수학자 보재 이상설(李相卨)의 근대자연과학 수용 -『백승호초(百勝胡艸)』를 중심으로-

이상구 ( Sang Gu Lee ),박종윤 ( Chong Yun Park ),김채식 ( Chae Sik Kim ),이재화 ( Jae Hwa Lee ) 한국수학교육학회 2013 수학교육논문집 Vol.27 No.4

본 논문은 한국 근대수학교육의 아버지 이상설(李相卨, 1870-1917)이 자연과학―물리학―에 기여한 내용을 다루고있다. 이상설은 ?수리(數理)?를 쓴 시기를 전후하여, 같은 시기에 붓으로 총 8면에 걸쳐 『백승호초(百勝胡艸)』라는이름의 고전물리학 원고를 써서 남겼다. 분석결과 이 책의 원전은 1879년에 동경제대 의학부 교재로 발간된 『물리학(物理學)』이다. 이상설은 『백승호초』에서 먼저 개념을 정의하고, 일상에서 나타난 대표적 현상을 선록하여 한문으로번역하였고, 『물리학』의 전체 분량에서도 특히 ‘통유성(通有性)’에 중점을 두고 설명하였다. 동양에서 서양의 수리과학이 들어와야만 말할 수 있는 ‘질량보존의 법칙’, ‘타성(惰性, 관성)’과 같은 고전물리학의 중요개념을 포함하는 내용이 19세기 말에 이미 이 책에 소개된 것으로 보아 이상설은 당대의 다른 저술에서 보기 힘들 정도로 당시 일반물리학의 최고수준의 원서를 통해 최신 정보를 수용하고 전파하기 위하여 노력하였음을 볼 수 있다. Sang-Seol Lee(1870-1917) wrote a manuscript BaekSeungHoCho(百勝胡艸) in the late 19th century. BaekSeungHo-Cho was transcribed in classical Chinese from the 1879 Japanese book Physics(物理學) by Teizo Ihimori (1851-1916). Sang-Seol Lee, a famous independence activist, is also called Father of the Modern Mathematics Education of Korea,because of his early contribution to the modern mathematics education in the 19th century. In this paper, we introduce contents of his manuscript BaekSeungHoCho for the first time and discuss the significance of this book. Also, we show his constribution on the introduction to modern physics in the late 19th century Korea.

경춘선 숲길 이용 만족도에 영향을 미치는 요인 분석 연구 - 공원의 안전성, 접근성, 쾌적성 중심으로 -

박세연(Park, Se-Yeon),황성은(Hwang, Sung Eun),최병윤(Choi, Byeong-Yun),강부성(Kang, Boo-Seong) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.2

The purpose of this study was to analyze the factors affecting satisfaction of the park by selecting Gyeongchun Line Forest Park as the target site to relieve the inconvenience of people using a park. As the number of park users increased after COVID-19, complaints about using the park also increased. Through the survery the factors affecting satisfaction were identified by dividing them into categories of saftey, accessibility, and comfort and do an on-site investigation. In order to increase the safisfaction of the park, lighting and visual connection were important in terms of saftey, accessibility and guidance width and movement speed were importatnt in comfort.

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Chung, Ji-Yun,Park, Hee Ra,Lee, Su-Jin,Lee, Sun-Hye,Kim, Jin Sik,Jung, Youn-Sang,Hwang, Sang Hyun,Ha, Nam-Chul,Seol, Won-Gi,Lee, Jaewon,Park, Bum-Joon United States and Canadian Academy of Pathology [e 2013 Laboratory investigation Vol.93 No.6

