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김경희, 강은주, 박샘이 신라대학교 부산학연구센터 2019 부산연구 Vol.17 No.2
본 연구는 지역관련 지식정보를 수집· 제공하고 있는 부산과 인천 공공도서관 중 대표적인 지역 관련 프로그램 비교분석을 통하여 유용성 및 시사점을 도출하고자 하였다. 연구방법은 문헌 및 현 장 연구와 기초데이터를 수집한 후, 비교분석을 위한 데이터는 부산과 인천 공공도서관 프로그램 사서와 협업하여 분류 · 처리하였다. 우선 지역관련 프로그램을 운영하기 위한 가용자원은 인천광 역시교육청화도진도서관이 많았고, 프로그램 다양성은 부산광역시립중앙도서관이 풍부하였다. 비 교분석 결과, 프로그램은 부산광역시립중앙도서관은 개항 · 근대, 지역의 미래, 역사 · 문화에 대한 주 내용과 함께 경제 · 정치 외 철학을 내용으로 하는 특성이 나타났고, 인천광역시교육청화도진도 서관은 화교(중국), 자연, 역사 · 문화에 대한 주 내용과 함께 언론을 내용으로 하는 특성이 나타 났다. 또 2015-2019년 운영을 통하여 구축된 인력풀은 부산광역시립중앙도서관은 지역대학교수 인력풀이 구축되어 부산학의 학문적 체계성 지향으로 나타났고, 도서관에서 양성된 지역문화해설 사가 사서와 함께 주요인력으로 운영되었다. 반면 인천광역시교육청화도진도서관은 사서 및 지역 연구가의 활동이 높았다. 향후 지역 문화기반시설 중 가장 이용률이 높고 친숙한 장소이자 지역 지식정보의 보고(寶庫) · 이야기주머니인 공공도서관은 지역관련 프로그램을 통하여 지역 정체성 및 공동체 회복, 지역의 미래에 대해 소통 · 공론의 광장으로 역할을 수행하기 위해서 지역관련 지 식정보와 장서 · 인력풀을 기반으로 다양하고 체계화된 프로그램을 기획 · 개발 · 운영해야 한다.
Severe adenovirus pneumonia in young military man: a case report
( Saem Na Lee ),( Ji Yun Noh ),( Min Joo Choi ),( Jin Gu Yoon ),( Ji Ho Jeon ),( Eun Ju Jung ),( Seonghui Kang ),( Joon Young Song ),( Hee Jin Cheong ),( Woo Joo Kim ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Human adenoviruses (HAdVs) is a common cause of acute upper respiratory tract infection in adults, but it rarely causes respiratory failure or septic shock, severe and life-threatening infection. Although severe adenovirus pneumonia is well described in neonates, young children, and immunocompromised hosts, it is relatively unusual in healthy adults. Outbreaks of HAdV pneumonia have been described in military and long term care settings. Herein, we report an adenovirus pneumonia case in a previously healthy young military man referred from a military hospital, who needed a care in ICU. A 19-year-old healthy male patient who was in a military training session referred from military hospital due to fever with aggravated respiratory symptoms. His initial chest X ray showed air-space consolidation and centrilobular densities were on both lungs, mainly RLL. Comparing the previous chest images taken in military hospital, his pneumonia was aggravated in only a few days. Ceftriaxone and levofloxacin were given to the patient.. On hospital day 3, the result of respiratory virus PCR was reported, and all other respiratory virus were negative except adenovirus. Though antibiotics administered continuously to cover concomitant bacterial infection, there was no evidence of any bacterial infection in all respiratory specimen including broncho-alveloar lavage fluid and induced sputum. His symptom and pneumonic infiltration became with supportive cares, finally he discharged without any respiratory sequelae. In a military, among the young soldiers, outbreak of adenovirus has been reported. This case emphasizes that surveillance for respiratory illness is required in a military, because adenovirus infection can presented with severe pneumonia especially among military trainees.
Targeting Acetate Kinase: Inhibitors as Potential Bacteriostatics
( Saeme Asgari ),( Parvin Shariati ),( Azadeh Ebrahim Habibi ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.11
Despite the importance of acetate kinase in the metabolism of bacteria, limited structural studies have been carried out on this enzyme. In this study, a three-dimensional structure of the Escherichia coli acetate kinase was constructed by use of molecular modeling methods. In the next stage, by considering the structure of the catalytic intermediate, trifluoroethanol (TFE) and trifluoroethyl butyrate were proposed as potential inhibitors of the enzyme. The putative binding mode of these compounds was studied with the use of a docking program, which revealed that they can fit well into the enzyme. To study the role of these potential enzyme inhibitors in the metabolic pathway of E. coli, their effects on the growth of this bacterium were studied. The results showed that growth was considerably reduced in the presence of these inhibitors. Changes in the profile of the metabolic products were studied by proton nuclear magnetic resonance spectroscopy. Remarkable changes were observed in the quantity of acetate, but other products were less altered. In this study, inhibition of growth by the two inhibitors as reflected by a change in the metabolism of E. coli suggests the potential use of these compounds (particularly TFE) as bacteriostatic agents.
Determination of hesperidin in mixed tea by HPLC
Saem Han(한샘),So-Youn Mok(목소연),Hye-Min Kim(김혜민),Jeong-Min Lee(이정민),Dong Gu Lee(이동구),Sook-Young Lee(이숙영),Jongkee Kim(김종기),Sun-Ju Kim(김선주),Sanghyun Lee(이상현) 충남대학교 농업과학연구소 2011 농업과학연구 Vol.38 No.2
The content of hesperidin in the mixed tea, which was composed of dried orange peel, laurel leaf, mulberry leaf, silver magnolia leaf, oriental melon tap, cassia seed, and licorice root, was determined by high performance liquid chromatography (HPLC). Hesperidin was quantified by a reverse phase column with gradient solvent system (watcr:acetonitrile = 80:20 to 35:65 for 30 min) and UV/VIS detection (280 ㎚). The How rate was kept constant at 1.0 ㎖/min. The content of hesperidin in the mixed tea was measured in depending on extraction time 1, 2, 3, and 4 min (29.07, 52.39, 52.45, and 88.35 ㎎/g, respectively).
( Han Saem Kim ),( Jae Yun Lim ),( Ju Yeon Choi ),( Jung In Kim ),( Jung Min ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Ho Joo Jung ),( Jae Hui Nam ),( Ga Young Lee ),( Won Serk Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Although alopecia areata (AA) shows a high rate of spontaneous remission, there are many treatment options applied for rapid clinical results. Intralesional corticosteroid is first-line therapy for patients with less than 50% scalp involvement. Most studies with intralesional corticosteroid reported 60-75% of patients experienced hair regrowth within 4 months. However, if there is no regrowth after 4 months of treatment, topical corticosteroids, minoxidil and immunotherapy would be considered. Polydeoxyribonucleotide (PDRN), deoxyribonucleotide polymers ranging between 50 and 2000 base pairs, stimulates the adenosine receptor. The receptor is closely associated with the mechanism of minoxidil, used in the treatment of AA. Therefore, we presumed that PDRN would also have a clinical effect on AA, but there is limited data on the effectiveness of PDRN in AA. Herein, we report that two AA patients, recalcitrant to intralesional corticosteroid, show a significant clinical effect of hair regrowth with intralesional PDRN.