수중 시체에서 내부 장기 및 대조수에 대한 규조류의 분석

조갑래,서원준,함석훈,이종석,최동호,전병원,김양정,김광훈 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

The Clinical Observation of Inflammation Theory for Depression: The Initiative of the Formosa Long COVID Multicenter Study (FOCuS)

Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.

The Crucial Role of the Establishment of Computed Tomography Density Conversion Tables for Treating Brain or Head/Neck Tumors

Yang, Shu-Chin,Lo, Su-Hua,Shie, Li-Tsuen,Lee, Sung-Wei,Ho, Sheng-Yow Korean Society of Medical Physics 2021 의학물리 Vol.32 No.3

Purpose: The relationship between computed tomography (CT) number and electron density (ED) has been investigated in previous studies. However, the role of these measures for guiding cancer treatment remains unclear. Methods: The CT number was plotted against ED for different imaging protocols. The CT number was imported into ED tables for the Pinnacle treatment planning system (TPS) and was used to determine the effect on dose calculations. Conversion tables for radiation dose calculations were generated and subsequently monitored using a dosimeter to determine the effect of different CT scanning protocols and treatment sites. These tables were used to retrospectively recalculate the radiation therapy plans for 41 patients after an incorrect scanning protocol was inadvertently used. The gamma index was further used to assess the dose distribution, percentage dose difference (DD), and distance-to-agreement (DTA). Results: For densities <1.1 g/cm³, the standard deviation of the CT number was ±0.6% and the greatest variation was noted for brain protocol conditions. For densities >1.1 g/cm³, the standard deviation of the CT number was ±21.2% and the greatest variation occurred for the tube voltage and head and neck (H&N) protocol conditions. These findings suggest that the factors most affecting the CT number are the tube voltage and treatment site (brain and H&N). Gamma index analyses for the 41 retrospective clinical cases, as well as brain metastases and H&N tumors, showed gamma passing rates >90% and <90% for the passing criterion of 2%/2 and 1%/1 mm, respectively. Conclusions: The CT protocol should be carefully decided for TPS. The correct protocol should be used for the corresponding TPS based on the treatment site because this especially affects the dose distribution for brain metastases and H&N tumor recognition. Such steps could help reduce systematic errors.

Employee Stress, Job Satisfaction, and Job Performance: A Comparison between High-technology and Traditional Industry in Taiwan

YANG, Shu Ya,CHEN, Shui Chuan,LEE, Liza,LIU, Ying Sing Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3

The use of human resources determines the success of enterprises. This study applies the questionnaire design method to analyze the relationship between job stress, job satisfaction, and job performance, noting that few studies have comparatively examined these variables between industries, especially between high-tech and traditional industries. The proposed assessment model in this study can facilitate decision-makers' ability to make the optimal business decisions through their personnel systems, thereby improving employee satisfaction and increasing job performance. This study found that in the traditional and high-tech industries, some demographic variables have significant differences in the job stress, job satisfaction and job performance, but the demographic variables that can significantly affect the differences in these job's variables are differences between industries. This study acknowledges that job stress and performance have a significantly negative correlation, and traditional industries will have more stress factors than high-tech industries. In addition, support for traditional industries exist in job satisfaction and performance has a significantly positive correlation, but not in high-tech industries. Job stress for performance has a significantly negative correlation in two industries. This study reconfirmed the relationship between job stress, satisfaction and performance, found some differences in this relationship and the respective industrial characteristics.

The Short-Term Fear Effects for Taiwan's Equity Market from Bad News Concerning Sino-U.S. Trade Friction

YANG, Shu Ya,LIN, Hsiu Hsu,LIU, Ying Sing Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3

Mainland China area has been a long-term, major trade rival and partner of Taiwan, accounting for more than 40% of Taiwan's total annual trade exports, and so Sino-US trade friction is expected to have a significant impact on Taiwan's economy in the future. This study focuses on major bad news of Sino-US trade frictions and how it generates short-term shocks for Taiwan's equity market and fear sentiment. It further explores the mutual interpretation relationship between price changes such as VIX, Taiwan's stock market index, and the VIX ETF to identify which factors have information leadership as leading indicators. The study period covers 750 trading days from 2017/1/3 to 2020/1/31. This study finds that, when a policy news is announced, the stock market index falls significantly, the change in the trading price (net value) of the VIX ETF rises significantly, and the overprice rate significantly drops, but VIX does not, showing that fear sentiment exists in the Taiwan's market. The net value of the VIX ETF shows an information advantage as a leading indicator. This study suggests that, when the world's two largest economies clash over trade, the impact on Taiwan's equity market is inevitable, and that short-term fear effects will arise.

