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Hu, X -T,Zhang, F -B,Fan, Y -C,Shu, X -S,Wong, A H Y,Zhou, W,Shi, Q -L,Tang, H -M,Fu, L,Guan, X -Y,Rha, S Y,Tao, Q,He, C Macmillan Publishers Limited 2009 Oncogene Vol.28 No.26
Located at the important tumor suppressor locus, 3p22, PLCD1 encodes an enzyme that mediates regulatory signaling of energy metabolism, calcium homeostasis and intracellular movements. We identified PLCD1 as a downregulated gene in aerodigestive carcinomas through expression profiling and epigenetic characterization. We found that PLCD1 was expressed in all normal adult tissues but low or silenced in 84% (16/19) gastric cancer cell lines, well correlated with its CpG island (CGI) methylation status. Methylation was further detected in 62% (61/98) gastric primary tumors, but none of normal gastric mucosa tissues. PLCD1 methylation was significantly correlated with tumor high stage. Detailed methylation analysis of 37 CpG sites at the PLCD1 CGI by bisulfite genomic sequencing confirmed its methylation. PLCD1 silencing could be reversed by pharmacological demethylation with 5-aza-2′-deoxycytidine, indicating a direct epigenetic silencing. Ectopic expression of PLCD1 in silenced gastric tumor cells dramatically inhibited their clonogenicity and migration, possibly through downregulating MMP7 expression and hampering the reorganization of cytoskeleton through cofilin inactivation by phosphorylation. Thus, epigenetic inactivation of PLCD1 is common and tumor-specific in gastric cancer, and PLCD1 acts as a functional tumor suppressor involved in gastric carcinogenesis.Oncogene (2009) 28, 2466–2475; doi:10.1038/onc.2009.92; published online 18 May 2009
A COLD NEPTUNE-MASS PLANET OGLE-2007-BLG-368Lb: Cold neptunes are common
Sumi, T.,Bennett, D. P.,Bond, I. A.,Udalski, A.,Batista, V.,Dominik, M.,Fouqué,, P.,Kubas, D.,Gould, A.,Macintosh, B.,Cook, K.,Dong, S.,Skuljan, L.,Cassan, A.,Abe, F.,Botzler, C. S.,Fukui, A.,Fu IOP Publishing 2010 The Astrophysical journal Vol.710 No.2
<P>We present the discovery of a Neptune-mass planet OGLE-2007-BLG-368Lb with a planet-star mass ratio of q = [9.5 +/- 2.1] x 10(-5) via gravitational microlensing. The planetary deviation was detected in real-time thanks to the high cadence of the Microlensing Observations in Astrophysics survey, real-time light-curve monitoring and intensive follow-up observations. A Bayesian analysis returns the stellar mass and distance at M(l) = 0.64(-0.26)(+0.21) M(circle dot) and D(l) = 5.9(-1.4)(+ 0.9) kpc, respectively, so the mass and separation of the planet are M(p) = 20(-8)(+7) M(circle plus) and a = 3.3(-0.8)(+1.4) AU, respectively. This discovery adds another cold Neptune-mass planet to the planetary sample discovered by microlensing, which now comprises four cold Neptune/super-Earths, five gas giant planets, and another sub-Saturn mass planet whose nature is unclear. The discovery of these 10 cold exoplanets by the microlensing method implies that the mass ratio function of cold exoplanets scales as dN(pl)/d log q alpha q(-0.7+/-0.2) with a 95% confidence level upper limit of n < -0.35 ( where dN(pl)/d log q alpha q(n)). As microlensing is most sensitive to planets beyond the snow-line, this implies that Neptune-mass planets are at least three times more common than Jupiters in this region at the 95% confidence level.</P>
Yang, Q.,Kwak, K.S.,Fu, F. IET 2010 IET COMMUNICATIONS Vol.4 No.3
<P>The authors investigate the symbol error rate (SER) performance of the cooperative decode-and-forward (DF) relaying strategy with orthogonal space-time block coding (OSTBC) applied at all links of source-relay, source-destination and relay-destination. Only when one relay node is able to correctly decode the OSTBC codeword of the source, it will forward source information to the destination with the same OSTBC codeword. The exact SER expressions of DF relaying with OSTBC are presented for M-PSK and M-QAM modulations, respectively, over dissimilar Rayleigh fading channels. By virtue of the multinomial theorem and the law of total probability, the derived expressions are further deduced in closed form. Simulations demonstrate the proposed closed-form analytical results. It is pointed out that such results have seldom appeared in literatures before.</P>
China Spallation Neutron Source: Accelerator Design Iterations and R&D Status
J. Wei,C.-D. Deng,C.-H. Wang,C.-T. Shi,H. Sun,H.-F. Ouyang,H.-M. Qu,H.-Y. Dong,J. Li,J. Zhang,J.-S. Cao,J.-Y. Tang,L. Dong,L.-L. Wang,Q. Qin,Q.-B. Wang,S. Wang,S.-N. Fu,S.-X Fang,T. -G. Xu,W. Kang,Y.- 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.I
The China Spallation Neutron Source (CSNS) is a high-power, accelerator-based project currently under preparation. The accelerator complex consists of an H$^-$ ion source, an H$^-$ linac, a rapid-cycling proton synchrotron, and the transport lines. During the past year, the design of most accelerator systems went through major iterations, and initial research and developments was started on the prototyping of several key components.