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Sarma Nittala S.,Baliarsingh Sanjiba Kumar,Lotliker Aneesh Anandrao,Pandi Sudarsana Rao,Samanta Alakes,Srichandan Suchismita 한국해양과학기술원 2023 Ocean science journal Vol.58 No.1
Green Noctiluca scintillans (NSG) is a mixotrophic dinofagellate that frequently forms intense blooms in the north Indian Ocean, especially in the northeastern Arabian Sea during winter. This study investigates the conducive conditions and drivers associated with NSG blooms and proposes signifcant models for estimating NSG based on in situ (time-series) study during the bloom cycles. Two critical factors with regard to the blooms, i.e., phytoplankton abundance and sea surface temperature (SST), were examined. The frst phase of heterotrophy dominance was when moderate blooms up to~ 2.26× 104 cells 1–1 occurred and, when NSG cells per unit chlorophyll-a (chl-a) increased, SST decreased up to~24.5 ºC. The bloom intensity was proportional to the feed (diatoms/phytoplankton) availability and the degree of cooling (by the winter convection, i.e., nutrient enrichment). In the second phase of autotrophy dominance, intense blooms up to 1.9× 105 cells l −1 occurred and NSG cells per unit chl-a fell, when the SST increased. During this period, bloom intensity was proportional to the degree of warming, i.e., nutrient and physiological stress. Phytoplankton are related to NSG by a single linear model through this SST cycle and is likely the NSG’s essential biotic precursor. Attention is then focused on developing a remote sensing refectance (Rrs) model for efcient synoptic monitoring of NSG using ocean color satellites. The Rrs band product ratio, a new metric, in combination with SST, notably modelled NSG abundance, which may be of potential routine application.
Sarma, Usha,Mahanta, Jagadish,Borkakoty, Biswajyoti,Sarmah, Bidula Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Infection of the uterine cervix by human papilloma viruses (HPV) may be associated with cervical pre-cancer and invasive cervical carcinoma if left untreated. With advance in molecular techniques, it has become easier to detect the resence of HPV DNA long before the appearance of any lesion. This study concerned cervical scrape samples of 310 married non-pregnant women attending a gynecology outpatient department for both Pap and PCR testing to detect HPV DNA. Nested PCR using primers for L1 consensus gene with My9/My11 and GP6+/GP5+followed by multiplex PCR were carried out to detect HPV 16 and HPV18. Result: HPV prevalence was 11.9% out of which 3.67% cases of negative for intra-epithelial lesion or malignancy (NILM) and in 71.1% (27/38) of atypical cervical smears were HPV positive. There was increasing trend of high-risk-HPV positivity (HR HPV 16 and 18), from 20% in benign cytology (NILM) to 42.9 % in LSIL, 71.41% in HSIL and 100% in SCC. There was highly significant association of HPV infection with cervical lesion ($x^2=144.0$, p<0.01) and also with type specific HPV prevalence ($x^2=7.761^*$, p<0.05).
ASYMPTOTIC BEHAVIOR OF SOLUTIONS OF MATRIX LYAPUNOV INTEGRO DIFFERENTIAL EQUATIONS
Sarma, Goteti V.R.L.,Hugo, Alfred The Korean Society for Computational and Applied M 2014 Journal of applied mathematics & informatics Vol.32 No.5
The asymptotic behavior of solutions of Lyapunov type matrix Volterra integro differential equation, in which the coefficient matrices are not stable, is studied by the method of reduction.
Sarma, Sailendra Nath,Kim, Youn-Jung,Jeon, Hee-Kyung,Ryu, Jae-Chun The Korean Society of Toxicogenomics and Toxicopro 2006 Molecular & cellular toxicology Vol.2 No.4
Volatile organic compounds (VOCs) are a major component of urban air pollution. It is documented that low exposure levels of VOCs induce alterations in immune reactivity resulting in a subsequent higher risk for the development of allergic reactivity and asthma. Despite these facts, there are few reports on the affected primary target and the underlying effective causal mechanisms. So in this study, to better understand the risk of BTX (benzene, toluene and o-xylene) which are the major VOCs and to identify novel biomarkers on immune response to these VOCs exposure in human T lymphocytes, we performed the toxicogenomic study by analyzing of gene expression profiles using 35 k human oligo-microarray. BTX generated specific gene expression patterns in Jurkat cell line. By clustering analysis, we identified some genes as potential markers on immuno-modulating effects of BTX. Four genes of these, HLA-DOA, ITGB2, HMGA2 and 5TAT4 were the most significantly affected by BTX exposure. Thus, this study suggests that these differentially expressed immune genes may play an important role in the pathogenesis on BTX exposure and have significant potential as novel biomarkers of exposure, susceptibility and response to BTC.
