암에 근입된 말뚝의 주면저항력 예측

Seidel,J.P.,조천환 한국지반공학회 2002 한국지반공학회논문집 Vol.18 No.5

Cancer Associated Genodermatoses

Seidel, Donald R .,Burgdorf, Walter H.C. 대한피부과학회 1991 대한피부과학회지 Vol.29 No.5

4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

Seidel, C.,Schnekenburger, M.,Mazumder, A.,Teiten, M.H.,Kirsch, G.,Dicato, M.,Diederich, M. Pergamon Press 2016 Biochemical pharmacology Vol.99 No.-

<P>Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including a-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing HDAC6 inhibitors. Here, we identified two new structurally related 4-hydroxybenzoic acids as selective HDAC6 inhibitors reducing proliferation, colony and spheroid formation as well as viability of prostate cancer cells. Both compounds strongly enhanced alpha-tubulin acetylation leading to remodeling of microtubular organization. Furthermore, 4-hydroxybenzoic acids decreased HSP90 alpha regulation of the human androgen receptor in prostate cancer cells by increasing HSP90 alpha acetylation levels. Collectively, our data support the potential of 4-hydroxybenzoic acid derivatives as HDAC6-specific inhibitors with anti-cancer properties. (C) 2015 Elsevier Inc. All rights reserved.</P>

Histone deacetylase 6 in health and disease.

Seidel, Carole,Schnekenburger, Michael,Dicato, Mario,Diederich, Marc Future Medicine 2015 Epigenomics Vol.7 No.1

<P>Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including 관-tubulin and HSP90관, and is involved in protein trafficking and degradation, cell shape and migration. Consequently, deregulation of HDAC6 activity was associated to a variety of diseases including cancer, neurodegenerative diseases and pathological autoimmune response. Therefore, HDAC6 represents an interesting potential therapeutic target. In this review, we discuss structural features of this histone deacetylase, regulation of its expression and activity, biological functions, implication in human disease initiation and progression. Finally will describe novel and selective HDAC6 inhibitors.</P>

Prediction of the Shaft Resistance of Pile Sockets

Seidel, J.P.,Cho, Chun-Whan 한국지반공학회 2002 지반 : 한국지반공학회지 Vol.18 No.5

Empiricism has characterized the traditional methods of pile design; in essence, pile design recommendations are based on the accumulated knowledge of pile behaviour based on the construction and subsequent load testing of piles in soil and rock. In this paper, the traditional approaches to design of piles in rock will be briefly reviewed. It will be shown that the unrelated empirical relationships developed fur rock lead to considerable uncertainty in the design of piles. A new method for predicting the shaft resistance of piles socketed into rock, and based on fundamental principles is outlined. It is shown that the shaft resistance predictions of this method agree well with the field test data for rock and hard soil. It is demonstrated by way of a limited parametric study that shaft roughness and socket diameter are critical factors in the performance of piles constructed in these materials. The application of the method to piles socketed into the granites and gneisses of Korea is discussed by way of a case study and by reference to recent direct shear tests on these rocks. 기존의 말뚝 설계방법들은 시공 및 재하시험 결과들로부터 축적된 말뚝거동에 대한 경험을 바탕으로 이루어 졌다고 할 수 있다. 이와 같이 만들어진 암에 근입된 말뚝의 설계에 대한 전통적인 방법들에 대해 고찰한 결과, 암에 근입된 말뚝의 경험적인 설계방법들은 설계시 상당한 불확실성을 내포하는 것으로 나타났다. 따라서 본 논문에서는 암에 근입된 말뚝의 주면저항을 예측하는 새로운 방법에 대한 기본원리를 고찰하였다. 이 방법으로 예측한 말뚝의 지지력은 현장에서 측정한 결과와 잘 일치하는 것으로 나타났다. 제한된 변수연구 결과이지만 본 연구를 통해 암의 거칠기와 말뚝의 직경은 암반에 근입된 말뚝의 거동에 중요한 역할을 하는 것을 알 수 있었다 또한 국내 화강편마암에 대한 현장 사례연구를 통해 이방법의 적용성을 검토하였다.

