Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway

SaHyun Hong,Kwan-Kyu Park,Tae-Sung Lee,Taeg Kyu Kwon,Cheorl-Ho Kim,Young-Chae Chang 한국생명과학회 2006 한국생명과학회 심포지움 Vol.46 No.-

Molecular Cloning of a Putative Gene Encoding Phospholipase B (plbA) from Aspergillus nidulans

Hong, SaHyun,Eun-Min Cho,송승은,엄치용 한국미생물·생명공학회 2008 한국미생물·생명공학회지 Vol.36 No.3

The phospholipase B (PLB) families are enzymes sharing phospholipase (PL), lysophospholipase (LPL) and lysophospholipase-transacylase (LPTA) activities. In this study, we report the putative gene encoding phospholipase B (plbA) containing lipase motifs was cloned for the first time from the filamentous fungus,Aspergillus nidulans. plbA was isolated from A. nidulans genomic DNA library using a PCR-amplified probe, which is designed on the basis of sequence information derived from the conserved lipase regions of various PLBs. The deduced product of plbA is of 626 amino acids. From the assigned sequence, PlbA showed 72% identity with Penicillium notatum PLB but have low similarity with phospholipase A of other organisms.

Asymptomatic healthy slaughterhouse workers in South Korea carrying Shiga toxin-producing<i>Escherichia coli</i>

Hong, Sahyun,Oh, Kyung-Hwan,Cho, Seung-Hak,Kim, Jong-Chul,Park, Mi-Sun,Lim, Hyun-Sul,Lee, Bok-Kwon Oxford University Press 2009 FEMS immunology and medical microbiology Vol.56 No.1

<P>A total of 1602 stool samples from healthy employees in a slaughter company were screened by PCR for Shiga toxin (Stx)-producing Escherichia coli (STEC). The PCR product of Stx-encoding genes was detected in 90 (5.6%) of 1602 stool samples. Among the 90 stx-positive workers, the Residual Products Handlers and Slaughterers had rates of 8.0% and 6.0%--higher than Inspectors, Grading Testers and Livestock Hygiene Controllers at 3.3%, 2.0% and 3.5%, respectively. Forty-nine (54.4%) were shown to have stx2; 25 (27.7%) carried stx1 and 16 (17.7%) had both stx1 and 2. Distribution of the stx PCR-positive workers by age revealed an increase in STEC infection with age (P<0.05). Phenotypic and genotypic traits of nine STEC strains isolated from eight slaughter plant workers were characterized. A variety of serotypes, five O serogroups (O8, O54, O59, O103 and O153) and two H serogroups (H7 and H32) were found, but none of the strains belonged to the serogroup O157. Eight Vero cell cytotoxicity assay-positive strains were isolated from the workers and these workers were asymptomatic and healthy. The results of the study show that slaughter plant workers are at high risk of STEC infection.</P>

속도 감응형 가변 오리피스를 갖는 쇽업저버 개발

문사현(Sahyun Moon),김옥현(Ock Hyun Kim) 한국생산제조학회 2013 한국생산제조학회지 Vol.22 No.3

Ascochlorin Inhibits Matrix Metalloproteinase-9 Expression by Suppressing Activator Protein-1-mediated Gene Expression through the ERK1/2 Signaling Pathway : INHIBITORY EFFECTS OF ASCOCHLORIN ON THE INVASION OF RENAL CARCINOMA CELLS

Hong, SaHyun,Park, Kwan-Kyu,Magae, Junji,Ando, Kunio,Lee, Tae-Sung,Kwon, Taeg Kyu,Kwak, Jong-Young,Kim, Cheorl-Ho,Chang, Young-Chae American Society for Biochemistry and Molecular Bi 2005 The Journal of biological chemistry Vol.280 No.26

Comparative Proteomic Label-Free Analysis of <i>Campylobacter jejuni</i> NCTC 11168 Cultured with Porcine Mucin

Hong, Sahyun,Cha, Injun,Kim, Nan-Ok,Seo, Jong-Bok,Kim, Soo-Young,Kim, Jong-Hyun,Chung, Gyung Tae,Jeon, Byeonghwa,Kang, Yeon-Ho Mary Ann Liebert 2014 Foodborne Pathogens and Disease Vol.11 No.3

한국인 복지태도의 변화양상 -집단중심 다중궤적모형의 적용-

김사현 ( Kim Sahyun ),황동진 ( Hwang Dongjin ),이민서 ( Lee Minseo ),김도한 ( Kim Dohan ) 한국사회복지정책학회 2021 사회복지정책 Vol.48 No.1

