Vitamin D and Autism Spectrum Disorder: An Intriguing Association

Raqshan Wajih Siddiqui,Tabish Wajih Siddiqui,Shiza Wajih Siddiqui 대한소아신경학회 2024 대한소아신경학회지 Vol.32 No.2

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects the overall cognitive, emotional, social, and physical health of the affected individual. It is characterised by challenges in social communication and interaction, repetitive and stereotyped behaviours, and narrow interests. The pathogenesis of ASD is thought to involve a combination of genetic and environmental factors. Increasing evidence suggests that vitamin D deficiency during pregnancy and early childhood may contribute to the development of ASD. While studies have indicated that vitamin D supplementation can significantly improve symptoms of ASD, the underlying mechanism remains elusive. This review summarises the association between vitamin D levels and ASD, explores potential mechanisms underlying vitamin D's role in ASD, and examines the effect of vitamin D supplementation on ASD symptoms.

Therapeutic Effect of Majoon Mundi and Qairooti Karnab in Dā al-Ṣadaf (Psoriasis): A Case Series

Siddiqui, Gulnaz Fatima,Siddiqui, Shahid Akhtar,Jabeen, Arzeena,Qamaruddin, Qamaruddin,Kazmi, Munawwar Husain Cellmed Orthocellular Medicine and Pharmaceutical 2019 셀메드 (CellMed) Vol.9 No.4

Introduction: Psoriasis is a major health concern around the world. Physicians of the Unani system of medicine have been treating psoriasis for centuries. Aim: The purpose of our study was to assess the effect of Majoon Mundi (a semisolid Unani medication intended for oral intake used as blood purifier) and Qairooti Karnab (a Unani medication in paste form intended for topical application used as emollient) in the treatment $na{\ddot{i}}ve$ psoriasis cases and to collect data to warrant further clinical trials. Material and Methods: Psoriasis cases were diagnosed clinically. Data were collected during treatment of five patients of psoriasis treated with the Majoon Mundi (oral intake of 5 gm twice daily with 200 ml of water for 12 weeks) and Qairooti Karnab (topical application on affected sites twice a day for 12 weeks). Patients were treated for 12 weeks. Treatment response was seen with clinical improvement in skin lesions and measurement of Psoriasis Area and Severity Index (PASI Scoring) before and after treatment. Results: Reduced PASI Score was observed in all five patients after 12 weeks of treatment [PASI before and after treatment was (mean${\pm}$SD) $20.7{\pm}4.6$ vs. $3.2{\pm}1.8$; p-value <0.05.]. Clinical improvement was noticed within an average of 4 weeks of treatment. Conclusion: Preliminary findings indicate the potential therapeutic role of Majoon Mundi and Qairooti Karnab in the treatment of psoriasis. Clinical trials based on this Unani pharmacopeial formulation should be conducted to explore the therapeutic potential of this formulation in psoriasis

Prevalence and Molecular Characterization of ESBL Producing Enterobacteriaceae from Highly Polluted Stretch of River Yamuna, India

Siddiqui, Kehkashan,Mondal, Aftab Hossain,Siddiqui, Mohammad Tahir,Azam, Mudsser,Haq., Qazi Mohd. Rizwanul The Korean Society for Microbiology and Biotechnol 2018 한국미생물·생명공학회지 Vol.46 No.2

The rapid increase in number and diversity of Extended Spectrum ${\beta}$-Lactamases (ESBLs) producing Enterobacteriaceae in natural aquatic environment is a major health concern worldwide. This study investigates abundance and distribution of ESBL producing multidrug resistant Enterobacteriaceae and molecular characterization of ESBL genes among isolates from highly polluted stretch of river Yamuna, India. Water samples were collected from ten different sites distributed across Delhi stretch of river Yamuna, during 2014-15. A total of 506 non duplicate Enterobacteriaceae isolates were obtained. Phenotypic detection of ESBL production and antibiotic sensitivity for 15 different antibiotics were performed according to CLSI guidelines (Clinical and Laboratory Standard Institute, 2015). A subset of ESBL positive Enterobacteriaceae isolates were identified by 16S rRNA gene and screened for ESBL genes, such as $bla_{CTX-M}$, $bla_{TEM}$ and $bla_{OXA}$. Out of 506 non-duplicate bacterial isolates obtained, 175 (34.58%) were positive for ESBL production. Susceptibility pattern for fifteen antibiotics used in this study revealed higher resistance to cefazolin, rifampicin and ampicillin. A high proportion (76.57%) of ESBL positive isolates showed multidrug resistance phenotype, with MAR index of 0.39 at Buddha Vihar and Old Delhi Railway bridge sampling site. Identification and PCR based characterization of ESBL genes revealed the prevalence of $bla_{CTX-M}$ and $bla_{TEM}$ genes to be 88.33% and 61.66%, respectively. Co-occurrence of $bla_{CTX-M}$ and $bla_{TEM}$ genes was detected in 58.33% of the resistant bacteria. The $bla_{OXA}$ gene was not detected in any isolates. This study highlights deteriorating condition of urban aquatic environment due to rising level of ESBL producing Enterobacteriaceae with multidrug resistance phenotype.

