다시마 푸코이단추출물과 지질대사의 연관성

강금석,남천석,김인덕,권륜희,이동찬,허예영,하배진 신라대학교 자연과학연구소 2007 自然科學論文集 Vol.16 No.-

The effects of Laminaria japonica fucoidan extract (LJFE) on the biochemical parameters of lipid-related function were investigated in liver and serum of CCl_(4)-treated rats. LJFE of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1.5 ml/kg for 14 days. On the day 15, 3.3 ml/kg of CCl_(4) dissolved in olive oil (1:1) was injected 12 hours before anesthetization. We examined the lipid-related functions and enzyme activitys by measuring the levels of total cholesterol (TC), triglyceride (TG), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in serum. The results showed that CCl_(4) treatment increased the high values of TG, LDH and ALP decreased the low values of TC but LJFE pretreatment decreased the high values of TG, LDH and ALP to the low values, increased the TC. It was suggested that LJFE can be used as the potential candidate for the lipid-metabolism natural supplement.

Effect of lateral lymph node dissection on the quality of life and genitourinary function after neoadjuvant chemoradiotherapy for rectal cancer

Ryun Kyong Ha,Boram Park,Sung Chan Park,Hee Jin Chang,Jae Hwan Oh 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.100 No.2

Purpose: This study was performed to evaluate the quality of life and genitourinary function after total mesorectal excision with lateral lymph node dissection compared to those after total mesorectal excision alone following neoadjuvant chemoradiotherapy for rectal cancer. Methods: Among patients who underwent rectal cancer surgery after completing neoadjuvant chemoradiotherapy between September 2011 and October 2018 at the National Cancer Center, Korea, patients who completed the validated questionnaires before initiation of neoadjuvant chemoradiotherapy and at 3 months and 1 year postoperatively were included in this study. The European Organization for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (QLQ-C30), colorectal cancer-specific quality of life questionnaire (QLQ-CR38), and International Prostate Symptom Score (IPSS) questionnaire were used for collecting data. Results: The total mesorectal excision alone group and the total mesorectal excision with lateral lymph node dissection group included 52 and 38 patients, respectively. The second group included significantly younger patients (P = 0.024), had a higher incidence of clinical T4 stage disease (P = 0.033), estimated blood loss (P = 0.003), and longer operation time (P < 0.001). Significant differences were not observed between the groups with respect to the EORTC QLQ-C30, QLQ-CR38, and IPSS. Multivariable analysis showed that lateral lymph node dissection had no statistically significant association with postoperative urinary dysfunction (P = 0.953). Conclusion: The overall quality of life and urinary function after total mesorectal excision does not differ significantly when lateral lymph node dissection is performed as well.

Comparison of patient-reported quality of life and functional outcomes following laparoscopic and transanal total mesorectal excision of rectal cancer

Ryun Kyong Ha,Sung Chan Park,Boram Park,Sung Sil Park,Dae Kyung Sohn,Hee Jin Chang,Jae Hwan Oh 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.1

Purpose: The effect of transanal total mesorectal excision (TaTME) on patients’ quality of life and functional outcomes is not fully understood. This study aimed to compare the quality of life and bowel, anorectal, and urogenital functions after laparoscopic and TaTME. Methods: Laparoscopic or TaTME was performed for 202 propensity score-matched patient pairs with rectal cancer between January 2014 and December 2017 at the National Cancer Center, Korea. The outcomes for all patients were assessed using anorectal manometry, the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30) and Colorectal Cancer-Specific Quality of Life Questionnaire (QLQ-CR38), low anterior resection syndrome (LARS) score, Fecal Incontinence Severity Index, and International Prostate Symptom Score (IPSS). This retrospective comparative study included patients who completed anorectal manometry and the questionnaires before treatment and at 1 year after surgery. Results: The EORTC QLQ-C30 and QLQ-CR38 showed comparable outcomes regarding the quality of life in both groups. More patients experienced major LARS in the transanal group at 1 year postoperatively (31.0% vs. 6.8% in the laparoscopic group, P = 0.004). Multivariable analysis revealed no significant difference in the LARS score between the groups at 1 year postoperatively (odds ratio, 2.30; 95% confidence interval, 0.79–6.72; P = 0.127). Significant differences in the IPSS were not noted between the groups. Conclusion: The quality of life and functional outcomes were comparable between the laparoscopic and transanal approaches; however, our findings suggest a higher rate of LARS after TaTME.

