요로감염증 환자의 치료에서 메로페넴(Meropenem)과 이미페넴/실라스타틴(Imipenem/Cilastatin)의 임상효과 및 안정성

김세웅,이승주,이지열,조용현,신완식,윤문수 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

목적 :메로페넴은 실라스타틴을 복합투여하지 않아도 되는 새로운 계열의 카바페넴계 항생물질이다. 요로감염 치료에 있어서의 메로페넴의 효과와 안전성을 평가하기 위하여 기존의 카바페넴계 항생물질인 이미페넴/실라스타틴과 동시에 비교임상실험을 실시하였다. 방법 : 본 임상시험은 전향적, 무작위 방법을 통하여 시행하였다. 1996년 10월부터 1998년 2월까지 가톨릭대학교 의과대학 부속 성모병원 및 울산대학교 외과대학 부속 중앙병원 비뇨기과에 입원한 신우신염과 복잡성방광염 환자 115명을 대상으로 하였고, 연속적 무작위 배정방법을 통하여 메로페spa군 58명과 이미페넴/실라스타틴군 57명으로 분류하였다. 두가지 약제는 모두 0.5 g을 12시간 간격으로 정맥주사 하였고, 평균 투약기간은 4일 (3-8일) 이었다. 임상효과, 세균학적 평가 및 부작용을 비교 관찰하였다. 결과 : 총 67명의 환자가 시험을 완료하여 평가가 가능하였고, 이 중 메로페넴군은 34명이었고, 이미페넴/실라스타틴군은 33명이었다. 증상의 치료 및 개선을 임상적 유효성이 있는 경우로 하였을 때, 메로페넴투여군은 34례중 32례 (94.1%)에서, 이미페넴/실라스타틴투여군은 33례중 29례 (87.9%)에서 유효율을 보였다. 세균학적 평가에서 메로페넴 투여군은 34례중 32례 (94.1%)에서, 이미페spa/실라스타틴투여군은 33례중 29례 (87.9%)에서 세균학적 소실율을 보였다. 세균학적 재발 은 각각 4명과 7명이 나타났고, 재감염은 메로페넴군은 나타나지 않았지만, 이미페넴/실라스타틴군은 2명이 나타났다. 임상효과와 세균학적 평가에서는 두 약제간의 통계학적 차이는 없었다. 부작용은 메로페spa투여군 56례중 1례 (1.8%)에서, 이미페넴/실라스타틴투여군 53례중 1례 (1.9%)에서 나타났으며, 임상검사치 이상은 메로페넴투여군 45례중 10례 (22.2%)에서, 이미페넴 실라스타틴투여군 44례중 8례 (18.2%)에서 나타났으나 전체적으로 특별히 문제가 된 증례는 없었다. 결론 :결론적으로 메로페spa은 신우신염 및 복잡성방광염과 같은 요로감염에 대하여 이미페넴/실라스타틴과 동등한 효과를 나타내는 유용한 약제라고 생각된다. Background : Metopenem is the first of a new class carbapenems which may be administered without cilastatin. The clinical study was carried out to assess efficacy and safety of metopenem in the treatment of urinary tract infections, in comparison to imipenem/cilastatin. Methods : This was a controlled, two-center, prospective, randomized study with two parallel groups. From October 1996 until February 1998, a total of 115 consecutive patients with urinary tract infections, such as pyeolonephritis and complicated cystitis, were randomly allocated into two groups, 58 in the meropenem group and 57 in the imipenem/cilastatin group. Both drugs were administered intravenously, at a dose of 0.5 g every 12 hours. The mean duration of therapy was 4 days (3-8 days) for both treatment. Clinical and bacteriological reponses were assessed at the begining of treatment, during treatment, at the end of treatment, and follow-up (1-2 weeks). Results : A total of 67 patients, 34 of meropenem and 33 of imipenem/cilastatin, were evaluable for response. Overall, a positive clinical response (recovery and improvement) was observed in 32 (94.1%) of 34 patients treated with meropenem and in 29 (87.9%) of 33 patients with imipenem/cilastin and the corresponding eradication rates of the primary pathogens were 32 (94.1%) of 34 patients and 29 (87.9%) of 33 patients, respectively. The microbiological relapse after the treatment completion was recorded in 4 patients treated with meropenem and 7 patients given imipenem/cilastath and superinfections occurred in none and 2 patients, respectively. No statistically significant differences in the clinical or bacteriological outcome were observed between the treatment groups. Both drugs were well tolerated with adverse events considered to be related to therapy being recorded for 1 (1.8%) of 56 patients treated with meropenem and 1 (1.9%) of 53 of those who had been given imipenenjcilastatin. Conclusion : Empirial monotherapy with meropenem was therefore as effective and as well tolerated as that with imipenem/cilastatin for the treatment of urinary tract infections.