Prevalence and Molecular Characterization of ESBL Producing Enterobacteriaceae from Highly Polluted Stretch of River Yamuna, India

( Kehkashan Siddiqui ),( Aftab Hossain Mondal ),( Mohammad Tahir Siddiqui ),( Mudsser Azam ),( Qazi Mohd. Rizwanul Haq ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 한국미생물·생명공학회지 Vol.46 No.2

The rapid increase in number and diversity of Extended Spectrum β-Lactamases (ESBLs) producing Enterobacteriaceae in natural aquatic environment is a major health concern worldwide. This study investigates abundance and distribution of ESBL producing multidrug resistant Enterobacteriaceae and molecular characterization of ESBL genes among isolates from highly polluted stretch of river Yamuna, India. Water samples were collected from ten different sites distributed across Delhi stretch of river Yamuna, during 2014-15. A total of 506 non duplicate Enterobacteriaceae isolates were obtained. Phenotypic detection of ESBL production and antibiotic sensitivity for 15 different antibiotics were performed according to CLSI guidelines (Clinical and Laboratory Standard Institute, 2015). A subset of ESBL positive Enterobacteriaceae isolates were identified by 16S rRNA gene and screened for ESBL genes, such as bla_CTX-M, bla_TEM and bla_OXA. Out of 506 non-duplicate bacterial isolates obtained, 175 (34.58%) were positive for ESBL production. Susceptibility pattern for fifteen antibiotics used in this study revealed higher resistance to cefazolin, rifampicin and ampicillin. A high proportion (76.57%) of ESBL positive isolates showed multidrug resistance phenotype, with MAR index of 0.39 at Buddha Vihar and Old Delhi Railway bridge sampling site. Identification and PCR based characterization of ESBL genes revealed the prevalence of bla_CTX-M and bla_TEM genes to be 88.33% and 61.66%, respectively. Co-occurrence of bla_CTX-M and bla_TEM genes was detected in 58.33% of the resistant bacteria. The bla_OXA gene was not detected in any isolates. This study highlights deteriorating condition of urban aquatic environment due to rising level of ESBL producing Enterobacteriaceae with multidrug resistance phenotype.

Singel Agent DAA in HCV PCR Positive Liver Transplant Patients, Experience from a Developing Country

( Hafiz Abdul Basit Siddiqui ),( Basit Siddiqui ),( Rabeea Azmat ),( Wasim Jafri ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Chronic hepatitis C (CHC) is the leading cause of decompensated liver disease and liver transplant indication in Pakistan, which is the second most prevalent country with a prevalence of 3.5% to 5.2%. Being the seventh most populous country in the world, lacking significantly on medical grounds reflected by only one liver transplant centre for more than 10 million chronically affected liver disease patients. Before the era of directly acting antiviral agents (DAAs) most common problem faced in the post liver transplant period was recurrence of HCV and most of the patients were non responders to interferon therapy well before transplantation of liver graft. Aim of this study is to see the outcomes of single agent DAA in HCV PCR positive liver transplant patients. Methods: This cross sectional analysis was carried out in CHC infected post liver transplant patients with high viremia. The effect of DAAs were noted in the form of eradication of virus and achievement of sustained virological response (SVR). DAAs used, were also recored. Also to note the interaction with immunosuppresants and development of side effects notably derangement of liver function test or failure of graft and anemia. And to note the development of acute kidney injury or any other untoward effect. Results: During study period of 24 months, from January 2015 to December 2016, 51 HCV positive liver transplant patients were enrolled in the study. 26 (52%) out of 51 found to have active viral replication with positive PCR. All 26 received combination of Sofosbuvir (only DAA avaialbe till December 2016 in Pakistan) and Ribavirin. Achievement of viral eradication was 100% so was for SVR. There was no interaction with immunosuppressants. Most commonly reported side effect was fatigue and a feeling of nausea. Kidney and liver function tests remained normal. Contrary to recent data, there was no recurrence of hepatocellular carcinoma (HCC) in patients who recieved liver graft for HCC on background of CHC cirrhosis. Conclusions: Directly acting antiviral therapy has revolutionized outcomes of HCV infected post liver transplant patients in a country lacking modern and advanced health care system. Even the single agent therapy has done wonders for the economically less privileged.

