green’s function formalism. Finally, we import the ANFIS model into the circuit simulator software as a subcircuit. The results show that the compact model based on ANFIS is an efficient tool for the simulation of nanoscale circuits.