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( Tae Hwan Ha ),( Tae Hoon Oh ),( Sung In Yu ),( Min Kim ),( Jong Wook Kim ),( Won Ki Bae ),( Jae Hyung Kim ),( Seung Suk Baek ),( Mi Jin Ryu ),( Ye Na Choi ),( Ji Young Park ),( Eileen L Yoon ),( Tae 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Non-variceal upper GI bleeding (NVUGIB) is a common medical problem that has signifi cant association with morbidity and mortality. Angiographic detection and subsequent transarterial embolization (TAE) is a primary treatment option when medical and endoscopic treatments fail. We investigated clinical factors that could affect the success of the angiographic detection and prognosis after TAE in patients with NVUGIB refractory to endoscopic therapy. Methods: A retrospective analysis of the clinical data was done in patients with failed endoscopic treatment who underwent angiography for the treatment of acute NVUGIB between May 2002 and May 2013. Patients were divided into detection or non-detection groups according to the presence of bleeding stigmata in angiographic fi nding. Rebleeding defi ned as subsequent bleeding event within 7 days and mortality within 30days were analyzed as outcome parameters after TAE following detection in angiography. Results: A total 45 patients 37 (male, mean age, 65.9±14.9 years) were analyzed and classifi ed as a detection group (n=25, 55.5%) and non-detection group (n=20, 44.6%). Peptic ulcers were the most common cause of refractory NVUGIB. Larger transfusion amount (5.7±3.9 unit vs. 3.5±2.8 unit; P=0.03), prolonged aPTT level (34.2±17.3 sec vs. 21.8±13.8 sec; P=0.01) and short time interval between last endoscopy and angiography (17.5±25.9 hours vs. 34.3±59.5 hours; P=0.04) were found to be signifi cant factors for predicting angiographic detection. TAE was performed in all patients detected in angiography. Rebleeding (44%) was significantly associated with higher Rockall score (8.3±1.5 vs. 6.6±2.4; P=0.046) and mortality (12%) was signifi cantly associated with higher Rockall score (9.3±0.6 vs. 7.1±2.2; P=0.002) and higher level of BUN (55.3±47.4 vs. 27.6±17.4; P=0.01). Conclusions: Clinical characteristics associated with angiographic detection in patients with NVUGIB refractory to endoscopic therapy were severe bleeding, bleeding tendency and early angiographic intervention. The Rockall score is useful parameter for predicting rebleeding and mortality after TAE.
Chaetoglobosin A, an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12,13-Dibutyrate
KO, HACK-RYONG,KIM, BO YEON,AHN, SOON-CHEOL,OH, WON KEUN,KIM, JIN-HEE,LEE, HYUN SUN,KIM, HWAN-MOOK,HAN, SANG-BAE,MHEEN, TAE0ICK,AHN, JONG-SEOG 한국미생물 · 생명공학회 1998 Journal of microbiology and biotechnology Vol.8 No.6
Lipid-based Liquid Crystalline Phases for Biocompatible and Versatile Drug Delivery
Sung-Hyun Kim(Sung-Hyun Kim),Min-Joon Seo(Min-Joon Seo),Hyung-sik Lim(Hyung-sik Lim),Jin-Tae Hong(Jin-Tae Hong) 대한약학회 2023 약학회지 Vol.67 No.3
The purpose of the paper was to overview the liquid crystalline phases that can be prepared with various lipids and to assess their characteristics as drug delivery systems for drugs to be administered to various routes. Glyceryl monooleate (GMO) was most frequently employed to deliver the drugs to topical, transdermal, oral, buccal and parenteral routes. In addition to bulk phase such as lamellar and cubic liquid crystalline phases, nano-sized cubosomes of GMO have offered a wide range of chances to administer drugs more precisely to oral and parenteral routes. In addition to GMO different types of lipids including phospholipids, triglycerides, fatty acids and cholesterol were able to form liquid crystalline phases even though most studies employing other lipids than GMO were focused on revealing their phase behaviors and physicochemical characteristics. However, it was expected that more research attempts will be made on utilizing new class of liquid crystalline phases that can be formed with various lipids. Based on the outcome published to date, more versatile drug delivery can be possible if new lipid materials can be developed and used to organize unique molecular orders suitable for a difficult-to-carry drugs.