<P>Parkinson's disease (PD) is the second leading neurodegenerative disease, and is known to be induced by environmental factors or genetic mutations. Among the verified genetic mutations of PD, Parkin, isolated from the PARK2 locus, shows an autosomal recessive inheritance pattern and is known to be an E3 ligase. However, the physiological target of Parkin and the molecular mechanism of Parkin-deficiency-induced PD have not been clearly demonstrated until now. It has recently been proposed that inflammation, suggesting as a causal factor for PD, is enhanced by Parkin deficiency. Thus, we examined the relationship between inflammation-related factors and Parkin. Here, we provide the evidence that Parkin suppresses inflammation and cytokine-induced cell death by promoting the proteasomal degradation of TRAF2/6 (TNF-α receptor-associated factor 2/6). Overexpression of Parkin can reduce the half-lives of TRAF2 and TRAF6, whereas si-Parkin can extend them. However, mutant Parkins did not alter the expression of TRAF2/6. Thus, loss of Parkin enhances sensitivity to TNF-α- or IL-1β-induced JNK activation and NF-κB activation. Indeed, si-Parkin-induced apoptosis is suppressed by the knockdown of TRAF6 or TRAF2. We also observed elevated expression levels of TRAF6 and a reduction of IκB in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mouse model. Moreover, elevated expression levels or aggregation of TRAF6 were detected in approximately half of the human PD tissues (7/15 cases) and 2 cases, respectively. In addition, TRAF6 and Parkin expression levels show a reverse relationship in human PD tissues. Our results strongly suggest that the reduction of Parkin or overexpression of TRAF2/6 by chronic inflammation would be the reason for occurrence of PD.</P>

커뮤니티공간으로서의 어린이공원 조성에 관한 연구

김연금,김성주,박환지,유다희,최성용,홍승모,Kim, Yun-Geum,Kim, Seong-Joo,Park, Hwan-Ji,Yu, Da-Hee,Choi, Sung-Young,Hong, Seung-Mo 한국조경학회 2008 韓國造景學會誌 Vol.35 No.6

This study deals with the participatory design process of renovating a children's park. The process should proceed with two major elements. Firstly, the children's park should be designed from the perspective of children. Secondly, it should be designed in consideration of the context of the community. This study is divided into two parts. First is the review of theory concerning the meaning and roles of the children's park as a community space, the importance of children's participation in the design and the participatory method of the children. The second is the case study. The site for the case study is Ssial Park in Nowon-Gu, Seoul. The entire process of the case study is with community participation, from identifying the park's problems to the actual construction. At every step, through the participatory programs, the community participates in the decision making. In addition, mutual understanding among participants is pursued through diverse means of communication. The following results of the case study were found. Firstly, diverse participatory programs and the active trial to enable the community to communicate contribute to the sense of ownership and responsibility concerning the park Secondly, the community can negotiate the differences in opinions without needing the help of experts. Of course, there are limits in the case study, such as the fact that the community organization, which is the core of communication and maintenance concerning the park, is not organized through the process of a case study. Another is that more diverse methods, which inform all community members of the participatory process, should have been used.

YMCA 체육의 역사적 함의

김영훈(Kim, Young-hun),장성호(Jang, Sung-Ho),박윤기(Park, Yun-Ki) 용인대학교 무도연구소 2012 武道硏究所誌 Vol.23 No.1

이 연구는 역대 YMCA 체육을 토대로 하여 구체적으로 살펴보고자 한다. 이에관해 생활체육 활성화 방안 모색을 제시하는데 논의 및 결론을 도출하였다. 이는 다음과 같이 확인할 수 있다. 첫째, 한국에서의 YMCA운동은 1899년 경성에서 선교활동을 시작되었다. 둘째, YMCA의 전인교육정신인 지(智)·덕(德)·체(體)의 정신과 통하는 정신으로서 비폭력, 민주주의의 실천교육과 상통하는 정신이었다. 셋째, 이상재의 교육사상은 인간의 본질적인 면에 치중하여 올바른 인격체로 양성하는 것으로 지·덕·체의 전인적 교육이었음 알 수 있었다. 넷째, 서울 YMCA의 창립과 역사적 배경을 보면 서울YMCA는 1903년 10월 28일 창립하였다. 다섯째, 서울YMCA를 도입, 회원들에게 지도한 스포츠로는 야구, 농구, 배구, 축구, 유도, 검도, 체조 등이 있었다. 이상과 같이 종합해 볼 때, 역대 YMCA 체육의 역사에서 보이듯이 그 정책을 통해 한국생활체육의 활성화를 위한 방안 모색에 따른 정체성을 제시할 수 있는 것이다. This research is looked at concretely is based on the generation of YMCA physical training. It derive a discussion and conclusion to grope a plan to activate living physical training. This can be confirmed by the following essay. First, the YMCA exercise in Korea started in Gyeong-sun, 1899 as a missionary activity. Second, the mind of former education of YMCA’s just·morality·formality was a mind connected to the communicating with anti-violence, democratic practice education. Third, Lee Sang-Jea’s educational method is to bring up the personality to the right side valued on true nature of a human being, which indicates that his educational method is for the whole man. Fourth, looking at the foundation and historical backround, Seoul YMCA was established on 28th October 1903. Fifth, sports that Seoul YMCA guided to members were baseball, basketball, volleyball, football, judo, kendo, gymnastics etc. To round up all the above statements, the identity following a plan to activate Korea living P.T can be derived through the policy as seen in YMCA physical training’s history in generations.