Alterations of Spontaneous Sleep Architecture and Cortical Electroencephalogram Power Spectra by Red Ginseng Extract via GABA_Aergic Systems

Yang, Shu-Long,Nam, Sang-Yoon,Han, Jin-Yi,Kim, Jun-Cheol,Lee, Ki-Nam,Hong, Jin-Tae,Oh, Ki-Wan,Eun, Jae-Soon The Korean Society of Ginseng 2010 Journal of Ginseng Research Vol.34 No.4

This study was undertaken to discover the effects and possible mechanisms of the effect of red ginseng extract (RGE) on spontaneous sleep. The effects of a low dose (10 mg/kg) and a high dose (200 mg/kg) of RGE were compared in rats. After recovery from a surgical operation enabling electroencephalograms recordings, rats were administered RGE orally. RGE was administered orally for 1 day or once per day for 5 days in either 10 or 200 mg/kg doses. Polygraphic signs were recorded for 12 h after oral administration of RGE. Both treatment with a large dose (200 mg/kg) of RGE for one day and treatment with either a large or a small dose for 5 days reduced the number of sleep.wake cycles. Daily treatment with RGE (either 10 or 200 mg/kg) for 5 days augmented NREM and total sleep, but reduced wakefulness. Delta wave activity recorded during non-REM (NREM) sleep and REM sleep was increased after one treatment with RGE (either 10 or 200 mg/kg). Delta wave activity during NREM was enhanced after daily treatment with RGE (either 10 or 200 mg/kg) for 5 days. Both alpha and beta subunits of the $\gamma$-aminobutyric acid $(GABA)_A$ receptor were significantly over-expressed in the hypothalamus of the RGE-treated groups. Moreover, the expression of glutamic acid decarboxylase was also increased in the hypothalamus. These results demonstrate that RGE may regulate spontaneous sleep via $GABA_A$ergic systems.

Alterations of Spontaneous Sleep Architecture and Cortical Electroencephalogram Power Spectra by Red Ginseng Extract via GABAAergic Systems

Shu-Long Yang,Sang-Yoon Nam,Jin-Yi Han,Jun-Cheol Kim,이기남,홍진태,오기완,은재순 고려인삼학회 2010 Journal of Ginseng Research Vol.34 No.4

This study was undertaken to discover the effects and possible mechanisms of the effect of red ginseng extract (RGE) on spontaneous sleep. The effects of a low dose (10 mg/kg) and a high dose (200 mg/kg) of RGE were compared in rats. After recovery from a surgical operation enabling electroencephalograms recordings, rats were administered RGE orally. RGE was administered orally for 1 day or once per day for 5 days in either 10 or 200 mg/kg doses. Polygraphic signs were recorded for 12 h after oral administration of RGE. Both treatment with a large dose (200 mg/kg) of RGE for one day and treatment with either a large or a small dose for 5 days reduced the number of sleep–wake cycles. Daily treatment with RGE (either 10or 200 mg/kg) for 5 days augmented NREM and total sleep, but reduced wakefulness. Delta wave activity recorded during non-REM (NREM) sleep and REM sleep was increased after one treatment with RGE (either 10 or 200 mg/kg). Delta wave activity during NREM was enhanced after daily treatment with RGE (either 10 or 200 mg/kg) for 5 days. Both alpha and beta subunits of the γ-aminobutyric acid (GABA)A receptor were significantly over-expressed in the hypothalamus of the RGEtreated groups. Moreover, the expression of glutamic acid decarboxylase was also increased in the hypothalamus. These results demonstrate that RGE may regulate spontaneous sleep via GABAAergic systems.