Treating Depression in the Elderly

Seidel, G.,Dunbabin, D.,Popplewell, P. Medical Publications Korea 1993 Medical Progress Vol.15 No.9

Sexing Bovine Sperm

Seidel George E. 한국발생생물학회 2001 한국발생생물학회 학술발표대회 Vol.2001 No.-

Original Human Nature and the Mandate of Dominion : An Exploration of Unification Thought

Seidel, Dietrich 선문대학교 통일사상연구원 1997 통일사상 연구논총 Vol.3 No.-

지식경제사회에서 국가의 경쟁력은 국가의 잠재적 지식자원을 어떻게 유형화하고 부가 가치화하느냐에 따라 결정된다. 국가의 지식자원을 각 개별 경제주체가 소유한 지식자원의 총체적 개념으로 정의할 때 이 개별 주체들의 지식자원을 공유하도록 유도하고 공유된 지식을 활용하여 부가가치화 하도록 하는 것이 국가의 지식경쟁력 강화와 직결되는 정부의 역할일 것이다. 이에 본 연구는 개별 경제주체가 소유하고 있는 지식을 국가적 차원에서 공유토록 유도하고 그것을 활용하여 경쟁력을 강화토록 하는 산업지식유통시스템 모형을 제안한다 정부의 정책적 배려와 지원하에 본 연구의 제안이 현실화된다면, 산업지식유통 시스템은 산업수준의 지식유통 활성화를 통하여 기업의 지식기반 경영능력의 향상에 기여하고 선진국과의 지식네트워크를 통한 선진 지식의 도입 활성화에 기여함으로써 지식경쟁력 강화를 통한 국가 경쟁력 향상에 이바지 할 것이다. To use an illustration from the medical field, I would argue that any attempt to heal sickness and to find the right therapy is intrinsically bound up with a profound knowledge about the healthy state. Likewise, even if we are confronted every day with actual or potential dangers emerging from abusive human behavior, and if most of our efforts are directed towards seeking to contain damage and pain, we still become increasingly aware of the need for understanding our latent capacity for achieving the state of harmony of man-in nature.

Genetic causes of primary aldosteronism

Eric Seidel,Julia Schewe,Ute I. Scholl 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Primary aldosteronism is characterized by at least partially autonomous production of the adrenal steroid hormone aldosterone and is the most common cause of secondary hypertension. The most frequent subforms are idiopathic hyperaldosteronism and aldosterone-producing adenoma. Rare causes include unilateral hyperplasia, adrenocortical carcinoma and Mendelian forms (familial hyperaldosteronism). Studies conducted in the last eight years have identified somatic driver mutations in a substantial portion of aldosterone-producing adenomas, including the genes KCNJ5 (encoding inwardly rectifying potassium channel GIRK4), CACNA1D (encoding a subunit of L-type voltage-gated calcium channel CaV1.3), ATP1A1 (encoding a subunit of Na+/K+-ATPase), ATP2B3 (encoding a Ca2+-ATPase), and CTNNB1 (encoding ß-catenin). In addition, aldosterone-producing cells were recently reported to form small clusters (aldosterone-producing cell clusters) beneath the adrenal capsule. Such clusters accumulate with age and appear to be more frequent in individuals with idiopathic hyperaldosteronism. The fact that they are associated with somatic mutations implicated in aldosterone-producing adenomas also suggests a precursor function for adenomas. Rare germline variants of CYP11B2 (encoding aldosterone synthase), CLCN2 (encoding voltage-gated chloride channel ClC2), KCNJ5, CACNA1H (encoding a subunit of T-type voltage-gated calcium channel CaV3.2), and CACNA1D have been reported in different subtypes of familial hyperaldosteronism. Collectively, these studies suggest that primary aldosteronism is largely due to genetic mutations in single genes, with potential implications for diagnosis and therapy.

Shedding light on nanoscale ferroelectrics

Jan Seidel,Lukas M. Eng 한국물리학회 2014 Current Applied Physics Vol.14 No.8

Light matter interactions in nanoscale ferroelectric materials have received growing interest over the last years due to new developments in scientific instrumentation and novel materials that allow for the study of so far scarcely investigated and/or hidden nanoscale phenomena. Here we provide an overview of these developments and investigations that have been carried out over a broad range of frequencies spanning from the X-ray to the THz regime. Of interest are the physical quantities and fingerprints stemming from nanoscale regions in ferroelectrics, including domain walls, upon light illumination.