各種 進行癌에 대한 Cisplatin의 抗癌效果 및 毒性에 關한 硏究

金三溶,金仙英 충남대학교 의과대학 지역사회의학연구소 1983 충남의대잡지 Vol.10 No.2

10 cases of advanced cancer patients were admitted and treated at Chungnam National University Hospital during the period July 1982 till October 1983 with combination chemotherapy containing cisplatin. Among 8 cases of lung caner, 1 each showed complete remission or partial remission and 3 each cases showed stable disease or progressive disease. Their survival ranged 8-42 weeks. 1 case of head and neck cancer and 1 case of endometrial cancer had partial remission respectively, so that among a total of 10 cases 4(40%) showed major response and 3 showed stable disease. A major side effect of cisplatin, nausea and vomiting were effectively prevented by high dose methylprednisolone administration. One case showed decrease of platelet count (61,000/㎣) and tetany during chemotherapy, but otherwise no patient showed elevation of serum creatinine or major toxicities.

성공적인 임플란트시술을 위한 방사선검사

이삼선,최순철 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

Recently implant has become an important field in dental clinic. Radiographic examination of pre- and postoperation is essential for successful treatment. Clinicians should have knowledge about the purpose of the radiographic examination, suitable imaging modality for the cases, anatomic landmarks of tooth and jaw bone, advantage and limitation of panoramic radiographic examination for implant, principle and interpretation of crosssectional imaging, bone mineral density, post-operative radiographic examination. This paper will be helpful to get above informations for dentists who want to do dental implant successfully.

치과에서의 방사선안전관리

이삼선 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.3

Although the diagnostic information provided by radiographs may be of definite benefit to the patients, the radio-graphic examination does carry the potential for harm from exposure to ionizing radiation. Therefore we should try to expose radiation as low as reasonably achievable and to give diagnostic information to patients as much as possible. All of dentists should have competence in radiation protection, I wish to deal with what we should do for the optimization of radiation protection in dental clinic.

교육용 송풍기의 개량과 그에 따른 특성 연구

승삼선,유신오,노경호 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.1

In this study, open type wind tunnel has been restructured instead air blower. its designed and fabricated part are diffuser. settling chamber with screen, contraction or nozzle, and test section. Also inverter enable to control variable speeds. And basic experiments have been performed to check the flow characteristics for restructured open type wind tunnel. In these procedures, we have got some conclusion. the control of contraction is valid for X = 0.40 considering Morel's and Fang's suggestion. it is confirmed that the two pressure coefficients for avoiding separation is satisfied with Fang's result. Distribution of uniform velocity in test section are stabilized above 95~99%.

발열체가 설치된 정육면체 공간내의 공기 및 이산화탄소에 의한 자연대류-복사 열전달 실험 연구

승삼선,이창형,이경영 三陟大學校 2000 論文集 Vol.33 No.1

Heat transfer by radiation is an important phenomena in industrial furnaces, combustors, and other high temperature thermal systems. Development of the numerical modeling schemes for the radiative transfer usually rely on the measured data for a well defined experimental system. It is the purpose of this paper to acquire measured heat transfer data where the effect of the radiative transfer is significant. We considered a closed enclosure filled with the two different gases; air and carbon dioxide. The natural convention an surface radiation are responsible for the heat transfer mechanism for the air, while the natural convention and the volumetric radiative transfer are important to the heat transfer mechanism for the carbon dioxide. The measured temerature distributions show that the carbon dioxide results in the higher temperature distibutions in the cold regions while the air results in the higher temperature distirbutions in the hot regions. The same trend is observed to be amplified as the heater temperature increased.

열원이 있는 정육면체 공간내의 공기 및 이산화탄소에 의한 자연대류-복사 열전달 수치해석

승삼선,이창형 三陟大學校 2001 論文集 Vol.34 No.1

In this study, natural convection-radiation heat transfer of air and CO2 gas in cubic enclosure is investigated numerically. The numerical results show that temperature profile is up about 5~15% compared with experimental results. But the trend for temperature profile is similar to experimental results. That means that the natural convection and surface radiation are responsible for the air, while the natural convection and volumetric radiative transfer are important to the heat transfer mechanism for the carbon dioxide.

방사선조사 후 유표피암종세포내 칼슘농도의 변화와 apoptosis 발현에 관한 연구

이삼선,문제운,허민석,박태원,유동수,최순철 大韓口腔顎顔面 放射線學會 1999 Imaging Science in Dentistry Vol.29 No.1

