치조골 상실에 따른 상악 치아군 저항중심의 변화에 관한 유한요소해석

성상진,김인태,국윤아,전윤식,김성훈,모성서 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.5

효과적인 교정치료계획의 수립을 위하여 치열군의 저항중심의 위치에 대한 평가는 필수적이다. 이번 연구의 목적은 상악 치열군(4전치, 6전치, 14치아)에서 치조골 손실에 따른 저항중심의 위치변화를 조사해보고자 하였다. 상악 전치열 14개 치아와 치주인대 및 0 mm, 2 mm, 4 mm 손실된 치조골의 3차원 유한요소 모델을 제작하였고 각 치아군(4전치, 6전치, 14치아)별로 치관부를 협측, 설측호선 및 splint wire로 고정하여 치아군 모델을 제작한 후 상악 중절치의 절단연 중점에서 연장된 splint wire에 4전치와 6전치군에는 200 g, 14치아군에는 400 g의 후방 견인력과 압하력을 적용하여 저항중심의 수직적, 수평적 위치를 분석하였다. 4전치군에서 저항중심의 수직 위치는 치조골 0 mm, 2 mm, 4 mm 손실에 따라 중절치의 절단연에서 치근방향 13.5 mm, 14.5 mm, 15 mm, 수평 위치는 후방 12 mm, 12 mm, 12.5 mm, 6전치군에서는 치근방향 13.5 mm, 14.5 mm, 15.5 mm, 후방 14 mm, 14 mm, 14.5 mm, 14치아군에서는 치근방향 11 mm, 13 mm, 14.5 mm, 후방 26.5 mm, 27 mm, 25.5 mm에 위치하였다. 모든 치아군에서 저항중심은 치조골 손실에 따라 치근첨 방향으로 이동하였으나, 치조정과의 거리는 가까워졌고, 4전치군과 6전치군에서 저항중심은 치조골 손실에 따라 후방으로 이동하였으나, 14치아군에서는 치조골 2 mm 손실 시에는 후방으로 이동하였으나, 4 mm 손실 시에는 전방으로 이동하였다. Objective: The aim of this study was to investigate the changes in the center of resistance of the maxillary teeth in relation to alveolar bone loss. Methods: A finite element model, which included the upper dentition and periodontal ligament, was designed according to the amount of bone loss (0 mm, 2 mm, 4 mm). The teeth in each group were fixed with buccal and lingual arch wires and splint wires. Retraction and intrusion forces of 200 g for 4 and 6 anterior teeth groups and 400 g for the full dentition group were applied. Results: The centers of resistance were at 13.5 mm, 14.5 mm, 15 mm apical and 12 mm, 12 mm, 12.5 mm posterior in the 4 incisor group; 13.5 mm, 14.5 mm, 15 mm apical and 14 mm, 14 mm, 14.5 mm posterior in the 6 anterior teeth group; and 11 mm, 13 mm, 14.5 mm apical and 26.5 mm, 27 mm, 25.5 mm posterior in the full dentition group respectively according to 0 mm, 2 mm, 4 mm bone loss. Conclusions: The center of resistance shifted apically and posteriorly as alveolar bone loss increased in 4 and 6 anterior teeth groups. However, in the full dentition group, the center of resistance shifted apically and anteriorly in the 4 mm bone loss model.

흰쥐 젖샘신경으로 투사하는 중추신경내 Oxytocin 신경로에 관한 연구

백상호,강기동,김은아,조경제,최완성,이봉희 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

요양급여 적정성 평가체계 혁신 중장기 계획

김상지,전숙경,이창원,정영애,안재영,안유미,권아영,임상희,최정남,윤미선,변의형,조미현 건강보험심사평가원 2021 HIRA RESEARCH Vol.1 No.2

개 비장 질환의 미세세침흡입술을 통한 세포병리학 검사 4례

김현아,윤기영,최호정,정성목,이영원,조성환,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

To evaluate the accuracy and diagnostic significance of cytopathological diagnosis of canine splenic disorders, cytopathological examination throgh fine-needle aspiration(FNA) referred to Veterinary Medical Teaching Hospital of Chungnam National University were retrospectived. Splenic neoplasm, hemolymphatic neoplasm, hyperplasia, extramedullary hematopoiesis and splenitis were diagnosed canine splenic disorders through cytopathological examination. The patient should be identified what coagulation profile are normal before aspiration, because complication such as hemorrhage could happen. The 4 cases were identified symmetric, asymmetric splenomegaly on abdominal ultrasonography and then were performed ultrasound-guided FNA. The 4 cases were diagnosed hemangiosarcoma(2), hyperplasia(1) and extramedullary hematopoiesis(1) by clinical signs, hematological examination, and cytopathological examination. Cytopathological examination through FNA was cost-effective, no gneral anesthesia, no complication, and non-invasive method of diagnosis for canine splenic disorders.

