1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] suppresses pro-inflammatory responses by blocking NF-κB and MAPK signaling pathways in activated microglia

Himaya, S.W.A.,Ryu, BoMi,Qian, Zhong-Ji,Li, Yong,Kim, Se-Kwon Elsevier 2011 european journal of pharmacology Vol.670 No.2

<P><B>Abstract</B></P><P>Unregulated activation of microglia is a key risk factor contributes to neurodegenerative diseases and suppression of this phenomenon is considered as a potential therapeutic target. The compound isolated from sea horse <I>Hippocampus kuda</I> Bleeler; 1-(5-bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] was characterized for its ability in suppressing LPS mediated activation of murine BV-2 cells. Despite the presence of various active molecular groups in the structure, SE1 has not well explored for its biological activities. The outcome of this study clearly indicated that SE1 inhibited the production of inflammatory mediators; nitric oxide, prostaglandin E<SUB>2</SUB> and pro-inflammatory cytokines. Furthermore, it inhibited the protein and gene expression levels of inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α, interleukin-1β and interleukin-6. The responsible signaling mechanisms leading to these inhibitions were identified as SE1 mediated blocking of phosphorylation of mitogen activate protein kinase (MAPK) molecules; C-jun-N-terminal kinase (JNK), p38 and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits. These results suggest that SE1 has the potential to be further developed as therapeutic against neuro-inflammation.</P> <P><B>Graphical abstract</B></P><P><ce:figure id='f0045'></ce:figure></P>

정신분열병 환자에서 가족력, 산과적 합병증 및 신체미세기형의 관련성에 관한 연구

안용민,김용식,정희연,신지용,윤세창,배안,이중서,주은정,이창인 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 저자들은 태생기 동안에 받는 유전외적 요인, 즉 환경적 요인이 산발성 정신분열병 환자들의 발병에 크게 관여할 것이라고 가정하였다. 이를 검증하기 위하여 형제 중 1인 이상이 발병하여 가족력을 분명히 알 수 있는 정신분열병 환자군(이하 형제 환자군)과 가족력이 없는 산발성 정신분열병 환자군(이하 산발성 환자군) 및 정상대조군을 대상으로 산과적 합병증, 신체미세기형 및 정신분열병의 임상 양상을 비교하였다. 방 법 : 연구 대상은 형제 환자군 43명(남 22명, 여 21명), 산발성 환자군 43명(남 23명, 여 20명), 정상대조군 43명(남 20명, 여 23명)이었다. 산과적 합병증은 Lewis 척도를 이용하여 평가하였고 신체미세기형은 Waldrop 척도를 이용하여 측정하였다. 임상 양상으로서 발병 연령, 병전 기능 수준, 정신병리, 약물에 대한 반응, 회복시의 전반적 기능 수준, 지연성 운동장애의 유무를 평가하였다. 결 과 : 정상대조군과 정신분열병 환자군 전체를 비교하였을 때 산과적 합병증과 신체미세기형의 총점과 각 소항목의 점수에 차이가 없었다. 산발성 환자군과 형제 환자군을 비교하였을 때 산과적 합병증의 전체 점수에서는 유의한 차이가 없었으나, 출생 당시에 태아가 받은 스트레스 항목의 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형에서는 전체 점수 및 입의 미세기형 점수가 산발성 환자군에서 유의하게 높았다. 신체미세기형의 전체 점수가 4점 이상인 환자수도 산발성 환자군에서 높은 경향성을 보였다. 산과적 합병증과 신체미세기형 사이의 상호 연관성은 찾을 수 없었다. 정신분열병의 임상 양상 중에서는 Krawiecka 척도의 총점 및 양성 증상 점수와 회복시의 전반적 기능 수준만이 형제 환자군에 비해 산발성 환자군에서 유의하게 높았다. 성별에 따라서는 형제 환자군에서 남자 환자의 산과적 합병증이 유의하게 높았다. 결 론 : 본 연구를 통해 산과적 합병증 및 신체미세기형 연구가 정신분열병의 원인을 규명하기 위한 유용한 방법임이 시사되었지만, 가족력, 산과적 합병증 및 신체미세기형의 관련성에 대해서는 분명한 결론을 내리지 못하였다. The authors hypothesized that sporadic schizophrenic patients had more chances of receiving environmental insults during the fetal neural development compared with familial schizophrenics. We tested our hypothesis by comparing obstetric complications(OCs), minor physical anomalies(MPAs) and other clinical features, and examining the correlation between OCs and MPAs in schizophrenic patients who had one or more sibling with schizophrenia(sibling group) and sporadic schizophrenics(sporadic group) and normal controls. OCs were evaluated by the scale of Lewis, and MPAs were measured by the Waldrop scale. There were no significant difference in OCs and MPAs between schizophrenic and control groups. Sporadic group had significantly higher fetal distress, total Waldrop score and Waldrop score for mouth than sibling group. And there was a tendency that the number of subjects having the Waldrop score over 4 points was greater in the sporadic group. No significant correlation was observed between CCs and MPAs. The scores of initial psychopathology and post-treatment functioning were much higher in the sporadic group, but the other clinical feature showed no difference. Although male patients had more OCs than female patients in sibling group, no sex difference were observed as a whole. Our results suggest that, if the methodological weakness were complemented, OCs and MPAs would be useful tools in the search for the cause of schizophrenia.

