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( Sangyoon Chung ),( Ja Seol Koo ),( Kwang Seok Kim ),( Chang Bum Bae ),( Ji Kyoung Lee ),( Joo Hee Park ),( Seung Young Kim ),( Jong Jin Hyun ),( Sung Woo Jung ),( Bora Keum ),( Beom Jae Lee ),( Yoon 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background/Aims: Immunomodulators such as azathioprine (AZA) and 6-mercaptopurine (6-MP) have been used for induction and maintenance treatment of Crohn`s disease (CD) and have effect on decrease of the steroid dose in active CD. The aims of study is to evaluate the predictive factors of response to AZA/6-MP in patients with moderate to severe CD. Methods: Among total 1,499 patients registered on Crohn`s cohort in Korea, 1,382 were enrolled in this study. The medical records including baseline characteristics, location and type of CD, complications, treatment agents, and surgical treatments were reviewed retrospectively. The patients with AZA/6-MP treatments were divided into two groups according to the additional treatments such as biologic agents and/or surgical treatment. Univariate and multivariate analyses were conducted to evaluate the predictive factors of clinical response to immunomodulators. Results: Among 1,382 patients with CD, AZA/6-MP treatment was used in 926 (67.0%). Between two groups according to AZA/6-MP treatment, the treatment group was younger than the other group (mean age, 25.8 vs 32.4, p<.001). AZA/6-MP treatment was used more frequently in patients with ileocolonic CD (62.5% vs 45.4%, p=.007) and with perianal disease (29.5% vs 21.0%, p<.001). In 926 patients with AZA/6-MP treatment, 376 (40.6%) were treated with biologic agents and/or surgical treatment. Between two groups according to the result of AZA/6-MP treatment, the disease locations were significantly different (p=.007), although the disease behaviors were not different. Multivariate analysis revealed that the disease location (p=.003) and age at diagnosis (p=.029) were significantly associated with AZA/6-MP treatment failure. Conclusions: AZA/6-MP treatment is effective on induction and maintenance treatment in CD. However, early biologic treatment should be considered in young age, colonic CD, since their AZA/6-MP treatment is less effective.
Analyzing the Interdependent Role of Network Centrality, Motivation and Ability in Knowledge Sharing
Sangyoon Jung(정상윤),Sangkyu Rho(노상규) 한국전자거래학회 2019 한국전자거래학회지 Vol.24 No.4
지식기반사회의 21세기에서 경쟁하는 기업들에게 조직구성원간의 지식공유는 기업의 핵심역량과 밀접한 연관을 갖는 핵심화두다. 특히 조직 내 네트워크의 위치 요인이 지식공유에 미치는 영향에 관해서는 학문적으로 논란이 계속되어 왔다. 이는 네트워크 중심성이 높을수록 정보에 대한 접근성이 높아지고 지식공유의 기회는 확대되는 반면에 약한 유대감으로 인해 실제 지식공유가 이루어지지 않는다는 논란이다. 본 연구에서는 지식 공유에 있어 세 가지 요소 - 네트워크 중심성, 자율적 동기, 그리고 지식공유능력 - 간의 상호작용이 지식공유에 미치는 영향을 보고자 한다. 그리고 더 나아가, 지식공유능력을 다양하고 깊이 있는 사전지식, SNS 활용능력, 그리고 자기효능감의 세 가지 측면으로 심도 있게 연구하였다. 그 결과, 부분적으로 네트워크 중심성과 자율적동기, 지식공유능력 간의 상호작용이 통계적으로 유의함을 밝혔다. 즉, 네트워크 중심성이 낮고, 높은 자율적동기, 그리고 사전지식이 많을 때 가장 높은 수준의 지식공유를 볼 수 있었다. 이를 통해, 동기와 능력이 강하면 네트워크의 주변적 위치라는 불리한 환경에서도 지식공유가 일어난다는 것을 알 수 있었다. 따라서 본 연구는 지식공유를 둘러싼 기존의 학문적 논쟁에 새로운 대안을 제시했다는 의의를 가진다. In the context of knowledge sharing, network position has been a controversial subject. A central position in the network provides access to non-redundant knowledge, leading to more opportunities of knowledge sharing. On the other hand, as “bridging” relationships, its characteristics as a “weak tie” suggest innate lack of trust and reciprocity which is considered an impediment to share knowledge. This paper attempts to enlighten the underlying dynamic by examining the interaction between network centrality, motivation and ability in knowledge sharing. Furthermore, this paper examines the concept of knowledge sharing ability in depth by operationalizing the construct into three aspects: extensive and diverse knowledge, social media utilization ability and self-efficacy. The results show a partially supported three-way interaction, where the highest level of knowledge provision is reported when the employee has low network centrality, high autonomous motivation and high knowledge sharing ability, i.e. extensive and diverse prior knowledge. Though all models indicate strong associations between network centrality and knowledge sharing, this suggests an even greater power of motivation and ability that gives the strength to overcome unfavorable environments of peripheral position. Therefore, this paper offers an alternative explanation to the existing debate whether network centrality positively or negatively influences knowledge sharing.