A set-top box for end-to-end QoS management and home network gateway in IMS

Siddiqui, M.S.,Amin, S.O.,Choong Seon Hong IEEE 2009 IEEE transactions on consumer electronics Vol.55 No.2

<P>As the next generation networks promise network convergence with services for both static and mobile networks, the research focus is converging towards standardizing a common infrastructure for all-IP networks. IP Multimedia Subsystem (IMS) is a recent initiative, which outlines a service delivery platform (SDP) framework. A flexible and robust QoS management system for IMS is essential to ascertain the achievability of service quality on these converged networks. As Triple and Quadruple Play services are the most celebrated services of IMS in the near future, the necessity of QoS assurance is becoming an imminent need of the hour. Multimedia services delivery in converged IP networks using IMS, concentrates on ensuring capabilities to ensure the best QoS. To meet these requirements, we have designed a set-top box which provides feedback in IMS management architecture to ensure end-toend QoS as well as enables the functionalities of Regional Gateway for the Home Network. Results of the simulation confirm the improvement of performance parameters and the quality of service.</P>

Resistive switching phenomena induced by the heterostructure composite of ZnSnO₃ nanocubes interspersed ZnO nanowires

Siddiqui, Ghayas Uddin,Rehman, Muhammad Muqeet,Choi, Kyung Hyun The Royal Society of Chemistry 2017 Journal of Materials Chemistry C Vol.5 No.22

Enhanced resistive switching in all-printed, hybrid and flexible memory device based on perovskite ZnSnO₃ via PVOH polymer

Siddiqui, G.U.,Rehman, M.M.,Choi, K.H. IPC Science and Technology Press 2016 Polymer Vol.100 No.-

Resistive switching effect has been explored in the hybrid nanocomposite of organic-inorganic materials by fabricating all printed memristive device on a flexible PET substrate. Configuration of as fabricated device is Ag/PVOH?ZnSnO<SUB>3</SUB>/Ag. Extremely uniform and high quality bottom Ag electrodes were deposited by reverse offset printing. Active layer of PVOH?ZnSnO<SUB>3</SUB> nanocomposite was deposited by electrohydrodynamic (EHD) atomization and top Ag electrode was deposited by a non-contact printing technique of EHD patterning. Electrical and mechanical characterization showed that resistive switching characteristics of ZnSnO<SUB>3</SUB> were remarkably enhanced by adding PVOH polymer in it. The fabricated device showed bipolar, nonvolatile and rewritable memory behavior at low operating voltage. A high off/on ratio, endurance and retention time of > 10<SUP>2</SUP>, 500 voltage cycles and 36 h respectively were recorded without any substantial change in either HRS or LRS. The fabricated memory device showed remarkable mechanical robustness when tested against 1500 bending cycles.

Chemical Constituents from the Aerial Parts of Lippia nodiflora Linn

Siddiqui, Bina S.,Ahmad, Fayaz,Sattar, Fouzia A.,Begum, Sabira 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12

Phytochemical investigation of the methanolic extract of the aerial parts of Lippia nodiflora Linn. led to the isolation of a new triterpenoid lippiacin (1) and a benzofuranone rengyolone (halleridone, 2) through repeated silica gel column chromatography and semi preparative HPLC. The structures of these compounds were determined by spectroscopic methods, including 1D and 2D NMR, as well as by comparison with published data. A complete assignment of the $^1H-\;and\;^{13}C-NMR$ data of 2 is reported based on 2D NMR (COSY-45, HMQC and HMBC) spectroscopic methods.

Effective use of aluminum-plastic laminate as a feedstock for catalytic pyrolysis over micro and mesoporous catalysts

Siddiqui, Muhammad Zain,Park, Young-Kwon,Kang, Yejin,Watanabe, Atsushi,Kim, Seungdo,Kim, Young-Min Elsevier 2019 JOURNAL OF CLEANER PRODUCTION Vol.229 No.-

<P><B>Abstract</B></P> <P>Thermal and catalytic pyrolysis of aluminum plastic laminate over zeolite catalysts were performed to produce high quality oil. Thermogravimetric analysis of aluminum plastic laminate indicated that the decomposition kinetics of aluminum plastic laminate were changed by interactions between the polymer components during the thermogravimetric analysis of aluminum plastic laminate. The effects of aluminum foil on the aluminum plastic laminate decomposition kinetics were negligible. The catalytic pyrolysis of aluminum plastic laminate over the acid catalysts using tandem-micro reactor-gas chromatography/mass spectrometry produced large amounts of aromatics due to the properties of the main polymers, polyethylene and poly (ethylene terephthalate), in aluminum plastic laminate. Among three catalysts, HZSM-5 (SiO<SUB>2</SUB>/Al<SUB>2</SUB>O<SUB>3</SUB>, 23), HY(30), and Al-MCM-41 (20), HZSM-5 (23) had the highest efficiency on aromatics production followed by HY(30) and Al-MCM-41 (20). Co-feeding aluminum plastic laminate to the catalytic pyrolysis of paper over HZSM-5 (23) and HY(30) was also effective on aromatics production, highlighting the potential use of aluminum plastic laminate to enhance the synergistic aromatics formation during the catalytic pyrolysis of biomass.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Interaction between polymers changed kinetic behavior of aluminum plastic laminate. </LI> <LI> Catalytic pyrolysis of aluminum plastic laminate produced aromatics efficiently. </LI> <LI> HZSM-5 was the most effective catalyst on aromatics formation. </LI> <LI> Co-feeding aluminum plastic laminate and paper produced additional aromatics. </LI> </UL> </P>