Alprazolam함유 poly(D,L-lactic acid) microsphere의 제조 및 평가

용철순,오두만,권미라,박새해 영남대학교 약품개발연구소 1996 영남대학교 약품개발연구소 연구업적집 Vol.6 No.-

Poly(D.L-lactic acid)(PLA) microspheres containing alprazolam(APZ) were prepared by a solvent-emulsion evaporation method and their release patterns were invostigated in vitro. Various batches of microspherss with different size and drug content were obtained by changing the ration of APZ to PLA, PLA concentration in the dispersed phase and stirring rate. Rod-like APZ crystals on microsphere surface, which were released rapidly and could act as a loading dose, were observed with increasing drug content. The release rate was increased with increase in drug contents and decresase in the molecular weight of PLA. The release rate of APZ for long-acting injectable delivery system in vitro, which would aid in predicting in vivo release profile, could be controlled by properly optimizing various factors affecting characteristics of microspheres.

최근 3년간 급성 단순 요로감염의 원인균에 따른 항생제 감수성

김세웅,이지열,박왕진,조용현,윤문수 대한감염학회 2000 감염 Vol.32 No.5

요관에 발생한 원발성 편평상피암

김세웅,이지열,이승주,박왕진,고준성,조용현,윤문수,이교영 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.8

방광암에서 TaqMan 탐식자를 이용한 실시간 정량적 PCR에 의한 c-erbB2/neu의 증폭 및 과발현

김세웅,정호석,이승주,이지열,조용현,윤문수,박용현 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.9

