Synthesis of New Trifluoromethylated 1,3-Oxazolecarboxanilides and Their Fungicidal Activities

Hoh-GyuHahn,SangWonLee,SuYeoulBae,HeduckMah,GyungJaChoi,KwangYunCho 한국응용생명화학회 2002 Journal of Applied Biological Chemistry (J. Appl. Vol.45 No.1

운동생리학: 남자대학생의 최대산소섭취량 측정을 위한 최대운동검사 부하방법의 비교분석

장명재(MyungJaeJang),이상원(SangWonLee),이만균(ManGyoonLee),공성아(SungAhKong) 한국체육학회 2002 한국체육학회지 Vol.41 No.5

The purpose of this study was to compare with the GXT protocol for maximal oxygen uptake. This study was conducted from March to April in 2002. Eight collegiate students were volunteered to participate in the study as subjects. They performed maximal treadmill exercise test according to the three GXT protocols by turns in a counterbalanced order. Maximal treadmill exercise tests were conducted in the exercise physiology laboratory of Department of Physical Education at K-University, Seoul, Korea. The maximal oxygen consumption and other variables obtained from each protocol were compared utilizing one-way ANOVA with repeated measures. When the significance was detected, post hoc test was performed utilizing LSD at .05 level of significant. The results were obtained as follows: 1) There were a significant difference in the maximal oxygen uptake, exercise time, maximal METs, and lactic acid of post maximal exercise according to the three GXT protocols(Bruce, Modified Bruce, PDI) at the .05 level of significance. 2) There was a significant difference in the maximal ventilation between PDI and Modified Bruce GXT protocol at the .05 level of significance. 3) There were no significant difference in the maximal heart rate, RQ according to the three GXT protocols. It was concluded that the development and appropriate selection of GXT protocol for specific population was very important to measure aerobic power accurately and to save the duration of the test.

트레드밀 운동이 모체감염으로 유발된 뇌손상 새끼 쥐의 해마에서 cyclooxygenase-2 발현과 신경세포사에 미치는 영향

김기정(KiJeongKim),이상원(SangWonLee),김경래(KyeongLaeKim),엄우섭(WooSoebEom),김유미(YouMiKim),서진희(JinHeeSeo),김창주(ChangJuKim),김홍(HongKim) 한국체육학회 2008 한국체육학회지 Vol.47 No.2

본 연구는 모체감염으로 유발된 뇌손상 새끼 쥐의 해마에서 cyclooxygenase-2(COX-2)의 발현과 신경세포사에 대한 트레드밀 운동의 효과를 규명하는데 그 목적이 있다. 새끼 쥐의 뇌손상 모델을 만들기 위하여 Sprague- Dawley 암컷 쥐에게 임신 9, 13, 17일차에 내독소인 lipopolysaccharide(LPS)를 1.0 mg/kg의 농도로 매회 0.5 ml를 자궁내로 직접 주입하여 모체감염을 유발하였다. 출산 후 태어난 새끼들은 각각 임신 중 생리식염수를 자궁내로 주입하여 위약 처치를 한 어미에게서 태어난 그룹(Sham; n=4), 임신중 LPS를 자궁내로 주입한 어미에게서 태어난 그룹(LPS; n=4), 임신중 생리식염수를 자궁내로 주입하여 위약 처치를 한 어미에게서 태어난 쥐에게 트레드밀 운동을 실시한 그룹(Sham+Ex; n=4), 그리고 임신중 LPS를 자궁내로 주입한 어미에게서 태어난 쥐에게 트레드밀 운동을 실시한 그룹(LPS+Ex; n=4)으로 나누었다. 운동 그룹의 쥐들은 출생 후 8주령부터 트레드밀을 이용하여 0°의 경사도와 8 m/min의 속도로 30분간에 걸쳐 달리기 운동을 주 3회, 4주간 실시한 후 모든 새끼 쥐를 희생하였다. 해마에서의 COX-2의 발현은 면역조직화학법을 이용하였으며, 신경세포사는 Nissl 염색법을 이용하여 측정하였다. 그 결과 해마에서의 COX-2 발현은 LPS 그룹에 비하여 운동을 실시한 그룹에서 유의하게 감소하였고, 신경세포사 역시 운동을 실시한 그룹에서 유의하게 감소하였다. 본 실험을 통하여 모체감염에 의해 유발될 수 있는 뇌손상에 대한 트레드밀 운동의 신경보호 효과를 과학적으로 규명하였다. Cyclooxygenase-2 (COX-2) is the predominant COX isoform expressed in the brain. COX-2 activity produces oxidative stress and results in the production of prostaglandins that exert many injurious effects on the brain. In this study, the effect of low-intensity treadmill exercise on the expression of COX-2 and neuronal cell death in the hippocampus in maternal endotoxin-induced brain injury rat pups. The present results showed that low-intensity treadmill exercise suppressed the expression of COX-2 in dentate gyrus and increased surviving cells in CA3 hippocampus of rat pups. These results suggest that low-intensity treadmill exercise exerts protective effect on neuronal cell death by maternal endotoxin-induced brain injury.

