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( Keji Quan ),( Zhuang Zhu ),( Sanjie Cao ),( Fei Zhang ),( Chang Miao ),( Xintian Wen ),( Xiaobo Huang ),( Yiping Wen ),( Rui Wu ),( Qigui Yan ),( Yong Huang ),( Xiaoping Ma ),( Xinfeng Han ),( Qin Z 한국미생물 · 생명공학회 2018 Journal of microbiology and biotechnology Vol.28 No.12
In our previous studies, we have identified several in vivo-induced antigens and evaluated their potential as subunit vaccine candidates in a murine model, in which the recombinant protein GalT showed the most potent immunogenicity and immunoprotective efficacy against Actinobacillus pleuropneumoniae. To exploit a more efficient way of delivering GalT proteins, in this study, we employed the widely studied E. coli outer membrane vesicles (OMVs) as a platform to deliver GalT protein and performed the vaccine trial using the recombinant GalTOMVs in the murine model. Results revealed that GalT-OMVs could elicit a highly-specific, IgG antibody titer that was comparable with the adjuvant GalT group. Significantly higher lymphocyte proliferation and cytokines secretion levels were observed in the GalT-OMVs group. 87.5% and 50% of mice were protected from a lethal dose challenge using A. pleuropneumoniae in active or passive immunization, respectively. Histopathologic and immunohistochemical analyses showed remarkably reduced pathological changes and infiltration of neutrophils in the lungs of mice immunized with GalT-OMVs after the challenge. Taken together, these findings confirm that OMVs can be used as a platform to deliver GalT protein and enhance its immunogenicity to induce both humoral and cellular immune responses in mice.
Chunxia Chai,Qiao Wang,Sanjie Cao,Qin Zhao,Yiping Wen,Xiaobo Huang,Xintian Wen,Qiguai Yan,Xiaoping Ma,Rui Wu 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.1
Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic flavivirus causing viral encephalitis in humans and reproductive disorder in swine. JEV is prevalent throughout China in human; however, spatiotemporal analysis of JEV in Chinese swine herds has not been reported previously. Herein, we present serological and molecular epidemiological results and estimates of prevalence of JEV infections among swine herds in various regions of China. The results suggest that JEV infections are widespread and genotype I and III strains co-exist in the same regions. Therefore, there is an urgent need to monitor JEV infection status among swine herds in China.
Democracy and its Impact on Economic Development in Sub-Saharan Africa
산지 월터스 무도,이창식,Mudoh, Sanji Walters,Lee, Chang Seek The Society of Digital Policy and Management 2014 디지털융복합연구 Vol.12 No.8
이 연구는 아프리카 사하라 이남의 민주정치와 현재 경제발전의 관계를 규명하는 것으로 목적으로 하였다. 특히 사하라 이남 지역에서 민주화 속도가 늦은 이유와 현재까지 민주정치에 따른 문제의 원인을 종합적으로 분석하였다. 그리고 민주정치 운동에도 불구하고 경제성장율이 평균 이하인 이유와 일부 국가들이 빠른 경제성장 궤도에 오른 이유도 초점을 두었다. 더 나아가서 다른 선진국들의 민주화과정에 적합한 요인들을 가지지 못하였기 때문에 이 지역의 민주정치가 독자적인 노선을 추구해야 하는 이유에도 초점을 두었다. 이러한 분석을 위하여 기존의 논문 및 보고서를 중심으로 내용분석하였다. 끝으로 경제성장에서 민주주의 역할을 제언하였다. This study aimed to clarify the relationship which exists between democracy and economic development within Sub-Saharan Africa. It strived to bring out a comprehensive analysis of the reasons why the pace of democratization is slow within this region and why until present date, there are just patches of real democracies there. The work also focuses on the reasons why despite democratic movements, economic growth rates have remained lagging behind average until of recent that, and some few countries have emerged to join the list of fastest growing economies in the world. The study further highlights the unique path of Sub-Saharan Africa democratization process should follow since it does not possess the various factors that favored the democratization processes of most developed countries. In order to obtain the objectives, previous studies and statistical data published by official institutes were analysed by using contents analysis methods. Lastly, it proceeds to explain the important role that democracy plays in inclusive economic growth.