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Sanjaya Kumar Pradhan,Min-Suk Oh 한국마린엔지니어링학회 2024 한국마린엔지니어링학회지 Vol.48 No.1
In this study, we investigated the microstructures and mechanical properties of annealed cold-rolled low-carbon steels. The specimens were subjected to different annealing temperatures and durations in an electric furnace to investigate their recrystallization phenomena. Recrystallization kinetics were analyzed through microstructural evolution by evaluating various mechanical properties. The results showed that the samples annealed at 700 °C were fully recrystallized with equiaxed grains, whereas equiaxed recrystallized grains began to grow in the samples annealed at 800 °C after 10 min of soaking. Electron backscatter diffraction grain orientation spread maps were used to quantify the percentage of recrystallized grains as a function of annealing temperature and soaking time. The samples annealed at 800 °C with 10 min of soaking exhibited good elongation (approximately 38%) and tensile strength (exceeding 270 MPa).
Immunostimulatory Properties of a Polysaccharide Isolated from Astraeus hygrometricus
Sanjaya K. Mallick,Swatilekha Maiti,Sujit K. Bhutia,Tapas K. Maiti 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3
Mushrooms have been used as food and for therapeutic purpose for decades, and various compounds derived from these have potential biological activities. Application of such agents of natural origin is vital with relevance to an increase in diseases involving immune dysfunction, cancer, and autoimmune conditions in recent years. These compounds belong mainly to polysaccharides, especially β-d-glucan, glycopeptide/protein complexes, proteoglycans, proteins, and triterpenoids. Among these compounds, polysaccharides and their peptide/protein derivates have extremely important roles in immunomodulating activities. The present study aims to explore the immunomodulatory properties of polysaccharide isolated from the mushroom Astraeus hygrometricus. The polysaccharide isolated by hot alkaline extraction and chromatography was designated as AE2 and studied for its immunostimulatory potential in vivo in a murine model. Macrophages from treated mice showed higher production of nitric oxide and interleukin-1 and also exhibited an increased phagocytic potential. It also enhanced natural killer cell activation and proliferation of splenocytes with an increase in the T-helper (Th) 1 cytokine level of splenocyte culture supernatant. The cytokine level in serum also indicated a Th1 skew. The observed activities were associated with no general toxicity to the organism. The findings will be helpful in considering A. hygrometricus as a potential source of an immunomodulator and in designing further studies to understand its mode of action on immune system.
Could Decimal-binary Vector be a Representative of DNA Sequence for Classification?
Sanjaya, Prima,Kang, Dae-Ki The Institute of Internet 2016 Journal of Advanced Smart Convergence Vol.5 No.3
In recent years, one of deep learning models called Deep Belief Network (DBN) which formed by stacking restricted Boltzman machine in a greedy fashion has beed widely used for classification and recognition. With an ability to extracting features of high-level abstraction and deal with higher dimensional data structure, this model has ouperformed outstanding result on image and speech recognition. In this research, we assess the applicability of deep learning in dna classification level. Since the training phase of DBN is costly expensive, specially if deals with DNA sequence with thousand of variables, we introduce a new encoding method, using decimal-binary vector to represent the sequence as input to the model, thereafter compare with one-hot-vector encoding in two datasets. We evaluated our proposed model with different contrastive algorithms which achieved significant improvement for the training speed with comparable classification result. This result has shown a potential of using decimal-binary vector on DBN for DNA sequence to solve other sequence problem in bioinformatics.
Calumenin Interacts with SERCA2 in Rat Cardiac Sarcoplasmic Reticulum
Sanjaya Kumar Sahoo,김도한 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.3
Calumenin, a multiple EF-hand Ca2+ binding protein is located in the SR of mammalian heart, but the functional role of the protein in the heart is unknown. In the present study, an adenovirus gene transfer system was employed for neonatal rat heart to examine the effects of calumenin over-expression (Calu-OE) on Ca2+ transients. Calu-OE (8 folds) did not alter the expression levels of DHPR, RyR2, NCX, SERCA2, CSQ and PLN. However, Calu-OE affected several parameters of Ca2+ transients. Among them, prolongation of time to 50% baseline (T50) was the most outstanding change in electrically-evoked Ca2+ transients. The higher T50 was due to an inhibition of SERCA2-mediated Ca2+ uptake into SR, as tested by oxalate-supported Ca2+ uptake. Furthermore, co-IP study showed a direct interaction between calumenin and SERCA2. Taken together, calumenin in the cardiac SR may play an important role in the regulation of Ca2+ uptake during the EC coupling process.
Sanjaya, I. Putu Gde,Mochtar, Chaidir Arief,Umbas, Rainy Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Background: To identify correlation and incidence of bone metastases in prostate cancer patient with low Gleason scores (GS) and prostate specific antigen (PSA) levels. Materials and Methods: This descriptive restrospective study covered patients with prostate cancer in Cipto Mangunkusumo Hospital in 2006-2011. Of a total of 478, those who had PSA values, histological examination, and bone scan were included, resulting in 358 eligible cases. PSA values were measured using the sandwich electrochemiluminescent immunoassay. Histological examination was graded according to Gleason's grading system and divided into 3 categories: well differentiated ($GS{\leq}6$), moderately differentiated (GS 7) and poorly differentiated (GS 8-10). Bone scans were performed using a radiopharmaceutical agent ($T_c$ 99m methylenen diphosphonate) with images captured by gamma camera. Results: The mean age was $67.5{\pm}7.8$, mean GS was $7.7{\pm}1.3$ and median PSA was 56.9 (range: 0.48-17000 ng/mL). There were 11 patients (3.0%) with positive bone scan with PSA<20 ng/mL and GS<8. Furthermore, there were 2 patients (0.6%) with $GS{\leq}6$ and PSA<10 ng/mL showing bone metastasis. Conclusions: In our study, there were still small percentage of patients with bone metastasis even when low values of PSA (PSA<10 ng/mL) and GS ($GS{\leq}6$) were applied.
Mini Review : Characterization of calumenin in mouse heart
( Sanjaya Kumar Sahoo ),( Do Han Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2010 BMB Reports Vol.43 No.3
Calumenin is a multiple EF-hand Ca2+-binding protein located in the endo/sarcoplasmic reticulum of mammalian hearts. Calumenin belongs to the CREC family of Ca2+-binding proteins having multiple EF-hands. Ca2+ homeostasis in the sarcoplasmic reticulum (SR) of mammalian hearts is maintained by RyR2, SERCA2 and other associated SR resident proteins. Evidence suggests that calumenin interacts with RyR2 and SERCA2, and therefore changes in the expression of calumenin could alter Ca2+ cycling in mouse heart. In this review, current knowledge of the biochemical and functional roles of calumenin in mouse heart is described. [BMB reports 2010; 43(3): 158-163]