토끼에서 요도카테터 유치기간에 따른 요로감염 정도 및 항생제 투여 효과

김세웅,이지열,김진호,조용현,윤문수 大韓泌尿器科學會 1998 Korean Journal of Urology Vol.39 No.9

급성 단순하부요로감염증 치료에서 노르플록사신과 루플록사신의 임상효과 및 안전성

김세웅,이지열,이승주,조용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 루플록사신은 긴 반감기와 넓은 항균력을 가진 퀴놀론계 항생물질이다. 급성 단순하부요로감염 치료에 있어서의 루플록사신의 효과와 안전성을 평가하기 위하여 기존의 퀴놀론계 항생물질인 노르플록사신과 비교임상시험을 실시하였다. 방법 : 본 임상시험은 전향적, 무작위 방법으로 진행하였으며 1997년 8월부터 1999년 3월까지 가톨릭대학교 의과대학 부속 성모병원 비뇨기과에 내원한 급성 단순하부요로감염 환자 72명을 대상으로 하였다. 연속적 무작위 배정방법을 통하여 루플록사신군 36명과 노르플록사신군 36명이 루플록사신 400㎎을 단회 경구투여 받거나 노르플록사신 400㎎을 12시간 간격으로 3일간 6회 경구투여 받았다. 임상효과, 미생물학적 평가 및 부작용을 비교 관찰하였다. 결과 : 총 64명의 환자가 시험을 완료하여 평가가 가능하였고, 이 중 루플록사신군은 32명이었고, 노르플록사신군은 32명이었다. 증상의 치료 및 개선을 임상적 유효성이 있는 경우로 하였을 때, 루플록사신투여군은 32례중 32예(100%)에서, 노르플록사신투여군은 32례 중 31례(96.9%)에서 만족할 만한 결과를 얻었다. 미생물학적 평가에서 루플록사신투여군은 32례 중 29례(90.6%)에서, 노르플록사신투여군은 32례 중 28례(87.5%)에서 미생물학적 소실을 보였다. 미생물학적 재발은 루플록사신군과 노르플록사신군에서 각각 1례(3.1%)과 2례(6.3%)가 나타났고, 재감염은 각각 2례(6.3%)와 1례(3.1%)가 나타났다. 임상효과와 미생물학적 평가에서는 두 약제간의 통계학적 차이는 없었다. 약물역동학적 검사상 루플록사신은 노르플록사신에 비해 높은 MIC를 갖고 있지만 긴 반감기를 통해 소변내에서 높은 농도와 요 살균력을 유지함을 알 수 있었다. 부작용은 루플록사신투여군 34례 중 5례(14/7%)에서, 노르플록사신투여군 35례 중 1례(2.9%)에서 나타났으며, 대부분의 소화기계통의 이상반응 이었으며, 모두 경증으로 24시간 이내에 소실되었다. 루플록사신투여군 중 2례에서는 경증의 중추신경계의 이상반응이 관찰되었다. 결론 : 결론적으로 루플록사신은 급성 단순하부요로감염에 대하여 1회 투여만으로도 노르플록사신의 3일 투여법과 동등한 효과를 나타내는 유용한 약제라고 생각된다. Background : Rufloxacin is a broad-spectrum quinolone that exhibits a prolonged elimination half-life. The purpose of this study is to evaluate the efficacy and safety of a single dose of rufloxacin, campared with those of a norfloxacin standard treatment. Methods : This was a open. randomized. parallel-group, phase 11 clinical trial. A total of 72 women with acute lower urinary tract infections were included and randomly assigned to one of the treatment regimens: rufloxacin 400㎎ single dose, or norfloxacin 400㎎ b.i.d. for 3 days. Clinical and bacteriological assessments were performed twice at the third day and the seventh or tenth day after inclusion. Results : A total of 64 patients(32 and 32 patients in the rufloxacin and norfloxacin groups, respectively) were considered clinically and bacteriologically evaluable. Overall, a clinical response(recovery and improvement) was observed in 32 (100%) of 32 patients treated with rufloxacin and in 31 (96.95) of 32 patients with norfloxacin. The corresponding eradication rates of the primary pathogens were 90.6%(29/32) and 87.5%(28/32), respectively. The microbiological relapses between the seventh and tenth day were recorded in 1 patient(3.1%) and 2 patients(6.3%) in the rufloxacin and norfloxacin groups, respectively. The superinfections occurred in 2(6.3%) and 1(3.1%) patients, respectively. No statistically significant differences in the clinical or bacteriological outcome were observed between the treatment groups. The pharmacodynamic evaluation showed similar median urine bactericidal titers(UBT) for both treatment groups against initial isolates, despite a higher MIC of rufloxacin than that of norfloxacin. Five patients (14.7%) in the rufloxacin group and 2 patients (5.7%) in the norfloxacin group reported 9 and 4 adverse events, respectively, almost all of them being mild and lasting <24 h. Overall, gastrointestinal reactions were the most frequent adverse events reported. However, 2 patients treated with rufloxacin reported 3 central nervous system adverse events. Conclusion : This study suggests that single dose of rufloxacin treatment is effective and well tolerated as norfloxacin 3-day standard treatment in acute uncomplicated lower urinary tract infections.

코니칼型 大刑消化槽탱크의 鋼壁强度에 대하여 스트레인 게이지法에 의한 實驗的 硏究

吳世旭,辛容建 동아대학교 환경문제연구소 1980 硏究報告 Vol.4 No.1

Recently the large type of steel tank has been widely used in the various industries such as the chemical, petroleum, food, water and sewerage works, pollution treatment facility industry and so on. For the safe, economical and reasonable design of those facilities, engineers have made their efforts, but even by such safety designs, there have happened unanticipated accidents, which have caused not only the damage of life and property but also the death of earth and sea by their pollution. The causes of those accidents have occurred from the problems of design, execution, low cycle fatigue, stress concentration or excessive residual stress, etc. Therefor, even after the complete design, the nondestructive measurement just before a test run after having manufactured the facilities should be necessarily carried out to prevent any accident. This study on the conical type large digester tank built, first in Korea, at the Yongho-dong Sewage Treatment Plant in Busan was dealt with the experimental consideration of its safety by using the strain gauge method, and the results are as the following: 1. The strength of the welded zone in circumferential direction at the shell plate of conical type tank is in safety. 2. By the first hydraulic test result, the maximum stress was brought about at the junction T welded zone in circumferential and axial directions near cone-skirt support bearing. By the second hydraulic test result, the safety strength was obtained more than the calculated values by the preloading effect. 3. The welded zone at the cone-skirt support bearing are under compression stress all in three axies directions, and their strength is in safety.