「龍飛御天歌」에 나타난 表記法 硏究

趙世用 건국대학교 중원인문연구소 1998 중원인문논총 Vol.17 No.-

This thesis is a study of orthography in 「Yongbiochonga」that was published in 1445 A.D. A conclusion of this thesis is as follows. 1) In the study of Korean linguistics history, a study of orthography in 「Yongbiochonga」 is very important. Because 「Yongbiochonga」 shows us that the King Se-Jong was morphologist. 2) Generally, in 「Yongbiochonga」, the law of 'the final spelling can be used in the position of the first(終聲復用初聲)' is completely keeped. But we can see some 'eight finalsounds law(八終聲法)' (Eight final sounds are /ㄱ, ㄴ, ㄷ, ㄹ, ㅁ, ㅂ, ㅅ, ㅇ/.), that is phonemic spelling style, for example 「맛디, 몃, 닛디」 is found, that's original final spelling is /ㅈ/. 3) Above fact shows us that the King Se-Jong did not completely investigate 「Yongbiochonga」 after the accomplishment of the volume, so phonemic spelling style of Chiphynjon(集賢殿) scholars appears in the volume. 4) Adnominal interval sound 'ㄱ, ㄷ, ㅂ, ㅅ,ㅿ,ㆆ ' were used variously and precisely, that deserves adnominal-case in the morphological aspect. 5) in 「Yongbiochonga」, 'connective spelling law(連綴)' was completely keeped. It shows that Chiphyonjon scholars' phonemic view of grammar came into effect. 6) In my opinion, the Chinese-sound in 「Yongbiochonga」 is mixed "inherited Korean Chinese-sound', '「Dongkukchongun(東國正韻)' Chinese sound」' and 'Mandarin's sound'.