Hippocampal Subfields Volume Reduction in High Schoolers with Previous Verbal Abuse Experiences

Sangwon Lee,유재현,Ko Woon Kim,Dongchan Kim,HyunWook Park,Jee Wook Choi,Martin H. Teicher,Bumseok Jeong 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.1

Objective: Reduced hippocampal volume and alterations in white matter tracts have been frequently reported in adults having the history of emotional maltreatment. We investigated whether these structural change occur in adolescents with previous verbal abuse (VA) experiences. Methods: Hippocampal subfield volume and white matter structural connectivity measures were assessed in 31 first year male high school students with various degrees of exposure to parental and peer VA. Results: The high VA group showed significant volume reduction in the left cornu ammonis (CA) 1 and left subiculum compared to the low VA group (p<0.05). Volumes of left hippocampal subfields CA1 and subiculum were negatively correlated with previous VA experiences (p<0.05). Increased mean diffusivity (MD) of the splenium of the corpus callosum was related to high VA score across all subjects (p<0.05). There was an inverse relationship between volume of the CA1 and subiculum and MD of the splenium (p<0.05). Conclusion: Exposure to parental and peer VA may affect development of the left hippocampal subfields and the splenium of corpus callosum. These structural alterations can be discernible during adolescence.

국제경제 : BDI(Baltic Dry Index)와 한국금융시장간의 상호 연관성 분석

( Sang Won Lee ),( Jin Soo Kim ) 국제지역학회 2014 국제지역연구 Vol.18 No.1

본 연구는 2006년 1월부터 2013년 3월까지를 표본기간으로 하여 국제 해운시장의 경기를 나타내는 BDI와 한국의 금융시장간의 연관성분석을 위해 그랜저인과관계분석, 충격반응함수분석 및 분산분해분석을 실시하였으며 주요 결과를 요약하면 다음과 같다. 첫째, 전체기간에서는 BDI와 KOSPI간에 양방향으로 그랜저인과하였으나 국채3개월 및 3년 금리와는 인과관계가 나타나지 않았다. 세부기간별로는 보면 글로벌 금융위기 기간에는 BDI가 국채3년 금리와 신용스프레드에 대해 단일방향으로 선도하였고 금융위기 이후 BDI가 KOSPI, 국채 금리 및 신용스프레드에 대해 선행성을 가지는 것으로 나타났다. 둘째, 충격반응함수 분석 결과 BDI 한 단위 변화에 대해 KOSPI는 약 2-3일 정도 영향력이 지속되었으며 신용스프레드는 8일, 국채 3년 금리는 3-6일 정도 반응을 보였다. 셋째, 분산분해 결과 자료 대부분은 자기 자신의 변화에 의한 것으로 나타났지만 금융위기 이후 한국 주식시장, 채권시장, 신용시장에 대한 BDI의 설명력이 대체로 증가하는 것으로 나타났다. 따라서 전체적으로 볼 때 글로벌 금융위기를 거치면서 BDI지수가 점차적으로 한국의 금융시장을 단일방향으로 선도하여 한국금융시장에 영향을 주는 것으로 추론되어 BDI가 향후 한국금융시장 예측에 도움이 될 것으로 기대된다. This study analyzed relationship between BDI and Korea`s financial markets during the period of January 2006 - March 2013, using Granger causality analysis, impulse response function analysis and variance decomposition analysis. Main results are summarized as follows. First, Granger causality analysis showed that BDI had been a leading indicator of KOSPI and credit spread in the entire sample period. After the global financial crisis, BDI also Granger-caused yields on government bonds. Second, impulse response analysis showed that lasting effect of one unit change in BDI rate of return on financial variables was the smallest in KOSPI (2-3 days) and the largest in credit spread(8 days). Third, variance decompositon analysis found that predictability of BDI on Korea`s financial markets had been gradually increasing over the sample period. Therefore, using BDI as a leading indicator of financial variables of Korea are expected to help correctly predict the movement of Korea`s financial markets.