Purpose: Ionizing radiations have been reported as an apoptosis initiating stimulus in various cells and it has established that sustained elevations in [Ca²+] can lead to DNA fragmentation by Ca²+-dependent endonucleases, ultimately resulting in apoptotic cell death. The previous experiments have been reported by using primarily thymocytes and lymphocytes and the change of [Ca²+] was measured only by minutes or hours respectively. We need to evaluate [Ca²+] in both several minutes and hours after irradiation of radiation of radiation therapy and verify the apoptotic cells. Materials and Methods: We have measured [Ca²+] in human gingival epitheloid cancer cell with 10 Gy irradiation, at minutely intervals and hourly intervals using digitized video-intensified fluorescence microscopy and the fluorescent Ca²+ indicator dye, fura-2. In order to find out that the transient rise in [Ca²+] could induced apoptosis, cells were incubated for 1 hour at 37℃ with TdT enzyme, rinsed and resuspended containing fluorescence and observed under a confocal fluorescence microscope. MTT assay was done to determine cell activity and LDH assay was done to determine the amount of necrotic cells. Results: After irradiation, the transient and temporal increasing of [Ca²+] in the KB cells was founded. Though, there was no change in the intracellular [Ca²+] at 30 minutes and 2 hours after irradiation. We could detect of DNA fragmented cells at 4 hours after 10 Gy irradiated cells. There were no significant differences between 4 hour, 1 day, 3 day cells. There were no significant differences in MTT and LDH assay between the irradiated group and the control group after 4 hours and 1 day. Though after 3 days there were differences in MTT and LDH assay between the irradiated group was significantly decreased than the control group, in LDH assay the number of necrotic cell death of the irradiated was higher than the control group. Conclusion: In KB cells there were incipient and temporal increasing of the [Ca²+] with 10 Gy irradiation and the apoptosis was founded from 4 hours later which was earlier than seeing of the change of the amount of the cellular ability and necrosis.(J Korean Oral Maxillofac Radiol 1999:29:109-117)

구개열환자의 상악동발육과 비중격전위에 관한 방사선학적 연구

이삼선,유동수 大韓口腔顎顔面 放射線學會 1992 Imaging Science in Dentistry Vol.22 No.2

This study was designed to investigate the effects of the maxillary sinus development and nasal septum deviation on diseases of maxillary sinus with cleft palate. The materials was 152 cephalometric Waters' projections consist of 76 cleft patients and 76 normal subjects. The results were as follows ; 1. The disease of maxillary sinus was present in 49% of a cleft group and 14% of control group, and prevalent in cleft side. 2. It showed no statistically significant difference in size of the maxillary sinus in cleft plate patients compared to the control population and in the cleft side to the noncleft side(p<0.05) 3. Nasal septum deviation was more severe in the cleft patient its average value was 3.55mm, compared to the control group, 0.99mm(p<0.01) and 77% of the deviated nasal septum was deviated to the cleft side.

일부 자동차 공장 근로자들의 職業的 特性과 社會 心理的 Stress의 相關性 硏究

김성삼,홍지우,한현정,최희석,권소희,정해경,김삼태,송용선,이기남 한국전통의학연구소 2004 한국전통의학지 Vol.14 No.1

〈Objective〉 This study were carried out to study to assess the relationship between job characteristics, general characteristics, health behaviors, and psychosocial distress and suggested the preventive oriental medicine approaches in occupational health area. 〈Methods〉 We measured job characteristics(job demand, job control, jop insecurity) by The Karasek's Job Content Questionnaire, health behaviors(smoking, drinking, exercise, coffee), general characteristics at work by a self-administered questionnaire. Psycho social distress was measured by PWI(Psychosocial Well-being Index), a 18-item self- administered instrument. 370 data for research were collected through the process of oriental health examination with questionnaire in workplace. Statistical analysis was done by t test, oneway ANOVA, and hierarchical multiple regression analysis with SPSSWIN (version 10.0) 〈Results〉 Among the 152 respondents, the prevalence of high job strain was 27%(41 persons). The Odds ratio of high job strain was 3.11(95 2.12~4.11), and those of passive group and active group were 2.01(95 0.83~2.76) and 1.80(95 0.83~2.76), respectively. Our results supported the association between psychosocial distress and job strain. 〈Conclusion〉 The odds ratio of high strain isolated group(high strain group+low social support) was 3.59(95 2.05 5.13), but the odds ratio of high strain collective group was 1.32(95 0.23 2.41). Social support at work was modifing factor of the association between psycho social distress and job strain. Therefore we reviewed the evidence that economic depression was associated with psycho social distress in this study, and that the strength of the social support was important in maintain health.

Saccharomyces uvarum의 인지질 생합성 및 지방산 조성에 미치는 탄소원의 효과에 관하여

이종삼,김선혜 성신여자대학교기초과학연구소 1988 基礎科學硏究誌 Vol.5 No.-

Saccharomyces uvarum을 30℃에서 Knopp's 최소배지에 자당결핍과 자당고농도 처리(15%)을 하여 배양시켰다. 이들 세포의 생장과 인지질 및 지방산 조성에 미치는 탄소원의 효과를 조사하기 위하여 배양 기간중 4, 7일 간격으로 일정량의 세포를 수확하여 생장률과 이에 따른 함량을 조사하였다. 자당 고농도 처리구는 배양 4일째에 생장감소 효과를 나타내었으며, 자당결핍구는 배양기간동안 세포생장을 관찰할 수 없었다. 주요 인지질의 지방산 palmitic acid와 oleic acid로 주로 이용되었으며, PC, PE에서는 대조구에 비하여 oleic acid가 조성상 급격한 이용의 증가를 나타내었다. Saccharomyces uvarum was cultured in the Knopp's media of the sucrose absence and the sucrose excess. In order to observe the effect of sucrose as carbon source on biosynthesis of phospholipids in these cells and the compositions of fatty acids, the cells were harvested at 4 and 7 days intervals of cultivations after inoculation. The growth rate at sucrose excess was decreased at 4 days of cultivation, but the growth rate of sucrose absence was not increase during whole period of cultivation. The fatty acids in major phospholipids were composed of palmitic acid and oleic acid. The amount of oleic acid in phosphatidylethanolamine and phosphatidylcholine was markedly increased to compared with those of the control.