Transmitting Duplicate Packets to New Network Using QoS Supporting Agent in FMIPv6

Ha Ryun Lee,Mun Gi Kim,Byung Ho Rhee 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7

In the future, a network infrastructure will be IP-based network. Today a mobile communication device’s user demands a QoS-guaranteed service. In Mobile IPv6, the handover latency problem is one factor to solve for QoS. To reduce a handover latency, a solution like “fast handover scheme” is proposed in IETF and there are also two more procedure to be considered at handover time. One is authentication procedure and another is Return Routability procedure in MIPv6. Because FMIPv6 doesn’t consider these two procedure, there is difficulty to provide QoSguaranteed service. we introduce a QoS-Supporting Agent (QSA) for FMIPv6 as optional entity. By transmitting duplicate packets to a Mobile Node’s new access network while handovering, seamless data communication is possible. Simulation result shows QSA scheme is more suitable than FMIPv6 for QoS service.

Histopathologic risk factors for lymph node metastasis in patients with T1 colorectal cancer

Ryun Kyong Ha,Kyung Su Han,Dae Kyung Sohn,Byung Chang Kim,Chang Won Hong,Hee Jin Chang,Jong Hee Hyun,Min Jung Kim,Sung Chan Park,Jae Hwan Oh 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.93 No.5

Purpose: Evaluating the risk of lymph node metastasis (LNM) is critical for determining subsequent treatments following endoscopic resection of T1 colorectal cancer (CRC). This study analyzed histopathologic risk factors for LNM in patients with T1 CRC. Methods: This study involved 745 patients with T1 CRC who underwent endoscopic (n = 97) or surgical (n = 648) resection between January 2001 and December 2015 at the National Cancer Center, Korea. LNM in endoscopically resected patients, which could not be evaluated directly, was estimated indirectly based on follow-up results and histopathologic reports of salvage surgery. The relationships of depth of submucosal invasion, histologic grade, budding, vascular invasion, and background adenoma with LNM were evaluated statistically. Results: Of the 745 patients, 91 (12.2%) were found to be positive for LNM. Univariate and multivariate analyses identified deep submucosal invasion (P = 0.010), histologic high grade (P < 0.001), budding (P = 0.034), and vascular invasion (P < 0.001) as risk factors for LNM. Among the patients with one, two, three, and four risk factors, 6.0%, 18.7%, 36.4%, and 100%, respectively, were positive for LNM. Conclusion: Deep submucosal invasion, histologic high grade, budding, and vascular invasion are risk factors for LNM in patients with T1 colorectal cancer. If any of these risk factors are present, additional surgery following endoscopic resection should be determined after considering the potential risk of LNM and each patient’s situation.

Histopathologic risk factors for lymph node metastasis in patients with T1 colorectal cancer

Ha, Ryun Kyong,Han, Kyung Su,Sohn, Dae Kyung,Kim, Byung Chang,Hong, Chang Won,Chang, Hee Jin,Hyun, Jong Hee,Kim, Min Jung,Park, Sung Chan,Oh, Jae Hwan The Korean Surgical Society 2017 Annals of Surgical Treatment and Research(ASRT) Vol.93 No.5

<P><B>Purpose</B></P><P>Evaluating the risk of lymph node metastasis (LNM) is critical for determining subsequent treatments following endoscopic resection of T1 colorectal cancer (CRC). This study analyzed histopathologic risk factors for LNM in patients with T1 CRC.</P><P><B>Methods</B></P><P>This study involved 745 patients with T1 CRC who underwent endoscopic (n = 97) or surgical (n = 648) resection between January 2001 and December 2015 at the National Cancer Center, Korea. LNM in endoscopically resected patients, which could not be evaluated directly, was estimated indirectly based on follow-up results and histopathologic reports of salvage surgery. The relationships of depth of submucosal invasion, histologic grade, budding, vascular invasion, and background adenoma with LNM were evaluated statistically.</P><P><B>Results</B></P><P>Of the 745 patients, 91 (12.2%) were found to be positive for LNM. Univariate and multivariate analyses identified deep submucosal invasion (P = 0.010), histologic high grade (P < 0.001), budding (P = 0.034), and vascular invasion (P < 0.001) as risk factors for LNM. Among the patients with one, two, three, and four risk factors, 6.0%, 18.7%, 36.4%, and 100%, respectively, were positive for LNM.</P><P><B>Conclusion</B></P><P>Deep submucosal invasion, histologic high grade, budding, and vascular invasion are risk factors for LNM in patients with T1 colorectal cancer. If any of these risk factors are present, additional surgery following endoscopic resection should be determined after considering the potential risk of LNM and each patient's situation.</P>

Association between change in working time arrangements and sleep disturbance

Ryun Ha,Jae Bum Park,Kyung-Jong Lee,Sunguk Choi,Inchul Jeong 대한직업환경의학회 2020 대한직업환경의학회지 Vol.32 No.-

