Management of Pregnant Patients to Prevent the Graft Loss after Liver Transplantation: First Experience in National Scientific Medical Research Center

( Sabit Dossanbayev ),( Alya Taganova ),( Zhaksylyk Doskaliyev ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: There were many studies showed the successful pregnancy and delivery in patients after liver transplantation. From 2012 more than 100 living donor liver transplantations has carried out in Kazakhstan and our report represents the first successful pregnancy and delivery in recipient after liver transplantation. Methods: Orthotopic transplantation of right liver lobe from a living related donor was performed to our patient from her elder brother. The main cause of liver cirrhosis was autoimmune hepatitis. After one year of LDLT the patient informed us about unplanned pregnancy. Results: Among complications in early postoperative period the portal vein thrombosis was detected and successfully treated by heparin monotherapy. No other complications found in late period after transplantation. The standard third-component immunosuppressive therapy (CNI + MMF + GCS) was applied during the first year after transplantation. After the sudden information of 2 weeks pregnancy the MMF application was canceled. In first three months no significant alterations were found during the childbearing. On 18-20 weeks the first signs of liver rejection was appeared where sensitization of HLA class 1 was 0% and HLA class 2 consisted 91%. As a main treatment the pulse therapy with GCS and plasmapheresis were performed. On 40 weeks delivery was successfully done by Cesarean section. The child was male with weight - 2830 g, and height - 54.3 cm and without no visible any defects. Conclusions: In our case, it was an acceptable outcome for both mother and baby, although considered a high risk pregnancy.

Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey

Ozalp, Sabit Sinan,Telli, Elcin,Oge, Tufan,Tulunay, Gokhan,Boran, Nurettin,Turan, Taner,Yenen, Mufit,Kurdoglu, Zehra,Ozler, Ali,Yuce, Kunter,Ulker, Volkan,Arvas, Macit,Demirkiran, Fuat,Bese, Tugan,Tok Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey. Materials and Methods: A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated. Results: From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients. Conclusions: Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.

Peel strength of denture liner to PMMA and polyamide: laser versus air-abrasion

Sedanur Turgut,Sabit Melih Ate,Rukiye Durkan,Mutlu Ozcan,Bora Bagi,Fatih Mehmet Korkmaz 대한치과보철학회 2013 The Journal of Advanced Prosthodontics Vol.5 No.3

PURPOSE This study investigated the effect of laser parameters and air-abrasion on the peel strength of silicon-based soft denture liner to different denture resins. MATERIALS AND METHODS Specimens (N=180) were prepared out of three different denture base resins (Rodex, cross-linked denture base acrylic resin; Paladent, heat-cured acrylic resin; Deflex, Polyamide resin) (75 mm × 25 mm × 3 mm). A silicon-based soft denture liner (Molloplast B) was applied to the denture resins after the following conditioning methods: a) Air-abrasion (50 µm), b) Er,Cr:YSGG laser (Waterlase MD Turbo, Biolase Technology) at 2 W-20 Hz, c) Er,Cr:YSGG laser at 2 W-30 Hz, d) Er,Cr:YSGG laser at 3 W-20 Hz, e) Er,Cr:YSGG laser at 3 W-30 Hz. Non-conditioned group acted as the control group. Peel test was performed in a universal testing machine. Failure modes were evaluated visually. Data were analyzed using two-way ANOVA and Tukey's test (α=.05). RESULTS Denture liner tested showed increased peel strength after laser treatment with different parameters (3.9±0.4 - 5.58±0.6 MPa) compared to the control (3.64±0.5 - 4.58±0.5 MPa) and air-abraded groups (3.1±0.6 - 4.46±0.3 MPa), but the results were not statistically significant except for Paladent, with the pretreatment of Er,Cr:YSGG laser at 3 W-20 Hz. Polyamide resin after air-abrasion showed significantly lower peel strength than those of other groups (3.1±0.6 MPa). CONCLUSION Heat-cured acrylic resin, PMMA, may benefit from Er,Cr:YSGG laser treatment at 3 W-20 Hz irradiation. Air-abrasion of polyamide resins should be avoided not to impair their peel bond strengths to silicon-based soft denture liners.