'프로세스 가능성'으로 정의된 디지털 건축의 구현 및 활용방법에 관한 기초적 연구 : An Operational Framework for Producing and Consuming Digital Building Products on the Internet

김성아,서기영,최윤 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

This study starts from a critical thinking that the meaning of digital architecture may or should be redefined in order for the research in computer aided architectural design to situate itself within the realm of design science. The meaning of digital architecture has been confused with the characteristics of the digital model in a sense. Thus, we criticize the nature of digital architecture revealed in design cases, then move to its definitions, and finally propose a framework of building digital architecture. This research is not to suggest an ism or even to discuss the trends of design practice, but to propose a structure of digital architecture. We analyze the differences between physical architecture and digital model, and finally formulate the concept of digital architecture. In order for the digital architecture to become a vehicle of design research as well as design practice while the cyber architecture is becoming a hype or buzzword, we argue that it has to feature fundamentally different role of representation from its physical counterpart, or the digital models so far. As a result, we propose the "process-ability" as the most important nature of the digital architecture. In order to facilitate the production and consumption of the digital architecture, we introduce the concept of semantic web and ontology from the recent advances in information technology. We illustrate a system architecture which integrate the digital architecture into the concept of semantic web, thus proposing an operational framework of producing and consuming digital building product on the Internet.

한국인 부정교합자의 하악 치열궁의 크기와 형태

이성준,백승학,김상철,국윤아 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.1

본 연구의 목적은 한국인 부정교합자에서 하악 치열궁간의 형태적 차이를 알아보고자 하였다. Ⅰ급 114명. Ⅱ급 119명, Ⅲ급 135명의 부정교합자를 대상으로 하악 모형의 교합면을 복사한 후 13개의 접촉점 중에서 가장 협측면으로 위치한 부분을 digitize 하였고 각 치아의 브라켓 위치에 해당하는 점을 하악치아의 두께에 의거하여 4개의 선계측과 2개의 비율을 측정하였다. 치열궁의 형태는 square ovoid, tapered형으로 분류하여 그 빈도를 조사한 결과 Angle 분류와 남녀 성별에 따른 특별한 치열궁 형태가 존재하지 않았으나, 특정 치열궁 형태의 빈도는 Angle 분류에 따라 다르게 나타났다. 치열궁 크기의 계측항목에서는 대구치간 폭경에서만 남녀 성별 차이를 보였으며, 치열궁 크기에 있어서 Ⅰ급과 Ⅲ급, Ⅱ급 부정교합군간에는 유의한 차이가 있었다. 치열궁 형태의 분포는 Ⅰ급과 Ⅲ급 부정교합군에서는 square, ovoid, tapered 형태 순이었고, Ⅱ급 부정교합군은 square, tapered ovoid 형태 순이었다. 치열궁 형태의 빈도분포에 있어서는 남녀간의 차이는 없었다. The purpose of this study was to clarify morphological differences among mandibular dental arch forms in Korean malocclusion patients. The sample in this study consisted of 114 Class Ⅰ, 119 Class Ⅱ, and 135 Class Ⅲ malocclusion cases. The most facial portions of 13 proximal contact areas were digitized from photocopied images of the mandibular dental arches. Clinical bracket points were calculated for each tooth based on the data of the mandibular tooth thickness. Four linear and two proportional measurements were undertaken. The dental arches were classified into square, ovoid, and tapered forms to compare the frequency distributions. Our results suggested that there was no single arch form specific to any particular Angle classification or sex. It appeared to be the frequency of a particular arch form that varies among the Angle classifications. In comparison of arch measure between male and female, there was no statistical difference except in the intermolar width. In comparison of arch size measurements among the different Angle classifications, there were statistically significant differences between Class Ⅰ and Class Ⅲ malocclusion groups and between Class Ⅱ and Class Ⅲ malocclusion groups. In comparison of frequency distribution of arch forms in Class Ⅰ and Ⅲ malocclusion groups, the square form demonstrated the highest distribution followed by the ovoid and tapered forms in that order. In the Class Ⅱ malocclusion group, the square form showed the highest distribution, followed by the tapered and ovoid forms in that order. There was no statistical difference in the frequency distribution of arch forms between male and female groups.