Background: Change in working time arrangement (WTA) can be harmful to workers" sleep and health. This study aimed to investigate the association between change in working time arrangement and sleep disturbance. Methods: This study used data from the Fifth Korean Working Condition Survey and included 33,203 paid workers. We performed a stratified analysis by sex. After dividing the participants into 6 groups based on whether or not they experienced WTA changes, and their weekly working hours (≤40, 41–52, ≥53 hours), we calculated odds ratio (OR) using the weekly working hours ≤40 hours and with no WTA change as the reference group. Results: Of the 33,203 paid workers, participants who experienced change in working time arrangement had higher prevalence of all three types of sleep disturbance symptoms (difficulty in falling asleep, waking up repeatedly during sleep, and waking up with a feeling of exhaustion and fatigue) in both sexes. Compared to the reference group at 95% confidence interval (CI), the group with change in WTA showed elevated OR values of 1.91 (95% CI: 1.73–2.11), 1.93 (95% CI: 1.74–2.14), 2.47 (95% CI: 2.26–2.71) for male workers; and 1.93 (95% CI: 1.73–2.16), 2.02 (95% CI: 1.80–2.27), 2.24 (95% CI: 2.01–2.50) for female workers, for difficulty in falling asleep, waking up repeatedly during the sleep, waking up with a feeling of exhaustion, and fatigue, respectively. Conclusions: Workers who experience change in work time arrangement show a high risk of sleep disturbance in both sexes.

Efficacy and safety of endoscopic clipping for acute anastomotic bleeding after colorectal surgery

Ha Ryun Kyong,Han Kyung Su,Park Sung Sil,Sohn Dae Kyung,Hong Chang Won,Kim Byung Chang,Kim Bun 대한대장항문학회 2022 Annals of Coloproctolgy Vol.38 No.3

Purpose: Anastomotic bleeding after colorectal surgery is a rare, mostly self-limiting, postoperative complication that could lead to a life-threatening condition. Therefore, prompt management is required. This study aimed to evaluate the efficacy and safety of endoscopic clipping for acute anastomotic bleeding after colorectal surgery. Methods: We retrospectively reviewed the data of patients pathologically diagnosed with colorectal cancer at National Cancer Center, Korea from January 2018 to November 2020, which presented with anastomotic bleeding within the first postoperative week and were endoscopically managed with clips. Results: Nine patients had anastomotic bleeding, underwent endoscopic management, and, therefore, were included in this study. All patients underwent laparoscopic (low/ultralow) anterior resection with mechanical double-stapled anastomosis. Anastomotic bleeding was successfully managed through a colonoscopy with clips on the first trial in all patients. Hypovolemic shock occurred in one patient, following anastomotic breakdown. Conclusion: Endoscopic clipping seems to be an effective and safe treatment for anastomotic bleeding with minimal physiologic stress, easy accessibility, and scarce postoperative complications. However, a surgical backup should always be considered for massive bleeding.

Can the Tinnitus Magnitude Index Reflect the Depression and Anxiety of Tinnitus Sufferers?

Ha Ryun Kim,Junghwa Bahng 한국청각언어재활학회 2021 Audiology and Speech Research Vol.17 No.4

Purpose: This study evaluates the relationship between tinnitus magnitude and depression and statetrait anxiety. Methods: A total of 65 subjects suffering from tinnitus participated. None reported any hearing problems. The participants filled in the Tinnitus Magnitude Index (TMI), the Korean version of the Beck depression inventory, and the Korean version of state-trait anxiety questionnaires with 61 out of 65 subjects completing all the questionnaires. Results: No significant relationships between tinnitus magnitude and depression or state-trait anxiety were found. However, items for the TMI were found to be significantly related (p < 0.05), and depression and state-strait anxiety also had a significant relationship (p < 0.05). Conclusion: We concluded that the TMI was not sensitive when used for assessing depression and anxiety in individuals who are suffering from tinnitus, which implying that the TMI questionnaire is useful for a quick assessment tool of the severity of tinnitus in individuals.

MIPv6상에서 QoS를 보장하기 위한 핸드오버간 셀 커버리지 확장방안

이하륜(Ha Ryun Lee),김문기(Mun Gi Kim),이병호(Byung Ho Rhee) 대한전자공학회 2006 대한전자공학회 학술대회 Vol.2006 No.11

MIPv6에서는 끊김 없는 데이터 전송 서비스를 지원하기 위하여 해드오버시의 지연시간을 줄이는 FMIPv6가 제안되었다. FMIPv6상에서 핸드오버시의 재설정과정동안은 데이터를 수신받지 못하므로 해드오버과정을 줄이는 방법을 사용한다. 만약 핸드오버시에도 끊김 없이 데이터를 계속 받을 수 있는 방법이 있다면 핸드오버과정은 QoS서비스를 제공하기 위한 고려대상이 될 필요는 없다. 본 논문에서는 이동단말이 이동중에도 데이터를 끊김 없이 받을 수 있는 새로운 방법과 이를 위한 새로운 통신 프로토콜 스택 구조를 제안하여 보았다.