종 분포 모형을 이용한 구상나무림의 지속 및 쇠퇴에 관한 연구 - 전라남도 광양시 백운산을 중심으로 -

조선희 ( Seon Hee Cho ),박종영 ( Jong Young Park ),박정호 ( Jeong Ho Park ),이양근 ( Yang Geun Lee ),문이만 ( Lee Man Mun ),강상호 ( Sang Ho Kang ),김광현 ( Gwang Hyun Kim ),윤종국 ( Jong Guk Yun ) 한국산림과학회 2015 한국산림과학회지 Vol.104 No.3

The present study investigated the habitats of Korean fir trees (Abies koreana E. H. Wilson) on Mt. Baekwun (Baekwun-san), determined the current distribution, quantified the contribution of biological and nonbiological environmental factors affecting the distribution, derived actual and potential habitats, presented a plan for the establishment of protected areas, applied RCP 8.5 climate change scenario to analyze the effects of climate change on the future distribution of Korean fir trees, and predicted future potential habitats. According to the results of the study, 3,325 Korean fir trees (DBH >= 2.5 cm) inhabited Mt. Baekwun, and their distribution area was approximately 150 ha. Populations of Korean fir trees were confirmed to exist at an altitude of 900 m above sea level and were distributed up to 1,200 m. Based on potential distribution, areas appropriate for habitation by Korean fir trees were analyzed to be 450 ha, three times the current distribution area, with a focus on Sang Peak (Sang-bong), Eokbul Peak (Eokbul-bong), Ddari Peak (Ddari-bong), and Dosol Peak (Dosol-bong). The forest stands near Sang Peak, the main peak, were evaluated as those with the most appropriate potential for the habitation of Korean fir trees, and populations of the trees tended to prefer the northern slope rather than the southern slope. When climate change scenario RCP 8.5 was applied and future potential distribution was analyzed, the habitats were expected to decrease in area to 20 ha by 2050, with a focus on Sang Peak, and areas appropriate for habitation were predicted not to exist by 2080. Judging from such results, as global warming accelerates, the habitats of Korean fir trees are clearly expected to move from lowlands to highlands.

[PA-0027] Analysis of transcriptome between GM soybean and Non-GM soybean using RNA sequencing and qRT-PCR

Sang Gu Lee(Sang Gu Lee),Yun Young Kang(Yun Young Kang),Seon Woo Oh(Seon Woo Oh),Eun Ha Kim(Eun Ha Kim),Soo Yun Park(Soo Yun Park),Hyoun Min Park(Hyoun Min Park),Young Soo Chung(Young Soo Chung) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

국립공원 탐방로 안전지수 및 등급분석에 관한 연구

박준효(Pak, Jun-hou),전계원(Jun, Kye-Won),박상준(Park, Sang-Jun),김명준(Kim, Myeong-Jun),윤주웅(Yun, Ju-Ung) 한국산림휴양복지학회 2020 한국산림휴양학회지 Vol.24 No.4