The effect of various polishing systems on surface roughness and phase transformation of monolithic zirconia

Ipek Caglar,Sabit Melih Ates,Zeynep Yesil Duymus 대한치과보철학회 2018 The Journal of Advanced Prosthodontics Vol.10 No.2

PURPOSE. The purpose of this study was to evaluate and compare three polishing systems on the surface roughness and phase transformation of monolithic zirconia. MATERIALS AND METHODS. 100 disk shaped specimens (10 mm diameter, 3 mm thickness) were fabricated from monolithic zirconia blocks. 20 specimens were left as a control group and remaining specimens were grinded by diamond bur to simulate the occlusal adjustments. Grinded specimens were randomly divided into 4 groups: group G (no polishing), group M (Meisinger, zirconia polishing kit), group E (EVE Diacera, zirconia polishing kit), and group P (EVE Diapol, porcelain polishing kit). Surface roughness was measured with profilometer and surface topography was observed with SEM. XRD analysis was performed to investigate the phase transformation. Statistical analysis was performed with one-way ANOVA and Tukey’s post hoc tests at a significance level of P=.05. RESULTS. All polishing groups showed a smoother surface than group G. Among 3 polishing systems, group M and group E exhibited a smoother surface than the group P. However, no significant differences were observed between group M and group E (P˃.05). Grinding and polishing did not cause phase transformations in zirconia specimens. CONCLUSION. Zirconia polishing systems created a smoother surface on zirconia than the porcelain polishing system. Phase transformation did not occur during the polishing procedure.

Permeability features of concretes produced with aggregates coated with colemanite

Özlem Salli Bideci,Alper Bideci,Sabit Oymael,Ali Haydar Gültekin,Hasan Yildirim 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.15 No.5

In the world total boron reserve rating, Turkey is taken place on the first rank, meeting the demand of refined mineral and main boron chemicals. Development of the new boron products and production technologies, spreading the using area of the boron are the study topics which must be finically discussed. In this study, with the help of colemanite taken in ratio as (0%, 7.5%, 12.5%, and 17.5%) by being mixed by the cement, surfaces of the pumice aggregates have been covered. Permeability of the samples has been investigated by producing lightweight concrete with 400 dose with the help of aggregates covered with colemanite. For this, the experiments of water absorption, capillary water absorption, depth of penetration of water under pressure and rapid chloride permeability have been performed. In addition, analyses of the thin section of covered and uncovered pumice aggregates and SEM (Scanning Electron Microscope) have been investigated. When the control samples produced with the covered aggregates and concretes produced with colemanite covered aggregates are compared each other, it has been determined that special lightweight concretes whose values of capillary water absorption experiment, depth of penetration of water under pressure experiment and rapid chloride permeability are low can be produced.

Lightweight aggregates coated with colemanite

Alper Bideci,Özlem Sallı Bideci,Sabit Oymael,Ali Haydar Gültekin,Hasan Yıldırım 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.5

Technological advancements in the field of building materials are achieved day by day. In this study, a new lightweight concrete aggregate is produced by mixing certain rates of colemanite (0%, 7.5%, 12.5%, 17.5%), cement and coating the surface of pumice aggregate with this mixture. Thin aggregate sections are analyzed with specific gravity, unit weight, water absorption, impact, and crushing experiments. In this way, the production of cement and cement+colemanite coated lightweight concrete aggregates is investigated and an opinion on the likely behavior of these concrete types is provided.

Efficient hydrogen generation from the NaBH4 methanolysis by waste material: banana peel

Elma Karakaş Duygu,Kaya Mustafa,Horoz Sabit 한국탄소학회 2022 Carbon Letters Vol.32 No.6

The aim and originality of our current study are to use the original biomass (activated carbon) obtained by functionalizing waste banana peels (commonly found in Turkey) with acid in NaBH4 methanolysis and to examine its contribution to the hydrogen generation rate (HGR). Our study consisted of three stages. In the first stage, the optimum conditions were determined by examining the catalyst under parameters such as different acid types, different carbonization temperatures, and different carbonization times. Thus, based on the maximum HGR value, the optimum conditions were determined as H3PO4, 600 °C, and 40 min. In the second step, the effects of parameters such as acid concentration, NaBH4 concentration, catalyst amount, and temperature on HGR were investigated. As a result of methanolysis experiments (condition: catalyst amount: 100 mg, acid amount: 30%, NaBH4 concentration: 2.5%, temperature: 30 °C, carbonization temperature: 400 °C, and carbonization time: 40 min.), the maximum HGR value, the reaction completion time and activation energy were found as 65,625 mLmin−1gcat−1, 0.233 min, and 4.56 kJ/mol, respectively. It was observed that the obtained activation energy was lower than that of some catalysts available in the literature. In addition, the structural and morphological examination of the banana peel (catalyst) with high HGR and low activation energy revealed that the acid functionalization process was successfully carried out.