A comparative study of academic dishonesty among university students in Mainland China and Taiwan

Shu Ching Yang,Feng Kuang Chiang,Chiao Ling Huang 서울대학교 교육연구소 2017 Asia Pacific Education Review Vol.18 No.3

The purpose of this study was to compare the academic dishonesty (AD) experience of students from Mainland China and Taiwan. Specifically, we investigated students’ current self-reported personal AD, their perception of peers’ AD, the climate of academic integrity and their awareness of AD’s seriousness. Furthermore, we sought to explore the relationship between AD behavior and several variables. In total, 605 students from Mainland China (n = 368) and Taiwan (n = 237) were recruited to participate in the study. All the participants perceived that they were less involved in AD than their peers, and students from both areas ranked the gravity of AD offenses similarly. However, Chinese students generally reported higher rates of improper credit attribution, fraudulence, and falsification than their Taiwanese counterparts. Finally, two regression models revealed gender, perception of peer AD, and awareness of AD’s seriousness were significant variables in terms of predicting self-reported personal AD, and there existed interactions between the students’ perception of peer AD and gender. Witnessing peers’ misconduct influenced males more than females in terms of engaging in AD for both Mainland Chinese and Taiwanese students.

Protein profiling predicts the response to anthracycline and taxanes based neo-adjuvant chemotherapy in breast cancer

Shu Wang,Houpu Yang,Jiajia Guo,Miao Liu,Fuzhong Tong,Yingming Cao,Bo Zhou,Peng Liu,Lin Cheng,Fei Xie,Deqi Yang,Jiaqing Zhang 한국바이오칩학회 2011 BioChip Journal Vol.5 No.1

Neo-adjuvant chemotherapy for breast cancer substantially benefits patients who achieve pathological response. However, clinical or pathological response information can only be obtained a period of time after chemotherapy. The identification of novel bio-markers or the application of new technique that can be used to predict treatment response before che-motherapy would allow therapy to be tailored on an individual patient basis. The purpose of this study is to identify the chemo-sensitivity and chemo-resistance related proteins using antibody microarray profiling, and to develop a multi-protein predictive model for breast cancer. Total protein was extracted from core needle biopsy samples obtained from 15 patients before treatment with neo-adjuvant TA(combination of taxanes and anthracycline) chemotherapy. Protein profiling was analyzed by antibody microarray. 10 pati-ents were used as training set to develop the predictive model using the software PAM(prediction analysis of microarray). Another 5 patients were used as a validation set to test the model. In cross-validation, the mole-cular predictive model showed an accuracy of 90%, in independent validation, the model classified the cases with an accuracy of 80%. In conclusion, the proteomic predictive model has the potential to predict pathological response to neo-adjuvant TA chemotherapy.

Validation of Actiwatch for Assessment of Sleep-wake States in Preterm Infants

Shu-Chen Yang,Asphodel Yang,Ying-Ju Chang 한국간호과학회 2014 Asian Nursing Research Vol.8 No.3

Purpose: The purpose of this study was to validate the Actiwatch with behaviorally determined sleepewake state in preterm infants and to explore the influence of postmenstrual age on the accuracy ofActiwatch. Methods: A prospective and comparative research design was used. Twenty-four preterm infants withpostmenstrual age ranging from 28e38 weeks were studied. The infants were studied for 2 hours betweentwo feedings. Infant's sleep and wake state was measured every 30 seconds using Actiwatch andthe Anderson Behavioral State Scale simultaneously. Results: Actiwatch demonstrated high agreement, sensitivity, and predictivity of sleep state, whenvalidated with the Anderson Behavioral State Scale at the setting of high and automatic activitythresholds, and was not influenced by the infant's postmenstrual age. However, lower specificity andpredictivity were found in the wake state, and influenced by postmenstrual age. Conclusion: Results of this study suggest that high activity thresholds are the most accurate for determiningsleep state in preterm infants, and health care professionals must take the limitations intoconsideration while using the Actiwatch to assess wake states.