Urapidil, Labetalol의 투여가 기관내 삽관시 심혈관계에 미치는 영향

신용섭,윤석화,손수창,이원형,이정은,황원재,김만수,김영주,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.2

We have examined the comparative efficacy of small doses of intravenous urapidil and labetalol in blunting hemodynamic response to endotracheal intubation and surgical incision in 30 patients without cardiovascular diseases. After intravenous urapidil 0.2 mg/kg or labetalol 0.2 mg/kg anesthesia was induced with thiopental 5mg/kg. Endotracheal intubation was facilitated by vecuronium 0.15 mg/kg with priming principle and anesthesia was maintained with enflurane and nitrous oxide in oxygen. Systolic, diastolic and mean arterial pressure and heart rate were measured before administration of the drugs, 5 minute after administration, just prior to endotracheal intubation and 1, 3, 5, 10 minute after intubatin. Also the peak blood pressures and heart rate within 10 minutes after surgical incision were measured. Endotracheal intubation and surgical stimulation were associated with significant increases in blood pressures and heart rate in both urapidil and labetalol group. Comparison of the changes in systolic, diastolic, and mean artrial pressures and heart rate between urapidil and labetalol group showed no significant difference except peak systolic pressure after surgical incision. It is concluded that the pressor response to endotracheal intubation and surgical stimulation are not influenced significantly by urapidil 0.2 mg/kg or labetalol 0.2 mg/kg. However, urapidil and labetalol preloading may be similarly effective in the blunting of the increases in blood pressures with larger doses of the durgs during anesthetic induction.

북한의 공경호 제도에 관한 연구

오세용,한창효 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

While fabrics and characters of guard system in the U.S., European and Southeast Asian countries have been open to public, those of North Korea's guard system are not still well known to outside world. For this reason we will discuss, in this report, fabrics and characteristics of North Korean Headquarters of Escort and Department of People's Security, which corresponds to S. Korean Escort Office of President and Police Headquarters respectively. For theoretical background we have studied economic and political situation in North Korea, and its nuclear ambitions - currently international hot issue. General concept of guard is also studied. The results of this study, with survey of theoretical background, are followings. First headquarters of escort corresponds to S. Korean escort office of president. It means that the office is actually an independent organization like department of people's security. The main duties of this organization are to escort Kim Jeong Il's family and inner circle of him, also late Kim Il Seong while he was living, and protect, patrol Pyongyang. Secondly department of people's security corresponds to S. Korean police headquarters. The organization is naturally police agency, main duty of which is to maintain public order. However its structure is similar to the military one, and it exerts powerful public power. That is to say, this organization takes important roles of maintaining the communist regime in North Korea, rather than the maintenance of public order. Considering the above, the original purpose of the Headquarters of Escort is to guard the members of Kim's family, and that of the Department of People's Security to maintain public order. However actually these agents surveille, prosecute and punish its people, which is the main duty of the agents. In N. Korea ruled by one man, this situation seems to be natural.

충남대학교병원 마취발전의 경향에 관한 분석 : 1967년부터 - 1996년까지 from 1967 to 1996

최세진,김상수,정규돈,윤석화,신용섭,손수창,이원형,김혜자,이정은 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

To evaluate the specificity and historical trends of the anesthesia in Chungnam National University Hospital, anesthetic experiences of 83,572 in total performed at Chungnam National University Hospital from January 1967 to December 1996 were analyzed statistically and clinically according to age, sex, surgical department, physical status, elective and emergency surgery, premedicants, IV anesthetics, anesthetic methods, inhalational anesthetics, muscle relaxants. The results were as follows : 1. The number of cases has been steadily increased year by year. 2. The ratio of male to female was 52.8% : 47.2%. 3. According to the age, There were 44,905 cases (54%) in the group of 13-45 years. 4. According to the ASA classification of physical status, most of the cases were belonged to the class 1 & 2 (72.5%). 5. The ratio of elective to emergency was 79.4% to 20.6%. 6. Recently, glycopyrrolate has been used increasingly. 7. Thiopental sodium has been mainly used for intravenous induction agent. 8. General anesthesia has been used mainly. 9. Enflurane is the most common inhalational anesthetic agent. but Isoflurane has been used increasingly. 10. Most of muscle relaxants are Pancuronium & Vecuronium(84.5%).