0.5% Bupivacaine을 이용한 척수마취시 마취제의 비중이 마취효과에 미치는 영향

김창열,윤석화,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1

Effects of solutions of 0.5% bupivacaine, containing different concentrations of dextrose (0%, 0.5%, 0.8%, 1%, 3%, 5%, 8%) were studied after intrathecal injection in seven (Group A-Group G) groups of 15 patients. The results are summarized as follows: 1. The mean specific gravity of solutions was 1.0065, 1.0087, 1.0092, 1.0094, 1.0152, 1.0198 and 1.0314 (Group A-Group G). These values are isobaric (Group A, B), hyperbaric (Group E, F, G), and slightly hyperbaric (Group C, D) compared to cerebrospinal fluid at 25℃. 2. The mean maximum level of sensory block was increased according to the increment of specific gravity of the solutions. But no significant differences between Group A and B, Group C and D, Group E, F, and G. 3. The mean time of sensory block to T11 was decreased according to the increment of specific gravity of the solutions. 4. The mean time to the expected level (T4) of sensory block at given dosage of each solution was 25.7, 18.4, 9.7 minutes(Group E, F, G, respectively). 5. Complete motor block of the legs was rapid according to the increment of specific gravity of the solutions.

수술중 SaO₂의 변동에 관한연구

최세진,김대열 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

Hypoxemia is a potentially serious complication after general anesthesia. The site of operation may influence the reduction of arterial oxygen tension (PaO_2) after general anestesia due to reduction in vital capacity. In this study, arterial oxygen saturation (SaO_2) were with pulse oximeter (Minolta-Pulsow-7) in 60 adult patients. Which were devided in 3 groups. Group I:20 patients who were performed nonabdominal operation, group II:20 patients who were performed lower abdominal operation, and group III:20 patients who were performed upper abdominal operation, SaO_2 was meaasured on preanesthetic period (control). Interaoperative period and on arrival in the recovery room and 4, 8, 12, 16 minute after arrival in recovery room. The results are as follows: 1. SaO_2 measured on arrival in recovery room decreased significantly (P<0.05) compare with preanesthetic SaO_2 in all groups. 2. SaO_2 measured on arrival in recovery room in group III decreased significantly compared with group I (P<0.05). 3. SaO_2 increased progressively in all groups, but the value of 12 and 16 minute after arrival in recovery room decreased significantly compared with preanesthetic SaO_2 in group II, III.