이 연구는 한국인 복지태도의 변화양상을 탐색한 것이다. 특별히 연구는 복지태도를 다차원적 관점에서 5가지 복지정책 관련 쟁점(불평등, 정부지출, 보편성, 정책평가, 증세)에 대한 태도로 규정하고, 동시에 변화의 양상을 공유하는 여러 집단들을 도출하는 보다 포괄적인 접근 전략을 취했다. 분석을 위해 한국복지패널조사의 복지인식 부가조사 8차, 11차, 14차년도 자료가 활용되었고, 집단중심 다중궤적모형(Group-based Multi-trajectory Model) 분석이 이루어졌다. 그 결과 변화양상이 상이한 집단은 4개, 곧 ‘선별확대군(48.7%)’, ‘확대반대군(25.7%)’, ‘비용회피군 (18.9%)’, ‘적극확대군(6.7%)’으로 식별되었다. 각 집단은 태도의 변화가 관찰되지만 개별 정책쟁점에 대한 초기값 차이를 일정 정도 유지한 채 안정적으로 변화하는 양상을 보였다. 한편, 각 집단에 속할 확률은 인구사회학적 특성과 정치적 이념에 따라 뚜렷한 차이를 보임으로써 한국사회 구성원들의 복지태도 역시 복지정책에 대한 이해관계를 따라 사회적으로 구조화되어 있음을 확인할 수 있었다. The purpose of this research is to explores changes of Korean welfare attitude using the group-based multi-trajectory model. For research, this research took a more comprehensive approach strategy by defining the welfare attitude as five types of attitudes towards welfare policies(inequality, government expenditure, universality, policy evaluation, tax increase) based on the multi-dimensional perspective, and also drawing many groups sharing the aspect of change at the same time. For the analysis, this study utilized the 8th, 11th, and the 14th-year additional research data of Korea Welfare Panel Study, by conducting the group-based multi-trajectory model analysis. In the results, there were four groups with different trajectory of change such as ‘selective expansion group(48.7%)’, ‘expansion opposition group(25.7%)’, ‘expense avoidance group(18.9%)’, and ‘active expansion group(6.7%)’. The differences of attitude in each group in relation to the five policy-level issues were stably maintained. Also, the probability belonging to each group showed such distinct differences according to the demographic characteristics and political ideology, which verified that the welfare attitude of Korean society members was also socially structured according to the interests of welfare policies.

정부지출에 대한 태도이중성 비교연구

김사현 ( Kim Sahyun ) 한국사회복지정책학회 2017 사회복지정책 Vol.44 No.4

이 연구는 정부지출에 대한 이중적 태도가 발생하는 원인을 탐색한 것으로, 특별히 비교론적 관점에서 정부의 복지지출 수준과 태도이중성 사이의 관계를 파악하는데 초점을 두었다. 선행연구들은 태도이중성이 발생하는 원인을 주로 심리학적 관점에서 개인 내부의 갈등에서만 찾는 경향이 있었다. 그러나 태도이중성에 대한 사회학적 설명은 보다 구조적이고 맥락적인 측면을 강조한다. 본 연구는 이러한 관점에 따라 정부지출에 대한 태도이중성이 한편으로 작은 정부를 지향하는 사회의 지배적 신념과 복지정책과 관련된 개인수준의 자기이해 및 이념 사이의 불일치에 의해, 다른 한편으로 국가수준의 복지정책 발전 수준에 따른 사회적 여건 사이의 불일치에 의해 발생한다고 보았다. 이에 OECD 17개국을 대상으로 ISSP: Role of Government Ⅳ 자료를 활용해 서열화로지스틱다층모형(multilevel ordered logistic model)을 활용한 실증분석을 시도하였다. 그 결과 개인수준의 가치갈등, 교육수준, 노인여부, 좌파정당지지 여부가, 그리고 국가수준에서 정부의 복지지출 수준이 태도이중성 발생과 관련이 있는 것을 확인하였다. 특히, 복지지출 수준이 낮은 사회일수록 태도이중성이 발생할 확률이 높으며, 반대로 복지지출수준이 높은 사회에서 현상유지적 태도를 보이는 확률이 큰 것으로 나타났다. 이러한 결과는 정부지출과 관련된 구조화된 태도이중성이 실제로 존재함을 보여주는 것으로 이해된다. This study explored the causes of ambivalent attitudes toward government spending, focusing specifically on the influence of government welfare expenditure levels in a comparative perspective. Previous studies have shown that ambivalence of welfare attitude tends to be found primarily in psychological internal conflicts. However, sociological explanations for ambivalent attitude emphasize more structural and contextual aspects. From this perspective, this study predicted that ambivalent attitude on government spending is influenced by the inconsistency between the dominant beliefs of society that are oriented toward small government and the individual self-interest and ideology related to welfare policy at the individual level, and the social conditions according to the level of welfare development at the national level. In this study, ISSP: Role of Government IV data from 17 OECD countries was used for empirical analysis using a multilevel ordered logistic model. As a result, the probability of ambivalent attitude was high in the aged, low education, and right-wing party support groups at the individual level and in societies where the welfare expenditure level of government is low at the national level. These results suggest that there is a structured ambivalence of welfare attitudes related to the welfare policy of the government.