( Sangyoon Lee ),( Ji Young Ryu ),( Dae-hwan Kim ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.2
Background: Tuberculosis (TB) is the most important disease screened for upon patient history review during preimmigration medical examinations as performed in South Korea in prospective immigrants to certain Western countries. In 2007, the U.S. Centers for Disease Control and Prevention (CDC) changed the TB screening protocol from a smearbased test to the complete Culture and Directly Observed Therapy Tuberculosis Technical Instructions (CDOT TB TI) for reducing the incidence of TB in foreign-born immigrants. Methods: This study evaluated the effect of the revised (as compared with the old) protocol in South Korea. Results: Of the 40,558 visa applicants, 365 exhibited chest radiographic results suggestive of active or inactive TB, and 351 underwent sputum tests (acid-fast bacilli smear and Mycobacterium tuberculosis culture). To this end, using the CDOT TB TI, 36 subjects (88.8 per 105 of the population) were found to have TB, compared with only seven using the older U.S. CDC technical instruction (TI) (p<0.001). In addition, there were six drug-resistant cases which were identified (16.7 per 105 of the population), two of whom had multidrug-resistance (5.6 per 105 of the population). Conclusion: The culture-based 2007 TI identified a great deal of TB cases current to the individuals tested, as compared to older U.S. CDC TI.
Piezoelectrically Actuated Self-Contained Quadruped Robot
Sangyoon Lee(이상윤),Thanhtam Ho(호탐탄) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5
This paper presents the development of a mesoscale quadruped mobile robot that employs two pieces of piezocomposite actuators for the bounding locomotion. The overall design of the robot is inspired by legged insects, and in particular the leg structure of insects or animals is reflected on the robot in a simplified form, such that each leg of the robot has only one degree of freedom. The lack of degree of freedom is compensated for by a slope of the robot frame relative to the horizontal plane. For the implementation of self-contained mobile robot, a small power supply circuit is designed and fabricated. Experiments showed that the robot can locomote with the circuit on board, which can be a significant step toward the goal of building an autonomous legged robot actuated by piezocomposite actuators.
( Sangyoon Lee ),( Kwang Il Kim ),( In Guk Hwang ),( Seon Mi Yu ),( Sang Gi Min ),( Mi Jung Choi ) 한국산업식품공학회 2015 산업 식품공학 Vol.19 No.3
Blanching and freezing of beef are important techniques used in developing frozen home meal replacement (HMR) products. These pre-thermal treatments minimize the deterioration of beef during storage. Beefs are washed, defatted, sliced (5.0×0.5×0.5 cm, fiber direction), and blanched by immersion in hot water for 2 min. Thereafter, the blanched beefs are spin-dried and frozen by individual quick freezing (IQF) method. Finally, the frozen beefs are packed using two methods: vacuum packages and air-containing packages. Packed beefs are stored at -12℃, -18℃, and -24℃ for nine months. One in every three months, they are thawed in a microwave (400W). While thawing, vacuum- packed samples possess lower thawing loss than air-containing-packed ones. Compared to raw beef, blanched beef have a higher L* and lower a* value. However, less changes are observed after blanching the beefs as the enzymes get inactivated in the blanching process. Shear force of beef also increase through blanching. Moreover, vacuum-packed samples have maintained their hardness to a greater extent than the air-containing-packed samples. All the samples have met microbial safety standards. Thus, it is inferred that vacuum-packaging and -18℃ storage temperatures are the best condition for maintaining beef that is later developed into HMR product.
Sangyoon Lee,Shagor Sarkar,Youngki Park,Jaekyeong Yang,Giyoung Kweon 경상대학교 농업생명과학연구원 2019 농업생명과학연구 Vol.53 No.3
In this study, we tried to find out the most appropriate pre-processing method and to verify the feasibility of developing a low-price sensing system for predicting the hardy kiwis sugar content based on VNIRS and subsequent spectral analysis. A total of 495 hardy kiwi samples were collected from three farms in Muju, Jeollabukdo, South Korea. The samples were scanned with a spectrophotometer in the range of 730-2300 nm with 1 nm spectral sampling interval. The measured data were arbitrarily separated into calibration and validation data for sugar content prediction. Partial least squares (PLS) regression was performed using various combinations of pre-processing methods. When the latent variable (LV) was 8 with the pre-processing combination of standard normal variate (SNV) and orthogonal signal correction (OSC), the highest R2 values of calibration and validation were 0.78 and 0.84, respectively. The possibility of predicting the sugar content of hardy kiwi was also examined at spectral sampling intervals of 6 and 10 nm in the narrower spectral range from 730 nm to 1200 nm for a low-price optical sensing system. The prediction performance had promising results with R2 values of 0.84 and 0.80 for 6 and 10 nm, respectively. Future studies will aim to develop a low-price optical sensing system with a combination of optical components such as photodiodes, light-emitting diodes (LEDs) and/or lamps, and to locate a more reliable prediction model by including meteorological data, soil data, and different varieties of hardy kiwi plants.