Enhancement of Keratinocyte Differentiation by Rose Absolute Oil
( Jin Hwa Kim ),( Dae Kyoung Choi ),( Sang Sin Lee ),( Sun Ja Choi ),( Chang Deok Kim ),( Tae Jin Yoon ),( Jeung Hoon Lee ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.3
Background: Through differentiation processes, keratinocytes provide a physical barrier to our bodies and control skin features such as moisturization, wrinkles and pigmentation. Keratinocyte differentiation is disturbed in several skin diseases such as psoriasis and atopic dermatitis. Objective: The aim of this study is to evaluate the keratinocyte differentiation-enhancing effect of rose absolute oil (RAO). Methods: Primary cultured human normal keratinocytes were treated with RAO, and differentiation then checked by the expression of marker genes. Results: RAO did not induce cytotoxicity on cultured keratinocytes at a dose of 10μM. The level of involucrin, an early marker for keratinocyte differentiation, was significantly increased by RAO. Concomitantly, RAO increased involucrin promoter activity, indicating that RAO increased involucrin gene expression at the mRNA level. Furthermore, RAO increased the level of filaggrin in cultured keratinocytes, and in the granular layer of mouse skin. In line with these results, RAO decreased the proliferation of keratinocytes cultured in vitro. When RAO was applied topically on the tape-stripped mouse skins, it accelerated the recovery of disturbed barrier function. Conclusion: These results suggest that RAO may be applicable for the control of skin texture and keratinocyte differentiation-related skin diseases. (Ann Dermatol 22(3) 255∼261, 2010)
Low Power Multiplier Design using Partial Product Reorder and Pass Transistor Delay Profile
Sang-Jin Hyun,Dong-Sun Kim,Tae-Ho Hwang,Yun-Sik Lee 대한전자공학회 2009 ITC-CSCC :International Technical Conference on Ci Vol.2009 No.7
This paper introduces a low power multiplier without deterioration of speed performance by the proposed algorithm for Power-delay-Product (PDP) and optimization through Complementary Pass Transistor Logic (CPL) synthesizer of circuit level. To demonstrate the performance of the proposed multiplier, a 24×24-bit multiplier is designed. PDP for proposed multiplier gets performance elevation than conventional pass transistor multipliers in a 0.35㎛ process by using the Matlab and HSPICE (level 28) simulations.
Hypoallergenic and Physicochemical Properties of the A2 β-Casein Fraction of Goat Milk
Tae-Hwan Jung,Hyo-Jeong Hwang,Sung-Seob Yun,Won-Jae Lee,Jin-Wook Kim,Ji-Yun Ahn,Woo-Min Jeon,Kyoung-Sik Han2.6* 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.6
Goat milk has a protein composition similar to that of breast milk and contains abundant nutrients, but its use in functional foods is rather limited in comparison to milk from other sources. The aim of this study was to prepare a goat A2 β-casein fraction with improved digestibility and hypoallergenic properties. We investigated the optimal conditions for the separation of A2 β-casein fraction from goat milk by pH adjustment to pH 4.4 and treating the casein suspension with calcium chloride (0.05 M for 1 h at 25°C). Selective reduction of β- lactoglobulin and αs-casein was confirmed using sodium dodecyl sulphate-polyacrylamide gel electrophoresis and reverse-phase high-performance liquid chromatography. The hypoallergenic property of A2 β-casein fraction was examined by measuring the release of histamine and tumor necrosis factor alpha from HMC-1 human mast cells exposed to different proteins, including A2 β-casein fraction. There was no significant difference in levels of both indicators between A2 β-casein treatment and the control (no protein treatment). The A2 β-casein fraction is abundant in essential amino acids, especially, branched-chain amino acids (leucine, valine, and isoleucine). The physicochemical properties of A2 β-casein fraction, including protein solubility and viscosity, are similar to those of bovine whole casein which is widely used as a protein source in various foods. Therefore, the goat A2 β-casein fraction may be useful as a food material with good digestibility and hypoallergenic properties for infants, the elderly, and people with metabolic disorders.