본 연구에서는 탐방로 안전성 평가 모델을 활용하여 21개 국립공원을 대상으로 안전지수와 등급분석을 수행하였다. 현장조사를 통해 탐방로 주변 위험요소 중 하나라도 확인되면 취약구간으로 판단하여 안전지수를 산출하였다. 취약구간은 총 180.4km로 조사되었으며 탐방로 총 연장 1,995.5km 대비 약 9.0%로 확인되었다. 안전지수는 총 200점 중 최소 42.3점에서 최대 167.0점 분포를 보이고 평균값은 101.5점으로 나타났다. 안전지수를 토대로 등급을 분석한 결과, ‘관심(Concern)’ 등급은 60.8km(34%), ‘주의(Caution)’ 등급은 57.8km(32%), ‘위험(Dangerous)’ 등급은 49.6km(27%), ‘매우위험(Very dangerous)’ 등급은 12.2km(7%)로 나타났다. 매우위험 구간은 북한산국립공원(6.0km), 지리산국립공원(3.3km), 오대산국립공원(1.6km), 설악산국립공원(0.9km), 월악산국립공원(0.4km), 속리산국립공원(0.01km) 등 6개 국립공원 탐방로에서 총 12.2km로 나타났다. 북한산국립공원은 Y계곡, 의상능선 등이 해당되며, 지리산국립공원은 칠선계곡, 구룡계곡에서 확인되었다. 오대산국립공원은 노인봉 일원, 설악산국립공원은 공룡능선, 흘림골 등에서 나타났다. 월악산국립공원은 금수산 일원, 속리산국립공원 막장봉 구간이 매우위험 구간으로 나타났다. 본 연구는 향후 재난위험 저감대책 수립과 탐방로 정비 우선순위 선정 등 국립공원 안전관리 정책을 수립하기 위한 기초자료로 활용될 수 있다. In this study, the safety indexing and grading analysis were conducted for 21 national parks, using the trail safety evaluation model. If any one of the risk factors around the trail was identified through a field survey, the safety index was calculated by judging it as a vulnerability zone. The vulnerability zone was 180.4km in total, and it was found to be about 9.0% compared to the total length of 1,995.5km. The safety index was distributed from the minimum of 42.3 to the maximum of 167.0, and the average value was 101.5 of total 200 scores. As a result of analyzing the grade based on the safety index, 60.8km (34%) was in the ‘Concern’ grade, 57.8km (32%) was in the ‘Caution’ grade, 49.6km (27%) was in the ‘Dangerous’ grade, and 12.2km (7%) was in the ‘Very dangerous’ grade. ‘Very dangerous’ sections were found to be a total of 12.2 km. including 6 national park trails: Bukhansan National Park (6.0km), Jirisan National Park (3.3km), Odaesan National Park (1.6km), Seoraksan National Park (0.9km), Woraksan National Park (0.4km), Songnisan National Park (0.01km). In terms of ‘Very dangerous’ section, Bukhansan National Park included Y Valley and Uisang Ridge, and Jirisan National Park included Chilseon Valley and Guryong Valley. The area of Noinbong in Odaesan National Park, and Gongnyong Ridge and Heulimgol in Seoraksan National Park were included. And the Geumsusan area in Wolaksan National Park and Makjangbong in Songnisan National Park were found to be ‘Very dangerous’. This study could be used as basic data to establish national park safety management policies, such as selecting priority of trail maintenance and establishing countermeasures to reduce disaster risk.

Genomic alterations in <i>BCL2L1</i> and <i>DLC1</i> contribute to drug sensitivity in gastric cancer

Park, Hansoo,Cho, Sung-Yup,Kim, Hyerim,Na, Deukchae,Han, Jee Yun,Chae, Jeesoo,Park, Changho,Park, Ok-Kyoung,Min, Seoyeon,Kang, Jinjoo,Choi, Boram,Min, Jimin,Kwon, Jee Young,Suh, Yun-Suhk,Kong, Seong-H National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.40

