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Kim, Jeong Eun,Kim, Deokhoon,Hong, Yong Sang,Kim, Kyu-pyo,Yoon, Young Kwang,Lee, Dae Ho,Kim, Sang-We,Chun, Sung-Min,Jang, Se Jin,Kim, Tae Won Neoplasia Press 2018 Translational oncology Vol.11 No.2
<P>Pemetrexed and platinum (PP) combination chemotherapy is the current standard first-line therapy for treatment of malignant mesothelioma (MM). However, a useful predictive biomarker for PP therapy is yet to be found. Here, we performed targeted exome sequencing to profile somatic mutations and copy number variations in 12 MM patients treated with PP therapy. We identified 187 somatic mutations in 12 patients (65 synonymous, 102 missense, 2 nonsense, 5 splice site, and 13 small coding insertions/deletions). We identified somatic mutations in 23 genes including <I>BAP1</I>, <I>TP53</I>, <I>NRAS,</I> and <I>EGFR</I>. Interestingly, rare <I>NRAS</I> p.Q61K and <I>EGFR</I> exon 19 deletions were observed in 2 patients. We also found somatic chromosomal copy number deletions in <I>CDKN2A</I> and <I>CDKN2B</I> genes. Genetic alteration related to response after PP therapy was not found. Somatic mutation profiling in MM patients receiving PP therapy revealed genetic alterations in potential therapeutic targets such as <I>NRAS</I> and <I>EGFR</I>. No alterations in genes with potential predictive role for PP therapy were found.</P>
중심정맥 도관 삽입술의 성공률과 합병증 발생 빈도에 대한 전향적 연구
배창황(Chang Hwang Bae),김우건(Woo Kun Kim),박완(Wan Park),박진희(Jin Hee Park),김정균(Jeong Kyun Kim),최성준(Sung Jun Choi),이제환(Je Hwan Lee),김성배(Sung Bae Kim),김상위(Sang We Kim),서철원(Cheol Won Suh),이규형(Kyoo Hyung Lee),이 대한내과학회 1998 대한내과학회지 Vol.55 No.2
N/A Objectives: The reported success rate of central venous catheterization ranged from 84% to 97.5%, and the complication rate from 0.3% to 12%. The most important contributing factor for complications reported by several authors was the physician's experience. We investigated the success and complication rates of central venous catheterization prospectively. We also evaluate the factors that contributed to complications at our institution as part of our quality assurance study. Methods: Four hundred sixty five central venous catheterizations were conducted at the medical intensive care unit and the general ward of the hemato1ogy/ oncology department of Asan Medical Center in Korea, from June to November, 1997. We surveyed the date and place of the procedures, lD numbers, age and sex of the patients, the training level of physicians, the types of catheters, initial puncture sites, success or failure, and complications. We grouped the purpose of procedures into 5categories, such as hemodynamic monitoring, fluid therapy, chemotherapy, total parenteral nutrition, and others, Results: The initial success rate, defined as the initial performer being able to insert the catheter without changing the skin puncture site, was 78.5%. The overall success rate for initial performers, including those who required multiple skin puncture sites, was 82.8%. The total success rate, including changing the performers (up to 4performers), was 96.1%. The overall complication rate was 5.2% including pneumothorax (2.8%), hemothorax (0.2%), subcutaneous hematoma (1.1%), catheter tip malposition (0.9%), and air-embolism (0.2%). There were no differences in the complication rates with regards to the sex and age of the patient, initial puncture sites, the physician's training level between 1st and 2nd year residency, and vein localization. However, the complication rate differed significantly in relation to the number of initial punctures. Patients with 1-3 punctures had a complication rate of 4.3%, while patients with 4 or more punctures had a complication rate of 18.5%. Conclusion: The overall complication rate was 5.2% and pneumothorax occured in 2.8%. We expect that we can decrease the number of complications by taking over the procedure if the initial performer fails on the first or second attempt and by attempting the skin puncture not more than 4times at initial trial.
Kim, Yeon Joo,Song, Si Yeol,Jeong, Seong-Yun,Kim, Sang We,Lee, Jung-Shin,Kim, Su Ssan,Choi, Wonsik,Choi, Eun Kyung The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.4
Purpose: To determine failure patterns and survival outcomes of T4N0-1 non-small cell lung cancer (NSCLC) treated with definitive radiotherapy. Materials and Methods: Ninety-five patients with T4N0-1 NSCLC who received definitive radiotherapy with or without chemotherapy from May 2003 to October 2014 were retrospectively reviewed. The standard radiotherapy scheme was 66 Gy in 30 fractions. The main concurrent chemotherapy regimen was $50mg/m^2$ weekly paclitaxel combined with $20mg/m^2$ cisplatin or AUC 2 carboplatin. The primary outcome was overall survival (OS). Secondary outcomes were failure patterns and toxicities. Results: The median age was 64 years (range, 34 to 90 years). Eighty-eight percent of patients (n = 84) had an Eastern Cooperative Oncology Group performance status of 0-1, and 42% (n = 40) experienced pretreatment weight loss. Sixty percent of patients (n = 57) had no metastatic regional lymph nodes. The median radiation dose was EQD2 67.1 Gy (range, 56.9 to 83.3 Gy). Seventy-one patients (75%) were treated with concurrent chemotherapy; of these, 13 were also administered neoadjuvant chemotherapy. At a median follow-up of 21 months (range, 1 to 102 months), 3-year OS was 44%. The 3-year cumulative incidences of local recurrence and distant recurrence were 48.8% and 36.3%, respectively. Pretreatment weight loss and combined chemotherapy were significant factors for OS. Acute esophagitis over grade 3 occurred in three patients and grade 3 chronic esophagitis occurred in one patient. There was no grade 3-4 radiation pneumonitis. Conclusion: Definitive radiotherapy for T4N0-1 NSCLC results in favorable survival with acceptable toxicity rates. Local recurrence is the major recurrence pattern. Intensity modulated radiotherapy and radio-sensitizing agents would be needed to improve local tumor control.