Symmetric Supercapacitor Application of Anhydrous Gel Electrolytes Comprising Doped Tetrazole Terminated Flexible Spacers

Seyda T. Gunday,Emre Cevik,Ismail Anil,Omar Alagha,Hussein Sabit,Ayhan Bozkurt 한국고분자학회 2020 Macromolecular Research Vol.28 No.12

The current research aimed to produce anhydrous gel organic electrolytes with superior performance for high-temperature supercapacitor applications. Within this scope, anhydrous electrolytes were designed by the termination of 1,4- butanediol diglycidyl ether (BDE) with 5-aminotetrazole (AT). The BDE(AT)2 was further doped with phosphoric acid (PA) and 1-Ethyl-3-methylimidazolium tetrafluoroborate (EMT, as an ionic liquid) at varied ratios. The structure of fabricated electrolytes was elucidated with various spectroscopic techniques, and thermal studies confirmed high thermal stabilities and low glass transition temperatures, suggesting that they could be used in a wide temperature range. Different supercapacitor systems, in combination with carbon-based electrodes and BDE(AT)2, BDE(AT)2-0.1EMT, and BDE(AT)2-PA-0.1EMT electrolytes, were constructed. The supercapacitor device in combination with BDE(AT)2-PA-0.1EMT electrolyte, showed the highest ionic conductivity value of 1.2×10-4 S cm-1. The electrode/electrolyte combination demonstrated a maximum specific capacitance (80.4 F g-1), the highest specific energy (2.91 Wh kg-1), and highly effective electrochemical reversibility (up to 2.250 cycles). The supercapacitor device illustrated a better performance at higher temperatures in terms of its specific capacitance value.

Peel strength of denture liner to PMMA and polyamide: laser versus air-abrasion

Korkmaz, Fatih Mehmet,Bagis, Bora,Ozcan, Mutlu,Durkan, Rukiye,Turgut, Sedanur,Ates, Sabit Melih The Korean Academy of Prosthodonitics 2013 The Journal of Advanced Prosthodontics Vol.5 No.3

PURPOSE. This study investigated the effect of laser parameters and air-abrasion on the peel strength of silicon-based soft denture liner to different denture resins. MATERIALS AND METHODS. Specimens (N=180) were prepared out of three different denture base resins (Rodex, cross-linked denture base acrylic resin; Paladent, heat-cured acrylic resin; Deflex, Polyamide resin) ($75mm{\times}25mm{\times}3mm$). A silicon-based soft denture liner (Molloplast B) was applied to the denture resins after the following conditioning methods: a) Air-abrasion ($50{\mu}m$), b) Er,Cr:YSGG laser (Waterlase MD Turbo, Biolase Technology) at 2 W-20 Hz, c) Er,Cr:YSGG laser at 2 W-30 Hz, d) Er,Cr:YSGG laser at 3 W-20 Hz, e) Er,Cr:YSGG laser at 3 W-30 Hz. Non-conditioned group acted as the control group. Peel test was performed in a universal testing machine. Failure modes were evaluated visually. Data were analyzed using two-way ANOVA and Tukey's test (${\alpha}$=.05). RESULTS. Denture liner tested showed increased peel strength after laser treatment with different parameters ($3.9{\pm}0.4-5.58{\pm}0.6$ MPa) compared to the control ($3.64{\pm}0.5-4.58{\pm}0.5$ MPa) and air-abraded groups ($3.1{\pm}0.6-4.46{\pm}0.3$ MPa), but the results were not statistically significant except for Paladent, with the pretreatment of Er,Cr:YSGG laser at 3 W-20 Hz. Polyamide resin after air-abrasion showed significantly lower peel strength than those of other groups ($3.1{\pm}0.6$ MPa). CONCLUSION. Heat-cured acrylic resin, PMMA, may benefit from Er,Cr:YSGG laser treatment at 3 W-20 Hz irradiation. Air-abrasion of polyamide resins should be avoided not to impair their peel bond strengths to silicon-based soft denture liners.

DNA methylation of GDF-9 and GHR genes as epigenetic regulator of milk production in Egyptian Zaraibi goat

Gamal Layaly,Noshy Magda M.,Aboul-Naga A. M.,Sabit Hussein,El-Shorbagy Haidan M. 한국유전학회 2024 Genes & Genomics Vol.46 No.1

Background DNA methylation is an epigenetic mechanism that takes place at gene promoters and a potent epigenetic marker to regulate gene expression. Objective The study aimed to improve the milk production of Zaraibi goats by addressing the methylation pattern of two milk production-related genes: the growth hormone receptor (GHR) and the growth differentiation factor-9 (GDF-9). Methods 54 and 46 samples of low and high milk yield groups, respectively, were collected. Detection of methylation was assessed in two CpG islands in the GDF-9 promoter via methylation-specific primer assay (MSP) and in one CpG island across the GHR promoter using combined bisulfite restriction analysis (COBRA). Results A positive correlation between the methylation pattern of GDF-9 and GHR and their expression levels was reported. Breeding season was significantly effective on both peak milk yield (PMY) and total milk yield (TMY), where March reported a higher significant difference in PMY than November. Whereas single birth was highly significant on TMY than multiple births. The 3rd and 4th parities reported the highest significant difference in PMY, while the 4th parity was the most effective one on TMY. Conclusion These results may help improve the farm animals' milk productive efficiency and develop prospective epigenetic markers to improve milk yield by epigenetic marker-assisted selection (eMAS) in goat breeding programs.