Molecular Dynamics Simulations on β Amyloid Peptide (25-35) in Aqueous Trifluoroethanol Solution

Sangwon Lee,Yangmee Kim* 대한화학회 2004 Bulletin of the Korean Chemical Society Vol.25 No.6

Characteristic Analysis of Probiotics Isolated from Companion Animals

Sang-Won Lee 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

Democracy, Faction and Diversity: An Analysis of the Existential Ground of Democratic Republic Reflected in The Federalist Papers

SangWon Lee 한국학술연구원 2020 Korea Observer Vol.51 No.2

The current situation of South Korean democracy displays severe partisan conflicts between two major factions around political reformation of the judiciary department and the ensuing social issues of justice and fairness. In this light, this article examines the problematic relationship of democracy, faction and diversity revealed in The Federalist Papers. I argue that Publius thinking in The Federalist Papers discloses the existential ground of democratic republic which embraces both the constant emergence of factious struggle and the political necessity of social diversification. Some scholarly views of The Federalist Papers merely focus on the economic aspects of Publius attempt to regulate the factional strife concerning property rights; other studies maintain that Publus constitutional scheme simply provides a formalistic basis for the institutional compromise of the clashing interests. But a close reading of The Federalist Papers reveals the Publius concern of faction is to deal with a deeper ground of political existence that cannot escape the differing movements of human passions, interests and opinions in everyday life. Furthermore, Publius constitutional design of the extended republic and the separation of powers ultimately discloses the political necessity of social diversification to sustain the self-ruling power of popular government facing the clashing movements of human differentiation. Thereby, this article suggests that the Publius political insights of the nature of popular regime help us to carefully approach the recurrent problem of democratic factions in the Republic of Korea.

A comparative study on determinants of housing mortgage prepayment of individual borrowers

( Sang Won Lee ),( Su Bok Ryu ),( Tae Young Kim ),( Jin Q. Jeon ) 한국파생상품학회 2022 선물연구 Vol.30 No.4

This paper examines how the macroeconomic environment affects the determinants of prepayment of mortgage loans from October 2004 to February 2020. For more accurate analysis, the authors define the timing of prepayment not only before the loan maturity but also at the time when 50% or more of the loan principal is repaid. The results show that, during the global financial crisis as well as the recent period of low interest rates, macroeconomic variables such as interest rate spreads and housing prices have a different effect compared to the normal situation. Also, significant explanatory variables, such as debt to income (DTI) ratio, loan amount ratio and poor credit score, have different effects depending on the macroenvironment. On the other hand, in all periods, the possibility of prepayment increases as comprehensive loan to value (CLTV) increases, and the younger the age, the shorter the loan maturity. The results suggest that, in the case of ultralong (40 years) mortgage loans recently introduced to support young people purchasing houses, the prepayment risk can be, at least partially, migrated by offsetting the increase in prepayment by young people and the decrease in prepayment due to long loan maturity. In addition, this study confirms that the accelerated time failure model compared to the logit model and COX proportional risk model has the potential to be more appropriate as a prepayment model for individual borrower analysis in terms of the explanatory power.

Prognosis in primary mucinous ovarian carcinoma: focusing on the five pathological findings indicating metastatic mucinous carcinoma to the ovary

Sang won Lee 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.2

Objective: Pathological features indicating metastatic mucinous carcinoma to the ovary (MMCO) have been rarely reported in primary mucinous ovarian carcinoma (PMOC). However, little is known about how often they are observed in PMOC and how they relate to patient prognosis. In this study, we investigated the pathological features indicating MMCO in a large cohort of PMOCs and analyzed their association with patient prognosis. Methods: We reviewed surgically treated PMOC patients diagnosed at the Seoul National University Hospital from 1995 to 2019, according to the updated WHO classification, and investigated the presence of pathological features indicating MMCO. Results: A total of 144 patients with PMOCs were included. The 5 pathological findings indicating MMCO, including an infiltrative invasive pattern, the absence of benign or borderline components, a smaller tumor size, the presence of signet ring cells and the presence of extracellular mucin were observed in PMOC (21.6%, 43.1%, 20.8%, 4.3% and 12.9%, respectively), and were significantly correlated with poor overall and progression-free survival rates in PMOC. The patient’s prognosis worsened as the extent of the infiltrative invasive pattern increased (p<0.001). In addition, the prognostic power was stronger when the 5 pathological factors were analyzed together (new grouping system) than when analyzed individually (p<0.001) and the new grouping system was identified as an independent prognostic factor regardless of FIGO stage. Conclusion: Five pathological findings indicating MMCO in PMOC were significantly associated with poor prognosis in PMOC patients. Also, the new grouping system combining these findings was identified as an independent prognostic factor.