급성 단순하부요로감염증 치료에서 노르플록사신과 루플록사신의 임상효과 및 안전성

김세웅,이지열,이승주,조용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.1

목적 : 루플록사신은 긴 반감기와 넓은 항균력을 가진 퀴놀론계 항생물질이다. 급성 단순하부요로감염 치료에 있어서의 루플록사신의 효과와 안전성을 평가하기 위하여 기존의 퀴놀론계 항생물질인 노르플록사신과 비교임상시험을 실시하였다. 방법 : 본 임상시험은 전향적, 무작위 방법으로 진행하였으며 1997년 8월부터 1999년 3월까지 가톨릭대학교 의과대학 부속 성모병원 비뇨기과에 내원한 급성 단순하부요로감염 환자 72명을 대상으로 하였다. 연속적 무작위 배정방법을 통하여 루플록사신군 36명과 노르플록사신군 36명이 루플록사신 400㎎을 단회 경구투여 받거나 노르플록사신 400㎎을 12시간 간격으로 3일간 6회 경구투여 받았다. 임상효과, 미생물학적 평가 및 부작용을 비교 관찰하였다. 결과 : 총 64명의 환자가 시험을 완료하여 평가가 가능하였고, 이 중 루플록사신군은 32명이었고, 노르플록사신군은 32명이었다. 증상의 치료 및 개선을 임상적 유효성이 있는 경우로 하였을 때, 루플록사신투여군은 32례중 32예(100%)에서, 노르플록사신투여군은 32례 중 31례(96.9%)에서 만족할 만한 결과를 얻었다. 미생물학적 평가에서 루플록사신투여군은 32례 중 29례(90.6%)에서, 노르플록사신투여군은 32례 중 28례(87.5%)에서 미생물학적 소실을 보였다. 미생물학적 재발은 루플록사신군과 노르플록사신군에서 각각 1례(3.1%)과 2례(6.3%)가 나타났고, 재감염은 각각 2례(6.3%)와 1례(3.1%)가 나타났다. 임상효과와 미생물학적 평가에서는 두 약제간의 통계학적 차이는 없었다. 약물역동학적 검사상 루플록사신은 노르플록사신에 비해 높은 MIC를 갖고 있지만 긴 반감기를 통해 소변내에서 높은 농도와 요 살균력을 유지함을 알 수 있었다. 부작용은 루플록사신투여군 34례 중 5례(14/7%)에서, 노르플록사신투여군 35례 중 1례(2.9%)에서 나타났으며, 대부분의 소화기계통의 이상반응 이었으며, 모두 경증으로 24시간 이내에 소실되었다. 루플록사신투여군 중 2례에서는 경증의 중추신경계의 이상반응이 관찰되었다. 결론 : 결론적으로 루플록사신은 급성 단순하부요로감염에 대하여 1회 투여만으로도 노르플록사신의 3일 투여법과 동등한 효과를 나타내는 유용한 약제라고 생각된다. Background : Rufloxacin is a broad-spectrum quinolone that exhibits a prolonged elimination half-life. The purpose of this study is to evaluate the efficacy and safety of a single dose of rufloxacin, campared with those of a norfloxacin standard treatment. Methods : This was a open. randomized. parallel-group, phase 11 clinical trial. A total of 72 women with acute lower urinary tract infections were included and randomly assigned to one of the treatment regimens: rufloxacin 400㎎ single dose, or norfloxacin 400㎎ b.i.d. for 3 days. Clinical and bacteriological assessments were performed twice at the third day and the seventh or tenth day after inclusion. Results : A total of 64 patients(32 and 32 patients in the rufloxacin and norfloxacin groups, respectively) were considered clinically and bacteriologically evaluable. Overall, a clinical response(recovery and improvement) was observed in 32 (100%) of 32 patients treated with rufloxacin and in 31 (96.95) of 32 patients with norfloxacin. The corresponding eradication rates of the primary pathogens were 90.6%(29/32) and 87.5%(28/32), respectively. The microbiological relapses between the seventh and tenth day were recorded in 1 patient(3.1%) and 2 patients(6.3%) in the rufloxacin and norfloxacin groups, respectively. The superinfections occurred in 2(6.3%) and 1(3.1%) patients, respectively. No statistically significant differences in the clinical or bacteriological outcome were observed between the treatment groups. The pharmacodynamic evaluation showed similar median urine bactericidal titers(UBT) for both treatment groups against initial isolates, despite a higher MIC of rufloxacin than that of norfloxacin. Five patients (14.7%) in the rufloxacin group and 2 patients (5.7%) in the norfloxacin group reported 9 and 4 adverse events, respectively, almost all of them being mild and lasting <24 h. Overall, gastrointestinal reactions were the most frequent adverse events reported. However, 2 patients treated with rufloxacin reported 3 central nervous system adverse events. Conclusion : This study suggests that single dose of rufloxacin treatment is effective and well tolerated as norfloxacin 3-day standard treatment in acute uncomplicated lower urinary tract infections.

벼 기계이앙 1회용 종이 육묘상자 개발

박성태,황정동,김상열,문헌팔,양세준,김순철,유남진 한국국제농업개발학회 2003 韓國國際農業開發學會誌 Vol.15 No.3

벼 기계이앙 육묘에 주로 사용하고 있는 플라스틱 육묘상자의 문제점을 개선하고 친환경 농업 실현에도 기여할 수 있는 벼 기계이양 종이 육묘상자개발 및 육묘시험 결과를 요약하면 다음과 같다. 1. 폐지 등 혼합물을 고열압착한 종이 육묘상자는 내부 길이가 가로 58㎝, 세로 28㎝, 높이는 2㎝이고 무게는 250g이다. 2. 종이 육묘상자 모의 파종 후 10일~30일 묘소질은 플라스틱 육묘상자 모에 비하여 초장이 1.1~1.8㎝ 짧고 본당 건물중은 0.3~3.7㎎이 떨어졌으나 엽수와 모 충실도는 비슷하였다. 3. 종이 육묘상자 모의 파종 후 30일(중묘) 이앙 시 결주율은 3.3%로 플라스틱 육묘상자 모 결주율 3.2%와 거의 같았고, 출수기, 벼 생육특성 및 수량도 플라스틱 육묘상자와 비슷하였다. 4. 종이 육묘상자의 이점은 플라스틱 육묘상자에 비하여 육묘상자 비용이 약 20% 절감되고 파종 후 운반, 치상 등 작업이 용이하며, 이앙 후 회수, 세척 및 보관관리 노력이 생략된다. 그리고 이앙 후는 논에서 유기물화되므로 친환경농업에도 부합된다. A light and bio-degradable paper tray for seedling raising in machine transplanting rice was developed for the first time and a possibility for rice seedling growth was evaluated. The paper tray was made of mixture of recycling paper and sawdust, and molded under high temperature and pressure. The tray was 58㎝ length x28㎝ width x2㎝ height in size and 250g in weight per tray. The seedling height and dry weight per plant grown at the paper tray were generally 1.1 to 1.8㎝ shorter and 0.3 to 3.7㎎ lighter than those grown at the conventional plastic tray, respectively. However, other characters such as leaf number, seedling health score, missing hill, heading date, panicle and spiketlet number, and milled rice yield were similar to those in the plastic tray. Based on the result of research, the paper tray had following advantages in comparison of the plastic tray. The paper tray could be reduced seedling raising cost by 20% as compared with the plastic tray. Since the paper tray was of lightness even after seedbed soil fill-up, it was more handy and convenient to carry over. Labor input for collecting, washing, and storing the empty tray after seedling transplanting was not needed as the plastic tray. The paper tray was also bio-degraded and transformed into an organic matter, once it was incorporated into soil, which was considered as an environmentally- safe cultivation technology.