특정 세균으로 유도된 백서의 치수염에서 T 세포 아군집의 분포와 interleukin-2, interferon-γ, interleukin-4의 수준에 관한 연구

김선아,임성삼 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.1

Immune response associated with bacterial infection involve inflammatory cells. Clinical symptoms and pathologic features are particularly influenced by the predominant cells. Among inflammatory cells. T cells have the heterogenity. T cells may develop into the mature cell expressing the cell surface markers with different functions and T helper cells are categorized into Th1 and Th2 cells based on their different patterns of cytokine production. The objective of this study was to investigate the change of expression of surface markers on T cells and the Th1/Th2 immune response in pulpal inflammation associated with specific bacteria. We experimentally induced pulpal inflammation in rat incisors by drilling without coolant and innoculated with Streptococcus mutans (S.M. group), Porphyromonas endodontalis (P.E.group), or only sterile cotton (control group). After 1, 2, and 5 days, mandibular incisors were extracted and the pulptissues were extirpated. The expressions of IL-2 recepters (CD25) and ICAM-1 (CD-54) on CD4+ and CD8+ cells in the pulps were determined using a flow cytometer, and the concentration of IL-2, IFN-γ, and IL-4 was measured by enzyme-linked immunosorbent assay. The results were as follows; 1. In the S.M.group. CD4+ cells were more increased at 2nd day than 1st day and in the P.E.group, CD8+ cells were more increased at 2nd day than 1st day. 2. The percentages of CD4+, CD4+25+ and CD4_54+ cells were decreased in the pulp tissues at 5th day after irritation in all groups. 3. The ratios of CD4+/CD8+, CD4+/CD4+25+ and CD4+/CD4+54+ in the pulps at 2nd day after irritation by P.endodontalis were significantly lower than the other groups. 4. The higher concentrations of IFN-γ than IL-4 in the pulps at 2nd day after irritation by P.endodontalis showed that T helper 1 reaction were predominant in the early stage of the pulpal in flammation induced by P.endodontalis. 5. The higher concentrations of IL-4 than IFN-γ in the pulps at 1st day and 5th day after irritation by S.mutans were measured but the differences were not significant.

수종의 니켈-티타늄 폐쇄형 코일 스프링의 하중-변위 특성 및 소성 변형 비교

손아영,임성훈 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.5

Objective: NiTi closed coil springs were reported to have relatively constant unloading forces. However, the characteristics of NiTi closed coil springs from various manufacturers have not been elucidated. The purpose of this study was to compare load-deflection characteristics of various NiTi closed coil springs and to find out the optimal range of extension. Methods: Seven kinds of NiTi closed coil springs from five manufacturers were tested. Load deflection curves were obtained at extension ranges from 2 mm to 30 mm. Also, springs were kept extended during a 4 week period, and then load deflection curves were obtained again. Results: Sentalloy (Tomy) and Jinsung blue (Jinsung) showed superelasticity in every extension ranges tested and showed plastic deformation of less than 1 mm. Ni-Ti (Ormco) showed superelasticity only after the springs were extended at or more than 10 mm, thereby meaning that clinicians should extend these springs at or more than 10 mm to utilize the superelasticity. Orthonol (RMO) and Nitanium (Ortho Organizers) did not show superelasticity. After 4 weeks of extension, all springs showed plastic deformation less than 1 mm when the extension was at or under 25 mm. Conclusions: The superelastic behavior of NiTi closed springs were different among various NiTi spring products, and some NiTi closed springs failed to show superelasticity. 폐쇄형 니켈-티타늄 코일 스프링은 탈부하 과정에서 힘이 거의 일정하게 유지되는 초탄성을 보이는 것으로 알려져있으나, 각 제조사에 따른 니켈-티타늄 스프링의 실제 특성에 대한 보고는 부족하다. 따라서 본 연구에서는 수종의 폐쇄형 니켈-티타늄 코일 스프링들의 하중-변위 특성과 소성 변형에 대해 비교하고 임상적으로 적용 가능한 신장 범위에 대해서 알아보고자 하였다. 다섯 개 제조회사에서 생산된 일곱 종의 폐쇄형 니켈-티타늄 코일 스프링을 각 종류별로 2 mm, 5 mm, 10 mm, 15 mm, 20 mm, 25 mm, 30 mm로 신장시켜 하중-변위 곡선을 얻은 후 같은 길이로 4주간 유지시킨 후 다시 하중-변위 곡선을 얻었다. 실험 결과 Sentalloy (Tomy, Tokyo, Japan), Jinsung (Jinsung, Seoul, Korea)은 모든 범위에서 초탄성을 나타내며 영구변형도 1 mm 이하로 작아 가장 바람직한 물성을 보였다. 반면 Ni-Ti (Ormco, Orange, CA, USA)는 10 mm부터 초탄성 구간을 보였는데, 이는 이러한 스프링을 적용 시에는 10 mm 이상 신장시켜야 초탄성 성질을 활용할 수 있다는 것을 의미한다. Orthonol (RMO, Denver, CO, USA)과 Nitanium (Ortho Oganizers, San Marcos, CA, USA)은 초탄성을 보이지 않았다. 4주 동안 신장 후의 소성 변형 정도를 측정한 결과 25 mm 이내의 신장 범위에서는 1 mm 이하의 소성 변형만이 나타났다. 폐쇄형 니켈-티타늄 코일스프링의 초탄성 성질은 제조사에 따라 다양하게 나타났으므로, 임상 적용 시 이를 고려하는 것이 바람직하다.

