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Comparison of Diethyl Ether and Halothane as the Anesthetic Choice for Moderate Hypothermia
Lee, Sang Choon,Chung, Woon Hyok CATHOLIC MEDICAL CENTER 1974 Bulletin of the Clinical Research Institute Vol.2 No.1
Beginning about 1940, increased number of studies have been made on physio1ogical effects of cold. In 1930, Bigelow provided a tremendous impetus in the field of hypothermic anesthesia when they reported some experiments on oxygen utilization by dogs at low body temperatures. They had in mind the possibility of occluding circulation of the dogs for a period of long enough to do intra-cardiac operations by direct vision. The hypothermia, of course, was to permit brain tissue to live without damage with a minimum of oxygenation during that time. Since 1960, this hypothermic technic was introduced to our country and was applied to cardiac- and neuro-surgery, especially cerebral aneurysm surgery. But the disadvantages of this technic were noticed that it may enhance ventricular fibrillation, depress the respiratory center, change blood coagulation mechanism and other metabolic changes. Also, the time for occlusion of blood circulation was not enough for certain complicated surgical procedures. The introduction of pump oxygenator has precluded the use of this hypothermic technic in this country before the knowledge becomes far from complete. This technic is easily applicable to clinical patients without any sophisticated apparatus and still a valuable tools for the patients who undergo cardiac- and neuro-surgery. In the practical point of view, the choice of anesthetic agents to induce hypothermic anesthesia is important for the safety of patients. Currently, ether and halothane are the most frequently used agents for this purpose. Some are stressing the superiority of ether for the induction agent but ether has many disadvantages. Halothane may cause cardiac depression in deep anesthesia. The authors have studied the difference of ether and halothane in inducing the hypothermic state and rewarming after hypothermia.
Hyok Bu Kwon,Yunseok Choi,Joon Ho Lee,Sang Yun Jin,Beom Joon Kim,Seung Ho Lee,이애영 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-
Verrucous carcinoma is an unusual, non-metastasizing,distinct variant of squamous cell carcinoma composed of four subtypes according to the site of occurrence: oral type,anogenital type, plantar type, and other cutaneous sites. Oral type verrucous carcinoma usually shows slow progression with a low incidence of metastases. Treatment of verrcous carcinoma is challenging; multiple medical and surgical therapies are often attempted, with limited success. We reported on 2 cases of verrucous carcinoma of the lip treated with topical imiquimod and debulking therapy. (Ann Dermatol 23(S1) S68∼S71, 2011)
( Hyok Bu Kwon ),( Yun Seok Choi ),( Joon Ho Lee ),( Sang Yun Jin ),( Beom Joon Kim ),( Seung Ho Lee ),( Ai Young Lee ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.1S
Verrucous carcinoma is an unusual, non-metastasizing, distinct variant of squamous cell carcinoma composed of four subtypes according to the site of occurrence: oral type, anogenital type, plantar type, and other cutaneous sites. Oral type verrucous carcinoma usually shows slow progression with a low incidence of metastases. Treatment of verrcous carcinoma is challenging; multiple medical and surgical therapies are often attempted, with limited success. We reported on 2 cases of verrucous carcinoma of the lip treated with topical imiquimod and debulking therapy. (Ann Dermatol 23(S1) S68~S71, 2011)
( Sang Hyok Lim ),( Hong Woo Cheon ),( Ho Sung Lee ),( Jae Sung Choi ),( Ki Hyun Seo ),( Yong Hoon Kim ),( Ju Ock Na ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1
Metastatic squamous cell carcinoma of intrathoracic lymph node with cancer of unknown primary (CUP) is very rare. We report a case of metastatic squamous cell carcinoma of hilar lymph node with CUP and review of the associated literatures. Abnormal mass in the right hilar was incidentally detected. The patient was performed a right pneumonectomy and mediastinal lymph node dissection. Microscopically, metastatic squamous cell carcinoma at hilar lymph nodes without primary lung or other lesion was diagnosed. He has currently been received adjuvant chemotherapy under diagnosis of T0N1M0 Lung cancer.
Lee, Mi Hee,Kwon, Byeong-Ju,Seo, Hyok Jin,Yoo, Kyeong Eun,Kim, Min Sung,Koo, Min-Ah,Park, Jong-Chul Hindawi Publishing Corporation 2014 Oxidative medicine and cellular longevity Vol.2014 No.-
<P>Dedifferentiated vascular smooth muscle cells (VSMCs) are phenotypically modulated from the contractile state to the active synthetic state in the vessel wall. In this study, we investigated the effects of resveratrol on phenotype modulation by dedifferentiation and the intracellular signal transduction pathways of platelet derived growth factor-bb (PDGF-bb) in rat aortic vascular smooth muscle cells (RAOSMCs). Treatment of RAOSMCs with resveratrol showed dose-dependent inhibition of PDGF-bb-stimulated proliferation. Resveratrol treatment inhibited this phenotype change and disassembly of actin filaments and maintained the expression of contractile phenotype-related proteins such as calponin and smooth muscle actin-alpha in comparison with only PDGF-bb stimulated RAOSMC. Although PDGF stimulation elicited strong and detectable Akt and mTOR phosphorylations lasting for several hours, Akt activation was much weaker when PDGF was used with resveratrol. In contrast, resveratrol only slightly inhibited phosphorylations of 42/44 MAPK and p38 MAPK. In conclusion, RAOSMC dedifferentiation, phenotype, and proliferation rate were inhibited by resveratrol via interruption of the balance of Akt, 42/44MAPK, and p38MAPK pathway activation stimulated by PDGF-bb.</P>
Lee, Jin-Yong,Seol, Yun-Jae,Shin, Dong-Woo,Kim, Dae-Young,Chun, Hong-Woo,Kim, Bo-Young,Jeong, Shin-Ok,Lim, Sang-Hyok,Jang, An-Soo The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.1
The drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a severe adverse drug-induced reaction which includes a severe skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytes) and internal organ involvement. The most frequently reported drug was anticonvulsants. The diagnosis of DRESS syndrome is challenging because the pattern of cutaneous eruption and the types of organs involved are various. The treatments for DRESS syndrome are culprit drug withdrawal and corticosteroids. Here we report a 71-year-old man with skin eruption with eosinophilia and hepatic and renal involvement that appeared 4 weeks after he had taken anti-tuberculosis drugs (isoniazid, ethambutol, rifampicin, and pyrazinamide), and resolved after stopping anti-tuberculosis drugs and the administration of systemic corticosteroids. DRESS recurred after re-challenging isoniazid, we identified isoniazid was causative drug.