ESHAP Salvage Therapy for Refractory and Relapsed Non-Hodgkin`s Lymphoma: A Single Center Experience
( Sang Hyoung Park ),( Shin Kim ),( Ok Bae Ko ),( Ja Eun Koo ),( Dan Bi Lee ),( Yong Pil Jeong ),( Joo Ryung Huh ),( Sung Bae Kim ),( Sang We Kim ),( Jae Lyun Lee ),( Cheol Won Suh ) 대한내과학회 2006 The Korean Journal of Internal Medicine Vol.21 No.3
Background: The ESHAP chemotherapy regimen, that is, the combination of the etoposide, methylprednisolone, high-dose cytarabine and cisplatin, has been shown to be active against relapsing or refractory non-Hodgkin`s lymphoma (NHL) in previous therapeutic trials. We attempted to determine whether ESHAP therapy would be effective and well-tolerated in Korean patients. Methods: Twenty two patients with refractory or relapsed NHLs (all aggressive types) were enrolled in this study. We retrospectively evaluated the treatment response, the survival rate and the time to progression. Results: Six patients (27.3%) attained complete remission and eight patients (36.4%) attained partial remission. The overall response rate was 63.6%. The median survival duration was 15.5 months (95% confidence interval; 10.7 to 20.3 months), and the median duration of the time to progression was 8.3 months (95% confidence interval; 0.3 to 16.3 months). Myelosuppression was the major toxicity, but severe neutropenia or thrombocytopenia was rare, and renal toxicity was also infrequent. Conclusions: ESHAP regimen is effective in Korean patients suffering with relapsed or refractory NHLs, but a more effective salvage modality is needed because of the short duration of remission and the insignificant impact on long-term survival.
( Sang Don Yoon ),( Sung Ae Kim ),( Kyu Suk Lee ),( Jae We Cho ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
Alopecia is a common disorder with significant negative impact on their social and psychological well-being. There are many modalities to treat various alopecia, such as oral finasteride, topical minoxidil, triamcinolone intralesional injection, excimer laser and so on. However, the treatment results of these treatment are not always satisfactory. In vitro study, PRP treated dermal papilla cells showed the increased cell proliferation rates, BCl-2 and KGF up-regulation. We tried to evaluate efficacy and safety of sequential treatment, Platelet-rich plasma(PRP) injection, followed by mesotherapy in various alopecia. Included in this study were males and females between the ages of 20 and 60 years, in good health. Two independent investigators evaluated clinical improvement using a quartile grading scale by comparing digital photographs taken prior to treatment and at 3 months after the last treatment. The result was a relatively clinical improvement in hair count and hair thickness demonstrated in all the patients. There were no significant side effects except mild pain, transient bleeding at injection or microneedling site. Taken together, PRP induced hair growth in alopecia patients partially through dermal papilla cell proliferation, BCl-2 and KGF up-regulation.
Primary Extramammary Paget’s Disease Combined with Bowen’s Disease in Vulva
Sung-Ae Kim,Jun-Il Kwon,Kyu-Suk Lee,Jae-We Cho,정혜라 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-
Extramammary Paget’s disease (EMPD) is a uncommon neoplastic condition of apocrine gland-bearing skin and its occurrence in combination with Bowen’s disease is very rare. The most common site of involvement is the vulva,although perineal, perianal, scrotal and penile skin may also be affected. EMPD is usually not combined with Bowen’s disease. We report an interesting case of EMPD combined with Bowen’s disease, which was confirmed by immunohistochemical stain. (Ann Dermatol 23(S2) S222∼S225,2011)
False-Positive Hypermetabolic Lesions on Post-Treatment PET-CT after Influenza Vaccination
( Jeong Eun Kim ),( Eun Kyoung Kim ),( Dae Ho Lee ),( Sang We Kim ),( Cheol Won Suh ),( Jung Shin Lee ) 대한내과학회 2011 The Korean Journal of Internal Medicine Vol.26 No.2
We report a case of a 59-year-old man with testicular germ cell tumor who showed new hypermetabolic lesions at the left axillary lymph nodes on a post-treatment positron emission tomography-computed tomography (PET-CT) scan. The hypermetabolic lesions were found to be caused by an influenza vaccination 10 days prior to the PET-CT scan and disappeared without additional treatment. To date, he is alive with complete remission. (Korean J Intern Med 2011;26:210-212)