트랙타 부착 대형이앙기 개발 및 재배적 실용성

박성태,장익주,정창화,김상열,김재현,문헌팔,양세준,김순철 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.3

쌀 생산비를 줄이고 대경지 규모화 영농에 적응할 수 있는 농기계 개발을 목적으로 연구개발한 대규모 경지적응 트랙터 부착 대형벼이앙기의 구성과 특징 및 개발시작기의 재배적 실용성 평가결과를 요약정리하면 다음과 같다. 1. 트랙터 부착 12조 대형벼이앙기는 크게 바퀴자국 제거로타리, 문짝형 정지판, 이앙장치부 등으로 구성되어 있다. 2. 트랙터 부착 12조 이앙기는 트랙터 동력을 이용하여 로타리, 정지 및 이앙작업이 동시에 이루어 질 수 있도록 개발하였다. 3. 바퀴자국을 없애는 날은 기존의 로타리 날을 교체하면 되도록 반달형 날로 제작하였다. 4. 이앙기는 이동시는 접을 수 있도록 설계 제작되어 대형화가 가능하므로 기존 6조 승용이앙기에 비하여 이앙작업 능력이 1.5배 이상이었다. 5. 트랙터 부착 대형벼이앙기는 트랙터와 같은 큰 동력원을 이용할 수 있으므로 측조시비기, 긴매트모 탑재 등 다양한 작업기 및 기능을 추가로 부착 가능하도록 설계되었다. 6. 트랙터 부착 대형벼이앙기는 어린모 및 중묘이앙시 결주율은 3.0∼4.3%로 기계이앙기 결주 허용범위 5% 미만이었다. 하지만 무경운 논에서는 이앙작업은 가능하나 부묘율이 다소 높은 점은 보완이 필요하다. To develop a labor saving rice cultivation technology, a new tractor attached rice transplanter has been developed for large scale farming and its field performance was evaluated. The rice transplanter consists of three major parts such as rotary for removing tractor tire furrow, door-shaped soil leveling plate and transplanting equipment. The rice transplanter is operated using the power of the tractor and performs rotary, harrow and seedling transplanting simultaneously. A half moon shaped rotary blade was found to be very efficient to remove tire furrow developed during seedling transplanting and the original rotary blade can be replaced easily with existed rotary blade. The seedling transplanting part of the transplanter was designed to fold into small size and the transplanting efficiency of the transplanter was found to be 1.5 times higher than that of the conventional riding type six row transplanter. Since the transplanter is operated through a strong power of the tractor, the additional attachment such as fertilizer application apparatus and long mat rice seedling carrier is possible. Based on the field performance of the transplanter, although the missing hill percentage showed roughly with 3.0∼4.3% for 10-day and 30-day old seedlings but the percentage is less than 5% which is maximum missing hill permit in the transplanting rice. Seedling transplanting in no-tillage field condition is acceptable but floating seedling percentage is still high and thus further technology improvement for minimizing floating seedling percontage is needed.