Sarma, Sailendra Nath,Kim, Youn-Jung,Ryu, Jae-Chun The Korean Society of Toxicogenomics and Toxicopro 2008 Molecular & cellular toxicology Vol.4 No.4
Benzene and ethylbenzene (BE), the volatile organic compounds (VOCs) are common constituents of cleaning and degreasing agents, paints, pesticides, personal care products, gasoline and solvents. VOCs are evaporated at room temperature and most of them exhibit acute and chronic toxicity to human. Chronic exposure of benzene is responsible for myeloid leukemia and also ethylbenzene is also recognized as a possible carcinogen. To evaluate the BE effect on human, whole human genome 35 K oligonucleotide microarray were screened for the identification of the differential expression profiling. We identified 280 up-regulated and 201 down-regulated genes changed by more than 1.5 fold by BE exposure. Functional analysis was carried out by using DAVID bioinformatics software. Clustering of these differentially expressed genes were associated with immune response, cytokine-cytokine receptor interaction, toll-like signaling pathway, small cell lung cancer, immune response, apoptosis, p53 signaling pathway and MAPKKK cascade possibly constituting alternative or subordinate pathways of hematotoxicity and immune toxicity. Gene ontology analysis methods including biological process, cellular components, molecular function and KEGG pathway thus provide a fundamental basis of the molecular pathways through BEs exposure in human lymphoma cells. This may provides a valuable information to do further analysis to explore the mechanism of BE induced hematotoxicity.
Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals
Bipul Sarma,Allan S. Myerson,Jie Chen,Huai-Ying Hsi 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.2
Control and selection of the properties of active pharmaceutical ingredients is a crucial part of the drug development process. One major part of this process is the selection of an appropriate solid form. This review will discuss three major types of crystalline solids, polymorphs, salts and cocrystals and processes used to develop and find these forms.
Random Synchronous Malignancy in Male Breast: A Case Report
Manjit Sarma,Chaitanya Borde,Padma Subramanyam,Palaniswamy Shanmuga Sundaram 한국유방암학회 2013 Journal of breast cancer Vol.16 No.4
We report here a case of a random synchronous male breastmalignancy in a patient with a known base of tongue malignancythat was incidentally detected on a whole body 18-fluorine deoxyglucosepositron emission tomography and computed tomography(18F-FDG PET/CT). Patient was referred to us for PET/CTstaging and radiotherapy planning for a poorly differentiatedsquamous cell carcinoma of base of tongue. Histopathologically,the incidentally detected breast lesion was proven to be an invasiveductal carcinoma. 18F-FDG PET/CT being a whole body imagingmodality is known to detect a considerable number of synchronousprimaries. Synchronous malignancies in the head andneck area and the upper aerodigestive tract are well established. However, synchronous malignancy in male breast is reportedlyuncommon. Our case is unique for the fact that a random synchronousdual malignancy of base of tongue and breast in amale patient was detected during a whole body 18F-FDG PET/CTimaging.
Upasana Sarma,Viney Kumar Govila,Akanksha Yadav 한국식품연구원 2020 Journal of Ethnic Foods Vol.7 No.-
Assam lies nestled in the far north-east corner of the Indian subcontinent. A country blessed with ample natural resources, the state of Assam also has a plethora of options in terms of choosing their core food sources. Banana or kol, as named in Assamese, has hundreds of varieties available in many parts of the world. They grow particularly well in tropical countries. It is found abundantly in the state of Assam and people have been making judicious use of the fruit and its plant parts in their cuisine since time immemorial. But nevertheless, a detailed review on its uses and importance and rising popularity in ethnic delicacies has not yet been documented well. This paper attempts to bring together the popular banana-based recipes of Assam state and its use in everyday religious ceremonies by the people of this community. It has age-old recipes used commonly in Assamese households and descriptive analysis of their microbial and biochemical diversity. It aims to bring to the fore the rising popularity of these ethnic dishes amongst modern population and is an attempt to revive these dishes and bring them into the mainstream Indian ethnic cuisine. As more and more people become aware of ethnic cuisine, it increases a global connectivity based on exchange of such information from lesser-known sources. The importance and significance of documenting these lesser-known recipes of Indian Assamese cuisine is an attempt to keep it relevant and take it to a broader audience who are appreciative of such oriental dishes. It is also high time a policy framework is worked upon by respective government of state and the centre for the true recognition and sustainability of such ethnic cuisine.