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김동익,허세호,이병붕,김은숙,문지영,황지혜 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1
Purpose: Given the increased frequency of operative therapy and radiation therapy on breast cancers and uterine cancers, there is very little information on lymphedema associated with these treatments in Korea. Thus, the authors conducted this study to describe and analyze the data which they had obtained from the patients. Method: A retrospective study was undertaken on 840 patients who registered to the Lymphedema Clinic of Samsung Seoul Hospital throughout the period of February 1995 to August 2001. Result: Out of 840 patients, 205 patients (24%) were confirmed as having primary lymphedema, while 635 patients (76%) had secondary lymphedema. The ratio of male to female for primary lymphedema was 1 :1.8(Male : Female), while secondary lymphedema demonstrated to be 1:21 (Male : Female), demonstrating a female preponderance. Secondary lymphedema mostly developed after undergoing treatment for uterine cancer (341 patients, 53.7%) and breast cancer (226 patients, 35.5%) The lesions of occurrence for both primary and secondary lymphedema were mainly in the lower extremities than the upper extremities. In regards to the degree of clinical edema, a large number of the patients, that is 633 patients (76%) had progressed to Stage Ⅱ~Ⅲ. Among the patients who developed edema after undergoing treatment for cancers, only 43 patients (7%) were provided information on the possibility of developing lymphedema, while the majority of the patients had no knowledge about this possibility. When the patients' subjective experiences were investigated on the degree of the edema, there was no significant increase in pain despite an increase in the degree of the edema (P<0.05), nevertheless, a significant increase was found in cosmetic problems (P>0.05). Conclusion: As a general rule, complete recovery from chronic lymphedema is not expected. However, early detection of lymphedema and timely appropriate treatment as well as aggressive patient education on lymphedema and its related complications can prevent its progression.
안 태 경,오 세 붕 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.1
The behavior of axially loaded pile was analyzed by using FLAC program. Load-displacement curves and distributions along the depth were evaluated appropriately for the measured. The analysis could capture the nonlinearity of load-displacement curve even for unloading and reloading cases, since the unloaded stress paths of fill layer elements occurred on the failure envelop. Futhermore, the measured load transfer curves were compared with the API recommendations and with the calculations from results of the FLAC analysis in order to interpret the transfer behavior between the soil and the pile under axial loadings. It was concluded that the axial behavior of open ended piles at Pusan could be evaluated by stress analysis.
김동익,이윤신,김덕경,허세호,이병붕,김지은 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1
Purpose: Small calibered prosthetic vascular grafts are prone to low patency rates after bypass surgery due to its high thrombogenicity and neointimal hyperplasia. Endothelial cells are known to inhibit thrombus formations, platelet aggregation and smooth muscle cells proliteration. The purpose of this study was to examine the development of autologous endothelial cell seeded prosthetic vascular graft. Method: The autologous endothelial cells (ECs) were harvested from canine external jugular veins. Approximately 5*10^4 ECs were obtained through passage 5 to 6 under the static condition. The cultured ECs were seeded into the polytetrafluoroethylenc (PTFE) graft and cultured for 3 days before implanting into the canine carotid artery.The PTFE graft was harvested at 6 weeks after implantation. Result: The primary cultured ECs were treated with Factor VⅢ/WF, CD3]/PECAM-1 antibodyand confirmed with fluorescence micrograph, The gratf patency rates were 2/6 (33%) in the control gratf and 5/6 (83%) in the ECs seeded graft at 6 weeks after implantation. the entire luminal surface of the EC seeded graft was covered with ECs. Only the vicinity of the anastomosis site was covered with ECs in the control graft. Conclusion: This is a pilot study for the development of autologous endothelial cell seeded prosthetic vascular graft. The results of our study demonstrate that the endothelialized PTFE are better than ninendothelialized PTFE.
김동익,김덕경,허세호,이병붕,김용신,김은숙,문지영,도영수,신성욱,김동수,김만태,진재욱,김용신 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1
As medical technology progresses rapidly, there is a rise in the average age along with the Korean dietary lifestyle becoming more westernized, which leads to an increase in the number of vascular disease patients in Korea. Thus, we need to manage the medical information of a disease systematically in order to diagnose and treat constructively. However, since there has been no standardized method of man agement to date, a great deal of information could not be properly utilized nor studied. Therefore, the departments of Cardiology, Radiology and Neurology of Samsung Seoul Hospital recently got together to develop an information management system called the Vascular Data System. This program was developed to be run on win98 O/S, upper Pentium Ⅲ, and upper 128 MB Memory, and its source code is Dephi 4.0. It was configured for the user to set the configurations as well as do a variety of search and analysis. If this program were to be updated continuously, it may be used extensively as well as in various parts of clinical research activities.
유소영,박찬영,정석,김동익,이병붕,허세호,한동철,장준근 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.2
Purpose: The spreading, orientation, and chemotaxis the gradient of a chemoattractant of smooth muscle cells (SMCs) were studied on the micro-grooved substrata by the light, fluorescence and scanning electron microscopy. Method: Vertical-walled grooves were produced in silicon wafers by the micromachining technique. All grooves were 4~20㎛ deep and 10~80㎛ wide, SMCs were cultured on each microgroove and examined under stereo-microscope. Result: Cell clusters were markedly oriented by all the grooved substrata examined. Tim-lapse images acquired from CCD (Charge Coupled Device) showed that the grooves directed the migration of SMCs. There was no prominent difference in the migration speed of SMCs according to the grooves. All the cytoskeletal fibers were reoragnized in the same direction with grooves. Especially the alignments of microtubule and intermediate filaments were distinguished in the SMCs on the micro grooves. Conclusion: These results could be applied to the analysis of vascular restenosis and the development of artificial blood vessels.
Large Deformation Formulation of a Hypoelasto-plastic Constitutive Model for Soils
Oh, Se-Boong,Lee, Seung-Hyun,Kwon, Oh-Kyun 한국지반공학회 2003 지반 : 한국지반공학회지 Vol.19 No.4
A constitutive equation was implemented in order to model the behavior in overall ranges from small to large strains, which is based on anisotropic hardening rule and total stress concept. The constitutive model was implemented in ABAQUS code in which large deformation analysis can be performed accurately and efficiently. The formulation includes (1) finite strain plasticity on the basis of Jaumann stress rate, (2) implicit stress integration and (3) consistent tangent moduli. A large deformation analysis was performed with the constitutive model using ABAQUS program. In the analysis of an actual embankment, it was found that the proposed model was formulated accurately and efficiently. 미소변형에서 대변형에 이르는 전변형도 영역의 거동을 모델하기 위하여 비등방 경화규칙과 전응력개념에 의거한 구성관계를 이용하였다. 이러한 구성관계는 ABAQUS 코드에 구현되었으며 대변형해석시 정확도와 수렴속도를 확보하도록 하였다. 이 정식화는 Jaumann 응력속도에 의거한 유한 변형도 소성론, 내재적 응력적분, 일관된 접선계수를 포함한다. ABAQUS를 이용한 대변형해석을 통하여 알고리즘의 정확도 및 수렴도 해석을 할 수 있었다.