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뉴로메드정(옥시라세탐 800㎎)에 대한 뉴라세탐정의 생물학적동등성
최성업,김종석,윤미경,김정일,박석,한상범,이재휘,최영욱 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3
The purpose of the present study was designed to evaluate the bioequivalence of two oxiracetam tablets, Neuromed tablet (Korea Drug Co., reference drug) and Neuracetam tablet (Sam Jin Pharmaceutical Co., test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). Release of oxiracetam from the tablet in vitro was tested using KP Ⅷ Apparatus Ⅱ method with various dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty-four healthy volunteers, 23.7 ± 2.4 year in age and 68.9 ± 6.2 ㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was performed. After oral administration of a tablet containing 800 ㎎ of oxiracetam, blood samples were taken at predetermined time intervals and concentrations of oxiracetam in plasma were determined using HPLC-MS-MS. The dissolution profiles of two formulations were very similar at all dissolution media. In addition, pharmacokinetic parameters such as AUCt, C_(max) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, and C_(max), untransformed T_(max). The results showed that the differences between two formulations based on the reference drug were 0.42%, 0.45% and -12.58% for AUCt, C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were within the acceptance range of log 0.8 to log 1.25 (e.g., log0.94 ~ log1.06 and log 0.90 - log 1.07 for AUCt and C_(max), respectively), indicating that Neuracetam tablet is bioequivalent to Neuromed tablet. The major pharmacokinetic parameters, AUCt, and C_(max), met the criteria set by KFDA for bioequivalence indicating that Neuracetam tablet is bioequivalent to Neuromed tablet.
이건범,정회민,편영식,주상윤 한국공작기계학회 1998 한국생산제조학회지 Vol.7 No.1
In order to increase the modeling power and productivity of CAD/CAM systems, demands for customization of CAD/CAM system increased. Customization of a CAM system involves making it easier to learn and use, adding new modeling features not supported in a general purpose CAM system, and providing parametric inputting mechanisms. A customization from a commercial CAM system (OMEGA) has implemented for two dimensional free curve CNC glass scribing machine of medium size company in Cheonan. A CAD technician who has no CAM experience can operate this customized CAM system satisfactorily.
장성종,김병수,부귀범,김동규,박찬국,김만우,김정용,박상헌 조선대학교 부설 의학연구소 2000 The Medical Journal of Chosun University Vol.25 No.1
Pancreatic pseudocysts usually develop as a complication of acute pancreatitis or repeated attacks of chronic pancreatitis. Pseudocysts may also develop as a result of traumatic injuries or neoplasms. An uncommon complication is massive hemorrhage inside the pancreatic pseudocyst. The exact mechanism of hemorrhage is unknown. Enzymatic digestion, pressure erosion from the cyst mass or a combination of these processes may play an important role. Gastrointestinal hemorrhage associated with a pancreatic pseudocyst can occur in 10 percent of cases. When hemorrhage occurs because of erosion into a blood vessel involved in the pseudocyst, surgery is indicated since the episodes of hemorrhage are often severe and may even be fatal. When there is colonic involvement, various complications may occur. The most dangerous one is spontaneous rupture into the colon, which requires immediate surgical treatment because of high incidence of fulminating sepsis or massive hemorrhage. We examined a sixty eight-year-old man complaining of hematochezia and dizziness, and reported that it was a case of massive lower gastrointestinal hemorrhage caused by pseudocyst of the pancreas ruptured into the colon associated with chronic pancreatitis. On operative findings, the peripancreatic fatty tissue had severe adhesions to transverse colon and tail portion of pancreas, where the pseudocyst had formed. A distal pancreatectomy, splenectomy and resection of transverse colon were performed. By microscopic examination, hemorrhagic necrosis and inflammatory change were observed in the pancreas specimen. The tail portion of pancreas had a 6×6 cm sized cystic mass and was proven to be a pseudocyst with no epithelial lining.
멀티미디어 데이터를 위한 웹 서버 성능 개선에 대한 연구
최승교,안효범 三陟大學校 1999 論文集 Vol.32 No.1
The method for improving web service was proposed and implemented. But, the methods only proposed to reduce response time for typical data and did not consider to multimedia data. In this paper, We propose to a method for improving performance of web server which process multimedia data, and evaluate a proposed method with trace-driven simulation.
劉範植,趙成敏 안성산업대학교 1993 論文集 Vol.25 No.-
Many scholars studied about the consolidation character of clay through oedometer test to find out the various phenomena. These studies can be explained by Terzaghi's consolidation theory, the effective stress theory studied by Gibson and Mikasa, Hansbo's theory about critical hydraulic gradient and Mitchell's clogging phenomenon. These researches could not explain the consolidation behavior adequately because of the unskilled manufaturing techniques of test apparatus. So the research of one-dimensional consolidation using adequate consolidometer is needed to get the more precise results. This paper analyzes the one-dimensional consolidation behavior through the loading, unloading and reloading using the oedometer test and triaxial compression consolidometer Generally, it is hard to get the precise stress path and the consolidation behavior of the each part of the specimen by odeometer because of the effect of side friction and unsaturation. To reduce these problems, the specimen is saturated by the increase of the back pressure during the unloading. Using this specimen, the test of normal consolidation and overconsolidation is analyzed. The results strongly support the principle of effective stress. Under the normal consolidation, the coefficient of compression Cc is constant regardless of the loading stages, but the 24-hour compression curve is nonlinear under the overconsolidation. therefore, the constitutive equation under the normal consolidation can not be applied to that under the overconsolidation.