저장 온도 및 상대습도가 비타민 정제 중 지용성 비타민 함량의 변화에 미치는 영향

김동섭,이재황,김세곤,이동언,박석준,이진희,이강표,최성원,백무열 경희대학교식량자원개발연구소 2007 硏究論文集 Vol.26 No.1

칼슘 나노분말과 마이크로 분말의 이화학적 특성 비교

백새열림 ( Sae Yeol Rim Paik ),류지나 ( Ji Na Ryu ),고상훈 ( Sang Hoon Ko ) 한국산업식품공학회 2012 산업 식품공학 Vol.16 No.2

The aim of this study was to compare the physicochemical properties of calcium carbonate nano- and micro-powders for safe food applications of nanomaterials. The morphologies and approximate sizes of calcium particles were observed by scanning electron and transmission electron microscopic methods, showing hexagonal shape with sharp and rough surface. The approximate sizes of the calcium nano- and micro-particles observed on the micrographs were around 100 nm and 100 nm to 3 μm, respectively. The average particle sizes of the calcium nano- and micropowders determined by the dynamic light scattering method were 440.2±73.8 and 547.1±105.3 nm at 0.5 mg/mL particle concentration and 388.8±123.2 and 1001.9±160.4 nm at 1.0 mg/mL particle concentration, respectively. The zeta-potential of the calcium nano- and micro-powders were -9.94±1.78 and -2.42±2.38 mV, respectively. It seemed that both calcium nano- and micro-powders were unstable in aqueous conditions but calcium nano-powder was relatively more stable. The results of specific surface area of the calcium nano- and micro-powders were 6.99 and 4.26 m2/g while the bulk densities of them were similar but the tap densities were 0.81±0.02 and 0.97±0.02 g/mL, respectively. The angles of repose were 35.40±1.32o (nano-powder) and 39.37±2.46o (micro-powder), implying that calcium nano-powder was more flowable. This study provides a potential of various mineral nanoparticles including calcium nanoparticles for future safe food applications.

의료기기 소프트웨어 정적검증을 통한 임베디드 코딩룰과 실행시간 오류 간 연관성 분석

유새열 ( Sae-yeol Yoo ),최기용 ( Ki-yong Choi ),이정원 ( Jung-won Lee ) 한국정보처리학회 2016 한국정보처리학회 학술대회논문집 Vol.23 No.2

최근 임베디드 소프트웨어의 신뢰성과 안전성을 보장하기 위하여 코딩룰인 MISRA-C를 자동차 뿐만 아니라 군사, 의료 분야등 광범위한 분야에서 이용하고 있다. 하지만 MISRA-C가 자동차 시스템분야의 MISRA 가이드를 이용하여 개발되었기 때문에 타 분야의 분야별 특성을 모두 고려하지 못한다는 문제점이 제시되고 있다. 따라서 본 논문에서는 향후 의료기기 분야의 특성을 고려한 코딩룰을 제시하기에 앞서, 의료기기 소프트웨어에서의 코딩룰 필요성을 제시한다. 이를 위해 개발 단계의 의료기기 소스코드에 MISRA-C를 적용하여 정적 분석을 해보고, 적용 유무 따른 실행시간 오류 결과를 분석한다. 분석 결과, 코딩룰을 이용하면 실질적으로 실행시간 오류 발생을 막을 수 있고, 적용 과정에서 기타 다른 실행시간 오류들 또한 해결됨을 확인하였다. 위 결과로 본 논문에서는 의료 분야의 특성을 고려한 특화 코딩룰의 필요성을 제시한다.

Effect of Task-Specific Lower Extremity Training on Cognitive and Gait Function in Stroke Patients: A Prospective Randomized Controlled Trial

Sae Hoon Chung,Ji Hyun Kim,Sang Yeol Yong,Young Hee Lee,Jung Mee Park,Sung Hoon Kim,Hi Chan Lee 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.1

Objective To elucidate the effect of task-specific lower extremity training (TSLET) on cognitive and gait function in stroke patients. Methods Thirty-eight patients were assigned to either the TSLET group or the control group. The individuals of TSLET group went through a TSLET plus conventional physical therapy. The control group received two sessions of conventional physical therapy. The primary outcome involved the assessment with visual and auditory digit span test. The secondary outcome was evaluated by the Korean version of Mini-Mental State Examination (K-MMSE) and Global Deterioration Scale (GDS) for cognitive function, Berg Balance Scale (BBS), Time Up and Go Test (TUG), 10 meters Walking Test (10mWT), 6 minutes Walking Test (6MWT), and Korean version of Modified Barthel Index (K-MBI) for gait, balance, and functional ability. Results After intervention (3 weeks) and 2 weeks of follow-up, the TSLET group showed statistically significant improvement in the visual digit span test backwards compared with the control group. In secondary outcome, a significant improvement was observed in GDS, BBS, TUG, and 10mWT in the TSLET group. There was no significant difference between the two groups concerning visual digit span test forward, auditory forward and backward digit span tests, K-MMSE, 6MWT, and K-MBI. Conclusion TSLET could be a useful alternative strategy for improving cognitive and gait function in stroke patients.