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      • Isotope Programming Model for Context aware Application

        Qi Saiyu,Xi Min,Qi Yong 보안공학연구지원센터 2007 International Journal of Software Engineering and Vol.1 No.1

        The context-aware application’s main feature is that the program can adjust its behavior according to the context environment. In the traditional object-oriented model, behaviors related to the context may be separated through branching statement, thus greatly reducing the degree of adaptation to environmental changes. This paper, after analyzing the issue of programming context-aware applications through the object-oriented model, puts forward Isotope Programming Model(IPM), which enlarges the concept of object and converts the object from the aggregation of attribute and behavior into the aggregation of attribute and a series of behavior code documents directed to different context. The analysis of IPM performances reveals that IPM model provides better adaptability for application development than the object-oriented model, and reduces environmental changes' impact. This paper also proposes the reason of isotope element’s conflict and gives the resolve method for the conflicts, which can make the IPM model more effective.

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        Efficacy of Sublingual Immunotherapy for House Dust Mite-Induced Allergic Rhinitis: A Meta-Analysis of Randomized Controlled Trials

        Bohai Feng,Haijie Xiang,Haiyong Jin,Jinjian Gao,Saiyu Huang,Yunbin Shi,Ruru Chen,Bobei Chen 대한천식알레르기학회 2017 Allergy, Asthma & Immunology Research Vol.9 No.3

        Purpose: Allergic rhinitis (AR) has become a global issue for a large part of the general population. Sublingual immunotherapy (SLIT) has been used extensively to treat persistent allergic rhinitis (PAR). Although systematic reviews have confirmed the effectiveness of SLIT for the treatment of AR, a considerable number of studies using extracts of house dust mites (HDMs) for immunotherapy found no consensus on basic treatment parameters and questioned the efficacy of SLIT. Methods: In this study, we evaluated SLIT for PAR by a meta-analysis of randomized controlled trials (RCTs). Medline, Embase, and Cochrane Library database searches were performed for RCTs on the treatment of PAR by SLIT that assessed clinical outcomes related to efficacy through May 2016. Descriptive and quantitative information was abstracted. An analysis was performed with standardized mean differences (SMDs) under a fixed or random effects model. Subgroup analyses were performed. Heterogeneity was assessed using the I2 metric. Results: In total, 25 studies were eligible for inclusion in the meta-analysis for symptom scores and 15 studies for medication scores. SLIT was significantly different from the controls for symptom scores (SMD=1.23; 95% confidence interval [CI]=1.74 to 0.73; P<0.001). For medication scores, significant differences for SLIT were also observed versus the controls (SMD=-1.39; 95% CI=-1.90 to -0.88; P<0.001). Conclusions: Our meta-analysis indicates that SLIT provided significant symptom relief and reduced the need for medications in PAR. In this study, significant evidence was obtained despite heterogeneity with regard to the use of mite extract. Specifically, the mite extract used was provided by the patients with PAR. Furthermore, to confirm both the objective outcomes and the effective doses of HDM allergen extracts, experimental data should be obtained from large high-quality population-based studies.

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