노년기 우울증상의 다중궤적 및 변화요인 연구

김사현 ( Kim Sahyun ),김소진 ( Kim Sojin ) 한국가족사회복지학회 2019 한국가족복지학 Vol.64 No.-

본 연구는 한국 노인의 우울궤적 및 궤적의 변화와 관련된 시가변 요인(time varying covariates)을 탐색한 것이다. 특히, 연구는 모집단 동질성 가정을 완화할 경우, 우울궤적 및 시가변 요인의 영향이 하위집단별로 차이가 있을 것으로 예상했다. 분석을 위해 집단중심궤적모형을 활용하였고, 5개의 시가변 요인(결혼지위, 가구소득, 신체기능, 단체활동, 노동활동)을 투입하기 전과 후의 결과를 비교하였다. 분석에 활용된 자료는 한국고령화연구패널 1∼6차 조사자료이며, 분석대상은 65세이상 노인 4,164명이다. 분석결과는 세 가지로 정리된다. 첫째, 5개 노년기 우울궤적이 도출되었다: 최저형, 저수준형, 감소형, 증가형, 고수준형. 둘째, 각 우울궤적의 초기값, 변화율, 그리고 집단비중은 시가변 요인의 투입으로 변화하였다. 셋째, 시가변 요인의 영향은 모든 궤적에게 동일하게 작용하지 않았다. 최저형은 결혼지위, 신체기능만이 통계적으로 유의했으며, 저수준형은 추가적으로 노동활동도 유의했다. 감소형은 단체활동만이 유의했으며, 증가형은 투입된 모든 변수가 유의했다. 마지막으로 고수준형은 가구소득과 단체활동, 그리고 노동활동이 유의했다. 연구결과는 다중우울궤적을 다룬 선행연구들의 분석결과를 보다 일반화하고, 시가변 요인의 효과를 검증하는 데 기여하였다. 또한 선행연구들이 지닌 자료의 문제, 영향요인의 활용문제, 그리고 모집단 동질성 가정의 문제를 보완한 것으로 평가될 수 있다. This study is about the time varying covariates related to the elderly’s depression trajectory and the change of the trajectory in Korea. Especially, this study expects that there can be different effects of the time varying covariates among sub-groups when population homogeneity assumptions are mitigated. For the analysis, the group-based trajectory model is used, and the results before and after applying the time-varying covariates(marital status, household income, physical function, social engagement, labor activity) to this model are compared. The data used for the analysis are the 1^st ∼6^th waves of longitudinal data from the Korean Longitudinal Study of Ageing, and the subjects of the analysis are 4,164 people age 65 and older. The results are summarized into the following three categories. First, five different trajectories are identified: minimal depressive symptoms, low depressive symptoms, high but decreasing depressive symptoms, low but increasing depressive symptoms, and high depressive symptoms. Second, the adjustment of time-varying covariates causes the significant change in the initial value, change rate and group proportion of each depression trajectory. Third, the time-varying covariates do not affect equally all trajectories. These findings have contributed to more generalizing the results of preceding researches on multiple trajectories of depressive symptoms of the elderly and verifying the effects of time-varying covariates. This study can be also considered to compensate such problems of preceding researches as data, influencing factors, and population homogeneity assumptions.

How Does Androgen Deprivation Therapy Affect Mental Health including Cognitive Dysfunction in Patients with Prostate Cancer?

Lee Hyung Ho,Park Sahyun,Joung Jae Young,Kim Sung Han 대한남성과학회 2021 The World Journal of Men's Health Vol.39 No.4

Androgen deprivation therapy (ADT) is used to block the release of androgen in prostate cancer to promote the regression of cancer cells, and hence, disease progression. Its indication has been widened from the metastatic setting to the localized setting in prostate cancer. Long-term ADT for suppressing androgen release leads to a rapid decrease in androgen, termed as andropause, resulting in several dose and duration dependent adverse effects, including cognitive dysfunction such as dementia. Many retrospective and prospective studies, as well as meta-analyses, have attempted to confirm the crucial relationship between ADT and cognitive dysfunction, but pro and contrary opinions regarding this issue are ongoing owing to the absence of randomized controlled trials. Additionally, several recent studies have suggested the negative effects of dose- and duration-dependent ADT on cognitive dysfunction, especially in 40–65-year-old patients with prostate cancer, who are currently active workers in the society. This review article discusses several studies examining the influence of ADT on mental health based on diverse significant perspectives, especially cognitive dysfunction.