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Numerical study of wet-steam flow in Moore nozzles
Santhosh Senguttuvan,이장창 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.10
Wet-steam flow is a two-phase mixture of vapor and tiny liquid droplets that occurs in the final stages of low pressure (LP) steam turbine process. These liquid droplets are formed by the non-equilibrium condensation of steam. This condensation of steam releases a significant amount of latent heat to the flow. As a result, the flow velocity is reduced and it affects the efficiency of the steam turbine. Since it is extremely difficult to perform numerical studies with the non-equilibrium condensation for turbines, they are usually done in convergent-divergent nozzles. In this paper, the effect of area ratio of the well-known Moore nozzles on the non-equilibrium condensation of steam is investigated numerically. The mathematical model for the non-equilibrium condensation is based on the classical homogeneous nucleation theory corrected with non-isothermal effects and Hill’s droplet growth law. The numerical results are successfully validated with the experimental data for Moore nozzle B. The numerical results represent that with increasing area ratio, the intensity of condensation decreases and the residue amount of liquid mass fraction in the flow field increases. Therefore, while designing the area ratio of the nozzle, the influences of both the condensation intensity and liquid mass fraction should be considered.
Santhosh, P.,Gopalan, A.,Vasudevan, T.,Lee, Kwang-Pill Wiley Subscription Services, Inc., A Wiley Company 2006 Journal of applied polymer science Vol.101 No.1
<P>Composites of thermoplastic polyurethane (TPU) with poly(diphenylamine) (PDPA) were prepared by entrapping diphenylamine (DPA) molecules into the matrix of TPU and polymerizing DPA within the TPU matrix. Swelling rate of the parent TPU and the composites in 1M LiClO<SUB>4</SUB> in propylene carbonate solution were compared to understand the influence of the presence of PDPA in the composite in altering the morphology, conductivity, and electrolyte behavior. The nitrogen atoms in the PDPA interact and are likely to form hydrogen bonding with the carbonyl and ether groups in TPU. As a result, different morphology, thermal, and impedance behavior were witnessed for the composites in comparison to TPU. Results from differential scanning calorimetry, scanning electron microscopy (SEM), thermogravimetric analysis, and ac impedance measurements were obtained as supporting evidences. An increase in glass transition temperature for the composite in comparison to TPU infers the increase in phase mixing of soft and hard segment of TPU. The SEM micrograph shows the presence of fibrillar morphology of PDPA molecules in the composite. The ionic conductivity of the swelled composite was 1-fold higher than that of pure TPU. A schematic representation showing the interaction of PDPA molecules with TPU is presented. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 101: 611–617, 2006</P>
Santhosh Kumar Veeramalla,V. K. Hanumantha Rao Talari 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.2
Tracking and detection of neural activity has numerous applications in the medical research fi eld. By considering neuralsources, it can be monitored by electroencephalography (EEG). In this paper, we focus primarily on developing advancedsignal processing methods for locating neural sources. Due to its high performance in state estimation and tracking, particlefi lter was used to locate neural sources. However, particle degeneracy limits the performance of particle fi lters in the mostutmost situations. A few resampling methods were subsequently proposed to ease this issue. These resampling methods,however, take on heavy computational costs. In this article, we aim to investigate the Partial Stratifi ed Resampling algorithmwhich is time-effi cient that can be used to locate neural sources and compare them to conventional resampling algorithms. This work is aimed at refl ecting on the capabilities of various resampling algorithms and estimating the performance oflocating neural sources. Simulated data and real EEG data are used to conduct evaluation and comparison experiments.
Protein Phosphatase 1D (PPM1D) Structure Prediction Using Homology Modeling
Santhosh Kumar Nagarajan, Thirumurthy Madhavan 조선대학교 기초과학연구원 2016 조선자연과학논문집 Vol.9 No.1
Protein phosphatase manganese dependent 1D (PPM1D) is one of the Ser/Thr protein phosphatases belongs to the PP2C family. They play an important role in cancer tumorigenesis of various tumors including neuroblastoma, pancreatic adenocarcinoma, medulloblastoma, breast cancer, prostate cancer and ovarian cancer. Even though PPM1D is involved in the pathophysiology of various tumors, the three dimensional protein structure is still unknown. Hence in the present study, homology modelling of PPM1D was performed. 20 different models were modelled using single- and multipletemplate based homology modelling and validated using different techniques. Best models were selected based on the validation. Three models were selected and found to have similar structures. The predicted models may be useful as a tool in studying the pathophysiological role of PPM1D.
Investigation of N-Arylsulfonylimidazole as Novel Scaffold for Anticancer Agents
Santhosh Subramanian,Hyun-Sun Yang,Manoj Manickam,윤지은,정상헌 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.5
To explore the possibility of isosteric replacement of imidazolidinone moiety of (S)-1-(1-(4-aminobenzoyl)indolin-5-ylsulfonyl)-4-phenylimidazolidin-2-one (1) for the anticancer activity, novel 1-(1-acyl substituted indolin-5-sulfonyl)-4-phenyl-1H-imidazoles 2 were prepared with varying the N-acyl group on the indoline ring and evaluated for their in vitro anticancer activity against six human cancer cell lines (renal ACHN, colon HCT-15, breast MDA-MB-231, lung NCI-H23, stomach NUGC-3, and prostrate PC-3). Among the analogs prepared, imidazoles with hydrophobic acyl substituents on indoline like cyclohexanecarbonyl (2e, mean 50% growth inhibition [GI50] = 2.29 μM) or benzoyl with electron-donating groups like 4-methoxybenzoyl (2g, mean GI50 = 4.11 μM) and 4-aminobenzoyl (2a, mean GI50 = 4.45 μM) exhibited relatively good cytotoxicity. Although imidazole moiety of arylsulfonylphenylimidazole 2 contains only hydrogen bonding acceptor property without a stereogenic center unlike imidazolidinone analogs, the high level of the activity of 2 proved that the imidazole motif is obviously good isostere of imidazolidinone moiety of arylsulfonylphenylimidazolidinone 1 for the anticancer activity.