논문 : 프랑스 방리유 문제와 이민자 통합정책 -차별과 배제의 공간정치-

류지석 ( Ji Seok Ryu ),장세용 ( Jang Se Yong ) 대구사학회 2013 대구사학 Vol.111 No.-

Banlieue et la politique d`integration des immigres en France - politique spatiale de discrimination et d`exclusion - Ryu, Ji-seok · Jang, Se-yong [Abstract] Notre travail a pour but d`etudier, de fa?on critique, la caracteristique spatiale de la banlieue fran?aise avec le point de vue historique et philosophique. Les emeutes dans les banlieues en 2005 ont souleve les questions sur la politique de ville en general et ont remis en question la nature de cet espace d`inclusion et d`exclusion en raison de son effet profond sur le probleme de l`immigration et la politique multiculturelle. Avec cette perspective de base, nous explorons egalement l`arriere-plan philosophique et ideologique de la formation du mecanisme de discrimination et d`inegalite pour les immigres. Banlieue est la zone satellite autour de la ville metropolitaine, construite au cours de la modernisation et de l`urbanisation, en particulier dans le but d`ameliorer l`environnement residentiel des travailleurs et de la classe humble. Il est devenu un espace problematique des conflits sociaux complexes lies non seulement a la crise economique, l`augmentation du ch?mage, et l`afflux des travaileurs etrangers principalement des pays du Maghreb mais aussi a la montee du racisme et du xenophobie aggravee par la provocation de l`extr?me droite et la politique endurcie de la droite. Le soulevement des banlieues de 2005, commence dans les banlieues de Paris a choque la France et le monde. La discrimination et le racisme contre les immigres originaires du Maghreb produisent des conflits socio-culturelles graves en France, ou les valeurs republicaines d`egalite considerees comme primordiales et la politique d`integration a ete mis en place depuis longtemps. Maintenant France se situe au carrefour des politiques d`integration republicaines fondees sur le principe de laicite et du besoin du multiculturalisme plus souple. Les philosophes et les intellectuels tels que Ranciere, Balibar, Badiou, Rosenvallon ou Noiriel remarquent cette situation contradictoire et critiquent violemment l`ideologie de la securite et sa recuperation politique par la droite. Notre etude sur la banlieue en France donnera l`occasion de reflexions sur le multiculturalisme et l`elaboration des politiques relatives a la coexistence avec les immigres dans la societe mondialisee.

[P8-292] Anti-inflammatory effects and mechanism of Hippocampus Kuda Bleeler derived compounds SE-1 and SE-2 on activated murine macrophages and microglial cells

S.W.A Himaya,BoMi Ryu,Zhong-Ji Qian,Li Yong,Se-Kwon Kim 한국식품영양과학회 2010 한국식품영양과학회 학술대회발표집 Vol.2010 No.10

부비동 환기의 연구를 위한 인체 비부비동 모형

정용수,김상렬,김동환,정동근,최순섭,정인호,서세훈 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.9

65세 이상의 노령층에서 고지혈증의 위험요인

김용배,장원기,황보영,김화성,안규동,이병국,이용진,김세훈,김승수,김승훈,김영록,김웅빈,이성수 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

..

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

韓國 男子 排球競技의 勝敗要因을 EFF方式에 의한 分析

文湧冠,崔世鎭 仁荷大學校 스포츠科學硏究所 1992 論文集 Vol.4 No.-

This study purports to analyze the factors of winning and losing volleyball by using efficiency factor method. Eight sample teams were selected for this study, all national teams from right countries such as U.S.S.R, U.S.A, BULGARIA, HOLLAND, FRANCE, JAPAN, CANADA, and they were compared with Korean team. The data were collected from the games of the 3rd F.I.V.B international cup held in Seoul 1987. The results were as follows; 1. At the blocking eff., Korea was significantly poor and was the lowest among 8 teams. 2. At the court defence eff., Korea was better than three other national teams from Holland, Bulgaria and France. However, there was no significant mean difference between Korea and other national teams. 3. At the serve receive eff., Korea was better than two other national teams from Bulgaria and Canada. However, there was no significant mean difference between Korea and other national terms. 4. At the setting eff., Korea was better than three other national teams from Holland, Bulgaria and Canada. However, there was no significant mean difference between Korea and other national teams. 5. At the points ratio eff., Korea was better than two other national teams from U.S.S.R and U.S.A. However, there was no significant mean difference between Korea and other national teams. 6. At the attack eff., serve eff. and side out eff., there was no significant mean difference between Korea and other national teams.