<P><B>Significance</B></P><P>Gastric cancer (GC) is one of the major causes of cancer-related deaths worldwide, but targeted therapy for GC is limited. Here, we identified two druggable targets from genomic alteration profiling of 103 patients with GC from Asia and validated the target suitability using patient-derived GC xenograft models, which recapitulate the tumor biology observed in patients. Combination therapy of irinotecan (standard treatment) with a <I>BCL2L1</I> (<I>BCL2</I>-like 1)-targeted drug was effective in size reduction of GC tumors having amplification of the <I>BCL2L1</I> gene, and genomic mutations of deleted in liver cancer 1 (<I>DLC1</I>) were associated with increased sensitivity to a ROCK inhibitor. Therefore, our study strongly suggests that <I>BCL2L1</I> and <I>DLC1</I> can serve as targets for novel GC therapies.</P><P>Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. Recent high-throughput analyses of genomic alterations revealed several driver genes and altered pathways in GC. However, therapeutic applications from genomic data are limited, largely as a result of the lack of druggable molecular targets and preclinical models for drug selection. To identify new therapeutic targets for GC, we performed array comparative genomic hybridization (aCGH) of DNA from 103 patients with GC for copy number alteration (CNA) analysis, and whole-exome sequencing from 55 GCs from the same patients for mutation profiling. Pathway analysis showed recurrent alterations in the Wnt signaling [<I>APC</I>, <I>CTNNB1</I>, and <I>DLC1</I> (deleted in liver cancer 1)], ErbB signaling (<I>ERBB2</I>, <I>PIK3CA</I>, and <I>KRAS</I>), and p53 signaling/apoptosis [<I>TP53</I> and <I>BCL2L1</I> (BCL2-like 1)] pathways. In 18.4% of GC cases (19/103), amplification of the antiapoptotic gene <I>BCL2L1</I> was observed, and subsequently a <I>BCL2L1</I> inhibitor was shown to markedly decrease cell viability in <I>BCL2L1</I>-amplified cell lines and in similarly altered patient-derived GC xenografts, especially when combined with other chemotherapeutic agents. In 10.9% of cases (6/55), mutations in <I>DLC1</I> were found and were also shown to confer a growth advantage for these cells via activation of Rho-ROCK signaling, rendering these cells more susceptible to a ROCK inhibitor. Taken together, our study implicates <I>BCL2L1</I> and <I>DLC1</I> as potential druggable targets for specific subsets of GC cases.</P>

Clinical Assessment of Usefulness, Effectiveness and Safety of Kyejibokryung-hwan on Various Neuropathies

Park, Seong-Uk,Jung, Woo-Sang,Kim, Yun-Kyung,Moon, Sang-Kwan,Kim, Young-Suk,Bae, Hyung-Sup,Cho, Ki-Ho,Ko, Chang-Nam The Society of Korean Medicine 2006 대한한의학회지 Vol.27 No.4

We were to assess clinical effectiveness, safety and usefulness of Kyejibokryung-hwan (KBH), which has been used for Er-hyul similar with vascular or neurologic disorders causing sensory or motor abnormalities. This study is a retrospective single case series. Two hundred ninety five patients were treated with KBH for various neuropathies in our hospital. Of them, 120 cases were excluded because of insufficient medical records or failure to follow up; the remaining 175 were included in the analysis. There were 18 patients with sensory abnormalities and 28 with motor abnormalities after stroke. Of peripheral type, there were 14 with diabetic neuropathy, 12 with carpal tunnel syndrome, 41 with spinal radiculopathies, and 62 with idiopathic neuropathies, for which the effectiveness was assessed as 55.6%, 21.4%, 64.3%, 83.3%, 45.0%, and 56.5%, respectively. Adverse effects including indigestion or diarrhea were seen in 3.4% of the total patients. Taking the effectiveness and the safety together into consideration, the usefulness was assessed as 55.6%, 21.4%, 64.3%, 83.3%, 45.0%, and 54.8% for treating post-stroke sensory and motor abnormalities, diabetic neuropathy, carpal tunnel syndrome, spinal radiculopathies, and idiopathic neuropathies, respectively. In conclusion, we suggest that KBH is a useful herbal medicine for various neuropathies, especially of sensory type.