치면열구전색제 도표 후 광중합 할 때까지의 경과시간이 전색제 침투에 미치는 영향

최선아,이창섭,이상호,이난영 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3

치면열구전색제 도포 후 시간에 따른 열구 내 침투율을 알아보고자 발치된 소구치 192개를 이용하여 전색제 도포 후 광중합 할 때까지 경과시간 3초, 5초, 10초, 20초별로 침투율을 비교 분석하였다. 여기에 추가적으로 상악과 하악, filled sealant와 unfilled sealant군으로 나누어 시간대별로 침투율에 차이가 있는지도 비교분석하였다. 그 결과 시간이 경과할수록, filled sealant군보다 unfilled sealant군에서, 상악보다는 하악에서 전색제의 침투율이 증가하였다. 이상의 결과에서 임상에서 치면열구전색을 시행할 때 이 결과를 임상적 지침으로 적용하면 유용하리라고 여겨진다. Occlusal fissures and pits are ideal places for the development of caries. Pit and fissure sealants are now considered as a very effective means to prevent dental caries. The purpose of this investigation was to examine the effect on the sealant penetration of the elapse of time from the application of sealant until exposure to visible light, and to examine the effect of the filler content and tooth position on the sealant penetration. 192 extracted human premolars were used to this experiment. Following enamel conditioning, a light-polymerized sealant was applied and 4 different periods of time(3, 5, 10, 20 seconds) were allowed until exposure to the light source. The results obtained were as follows: 1. According to time, in both unfilled sealant and filled sealant penetration increases deeply through mindfulness. 2. Sealant that apply to mandiblar premolar penetrated deeply through than to maxillay teeth. 3. Penetration difference according to filler content, unfilled sealant penetrated deeply through than filled sealant. The result from this study indicated that unfilled sealant penetrated most deeply in mandible when at least 20s time elapsed.

식중독 세균 5속을 검출하기 위한 4개 주요 REP-PCR 반응성분의 최적화

서현아,박성희,송대식,김근성 한국산업식품공학회 2003 산업 식품공학 Vol.7 No.4

반복성 염기서열을 응용한 PCR법인 REP-PCR을 사용하여 식중독 미생물의 분리와 동정을 위한 연구에 적용하기 위하여 주요 식중독 유발세균 5속(genus), 6종의 균주를 사용하여 실험을 실시하였다. PCR 구성성분인 MgCl₂, dNTPs, REP sequence primer, 주형 DNA의 농도를 최적화하기 위한 연구 결과, MgCl₂의 농도가 2.0mN과 2.5mN일 때, 균주들의 fingerprinting pattern의 변화가 없거나 적은 것으로 관찰되어, 모든 속의 균주를 단일조건으로 분리?동정하기 위해서 MgCl₂의 농도는 2.5mN이 최적인 것으로 결론을 내렸다. dNTPs는 50μM의 농도를 적용하였을 때부터 전체 fingertprinting pattern범위의 주 단편들을 나타내는 균주들도 있었으나 총 단편의 수가 완벽하게 나타나지는 않았고, 200μM의 적용시점에서 6종의 균주 모두 단편의 수나 강도의 변화가 관찰되지 않았기 때문에 fingerprinting pattern의 파악을 위한 목적에는 200μM의 dNTPs 농도만으로도 충분하였다. REP primer는 적용한 농도가 증가함에 따라 단편의 수와 강도가 증가하였으며 Vibrio를 제외한 5종의 균주가 2.0μM의 primer를 적용했을 때 고유한 fingerprinting pattern을 나타냈다. 주형 DNA의 양을 변화시켜 적용하였을 때 DNA 양의 비율이 2배에서 5배까지 증가하여도 초기 미량 적용 시 생성되었던 fingerprinting pattern은 많은 차이를 보이지는 않았다. 그러나 적용되는 DNA 양에 따라 단편들의 강도와 수가 약간씩 점증하는 양상을 보였다. This experiment was conducted to optimize REP(repetitve extragenic palindromic sequence)-PCR reaction conditions in order to simultaneously differentiate the five different foodborne pathogenic bacterial genera of Escherichia, Salmonella, Shigella, Vibrio and Listeria. The four major PCR cocktail components of MgCl₂, dNTPs, primers and teplate DNA were considered and their optimum concentrations were determined using six reference strains. the optimized condentration of MgCl₂ was determined to be 2.5 mM in order to obtatin a consistent fingerprinting pattern. The similar fingerprinting pattern was obtatined when REP primers and dNTPs were added up to the concentration of 2μM and 200μM, respectively. As for template DNA, the numbers of PCR fragments were not mostly affected, but their intensities were slightly increased as the concentrations of the DNA were increased from 2 times to 5 times.